期刊文献+
共找到12篇文章
< 1 >
每页显示 20 50 100
Crystal and Molecular Structure of 4-Benzoyl-1,5-diphenyl-1H-pyrazole-3-carbonitrile
1
作者 E.Korkusuz E.Sahin I.Yildirim 《Crystal Structure Theory and Applications》 2012年第1期1-8,共8页
The crystal structure of potential active 4-benzoyl-1,5-diphenyl-1H*-pyrazole-3-carbonitrile (C23H15N3O) (I) has been determined from single crystal X-ray diffraction data. Also IR, Uv-vis and NMR spectral data were d... The crystal structure of potential active 4-benzoyl-1,5-diphenyl-1H*-pyrazole-3-carbonitrile (C23H15N3O) (I) has been determined from single crystal X-ray diffraction data. Also IR, Uv-vis and NMR spectral data were determined. The title compound crystallizes in the monoclinic space group P* 21/c, with a* = 9.3167(2), b* = 20.6677(3), c* = 10.6143(3) ?, β* = 112.665(3)°, V* = 1886.00(8) ?3, Dcalc* = 1.23g cm-3, Z* = 4. In the structure, intermolecular H*-bonds lead to the formation of a centrosymmetric dimmer of the molecule. Furthermore, the compound has a wide transmission window (300 to 1100 nm) with a transparency of nearly 100% and the UV cut-off wavelength occurs at 242 nm. 展开更多
关键词 pyrazole-3-carbonitrile 2 3-Furandione Single Crystal Structure X-Ray Diffraction IR NMR Spectra
下载PDF
Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives
2
作者 Shu Lan Zhang Xin Zhai Shi Jiao Zhang Hong Hao Yu Ping Gong 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第8期939-942,共4页
A series of quinoline-3-carbonitrile derivatives were designed and synthesized.Their cytotoxicity in vitro against four cancer cell lines(A549,HT-29,MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay.The... A series of quinoline-3-carbonitrile derivatives were designed and synthesized.Their cytotoxicity in vitro against four cancer cell lines(A549,HT-29,MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay.The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line.Among them, compounds 7c,7e,11b,11f and 11g were more active than Gefitinb against SMMC-7721 cell line. 展开更多
关键词 Quinoline-3-carbonitrile SYNTHESIS CYTOTOXICITY
下载PDF
Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents
3
作者 Chunxia Chen Minghui Lu +4 位作者 Zhihui Liu Junting Wan Zhengchao Tu Tianyu Zhang Ming Yan 《Open Journal of Medicinal Chemistry》 2013年第4期128-135,共8页
A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H... A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious antitubercular activities could be observed (MIC > 10 ug/mL). The results are in sharp contrast with the previously reported data. 展开更多
关键词 2-Amino-4H-Pyran-3-carbonitrile SYNTHESIS ANTITUBERCULAR Activity
下载PDF
Theoretical Study on the Reaction Mechanism of 2-Methoxybenzaldehyde,4-Bromo-indanone,Malononitrile and Ammonium Acetate One-pot to Form 6-(2-Methoxyphenyl)-2-amino-6-bromo-5H-indeno[1,2-b]pyridine-3-carbonitrile
4
作者 张福兰 黄辉胜 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2017年第10期1685-1696,共12页
The reaction mechanism of 2-methoxybenzaldehyde, 4-bromo-indanone, malononitrile and ammonium acetate one-pot to form 6-(2-methoxyphenyl)-2-amino-6-bromo-5 Hindeno[1,2-b]pyridine-3-carbonitrile was studied by densit... The reaction mechanism of 2-methoxybenzaldehyde, 4-bromo-indanone, malononitrile and ammonium acetate one-pot to form 6-(2-methoxyphenyl)-2-amino-6-bromo-5 Hindeno[1,2-b]pyridine-3-carbonitrile was studied by density functional theory. The geometries of the reactants, transition states, intermediates and products were optimized at the PW91/DNP level. Vibration analysis was carried out to confirm the transition state structure. Reaction pathways were investigated in this study. The result indicates that the reaction Re→ TSB1→IMB1→ TSB2→ IMB2→TSB3→IMB3→TSB4→IMB4→TSB5→IMB5→TSB6→IMB6→TSB7→IMB7→ TSB8→IMB8→TSB9→IMB9→P2 is the main pathway, the activation energy of which is the lowest. The dominant product predicted theoretically is in agreement with the experiment results. 展开更多
关键词 2-methoxybenzaldehyde 4-bromo-indanone 6-(2-methoxyphenyl)-2-amino-6-bromo-5H-indeno[1 2-b]pyridine-3-carbonitrile density functional reaction mechanism
下载PDF
吡唑化合物pyr3干预对压力负荷诱导的大鼠左心室肥厚的影响 被引量:3
5
作者 田小芍 陈明 刘春霞 《中国循环杂志》 CSCD 北大核心 2013年第3期226-229,共4页
目的:探讨瞬时受体电位通道C亚族3亚型(TRPC3)的选择性阻滞剂吡唑化合物Ethyl-1-(4-f2,3,3一trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H—pyrazole-4-carboxylate(pyr3)的体内干预对压力负荷大鼠左心室肥厚(LvH... 目的:探讨瞬时受体电位通道C亚族3亚型(TRPC3)的选择性阻滞剂吡唑化合物Ethyl-1-(4-f2,3,3一trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H—pyrazole-4-carboxylate(pyr3)的体内干预对压力负荷大鼠左心室肥厚(LvH)程度的影响。方法:采用腹主动脉缩窄手术建立左心压力负荷模型。30只200—240g雄性SD大鼠随机分为五组(n=6):假手术对照组、手术对照组、假手术后全程给药组、手术后后期给药组,手术后全程给药组。6周后,计算各组大鼠左心室质量指数、左心室心肌细胞横径,逆转录多聚酶连反应(RT—PCR)、免疫组织化学和蛋白免疫印迹检测TRPC3和钙调神经磷酸酶A13信使核糖核酸(mRNA)和蛋白的表达水平。结果:与假手术对照组相比,手术对照组左心室肥厚相关指标(左心室质量指数和左心室心肌细胞横径)及TRPC3、钙调神经磷酸酶AB蛋白和mRNA的表达显著升高;假手术后全程给药组左心室肥厚相关指标无显著变化,而TRPC3和钙调神经磷酸酶AB蛋白及mRNA的表达量显著升高,差异均有统计学意义(P均〈0.05)。与手术对照组比较,手术后全程给药组左心室肥厚相关指标、TRPC3及钙调神经磷酸酶A13蛋白和mRNA表达均明显降低(P均〈0.05);手术后后期给药组左心室肥厚相关指标及钙调神经磷酸酶AB蛋白和mRNA的表达下降,差异均有统计学意义(P均〈0.05),而TRPC3的蛋白和mRNA表达未见显著降低。结论:pyr3体内干预能够一定程度上阻止压力负荷导致的大鼠左心室肥厚,降低压力负荷大鼠左心室TRPC3和钙调神经磷酸酶AB表达的上调。 展开更多
关键词 Ethyl-1-(4-(2 3 3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H—pyrazole-4-carboxylate 压力负荷 左心室肥厚 瞬时受体电位通道C亚族3亚型 钙调神经磷酸酶Aβ
下载PDF
Synthesis, Reactions and Characterization of 1,1’-(1,4-Phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(ethan-1-one)
6
作者 Ahmed A. M. Elreedy Hameed M. Alkubaisi Fawzy A. Attaby 《International Journal of Organic Chemistry》 CAS 2016年第1期65-76,共12页
Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). Th... Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). The reaction of 2 with hydrazine hydrate followed by diazotization reaction af-forded the 1,1’-(1,4-phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(e-than-1-one) (3) and 1,1’-(1,4-phenylenebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3,4-b]-pyridine-4,5-diyl))bis(ethan-1-one) (4) respectively. On the other hand, reaction of 4 with malononitrile, 2-cyanoethanethioamide, ethyl acetoacetate, acetyl acetone, ethyl benzoylacetate, diethylmalonate, ethyl cyanoacetate and phenacylbromide aiming to build up pyrazolotriazine or pyrazole ring on the ring system of 4. Structures of all newly synthesized heterocyclic compounds in the present study were confirmed by considering the data of IR, 1H NMR, mass spectra as well as that of elemental analyses. 展开更多
关键词 Bis-1 2-dihydropyridine-3-carbonitrile Bis-Nicotinonitrile 1 1’-(1 4-Phenyl-enebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3 4-b]pyri-dine-4 5-diyl))bis(ethan-1-one) Bis-dihydropyrido[2’ 3’:3 4]pyrazolo[5 1-c][1 2 4]triazine-3-carboxylate Bis-1H-pyrazolo[3 4-b]pyridine
下载PDF
Preparation of 2-amino-5,7-dimethoxy-4-aryl/alkyl-4H-chromene-3-carbonitriles using Na_2O-Al_2O_3-P_2O_5 glass–ceramic system 被引量:1
7
作者 Saeid Jabbarzare Majid Ghashang 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第11期1385-1388,共4页
A highly efficient and environmentally benign protocol for the synthesis of 2-amino-5,7-dimethoxy-4- aryl/alkyl-4H-chromene-3-carbonitrile derivatives by one-pot three-component coupling reacting of aromatic aldehydes... A highly efficient and environmentally benign protocol for the synthesis of 2-amino-5,7-dimethoxy-4- aryl/alkyl-4H-chromene-3-carbonitrile derivatives by one-pot three-component coupling reacting of aromatic aldehydes, malononitrile and 3,5-dimethoxy phenol under reflux condition has been developed in aqueous EtOH media using Na2O-Al2O3-P2O5 glass-ceramic system. 展开更多
关键词 Na2O-Al2O3-P2O5 glass-ceramic system2-Amino-4H-chromene3 5-Dimethoxy phenol2-Amino- 5 7-dimethoxy-4-aryl/alkyl-4H-chromene-3-carbonitriles
原文传递
Synthesis and anti-tumor activity of 1,4-dihydrothieno[3',2':5,6] thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives
8
作者 孙蕊 宋菁 +5 位作者 赵辉 严春丽 张爱君 Koirala Diwa 李大伟 胡春 《Journal of Chinese Pharmaceutical Sciences》 CAS 2011年第1期32-36,共5页
Five 1,4-dihydrothieno[3',2':5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives were synthesized from 2- mercaptothiophene via a six-step procedure. The prepared compounds were initially evaluated for the... Five 1,4-dihydrothieno[3',2':5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives were synthesized from 2- mercaptothiophene via a six-step procedure. The prepared compounds were initially evaluated for their antiprolifemtive activity using the estrogen receptors expressing MCF-7 human mammary tumor cell line in vitro. All of the prepared compounds showed moderate anti-tumor activity. 展开更多
关键词 SYNTHESIS 1 4-Dihydrothieno[3 2':5 6]thiopyrano[4 3-c]pyrazole-3-carboxylic amide derivatives Anti-tumor activity
原文传递
Dimethylformamide Dimethyl Acetal (DMFDMA) in Heterocyclic Synthesis: Synthesis of Polysubstituted Pyridines, Pyrimidines, Pyridazine and Their Fused Derivatives 被引量:1
9
作者 Fathi A. Abu-Shanab Sayed A. S. Mousa +2 位作者 E. A. Eshak Ahmed Z. Sayed Ahmed Al-Harrasi 《International Journal of Organic Chemistry》 2011年第4期207-214,共8页
Reaction of N,N’-dimethylformamide dimethyl acetal (DMFDMA) with malononitrile dimer 8 (1:1) mole afforded 9 while, this reaction when carried out in (2:1) mole to give amidine 11 which can be used for the preparatio... Reaction of N,N’-dimethylformamide dimethyl acetal (DMFDMA) with malononitrile dimer 8 (1:1) mole afforded 9 while, this reaction when carried out in (2:1) mole to give amidine 11 which can be used for the preparation of pyrimidine 13, amidine 14 and pyridine 19 when reacted with 4-nitroaniline, 4-methylaniline and alkoxide respectively. Malononitrile dimer reacted with diazonium chloride to give pyridazine 21, which can be reacted with DMFDMA, AcOH/HCl and cyanoacetamide to give pyridazine 22, 23 and pyrido[4,3-c] pyridazine 24 respectively. The latter reacted with DMFDMA to afford tricyclic compound 25. 展开更多
关键词 DMFDMA MALONONITRILE Dimer Pyridazine-3 5-carbonitrile Pyridine-4-alkoxide
下载PDF
An Efficient One-pot Synthesis of Aryl-substituted 1-(Thiazol-2-yl)-1H-pyrazole-3-carboxylates via a Hantzsch Synthesis-Knorr Reaction Sequence
10
作者 Chunhui Gu Jiaojiao Zhai +4 位作者 Jianan Jiang Hongwei Liu Lei Wang Dunru Zhu Yafei Ji 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2014年第2期179-190,共12页
The treatment ofα-bromoalkyl aryl ketones and 2-(propan-2-ylidene)hydrazine carbothioamide afforded 4-aryl-2-(2-(propan-2-ylidene)hydrazinyl)thiazoles via a Hantzsch-thiazole synthesis,which reacted with 4-aryl-2,4-d... The treatment ofα-bromoalkyl aryl ketones and 2-(propan-2-ylidene)hydrazine carbothioamide afforded 4-aryl-2-(2-(propan-2-ylidene)hydrazinyl)thiazoles via a Hantzsch-thiazole synthesis,which reacted with 4-aryl-2,4-diketoesters via a sequential Knorr-pyrazole reaction to deliver a variety of aryl-substituted ethyl 1-(thiazol-2-yl)-1Hpyrazole-3-carboxylates in a one-pot fashion with moderate to high yields.The key intermediates 4-aryl-2,4-diketoesters,existing as its enolic lithium salt,were synthesized in situ by a high-yield tert-BuOLi-mediated Claisen condensation of alkylphenones and diethyl oxalate.This class of elegant molecule comprises aryl groups on the two different heterocyclic cores,and the configurations of two representative molecules were determined by single crystal X-ray crystallography. 展开更多
关键词 one-pot synthesis Claisen condensation Hantzsch synthesis Knorr reaction 1-(thiazol-2-yl)pyrazole-3-carboxylates
原文传递
Utility of Styrylpyrazoloformimidate in the Synthesis of Fused Heterocyclic Compounds
11
作者 Hamdi M. Hassaneen Zakaria Ahmed Gomaa 《International Journal of Organic Chemistry》 2015年第4期213-222,共10页
Refluxing of (E)-5-amino-1-phenyl-3-styryl-1H-pyrazole-4-carbonitrile 2 with triethylor-thoformate in acetic anhydride afforded the corresponding formimidate 3. Treatment of 3 with hydrazine hydrate in ethanol afforde... Refluxing of (E)-5-amino-1-phenyl-3-styryl-1H-pyrazole-4-carbonitrile 2 with triethylor-thoformate in acetic anhydride afforded the corresponding formimidate 3. Treatment of 3 with hydrazine hydrate in ethanol afforded amino imino compound 4. Reaction of 4 with diethyl dicarbonate at reflux gave (E)-7-phenyl-9-styryl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine 7. Refluxing of 4 with hydrazine hydrate afforded (E)-4-hydrazinyl-1-phenyl-3-styryl-1H-pyrazolo[3,4-d] pyrimidine 8. Treatment of the latter compound 8 with aldehydes in boiling ethanol in the presence of acetic acid afforded the corresponding hydrazone 10. Oxidative cyclization of the hydrazone 10 led to the formation of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 11. The latter products re-arranged to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines 13. The structures of the new products were established on the basis of elemental analysis and spectral data. 展开更多
关键词 (Z)-N'-Phenylcinnamohydrazonoyl Chloride (E)-5-Amino-1-Phenyl-3-Styryl-1H-pyrazole-4-carbonitrile Formimidate Dimroth REARRANGEMENT
下载PDF
A novel and efficient synthesis of pyrazolo[3,4-d]pyrimidine derivatives and the study of their anti-bacterial activity 被引量:7
12
作者 Shahnaz Rostamizadeh Masoomeh Nojavan +2 位作者 Reza Aryan Hamid Sadeghian Mahdieh Davoodnejad 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第7期629-632,共4页
In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot, three-component reaction of an aldehyde, malononitrile and benzamidine hydrochloride, in the presence of m... In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot, three-component reaction of an aldehyde, malononitrile and benzamidine hydrochloride, in the presence of magnetic nano Fe304 particles as a catalyst under solvent-free conditions. 3-Amino-6-aryl- 2-phenylpyrazolo[3,4-d]pyrimidine derivatives were prepared through an efficient and environmentally friendly reaction between 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives and hydra- zine hvdrate and their antibacterial activity has been evaluated 展开更多
关键词 Pyrrazolo[3 4-d]pyrimidine derivatives Pyrimidine-5-carbonitrile derivatives Antibacterial activity Staphylococcus aureus Enterococcus raffinosus
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部