Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.

A Model of Grand Unified Theory: Suggested Solution for CP-Violation Using Ideas of Phase Paths

This study demonstrates that beyond standard model (BSM) cosmic fundamental interactions—weak, strong, and electromagnetic forces—can be unified through a common basis of representation. This unification allows for the derivation of the fine structure constant with running points of α(t) ≈ 1/(136.9038) at high energy scales, based on electroweak interactions. Through the application of the Ising model, the running point of the elementary charge e at high energy scales is determined, and Coulomb’s law is actually derived from the Yukawa potential. Theoretically, based on S. Weinberg’s electroweak interaction theory, this study unifies the strong and electromagnetic forces by representing them with rYuka, and further advances the reconstruction of the SU(3)C×SU(1)L×U(1)EMframework on the basis of electroweak interaction concepts. In fact, the cosmic fundamental forces can interchange at the mass gap, defined as the Yukawa turning phase at rYuka ≃1.9404 fm, with the SU(3)Diag structural constant fijk on glueballs calculated, estimating a spectrum mass gap of ∆0 > 0.

Evaluating the role of large language models in inflammatory bowel disease patient information

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease patients.While promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and reliability.Emphasizing that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

Solving the Olbers’s Paradox, Explaining the “Red-Shift”, and Challenging the Relativities by “Sun Matters Theory” and “Sun Model of Universe”, an Evolution of the Einstein’s Static Universe Model

Olbers’s paradox, known as the dark night paradox, is an argument in astrophysics that the darkness of the night sky conflicts with the assumption of an infinite and eternal static universe. Big-Bang theory was used to partially explain this paradox, while introducing new problems. Hereby, we propose a better theory, named Sun Matters Theory, to explain this paradox. Moreover, this unique theory supports and extended the Einstein’s static universe model proposed by Albert Einstein in 1917. Further, we proposed our new universe model, “Sun Model of Universe”. Based on the new model and novel theory, we generated innovative field equation by upgrading Einstein’s Field Equation through adding back the cosmological constant, introducing a new variable and modifying the gravitationally-related concepts. According to the Sun Model of Universe, the dark matter and dark energy comprise the so-called “Sun Matters”. The observed phenomenon like the red shift is explained as due to the interaction of ordinary light with Sun Matters leading to its energy and frequency decrease. In Sun Model, our big universe consists of many universes with ordinary matter at the core mixed and surrounded with the Sun Matters. In those universes, the laws of physics may be completely or partially different from that of our ordinary universe with parallel civilizations. The darkness of night can be easily explained as resulting from the interaction of light with the Sun Matters leading to the sharp decrease in the light intensity. Sun Matters also scatter the light from a star, which makes it shining as observed by Hubble. Further, there is a kind of Sun Matters named “Sun Waters”, surrounding every starts. When lights pass by the sun, the Sun Waters deflect the lights to bend the light path. According to the Sun Model, it is the light bent not the space bent that was proposed in the theory of relativities.

Hubble Tension Explanation from This Cosmological Model AΛΩ (Slow Bang Model, SB)

In this article we present a model of Hubble-Lemaître law using the notions of a transmitter (galaxy) and a receiver (MW) coupled to a model of the universe (Slow Bang Model, SB), based on a quantum approach of the evolution of space-time as well as an equation of state that retains all the infinitesimal terms. We find an explanation of the Hubble tension H0. Indeed, we have seen that this constant depends on the transceiver pair which can vary from the lowest observable value, from photons of the CMB (theoretical [km/s/Mpc]) to increasingly higher values depending on the earlier origin of the formation of the observed galaxy or cluster (ETG ~0.3 [Gy], ~74 [km/s/Mpc]). We have produced a theoretical table of the values of the constant according to the possible pairs of transmitter/receiver in the case where these galaxies follow the Hubble flow without large disturbance. The calculated theoretical values of the constant are in the order of magnitude of all values mentioned in past studies. Subsequently, we applied the models to 9 galaxies and COMA cluster and found that the models predict acceptable values of their distances and Hubble constant since these galaxies mainly follow the Hubble flow rather than the effects of a galaxy cluster or a group of clusters. In conclusion, we affirm that this Hubble tension does not really exist and it is rather the understanding of the meaning of this constant that is questioned.

Analysis of Porter’s Five Forces Competitive Model in China’s Property Rights Trading Market

In recent years,China’s property rights trading market has been extremely competitive,but there are also new contradictions and challenges.This paper aims to analyze the external and internal competitive market of the property rights market through Porter’s five forces competition model,then find out the problems and defects in the development,thereby promoting the better development and progress of China’s property rights trading market.

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

Rock skeleton models and seismic porosity inversion

By substituting rock skeleton modulus expressions into Gassmann approximate fluid equation, we obtain a seismic porosity inversion equation. However, conventional rock skeleton models and their expressions are quite different from each other, resuling in different seismic porosity inversion equations, potentially leading to difficulties in correctly applying them and evaluating their results. In response to this, a uniform relation with two adjusting parameters suitable for all rock skeleton models is established from an analysis and comparison of various conventional rock skeleton models and their expressions including the Eshelby-Walsh, Pride, Geertsma, Nur, Keys-Xu, and Krief models. By giving the two adjusting parameters specific values, different rock skeleton models with specific physical characteristics can be generated. This allows us to select the most appropriate rock skeleton model based on geological and geophysical conditions, and to develop more wise seismic porosity inversion. As an example of using this method for hydrocarbon prediction and fluid identification, we apply this improved porosity inversion, associated with rock physical data and well log data, to the ZJ basin. Research shows that the existence of an abundant hydrocarbon reservoir is dependent on a moderate porosity range, which means we can use the results of seismic porosity inversion to identify oil reservoirs and dry or water-saturated reservoirs. The seismic inversion results are closely correspond to well log porosity curves in the ZJ area, indicating that the uniform relations and inversion methods proposed in this paper are reliable and effective.

Modeling foraging habitats of Hume’s Pheasant (Syrmaticus humiae) in Dazhong Mountain, Yunnan, southwestern China

We modeled foraging habitats of Hume’s Pheasant (Syrmaticus humiae) on a macro-habitat level using ArcGIS in an attempt to provide scientific reference for management and restoration of habitats. Field work was conducted from March to April in 2006 and 2008, and from October to November in 2005 and 2008 in Dazhong Mountain, Yunnan Province, southwestern China. The selection of ecological factors was estimated by means of a resource selection index, distance analysis and the method of hierarchical habitat selection. The foraging habitat patches were modeled spatially by ArcGIS. The results show that actual and potential foraging patches overlapped considerably in spring and autumn. The number and total areas of patches in the autumn were smaller than those in the spring. The minimum and average areas of patches in the autumn were larger than those in the spring, while the maximum areas of actual and potential foraging patches in the autumn were equal to those in the spring. Similarity in the selection for survival and safety consideration in both seasons was the main strategy for landscape factors of habitats by Hume’s Pheasant, while seasonal difference in selecting a landscape matrix was their secondary strategy, affecting landscape factors in the habitat. Changes of foraging patches in both seasons reflect a difference of resources requirement by the bird. Fragmentation and miniaturization of foraging patches would result in the formation of a meta-population of Hume’s Pheasant.

Leaf Area Calculation Model of E.urophylla and E.grandis×E.urophylla

[Objective] The aim was to build an optimal leaf area measurement model of E. urophylla and E. grandis×E.urophylla. [Method] The correlation between leaf area and leaf＇s eigenvalue of E. urophylla and E. grandis×E.urophylla were studied. [Result] There was certain difference in leaf characteristics values between the 2 species. The leaf areas of E. urophylla and E. grandis×E.urophylla both had significant correlation with leaf length,leaf width,leaf perimeter,leaf length × leaf width,the ratio of leaf length to leaf width,shape factor,etc.,so the factors could be constructed into a regression model with leaf area. Among them,the best 2 models for leaf area calculation which were built by leaf length × leaf width of E. urophylla and E. grandis×E.urophylla both had relatively high accuracy and practical applications. [Conclusion] The research provides a simple and effective leaf area measurement method for studies on the 2 tree species.

The Cultural Implication of Brick Carving Model Calligraphy in Shanxi Chang's Manor

Focusing on the unique style of brick carving model calligraphy in Shanxi Chang's manor,this research analyses the content and feature of the different parts of brick carving,and discuses the presenting cultural deposits.It reflects the deep Confucian culture of Shanxi Chang's manor,with the peculiar charming in culture and aesthetic value.

高压管汇材料疲劳性能测试及P-S-N模型曲线的拟合

高压管汇作为压裂设备中的主要易损件之一,其失效危害较大。它的失效原因主要是疲劳、冲蚀、腐蚀或者材料缺陷引起的刺漏和爆裂,其中尤以疲劳失效最不可预估。目前,对于高压管汇材料的疲劳性能研究不够深入,为解决高压管汇材料疲劳寿命的准确描述问题,以某国产高压管汇材料为例,进行了一系列疲劳试验,并基于试验数据,采用多种分布模型和不同S-N模型进行拟合分析,得出综合评价拟合能力最强的P-S-N模型。结果表明,该材料在中长疲劳寿命区,Weibull三参数模型在7级应力水平下综合评价能力最好;在存活率分别为50%、90%、99%、99.9%时,指数S-N模型的拟合系数均大于0.98,拟合能力最好。得出的P-S-N模型曲线可以为高压管汇的疲劳寿命以及安全设计提供依据。

Analysis of the Self-correction Model——from the view of cognitive psychology

In view of the learners Chinglish,this paper puts forward a new teaching model-the Self-correction Model and makes an analysis of it from the view of cognitive psychology.

深水采油树Spring-Seal密封圈接触模型构建与实验测试

为提高深水采油树在高压、高温、低温等工况下长时间工作的稳定性,对采油树密封圈进行重新设计,提出Spring-Seal密封圈(以下简称S密封圈);基于赫兹接触理论、填料密封接触理论,重新构建S密封圈接触力学模型;建立有限元仿真分析模型,分析不同条件下S密封圈的密封性能,同时验证新建接触模型的合理性;利用实验测试S密封圈的实际密封效果。研究结果表明:S密封圈在高压、高温、低温等工况下能够长时间稳定工作且密封性能良好。研究结果可为S密封圈的接触研究及工程运用提供理论参考。

Functions of Allusions from Leppihalme’s model

The general function of allusions is often thought to add clarity and significance to ideas and descriptions.However,it would be difficult to establish an exhaustive list of mutually exclusive category

DYNAMIC MODELING FOR AIRSHIP EQUIPPED WITH BALLONETS AND BALLAST

Total dynamics of an airship is modeled. The body of an airship is taken as a submerged rigid body with neutral buoyancy, i. e. , buoyancy with value equal to that of gravity, and the coupled dynamics between the body with ballonets and ballast is considered. The total dynamics of the airship is firstly derived by Newton-Euler laws and Kirchhoff＇ s equations. Furthermore, by using Hamiltonian and Lagrangian semidirect product reduction theories, the dynamics is formulated as a Lie-Poisson system, or also an Euler-Poincare system. These two formulations can be exploited for the control design using energy-based methods for Hamiltonian or Lagrangian system.

D-S理论和Markov链组合的桥梁性能退化预测研究

为准确预测桥梁性能退化,考虑到数据随机性和微小扰动发生状态跳跃,提出了一种D-S(Dempster-Shafer)证据理论和Markov链组合的桥梁性能退化组合预测模型和性能退化率的概念.该模型基于指数平滑(exponential smoothing,ES)方法获得新的预测数据序列,并利用Markov链和D-S理论不断进行优化,从而实现桥梁性能退化的组合预测.实际工程的应用结果表明:性能退化率可以直观地表征在梁性能退化的速度.其次,该模型的平均相对误差为1.54%,较于回归、灰色和模糊加权Markov链模型,精度分别提高了1.11%,0.88%和2.8%,而后验差比值为0.242,小于0.35;模型的标准差为9.021,相比其他模型分别减小了3.978,3.405和7.500,而变异系数为0.109,均小于其他模型,验证了组合预测模型在精度和稳定性方面的优越性,可为在役桥梁结构性能退化预测与维护提供理论基础.

基于量子衍生涡流算法和T⁃S模糊推理模型的储层岩性识别

鉴于梯度下降法易陷入局部极值、普通群智能优化算法易早熟收敛,提出一种基于量子衍生涡流算法(Quantum Vortex Search Algorithm,QVSA)和T⁃S模糊推理模型的岩性识别方法,QVSA具有操作简单、收敛速度快、寻优能力强等优点,有助于T⁃S模糊推理模型获得最优参数配置,从而实现储层岩性的准确识别。首先利用具有全局搜索能力的QVSA优化T⁃S模糊推理模型的各种参数;然后利用主成分分析方法降低获取的地震属性维度;再利用优化的T⁃S模糊推理模型识别储层岩性。实验结果表明,利用反映储层特征的8个地震属性识别储层岩性时,所提方法的识别正确率达到92%,比普通BP网络方法高5.1%,同时查准率、查全率、F1分数等指标也较BP网络方法提升明显。

Numerical Investigation of Penetration in Ceramic/Aluminum Targets Using Smoothed Particle Hydrodynamics Method and Presenting a Modified Analytical Model

Radius of ceramic cone can largely contribute into final solution of analytic models of penetration into ceramic/metal targets.In the present research,a modified model based on radius of ceramic cone was presented for ceramic/aluminum targets.In order to investigate and evaluate accuracy of the presented analytic model,obtained results were compared against the results of the Florence’s analytic model and also against numerical modeling results.The phenomenon of impact onto ceramic/aluminum composites were modeled using smoothed particle hydrodynamics(SPH)implemented utilizing ABAQUS Software.Results indicated that,with increasing initial velocity and ceramic thickness and decreasing support layer thickness,the radius of ceramic cone decreases;this ends up increasing residual velocity of the projectile and penetration time and extending the area across which the pressure is distributed.These findings indicate enhanced levels of target energy absorption and the required energy for bending and tensioning the target.As such,it can be observed that,at the same thickness and areal density,the ceramic target has its efficiency enhanced with increasing ceramic thickness and decreasing the support layer thickness.Finally,the results revealed that the associated data with SPH confirm the modified analytic model at higher accuracy than the Florence’s analytic model.

Animal models of Alzheimer’s disease: Applications, evaluation, and perspectives

Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer’s disease(AD)have been made and multifarious novel therapeutic approaches have been developed,AD remains an incurable disease.Evidence shows that AD neuropathology occurs decades before clinical presentation.AD is divided into three stages:preclinical stage,mild cognitive impairment(MCI),and AD dementia.In the natural world,some animals,such as non-human primates(NHPs)and canines,can develop spontaneous AD-like dementia.However,most animals do not develop AD.With the development of transgenic techniques,both invertebrate and vertebrate animals have been employed to uncover the mechanisms of AD and study treatment methods.Most AD research focuses on early-onset familial AD(FAD)because FAD is associated with specific genetic mutations.However,there are no well-established late-onset sporadic AD(SAD)animal models because SAD is not directly linked to any genetic mutation,and multiple environmental factors are involved.Moreover,the widely used animal models are not able to sufficiently recapitulate the pathological events that occur in the MCI or preclinical stages.This review summarizes the common models used to study AD,from yeast to NHP models,and discusses the different applications,evaluation methods,and challenges related to AD animal models,as well as prospects for the evolution of future studies.