A 78-year-old woman was referred to our university hospital due to dry cough, fever, and weight loss. Laboratory revealed blood eosinophilia, high ESR, CRP and LDH. Rheumatologic markers were negative. Chest X-ray sho...A 78-year-old woman was referred to our university hospital due to dry cough, fever, and weight loss. Laboratory revealed blood eosinophilia, high ESR, CRP and LDH. Rheumatologic markers were negative. Chest X-ray showed ground glass opacities in upper lobes. Uveitis developed in the left eye 1 week after admission. Thorax CT revealed ground glass opacities, reticular appearence in the upper lobes, enlarged axillary and mediastinal lymph nodes. Bronchoalveolar lavage CD4/CD8 was 2.1 and had 48% eosinophils. Histopathologic examination revealed eosinophilic infiltration and non-caseating epitheloid granulomas in the lung and mediastinal lymph nodes without vasculitis. Symptoms, blood eosinophilia and initial thorax CT findings improved after two months of methylprednisolone treatment. Chronic eosinophilic pneumonia is a rare disease characterized by systemic and pulmonary manifestations. It may be associated with other diseases.展开更多
Background:There is compelling evidence that not only do anti-filarials significantly reduce larval forms,but that host immune responses also contribute to the clearance of filarial parasites;however,the underlying me...Background:There is compelling evidence that not only do anti-filarials significantly reduce larval forms,but that host immune responses also contribute to the clearance of filarial parasites;however,the underlying mechanisms have not been fully elucidated.Main text:Filarial infections caused by Wuchereria bancrofti and Brugia species(lymphatic filariasis)and Onchocerca volvulus(onchocerciasis)affect almost 200 million individuals worldwide and pose major public health challenges in endemic regions.Indeed,the collective disability-adjusted life years for both infections is 3.3 million.Infections with these thread-like nematodes are chronic and,although most individuals develop a regulated state,a portion develop severe forms of pathology.Mass drug administration(MDA)programmes on endemic populations focus on reducing prevalence of people with microfilariae,the worm's offspring in the blood,to less than 1%.Although this has been successful in some areas,studies show that MDA will be required for longer than initially conceived.Conclusion:This paper highlights the mode of action of the various antifilarial treatment strategies and role of host immune response.展开更多
文摘A 78-year-old woman was referred to our university hospital due to dry cough, fever, and weight loss. Laboratory revealed blood eosinophilia, high ESR, CRP and LDH. Rheumatologic markers were negative. Chest X-ray showed ground glass opacities in upper lobes. Uveitis developed in the left eye 1 week after admission. Thorax CT revealed ground glass opacities, reticular appearence in the upper lobes, enlarged axillary and mediastinal lymph nodes. Bronchoalveolar lavage CD4/CD8 was 2.1 and had 48% eosinophils. Histopathologic examination revealed eosinophilic infiltration and non-caseating epitheloid granulomas in the lung and mediastinal lymph nodes without vasculitis. Symptoms, blood eosinophilia and initial thorax CT findings improved after two months of methylprednisolone treatment. Chronic eosinophilic pneumonia is a rare disease characterized by systemic and pulmonary manifestations. It may be associated with other diseases.
文摘Background:There is compelling evidence that not only do anti-filarials significantly reduce larval forms,but that host immune responses also contribute to the clearance of filarial parasites;however,the underlying mechanisms have not been fully elucidated.Main text:Filarial infections caused by Wuchereria bancrofti and Brugia species(lymphatic filariasis)and Onchocerca volvulus(onchocerciasis)affect almost 200 million individuals worldwide and pose major public health challenges in endemic regions.Indeed,the collective disability-adjusted life years for both infections is 3.3 million.Infections with these thread-like nematodes are chronic and,although most individuals develop a regulated state,a portion develop severe forms of pathology.Mass drug administration(MDA)programmes on endemic populations focus on reducing prevalence of people with microfilariae,the worm's offspring in the blood,to less than 1%.Although this has been successful in some areas,studies show that MDA will be required for longer than initially conceived.Conclusion:This paper highlights the mode of action of the various antifilarial treatment strategies and role of host immune response.
