Psychotraumatic Interventions and Post-Traumatic Stress Disorder among the Lomé Firefighters

Aim: This study aimed to assess the quality of the psychological experience of mobile emergency teams, in particular firefighters (FF) in Togo and to identify the psychotraumatic interventions (PI) they face. Method: This was a cross-sectional, descriptive, statistical analysis and discourse content analysis study on the PIs of the Lomé FFs. Results: PIs were found to be: road accidents;defenestrations;self-immolation murders;bloody and non-bloody suicides;well interventions with or without drowning;extensive burns;and paediatric procedures. Adults aged 25 to 45 were at a percentage of 69.1% and with a sex ratio of 7.1. More than half of the respondents (53%) had PTSD. Conclusion: More than half of the respondents had PTSD, however, coping strategies were not explored, suggesting the need for further research.

荷莲饮对糖尿病前期合并代谢综合征的影响

观察中药荷莲饮联合一般生活方式干预的综合干预,对于糖尿病前期合并代谢综合征(MS)患者转糖尿病风险的影响。方法:采用随机、双盲平行对照临床研究。60例糖尿病前期合并代谢综合征患者,随机分为中药联合一般生活方式干预组(A)及一般生活方式干预组(B),观察12个月。结果:纳入统计60例,治疗组A30例,对照组B30例,两组入选患者各项资料无明显统计学差异。结果显示,中医综合干预可降低糖尿病前期合并MS患者发生糖尿病的发生率,同时可控制血糖,改善代谢综合征。结论:中医综合干预可改善糖尿病前期合并MS患者,延缓糖尿病的发生。

聚焦解决模式心理干预对骨折患者焦虑抑郁情绪的影响

目的：探讨以聚焦解决模式为基础的心理干预对骨折患者焦虑抑郁情绪的影响。方法将100例骨折伴焦虑抑郁情绪患者按随机数字表法分为两组，每组50例，均予以常规治疗及护理干预，观察组在此基础上实施以聚焦解决模式为基础的心理干预，观察住院全程。干预前后采用汉密顿焦虑量表、汉密顿抑郁量表评定焦虑抑郁状况，统计患者的满意度。结果干预后两组汉密顿焦虑量表、汉密顿抑郁量表评分均较干预前显著下降（P＜0．01），但观察组评分显著低于对照组（ P＜0．01）；观察组总满意率为96．0％，对照组为78．0％，观察组总满意率显著高于对照组（P＜0．01）。结论以聚焦解决模式为基础的心理干预能显著缓解各种骨折患者的焦虑抑郁情绪，增强治疗信心，提高治疗依从性及满意度。

Impact of an Active Pharmacovigilance Program in a Third-Level Clinic in Barranquilla, Colombia

The objective of this study is to assess the impact of APV （active pharmacovigilance） and PPV （passive pharmacovigilance） by detection of ADEs （adverse drug events）, through PIs （pharmaceutical interventions）. Authors have used observational pre-post intervention study. Dader methodology was used in 123 patients with data obtained from medical records and pharmaceutical interview. Detection of ADE was made by direct observation and laboratory tests, with statistical significance 0.05. In PPV, 47 ADEs were detected： nausea, vomiting, skin rash and skin redness. In APV, 100 ADEs are presented, similar to those described in the PPV, in which Dipyrone produced 26.2%. The causes of DRPs （drug related problems） were： probability of adverse events 36%, personal characteristics 30%, and dose regimen and/or inadequate duration 22%. Out of 127 PIs performed, 91.34% were accepted and resolved. The patient satisfaction rate was 82.7% for APV and doctor satisfaction 90.4% with high impact, surpassing the 80%. The impact of APV was 93.6% and 53% in PPV for PIs and ADEs. PIs were performed to the ADEs with a high percentage of accepted and solved ones. Evaluation of satisfaction of patients and doctors in APV had a high impact. The assessment of APV generated a high impact on compliance and PPV a low one.

电针对胰岛素抵抗大鼠下丘脑磷脂酰肌醇3激酶及磷脂酰肌醇3激酶催化亚基蛋白表达的影响

目的:观察"双固一通"电针法对胰岛素抵抗模型大鼠下丘脑中的磷脂酰肌醇3激酶(PI 3Kp 110)及磷脂酰肌醇3激酶催化亚基(p-PI 3Kp 110)蛋白表达的影响,探讨"双固一通"电针法改善胰岛素抵抗的机制。方法:雄性Wistar大鼠随机分为正常组、模型组、预防组、电针组、脑脊液组及阻滞剂组,每组10只。以高脂饮食喂养复制胰岛素抵抗模型大鼠。预防组、电针组、脑脊液组和阻滞剂组电针"关元""后三里""丰隆""中脘",每周治疗5次,预防组治疗16周,其余各组治疗8周。脑脊液组进行脑室内人工脑脊液灌注,阻滞剂组脑室内灌注渥曼青霉素。观察造模后及治疗后各组大鼠体质量(BW)、空腹血糖(FPG)、血清胰岛素(FINS)水平,并比较各组胰岛素敏感指数(IAI);Western blot法检测大鼠下丘脑PI 3Kp 110及p-PI 3Kp 110蛋白表达。结果:与正常组比较,模型组、预防组、电针组、脑脊液组及阻滞剂组造模后BW、FPG及FINS明显升高(P<0.01,P<0.05),IAI降低(P<0.01);与模型组比较,治疗后预防组与电针组大鼠BW、FPG、FINS降低(P<0.05,P<0.01),脑脊液组BW、FPG降低(P<0.05,P<0.01),预防组、电针组及脑脊液组IAI升高(P<0.05);与阻滞剂组比较,脑脊液组、电针组及预防组BW、FPG、FINS降低(P<0.05,P<0.01),IAI升高(P<0.05)。与正常组比较,模型组下丘脑PI 3Kp 110及pPI 3Kp 110蛋白表达减少(P<0.01);与模型组比较,预防组、电针组、脑脊液组PI 3Kp 110及p-PI 3Kp 110蛋白表达升高(P<0.01,P<0.05);与阻滞剂组比较,预防组、电针组、脑脊液组PI 3Kp 110及pPI 3Kp 110蛋白表达升高(P<0.01,P<0.05)。结论:"双固一通"电针法改善胰岛素抵抗状态,与提高模型大鼠下丘脑中PI 3Kp 110蛋白及p-PI 3Kp 110蛋白表达有关。