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Significance of Fractional Exhaled Nitric Oxide Combined with Serum Procalcitonin and C-Reactive Protein in Evaluation of Elderly Asthma 被引量:7
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作者 吴纪珍 马利军 +3 位作者 赵丽敏 张晓宇 陈献亮 况红艳 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2013年第2期185-188,共4页
Bronchial asthma is a common chronic airway inflammatory disease. Asthma is associated with high mortality, especially in the elderly patients. Repeated exacerbations cause disease progression. Therefore, identifying ... Bronchial asthma is a common chronic airway inflammatory disease. Asthma is associated with high mortality, especially in the elderly patients. Repeated exacerbations cause disease progression. Therefore, identifying the onset of acute elderly asthma as soon as possible and giving the effective treatment is crucial to improve the prognosis. This study was to investigate the significance of fractional exhaled nitric oxide (FeNO) combined with serum procalcitonin (PCT) and C-reactive protein (CRP) in the evaluation of elderly asthma. A total of 120 elderly patients with an acute attack of asthma from July, 2010 to May, 2012 were studied. On presentation, FeNO, serum PCT and CRP concentrations were measured and sputum culture was also performed. The elderly patients were re-evaluated when they had returned to their stable clinical state. The elderly patients were classified into two groups: positive bac- terial culture group (A) and negative bacterial culture group (B). The results showed that: (1) In patients with an acute exacerbation of asthma, 48 (40%) patients had positive sputum bacterial culture and 72 (60%) had negative sputum bacterial culture. (2) The levels of FeNO in patients with acute exacerbation of asthma were significantly higher than in those with no acute exacerbation state (63.8±24.6 vs. 19±6.5 ppb, P〈0.05). There was no significant difference in FeNO between group A and group B (P〉0.05). (3) The levels of PCT and CRP in group A patients with an acute exacerbation of asthma were significantly higher (P〈0.05) than in group B (for PCT: 27.46±9.32 vs. 7.85±3.52 ng/mL; for CRP: 51.25±11.46 vs. 17.11±5.87 mg/L, respectively). When they had returned to stable clinical state, the levels of PCT and CRP in group A were decreased significantly (P〈0.05), and those in group B had no significant change (P〉0.05) when compared with the exacerbation group. There were no significant differences in the levels of PCT and CRP between the two groups in non-acute exacerbation state (/9〉0.05). These results suggest that the increase in FeNO indicates the acute exacerbation of asthma, and the elevation of serum PCT and CRP levels may be associated with bacterial infection. 展开更多
关键词 ELDERLY ASTHMA fractional exhaled nitric oxide procalcitonin c-reactive protein bacterial infection
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Infection recurrence following minimally invasive treatment in patients with infectious pancreatic necrosis 被引量:5
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作者 Chong-Chong Gao Jia Li +4 位作者 Feng Cao Xiao-Hui Wang Ang Li Zhe Wang Fei Li 《World Journal of Gastroenterology》 SCIE CAS 2020年第22期3087-3097,共11页
BACKGROUND In recent decades,an increasing number of patients have received minimally invasive intervention for infected pancreatic necrosis(IPN)because of the benefits in reducing postoperative multiple organ failure... BACKGROUND In recent decades,an increasing number of patients have received minimally invasive intervention for infected pancreatic necrosis(IPN)because of the benefits in reducing postoperative multiple organ failure and mortality.However,there are limited published data regarding infection recurrence after treatment of this patient population.AIM To investigate the incidence and prediction of infection recurrence following successful minimally invasive treatment in IPN patients.METHODS Medical records for 193 IPN patients,who underwent minimally invasive treatment between February 2014 and October 2018,were retrospectively reviewed.Patients,who survived after the treatment,were divided into two groups:one group with infection after drainage catheter removal and another group without infection.The morphological and clinical data were compared between the two groups.Significantly different variables were introduced into the correlation and multivariate logistic analysis to identify independent predictors for infection recurrence.Sensitivity and specificity for diagnostic performance were determined.RESULTS Of the 193 IPN patients,178 were recruited into the study.Of them,9(5.06%)patients died and 169 patients survived but infection recurred in 13 of 178 patients(7.30%)at 7(4-10)d after drainage catheters were removed.White blood cell(WBC)count,serum C-reactive protein(CRP),interleukin-6,and procalcitonin levels measured at the time of catheter removal were significantly higher in patients with infection than in those without(all P<0.05).In addition,drainage duration and length of the catheter measured by computerized tomography scan were significantly longer in patients with infection(P=0.025 and P<0.0001,respectively).Although these parameters all correlated positively with the incidence of infection(all P<0.05),only WBC,CRP,procalcitonin levels,and catheter length were identified as independent predictors for infection recurrence.The sensitivity and specificity for infection prediction were high in WBC count(≥9.95×109/L)and serum procalcitonin level(≥0.05 ng/mL)but moderate in serum CRP level(cut-off point≥7.37 mg/L).The catheter length(cut-off value≥8.05 cm)had a high sensitivity but low specificity to predict the infection recurrence.CONCLUSION WBC count,serum procalcitonin,and CRP levels may be valuable for predicting infection recurrence following minimally invasive intervention in IPN patients.These biomarkers should be considered before removing the drainage catheters. 展开更多
关键词 infectious pancreatic necrosis Drainage Minimally invasive intervention infection recurrence c-reactive protein procalcitonin
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Study on the relationship between serum PCT, CRP level and atypical lymphocyte ratio and severity of respiratory virus infection
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作者 Yi Cheng Jin-Xiang Liu 《Journal of Hainan Medical University》 2018年第21期5-8,共4页
Objective: To investigate the relationship between serum procalcitonin (PCT) and C-reactive protein (CRP) combined with the proportion of atypical lymphocytes and severity of respiratory virus infection. Methods: A to... Objective: To investigate the relationship between serum procalcitonin (PCT) and C-reactive protein (CRP) combined with the proportion of atypical lymphocytes and severity of respiratory virus infection. Methods: A total of 113 children with respiratory infection in our hospital from January 2018 to August 2018 were enrolled. According to the type of infection, they were divided into bacterial infection group (n=38) and virus infection group (n=52), 60 healthy children were selected as the control group. Serum PCT, CRP and atypical lymphocyte ratios were measured in each group, and the relationship between them and the severity of the disease was analyzed. Results: The serum CRP and PCT in the bacterial infection group were significantly higher than those in the virus-infected group and the control group. While The ratio of atypical lymphocytes in the virus-infected group was significantly higher than that in the bacterial-infected group and the control group;The serum PCR, CRP and atypical lymphocyte ratio gradually increased with the severity of the disease, the difference was statistically significant. Pearson correlation analysis showed that serum PCT, CRP content and atypical lymphocyte ratio were significantly positively correlated with the severity of the disease. The positive rate of PCR and CRP in the bacterial infection group was significantly higher than that in the virus infection group. The positive rate of heterotypic lymphocyte ratio was significantly lower than that in the virus infection group. Conclusion: The detection of serum PCT and CRP levels has a good diagnostic value for bacterial respiratory infections. The ratio of atypical lymphocytes can be used as a preliminary aid in the diagnosis of respiratory virus infection-related diseases. The combination of the two is of great significance for the clinical diagnosis of children with respiratory infections. 展开更多
关键词 procalcitonin c-reactive protein ATYPICAL LYMPHOCYTES RESPIRATORY infection
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血培养联合血清PCT、CRP水平检测对产科重症产褥感染患者诊断准确率的影响 被引量:5
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作者 焦江琴 《临床研究》 2020年第4期132-133,共2页
目的探究血培养联合血清降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)检测对产科重症产褥感染患者诊断准确率的影响。方法选取河南科技大学第二附属医院检验科2016年6月-2018年6月产褥感染患者86例、同期正常产后... 目的探究血培养联合血清降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)检测对产科重症产褥感染患者诊断准确率的影响。方法选取河南科技大学第二附属医院检验科2016年6月-2018年6月产褥感染患者86例、同期正常产后体检健康者56例为研究对象,于产后3d抽取空腹静脉血,行血培养、血清PCT、CRP检测,分析对比检测结果。结果产褥感染患者86例,PCT检出64例,血培养检出75例,CRP检出64例,三者联合检出83例,三者联合诊断准确率92.25%、灵敏度96.51%高于PCT(80.28%、74.42%)、血培养(87.32%、87.21%)、CRP(78.87%、74.42%)单独诊断(P<0.05);血培养联合PCT、CRP检测漏诊率3.49%低于PCT(25.58%)、血培养(12.79%)、CRP(25.58%)单独检测(P<0.05)。结论血培养联合PCT、CRP检测具有较高应用价值,可提高准确率和灵敏度,降低漏诊率,有利于产科重症产褥感染的早期诊断,对治疗产褥感染治疗有重要指导作用。 展开更多
关键词 血培养 降钙素原 C反应蛋白 产褥感染
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血清PCT及CRP对产妇并发产褥期感染的临床预判价值 被引量:6
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作者 翁科娜 应元首 毛佳瑜 《浙江临床医学》 2017年第10期1903-1904,共2页
目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)联合检测对产妇发生产褥期感染的临床预判价值。方法回顾性分析2014年1月&2016年12月收治的8994例产妇的临床资料。结果899例产妇中有42例发生产褥感染,其发生率为4.67%。感染组PCT、... 目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)联合检测对产妇发生产褥期感染的临床预判价值。方法回顾性分析2014年1月&2016年12月收治的8994例产妇的临床资料。结果899例产妇中有42例发生产褥感染,其发生率为4.67%。感染组PCT、CRP及白细胞水平均明显高于非感染组(P〈0.05)。ROC曲线分析显示,PCT、CRP及白细胞对应Auc分别为0.912、0.872和0.664,计算所对应最佳临界值分别为2.25ng/ml、7.05mg,/L和11.1×10^9/L,敏感度分别为88.1%、85.7%和71.4%,特异度分别为87.3%、78.3%和61.9%。结论PCT72.CRP的升高对产妇产褥期发生感染有较大的早期预判价值。 展开更多
关键词 产妇 产褥期感染 C反应蛋白 降钙素原
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PCT与CRP在产后感染中的相关意义及临床价值分析 被引量:3
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作者 李明霞 《中国医药导刊》 2013年第5期863-863,865,共2页
目的:探讨和研究PCT(血浆降钙素原)与CRP(C-反应蛋白)在产后感染中的相关意义及临床价值。方法:选取我院近年来收治的446例剖宫产产妇的临床资料作为研究对象,应用酶联免疫荧光分析法对以上患者产后(24~48)h内血浆PCT含量进行测... 目的:探讨和研究PCT(血浆降钙素原)与CRP(C-反应蛋白)在产后感染中的相关意义及临床价值。方法:选取我院近年来收治的446例剖宫产产妇的临床资料作为研究对象,应用酶联免疫荧光分析法对以上患者产后(24~48)h内血浆PCT含量进行测定,并采用免疫比浊法测定CRP水平。结果:446例患者中细菌感染32例,以0.05ug/L作为PCT临界标准,感染患者的PCT检测阳性率为96.88%,非细菌感染者的阳性率为0.24%,差异显著(P〈0.01);以8mg/L作为CRP临界标准,细菌感染患者阳性率为93.75%,而非细菌感染者则为92.03%,差异不具有显著性(P〉0.05)。结论:剖宫产产妇产后24~48h内的PCT检测更能反映出是否发生细菌感染,特异性显著高于CRP,能够为临床诊断和治疗提供可靠依据。 展开更多
关键词 血浆降钙素原 C-反应蛋白 剖宫产 产后感染
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降钙素原联合C-反应蛋白的检测对产褥期产妇感染的临床价值 被引量:3
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作者 闫俊霞 吴亚丽 +1 位作者 张建文 朴文花 《宁夏医科大学学报》 2020年第10期1028-1030,共3页
目的探讨降钙素原与C-反应蛋白的联合检测对产褥期产妇感染的临床价值。方法选取2016年4月至2019年1月我院妇产科诊治的产褥期发生感染的75例产妇作为研究对象(实验组),同时选取同时期未发生感染的80例产妇作为对照组。两组患者均采用... 目的探讨降钙素原与C-反应蛋白的联合检测对产褥期产妇感染的临床价值。方法选取2016年4月至2019年1月我院妇产科诊治的产褥期发生感染的75例产妇作为研究对象(实验组),同时选取同时期未发生感染的80例产妇作为对照组。两组患者均采用酶联免疫荧光技术检测降钙素原的含量,采用免疫比浊法测定C-反应蛋白的含量,对比两组血清中降钙素原和C-反应蛋白的阳性率及含量,对比降钙素原与C-反应蛋白联合检测与单项检测的灵敏度及特异度。结果实验组降钙素原和C-反应蛋白的含量均高于对照组(P均<0.05),实验组降钙素原与C-反应蛋白的阳性率均高于对照组(P均<0.05),降钙素原与C-反应蛋白的联合检测灵敏度高于单项检测(P<0.05)。结论产褥期产妇发生感染后,血清降钙素原和C-反应蛋白升高,联合检测降钙素原和C-反应蛋白可以为临床的诊治提供有效的理论依据。 展开更多
关键词 产褥期感染 降钙素原 C-反应蛋白
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血培养联合血清降钙素原、C反应蛋白检测对重症产褥感染患者诊断准确率的影响 被引量:11
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作者 刘录勤 李洁 《实用临床医药杂志》 CAS 2018年第15期116-117,120,共3页
目的探讨血培养联合血清降钙素(PCT)、C反应蛋白(CRP)检测对重症产褥感染患者诊断准确率的影响。方法选取78例产妇作为研究对象,均行血培养和血清PCT、CRP检测,以临床综合诊断结果为金标准,比较单独检测与联合检测对重症产褥感染患者的... 目的探讨血培养联合血清降钙素(PCT)、C反应蛋白(CRP)检测对重症产褥感染患者诊断准确率的影响。方法选取78例产妇作为研究对象,均行血培养和血清PCT、CRP检测,以临床综合诊断结果为金标准,比较单独检测与联合检测对重症产褥感染患者的诊断准确率、敏感度、特异度。结果联合检测与单独检测对重症产褥感染患者诊断敏感度比较无显著差异(P>0.05);联合检测对重症产褥感染患者诊断特异度、准确率显著高于单独检测(P<0.05)。结论血培养联合血清PCT、CRP检测可提高重症产褥感染患者诊断特异度、准确度。 展开更多
关键词 血培养 血清降钙素 C反应蛋白 产褥感染
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剖宫产与自然分娩对产妇产褥感染、血清WBC、CRP及PCT水平的影响 被引量:7
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作者 杨丽萍 《临床医学研究与实践》 2019年第18期130-132,共3页
目的探究剖宫产、自然分娩对产妇产褥感染、血清白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)表达的影响。方法选取本院2016年2月至2018年2月剖宫产与自然分娩产妇各198例为研究对象,分别设为剖宫产组和自然分娩组。观察两组产褥感... 目的探究剖宫产、自然分娩对产妇产褥感染、血清白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)表达的影响。方法选取本院2016年2月至2018年2月剖宫产与自然分娩产妇各198例为研究对象,分别设为剖宫产组和自然分娩组。观察两组产褥感染发生率,并比较两组产前1d、产后3d血清WBC、CRP及PCT水平。结果剖宫产组产褥感染总发生率为8.08%,高于自然分娩组的3.03%,差异具有统计学意义(P<0.05);剖宫产组切口感染发生率高于自然分娩组(P<0.05)。产后3d,两组产妇WBC、CRP、PCT水平均高于产前1d,但自然分娩组WBC、CRP、PCT水平均低于剖宫产组,差异具有统计学意义(P<0.05)。结论不同分娩方式对产妇产褥感染及血清WBC、CRP、PCT水平存在影响,剖宫产产妇的产褥感染发生率及WBC、CRP、PCT表达高于自然分娩产妇。 展开更多
关键词 剖宫产 自然分娩 产褥感染 白细胞计数 C反应蛋白 降钙素原
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不同分娩方式对产褥感染与血清白细胞计数和C-反应蛋白及降钙素原水平的影响 被引量:36
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作者 李艺 郭静 +2 位作者 郑多丽 邱进俊 刘茂永 《中华医院感染学杂志》 CAS CSCD 北大核心 2017年第7期1604-1607,共4页
目的探讨不同分娩方式对产褥感染血清白细胞计数(WBC)、C-反应蛋白(CRP)、降钙素原(PCT)水平的影响,为预防产褥感染提供参考依据。方法选取2014年1月-2016年7月医院采用剖宫产(剖宫产组)及阴道分娩(阴道分娩组)的产妇各300例,观察产妇... 目的探讨不同分娩方式对产褥感染血清白细胞计数(WBC)、C-反应蛋白(CRP)、降钙素原(PCT)水平的影响,为预防产褥感染提供参考依据。方法选取2014年1月-2016年7月医院采用剖宫产(剖宫产组)及阴道分娩(阴道分娩组)的产妇各300例,观察产妇产褥感染情况,检测产妇分娩前及产后3d时WBC、CRP及PCT水平。结果剖宫产组产褥感染临床诊断26例、确诊23例,临床感染率与确诊感染率分别为8.67%、7.67%,阴道分娩组产褥感染临床诊断12例、确诊8例,临床感染率与确诊感染率分别为4.00%、2.67%,两组比较差异有统计学意义(P<0.05);剖宫产组产后3d呼吸系统感染、切口感染、乳腺感染等指标均高于阴道分娩组,且两组产妇产后3d时以上指标较分娩前升高(P<0.05)。结论分娩方式对产褥感染及血清WBC、CRP及PCT水平存在一定影响,剖宫产产妇产后产褥感染及相关炎性因子水平均高于阴道分娩产妇。 展开更多
关键词 分娩方式 产褥感染 白细胞计数 C-反应蛋白 降钙素原
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白细胞介素、降钙素原及C-反应蛋白与产妇产褥感染的相关性分析 被引量:7
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作者 严春华 郑云英 +1 位作者 张建果 张媚娜 《中国妇幼保健》 CAS 2020年第5期803-807,共5页
目的探讨分娩后产褥感染患者血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、降钙素原(PCT)及C-反应蛋白(CRP)的表达水平,并分析其与产褥感染的关系。方法选取2015年6月-2018年6月在该院分娩并确诊为产褥感染的产妇112例为研究组,另选... 目的探讨分娩后产褥感染患者血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、降钙素原(PCT)及C-反应蛋白(CRP)的表达水平,并分析其与产褥感染的关系。方法选取2015年6月-2018年6月在该院分娩并确诊为产褥感染的产妇112例为研究组,另选取同期在该院住院的100例未发生感染的产妇为对照组。通过检测所有产妇生殖道病原体感染情况及血清IL-6、IL-10、PCT、CRP水平,分析其与产褥感染的关系。结果研究组检出支原体感染52例(66.67%),革兰氏阳性菌感染15例(19.23%),革兰氏阴性菌感染11例(14.10%)。分娩前,两组产妇血清IL-6、IL-10、PCT、CRP水平比较,差异无统计学意义(P>0.05)。分娩后24 h,研究组产妇血清IL-6、IL-10、PCT、CRP水平均高于对照组,差异均有统计学意义(均P<0.05);分娩后72 h,研究组产妇血清IL-6、PCT、CRP水平均高于对照组,差异均有统计学意义(均P<0.05);且研究组产妇血清IL-6、IL-10、PCT、CRP水平随感染时间延长而上升(P<0.05),对照组产妇血清IL-6、IL-10、PCT、CRP水平随着时间延长先上升,后下降至分娩前水平(P<0.05)。盆腔腹膜炎患者分娩后72 h的血清IL-6、IL-10、PCT、CRP水平高于子宫内膜及附件炎,子宫内膜及附件炎血清各指标水平高于外阴阴道及宫颈炎。结论产褥感染产妇分娩后血清IL-6、IL-10、PCT、CRP水平明显高于正常产妇分娩后水平,三者与产褥感染的发生、进展密切相关,对早期发现并干预产褥感染具有一定的临床价值。 展开更多
关键词 产褥感染 白细胞介素-6 白细胞介素-10 降钙素原 C-反应蛋白 剖宫产术后
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产后早期PCT、CRP、IFN-γ、IL-6水平对产褥感染的诊断价值 被引量:12
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作者 钟影 符爱贞 +2 位作者 吴春 李王雅 汤琼瑶 《中华医院感染学杂志》 CAS CSCD 北大核心 2021年第7期1085-1088,共4页
目的分析产后早期降钙素原(PCT)、C反应蛋白(CRP)、干扰素(IFN)-γ、白细胞介素(IL)-6水平对产褥感染的诊断价值,为产褥感染的预防和诊断工作提供依据。方法选取海口市妇幼保健院2017年12月-2019年12月的50例产褥感染患者作为病例组,选... 目的分析产后早期降钙素原(PCT)、C反应蛋白(CRP)、干扰素(IFN)-γ、白细胞介素(IL)-6水平对产褥感染的诊断价值,为产褥感染的预防和诊断工作提供依据。方法选取海口市妇幼保健院2017年12月-2019年12月的50例产褥感染患者作为病例组,选取同期未发生产褥感染的50名产妇作为对照组,对两组产妇产后1 d时血清PCT、CRP、IFN-γ、IL-6水平进行检测并分析其预测产褥感染的价值。结果病例组患者在产后1 d时的血清PCT、CRP、IFN-γ、IL-6水平均高于对照组,差异均有统计学意义(P<0.05)。产后早期血清PCT、CRP、IFN-γ、IL-6水平预测产褥感染的受试者工作特征曲线下面积(AUC)均有统计学意义(P<0.05),分别为0.779、0.751、0.757、0.932,以血清IL-6水平的AUC最高,在最佳界值下,灵敏度和特异度分别为0.700和1.000。结论产褥感染患者产后早期即可出现血清PCT、CRP、IFN-γ、IL-6水平的升高,这些血清指标可用于辅助预测感染风险,临床医生应重视产后早期相关血清标志物的监测,达到预防感染及早期诊断的目的。 展开更多
关键词 降钙素原 C-反应蛋白 干扰素-Γ 白细胞介素-6 产褥感染
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甲硝唑联合过氧化氢对产褥感染产妇白细胞、C-反应蛋白和降钙素原水平的影响 被引量:6
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作者 罗利平 刘清秀 《中华实验和临床感染病杂志(电子版)》 CAS 2020年第1期57-62,共6页
目的探究甲硝唑联合过氧化氢溶液冲洗宫腔配合抗菌药物对产褥感染产妇白细胞(WBC)、C-反应蛋白(CRP)和降钙素原(PCT)水平的影响。方法选择2016年9月至2018年12月重庆市开州区人民医院收治的产褥感染产妇120例,根据随机数表法分为观察组... 目的探究甲硝唑联合过氧化氢溶液冲洗宫腔配合抗菌药物对产褥感染产妇白细胞(WBC)、C-反应蛋白(CRP)和降钙素原(PCT)水平的影响。方法选择2016年9月至2018年12月重庆市开州区人民医院收治的产褥感染产妇120例,根据随机数表法分为观察组和对照组,每组60例。对照组产妇给予静脉滴注青霉素和口服氨苄西林的常规抗菌药物治疗,观察组患者在对照组用药基础上加甲硝唑联合过氧化氢溶液冲洗宫腔。分别检测两组观察对象全血WBC计数和血清CRP与PCT水平。结果产后1 d两组产妇全血WBC计数、血清CRP和PCT水平差异均无统计学意义(P均>0.05)。产后3 d和5 d,观察组患者WBC计数分别为(9.39±1.79)×10^9/L和(6.93±1.23)×10^9/L,显著低于对照组[(12.05±2.33)×10^9/L和(9.93±1.94)×10^9/L],差异有统计学意义(t=7.03、P<0.001,t=10.05、P<0.001);观察组产妇血清CRP水平分别为(22.97±10.57)mg/L和(15.42±8.82)mg/L,显著低于对照组[(31.67±12.59)mg/L和(20.86±10.83)]mg/L,差异均有统计学意义(t=3.92、P<0.001,t=2.98、P=0.01);观察组产妇血清PCT水平分别为(2.87±1.47)μg/L和(0.81±0.50)μg/L,显著低于对照组[(3.78±1.90)μg/L和(1.68±0.99)μg/L],差异有统计学意义(t=2.96、P=0.01,t=5.92、P<0.001)。观察组产妇治疗后整体有效率为98.33%(59/60),显著高于对照组[80.00%(48/60)],差异有统计学意义(χ^2=10.44、P<0.001)。多因素Logistic回归分析显示,治疗(OR=0.35、95%CI:0.15~0.87、P<0.01)为影响产褥感染临床疗效的保护因素,而孕期阴道炎病史(OR=3.49、95%CI:1.12~1.89、P=0.01)和年龄(OR=1.12、95%CI:1.02~1.19、P=0.01)均为影响产褥感染临床疗效的危险因素;第2产程延长并非产褥感染临床疗效的独立危险因素(OR=2.15、95%CI:1.01~5.11、P=0.08)。结论产妇发生产褥感染时,及时有效的抗感染干预措施是必需的,是影响产褥感染临床疗效的保护因素。采用甲硝唑联合过氧化氢溶液冲洗宫腔配合抗菌药物的治疗方式对已发生产褥感染者疗效较好。 展开更多
关键词 产褥感染 抗感染 白细胞 C-反应蛋白 降钙素原
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