In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (M...In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.展开更多
目的:探讨iRoot BP plus对成人龋源性露髓治疗疗效及对牙髓血流的影响。方法:选择2020年1月—2022年1月收治的成人龋源性露髓患者126例(156颗恒牙),采用信封法将患者分为试验组(63例、79颗恒牙)和对照组(63例、77颗恒牙),试验组给予iRoo...目的:探讨iRoot BP plus对成人龋源性露髓治疗疗效及对牙髓血流的影响。方法:选择2020年1月—2022年1月收治的成人龋源性露髓患者126例(156颗恒牙),采用信封法将患者分为试验组(63例、79颗恒牙)和对照组(63例、77颗恒牙),试验组给予iRoot BP plus治疗,对照组给予矿物三氧化聚合体治疗,观察2组治疗效果、操作时间、牙变色等情况。采用SPSS 22.0软件包对数据进行统计学分析。结果:试验组和对照组术后3、6和12个月治疗成功率相比,差异无统计学意义(P>0.05)。试验组每颗牙操作时间为(2.53±0.41)min,显著少于对照组(P<0.05)。试验组术后12个月牙变色发生率为3.80%,显著低于对照组(P<0.05)。试验组术后12个月咬合力和咀嚼效率分别为(16.65±1.14)Ibs和(94.45±5.65)%,显著高于对照组(P<0.05)。结论:iRootBPplus在成人龋源性露髓治疗中疗效较好,具有操作便利、牙变色少、牙髓血流下降后维持平稳、炎症反应程度轻等优点。展开更多
文摘In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.
文摘目的:探讨iRoot BP plus对成人龋源性露髓治疗疗效及对牙髓血流的影响。方法:选择2020年1月—2022年1月收治的成人龋源性露髓患者126例(156颗恒牙),采用信封法将患者分为试验组(63例、79颗恒牙)和对照组(63例、77颗恒牙),试验组给予iRoot BP plus治疗,对照组给予矿物三氧化聚合体治疗,观察2组治疗效果、操作时间、牙变色等情况。采用SPSS 22.0软件包对数据进行统计学分析。结果:试验组和对照组术后3、6和12个月治疗成功率相比,差异无统计学意义(P>0.05)。试验组每颗牙操作时间为(2.53±0.41)min,显著少于对照组(P<0.05)。试验组术后12个月牙变色发生率为3.80%,显著低于对照组(P<0.05)。试验组术后12个月咬合力和咀嚼效率分别为(16.65±1.14)Ibs和(94.45±5.65)%,显著高于对照组(P<0.05)。结论:iRootBPplus在成人龋源性露髓治疗中疗效较好,具有操作便利、牙变色少、牙髓血流下降后维持平稳、炎症反应程度轻等优点。
