Partial least squares（PLS）,back-propagation neural network（BPNN）and radial basis function neural network（RBFNN）were respectively used for estalishing quantative analysis models with near infrared（NIR）diffuse r...Partial least squares（PLS）,back-propagation neural network（BPNN）and radial basis function neural network（RBFNN）were respectively used for estalishing quantative analysis models with near infrared（NIR）diffuse reflectance spectra for determining the contents of rifampincin（RMP）,isoniazid（INH）and pyrazinamide（PZA）in rifampicin isoniazid and pyrazinamide tablets.Savitzky-Golay smoothing,first derivative,second derivative,fast Fourier transform（FFT）and standard normal variate（SNV）transformation methods were applied to pretreating raw NIR diffuse reflectance spectra.The raw and pretreated spectra were divided into several regions,depending on the average spectrum and RSD spectrum.Principal component analysis（PCA）method was used for analyzing the raw and pretreated spectra in different regions in order to reduce the dimensions of input data.The optimum spectral regions and the models＇ parameters were chosen by comparing the root mean square error of cross-validation（RMSECV）values which were obtained by leave-one-out cross-validation method.The RMSECV values of the RBFNN models for determining the contents of RMP,INH and PZA were 0.00288,0.00226 and 0.00341,respectively.Using these models for predicting the contents of INH,RMP and PZA in prediction set,the RMSEP values were 0.00266,0.00227 and 0.00411,respectively.These results are better than those obtained from PLS models and BPNN models.With additional advantages of fast calculation speed and less dependence on the initial conditions,RBFNN is a suitable tool to model complex systems.展开更多
目的:观察隔蒜灸联合化疗治疗气阴两虚型肺结核的临床疗效。方法:将73例气阴两虚型肺结核患者按照随机数字表法分为观察组37例和对照组36例。对照组给予常规抗结核药物治疗,观察组在对照组的基础上联合隔蒜灸治疗。比较两组患者的临床...目的:观察隔蒜灸联合化疗治疗气阴两虚型肺结核的临床疗效。方法:将73例气阴两虚型肺结核患者按照随机数字表法分为观察组37例和对照组36例。对照组给予常规抗结核药物治疗,观察组在对照组的基础上联合隔蒜灸治疗。比较两组患者的临床疗效及治疗前后中医证候评分、痰菌转阴率、胸部CT病灶变化、健康调查简表(the MOS item short from health survey,SF-36)生活质量量表评分变化情况。结果:两组患者治疗后中医证候积分低于本组治疗前,且观察组治疗后低于对照组治疗后,差异具有统计学意义(P<0.05)。对照组有效率为77.78%,观察组有效率为94.59%,两组患者有效率比较,差异具有统计学意义(P<0.05)。治疗1个月后,观察组痰菌转阴及肺部病灶吸收例数高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后SF-36量表评分高于本组治疗前,且观察组治疗后高于对照组治疗后,差异具有统计学意义(P<0.05)。结论:隔蒜灸联合化疗治疗气阴两虚型肺结核,能够改善患者中医证候及生活质量,提高痰菌转阴率,加速肺部病灶的吸收速度。展开更多
基金Supported by the Science Technology Development Project of Jilin Province,China(No.20020503-2).
文摘Partial least squares（PLS）,back-propagation neural network（BPNN）and radial basis function neural network（RBFNN）were respectively used for estalishing quantative analysis models with near infrared（NIR）diffuse reflectance spectra for determining the contents of rifampincin（RMP）,isoniazid（INH）and pyrazinamide（PZA）in rifampicin isoniazid and pyrazinamide tablets.Savitzky-Golay smoothing,first derivative,second derivative,fast Fourier transform（FFT）and standard normal variate（SNV）transformation methods were applied to pretreating raw NIR diffuse reflectance spectra.The raw and pretreated spectra were divided into several regions,depending on the average spectrum and RSD spectrum.Principal component analysis（PCA）method was used for analyzing the raw and pretreated spectra in different regions in order to reduce the dimensions of input data.The optimum spectral regions and the models＇ parameters were chosen by comparing the root mean square error of cross-validation（RMSECV）values which were obtained by leave-one-out cross-validation method.The RMSECV values of the RBFNN models for determining the contents of RMP,INH and PZA were 0.00288,0.00226 and 0.00341,respectively.Using these models for predicting the contents of INH,RMP and PZA in prediction set,the RMSEP values were 0.00266,0.00227 and 0.00411,respectively.These results are better than those obtained from PLS models and BPNN models.With additional advantages of fast calculation speed and less dependence on the initial conditions,RBFNN is a suitable tool to model complex systems.
文摘目的:观察隔蒜灸联合化疗治疗气阴两虚型肺结核的临床疗效。方法:将73例气阴两虚型肺结核患者按照随机数字表法分为观察组37例和对照组36例。对照组给予常规抗结核药物治疗,观察组在对照组的基础上联合隔蒜灸治疗。比较两组患者的临床疗效及治疗前后中医证候评分、痰菌转阴率、胸部CT病灶变化、健康调查简表(the MOS item short from health survey,SF-36)生活质量量表评分变化情况。结果:两组患者治疗后中医证候积分低于本组治疗前,且观察组治疗后低于对照组治疗后,差异具有统计学意义(P<0.05)。对照组有效率为77.78%,观察组有效率为94.59%,两组患者有效率比较,差异具有统计学意义(P<0.05)。治疗1个月后,观察组痰菌转阴及肺部病灶吸收例数高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后SF-36量表评分高于本组治疗前,且观察组治疗后高于对照组治疗后,差异具有统计学意义(P<0.05)。结论:隔蒜灸联合化疗治疗气阴两虚型肺结核,能够改善患者中医证候及生活质量,提高痰菌转阴率,加速肺部病灶的吸收速度。
