The pulmonary arteriole remodeling in Wistar rats with respiratory infection induced by mycoplasma pneumoniae was observed using light microscopy and morphometry. The pulmonary artery pressure(PAP) and index of right ...The pulmonary arteriole remodeling in Wistar rats with respiratory infection induced by mycoplasma pneumoniae was observed using light microscopy and morphometry. The pulmonary artery pressure(PAP) and index of right ventricular hypertrophy (RVHI) were measured. The intimal and medial hypertrophy can be seen in the pulmonary arterioles, leading to vessei wall thickening and narrowing of the lumina. The total number of the pulmonary arterioles decreased (P <0.01) , and both pulmonary hypertension (Ppa 4.11±0. 19 kPa) and right ventricular hypertrophy (RVHI=34.96±3. 91%) occurred. In addition, an interstitial pulmonary fibrosis (IPF) was found, in which the content of collagen in the lung tissue changed, i. e. , type Ⅰcollagen increased whereas type Ⅲ one decreased, and the ratio of type Ⅰ collagen to type Ⅲ one increased. It suggested that respiratory infection induced by repeated MP may result in remodeling of pulmonary arterioles and are closely related to pulmonary hypertension.展开更多
文摘The pulmonary arteriole remodeling in Wistar rats with respiratory infection induced by mycoplasma pneumoniae was observed using light microscopy and morphometry. The pulmonary artery pressure(PAP) and index of right ventricular hypertrophy (RVHI) were measured. The intimal and medial hypertrophy can be seen in the pulmonary arterioles, leading to vessei wall thickening and narrowing of the lumina. The total number of the pulmonary arterioles decreased (P <0.01) , and both pulmonary hypertension (Ppa 4.11±0. 19 kPa) and right ventricular hypertrophy (RVHI=34.96±3. 91%) occurred. In addition, an interstitial pulmonary fibrosis (IPF) was found, in which the content of collagen in the lung tissue changed, i. e. , type Ⅰcollagen increased whereas type Ⅲ one decreased, and the ratio of type Ⅰ collagen to type Ⅲ one increased. It suggested that respiratory infection induced by repeated MP may result in remodeling of pulmonary arterioles and are closely related to pulmonary hypertension.
