Schistosomiasis,caused by parasitic bloodflukes of the genus Schistosoma,is a major source of human disease in developing tropical nations.This paper reviews the diagnostic various assays for schistosomiasis,with part...Schistosomiasis,caused by parasitic bloodflukes of the genus Schistosoma,is a major source of human disease in developing tropical nations.This paper reviews the diagnostic various assays for schistosomiasis,with particular reference to recent advances in assays incorporating direct parasitological examination,serology,antigen detection,and polymerase chain reaction detection of parasite genetic material.展开更多
AIM:To make a retrospective analysis of endoscopy findings and clinicopathologic characteristics of colonic schistosomiasis in order to further improve our understanding of the disease and decrease its misdiagnosis. M...AIM:To make a retrospective analysis of endoscopy findings and clinicopathologic characteristics of colonic schistosomiasis in order to further improve our understanding of the disease and decrease its misdiagnosis. METHODS:Endoscopy findings and clinicopathologic characteristics of 46 intestinal schistosomiasis patients were retrospectively analyzed.All the patients underwent colonoscopy and all biopsy specimens stained with hematoxylin and eosin were observed under a light microscope. RESULTS:Of the 46 colonic schistosomiasis patients,1 was diagnosed as acute schistosomal colitis,16 as chronic schistosomal colitis and 29 as chronic active schistosomal colitis according to their endoscopic findings and pathology.Not all patients were suspected of or diagnosed as colonic schistosomiasis.Of the 12 misdiagnosed patients,4 were misdiagnosed as ulcerativecolitis,1 as Crohn's disease,and 7 as ischemic colitis.The segments of rectum and sigmoid colon were involved in 29 patients(63.0%) .Intact Schistosoma ova were deposited in colonic mucosa accompanying infiltration of eosinocytes,lymphocytes,and plasma cells in acute schistosomal colitis patients.Submucosal fibrosis was found in chronic schistosomal colitis patients.Among the 17 patients with a signal polyp,hyperplastic polyp,canalicular adenoma with a low-grade intraepithelial neoplastic change,tubulovillous adenoma with a highgrade intraepithelial neoplastic change were observed in 10,5,and 2 patients,respectively.Eight out of the 46 patients were diagnosed as colonic carcinoma. CONCLUSION:Endoscopy contributes to the diagnosis of colonic schistosomiasis although it is nonspecific. A correct diagnosis of colonic schistosomiasis can be established by endoscopy in combination with its clinicopathologic characteristics.展开更多
INTRODUCTIONSchistosomiasis,also commonly known asbilharziasis,is one of the most significant parasiticdiseases of humans.A report of World HealthOrganization in 1996 estimated that over 200 millionpeople were infeste...INTRODUCTIONSchistosomiasis,also commonly known asbilharziasis,is one of the most significant parasiticdiseases of humans.A report of World HealthOrganization in 1996 estimated that over 200 millionpeople were infested worldwide,mainly in ruralagricultural and periurban areas.Of these,20million suffer severe consequences from the展开更多
Objective To describe the characteristic magnetic resonance imaging （MRI） appearance of cerebral schistosomiasis. Methods Twenty-five patients whose diagnosis of central nervous system （CNS） schistosomiasis had b...Objective To describe the characteristic magnetic resonance imaging （MRI） appearance of cerebral schistosomiasis. Methods Twenty-five patients whose diagnosis of central nervous system （CNS） schistosomiasis had been pathologically （n = 8 ） and clinically （n = 17） confLrmed were randomly selected. MRI was performed on a Signal 1.5T MRI scanner before and after the intravenous administration of gadopentetate dimeghimine constrast medium. We reviewed the MRI studies obtained at the time of initial presentation, as well as follow-up studies obtained during and after medical treatment Results ImmunoLogicaL tests in L5 patients indicated schistosomiasis haematobium. Contrast-enhanced TL-weighted images in 22 cases showed central linear enhancement surrounded by multiple enhancing punctate nodules, which ap- peared “arborized”. Through operation and pathological examination, 8 cases had the granuloma formation of schistoso- mal eggs extensive surrounded by inflammation and venous congestion. And 17 cases were treated with praziquantel and corticosteroid therapy. And they were followed up for 2 months by taking MRI, which turned out to be complete resolution of the enhancing structure and edema. At follow-up, all the patients＇ initial symptoms also resolved. Conclnsion The specified MRI enhancement pattern of cerebral schistosomiasis is common in most cases of CNS schistosomiasis, so it should be taken account into the diagnosis of cerebral schistosomiasis.展开更多
To the Editor,Schistosomiasis is an infectious disease caused by trematode parasites of the genus Schistosoma.According to the World Health Organization(WHO),it is estimated that about 250 million people in the world ...To the Editor,Schistosomiasis is an infectious disease caused by trematode parasites of the genus Schistosoma.According to the World Health Organization(WHO),it is estimated that about 250 million people in the world are infected with the disease,nearly 800 million people are at risk of infection,and more than 200,000 people die of schistosomiasis every year.1,2 In China,the endemic species of schistosome that primarily infects humans is Schistosoma japonicum.Schistosomiasis japonica has been a major public health problem affecting human health and economic development in the past decades.The latest national epidemiological data showed that there were still 29,517 advanced cases of schistosomiasis japonica at the end of 2020.Moreover,approximately 842,500 patients had been previously infected with S.japonicum nationwide,of whom 83.3%had chronic schistosomiasis.3 Our previous studies confirmed that past cases have no possibility of re‐infection after antiparasitic treatment and that liver fibrosis continues to progress and eventually develops into advanced schistosomiasis.4 Some studies have also shown that although chemotherapy with praziquantel is readily available and has good efficacy,liver fibrosis remains the most serious consequence of S.japonicum chronic infection,with an incidence of nearly 20%in infected patients.5 Hence,nearly one million patients with chronic schistosomiasis are at risk of later developing liver fibrosis.展开更多
Parasitic liver diseases can be caused by trematodes,cestodes,nematodes,and protozoa.This pathology is significant because millions of people in different parts of the world have liver parasites,which can manifest the...Parasitic liver diseases can be caused by trematodes,cestodes,nematodes,and protozoa.This pathology is significant because millions of people in different parts of the world have liver parasites,which can manifest themselves in the development of inflammation,liver cysts,cholecystitis,cholelithiasis,pancreatitis and liver cirrhosis that are often threatening their lives.The International Agency for Research on Cancer considers three species of trematodes,Schistosoma haematobium,Opisthorchis viverrini and Clonorchis sinensis,to be carcinogens.Complex modern examination methods,in some cases including extensive screening of large populations,are required for diagnosing liver parasites.Treatment of parasitic liver diseases is differentiated and can involve a combination of surgical and therapeutic measures.There is no doubt that the clinical and epidemiological scale allows one to regard parasitic liver diseases as a global healthcare problem.展开更多
文摘Schistosomiasis,caused by parasitic bloodflukes of the genus Schistosoma,is a major source of human disease in developing tropical nations.This paper reviews the diagnostic various assays for schistosomiasis,with particular reference to recent advances in assays incorporating direct parasitological examination,serology,antigen detection,and polymerase chain reaction detection of parasite genetic material.
文摘AIM:To make a retrospective analysis of endoscopy findings and clinicopathologic characteristics of colonic schistosomiasis in order to further improve our understanding of the disease and decrease its misdiagnosis. METHODS:Endoscopy findings and clinicopathologic characteristics of 46 intestinal schistosomiasis patients were retrospectively analyzed.All the patients underwent colonoscopy and all biopsy specimens stained with hematoxylin and eosin were observed under a light microscope. RESULTS:Of the 46 colonic schistosomiasis patients,1 was diagnosed as acute schistosomal colitis,16 as chronic schistosomal colitis and 29 as chronic active schistosomal colitis according to their endoscopic findings and pathology.Not all patients were suspected of or diagnosed as colonic schistosomiasis.Of the 12 misdiagnosed patients,4 were misdiagnosed as ulcerativecolitis,1 as Crohn's disease,and 7 as ischemic colitis.The segments of rectum and sigmoid colon were involved in 29 patients(63.0%) .Intact Schistosoma ova were deposited in colonic mucosa accompanying infiltration of eosinocytes,lymphocytes,and plasma cells in acute schistosomal colitis patients.Submucosal fibrosis was found in chronic schistosomal colitis patients.Among the 17 patients with a signal polyp,hyperplastic polyp,canalicular adenoma with a low-grade intraepithelial neoplastic change,tubulovillous adenoma with a highgrade intraepithelial neoplastic change were observed in 10,5,and 2 patients,respectively.Eight out of the 46 patients were diagnosed as colonic carcinoma. CONCLUSION:Endoscopy contributes to the diagnosis of colonic schistosomiasis although it is nonspecific. A correct diagnosis of colonic schistosomiasis can be established by endoscopy in combination with its clinicopathologic characteristics.
文摘INTRODUCTIONSchistosomiasis,also commonly known asbilharziasis,is one of the most significant parasiticdiseases of humans.A report of World HealthOrganization in 1996 estimated that over 200 millionpeople were infested worldwide,mainly in ruralagricultural and periurban areas.Of these,20million suffer severe consequences from the
文摘Objective To describe the characteristic magnetic resonance imaging （MRI） appearance of cerebral schistosomiasis. Methods Twenty-five patients whose diagnosis of central nervous system （CNS） schistosomiasis had been pathologically （n = 8 ） and clinically （n = 17） confLrmed were randomly selected. MRI was performed on a Signal 1.5T MRI scanner before and after the intravenous administration of gadopentetate dimeghimine constrast medium. We reviewed the MRI studies obtained at the time of initial presentation, as well as follow-up studies obtained during and after medical treatment Results ImmunoLogicaL tests in L5 patients indicated schistosomiasis haematobium. Contrast-enhanced TL-weighted images in 22 cases showed central linear enhancement surrounded by multiple enhancing punctate nodules, which ap- peared “arborized”. Through operation and pathological examination, 8 cases had the granuloma formation of schistoso- mal eggs extensive surrounded by inflammation and venous congestion. And 17 cases were treated with praziquantel and corticosteroid therapy. And they were followed up for 2 months by taking MRI, which turned out to be complete resolution of the enhancing structure and edema. At follow-up, all the patients＇ initial symptoms also resolved. Conclnsion The specified MRI enhancement pattern of cerebral schistosomiasis is common in most cases of CNS schistosomiasis, so it should be taken account into the diagnosis of cerebral schistosomiasis.
基金funded by the National Natural Science Foundation of China(Grant No.:82173586)Jiangsu Provincial Department of Science and Technology(Grant No.:BZ2020003).
文摘To the Editor,Schistosomiasis is an infectious disease caused by trematode parasites of the genus Schistosoma.According to the World Health Organization(WHO),it is estimated that about 250 million people in the world are infected with the disease,nearly 800 million people are at risk of infection,and more than 200,000 people die of schistosomiasis every year.1,2 In China,the endemic species of schistosome that primarily infects humans is Schistosoma japonicum.Schistosomiasis japonica has been a major public health problem affecting human health and economic development in the past decades.The latest national epidemiological data showed that there were still 29,517 advanced cases of schistosomiasis japonica at the end of 2020.Moreover,approximately 842,500 patients had been previously infected with S.japonicum nationwide,of whom 83.3%had chronic schistosomiasis.3 Our previous studies confirmed that past cases have no possibility of re‐infection after antiparasitic treatment and that liver fibrosis continues to progress and eventually develops into advanced schistosomiasis.4 Some studies have also shown that although chemotherapy with praziquantel is readily available and has good efficacy,liver fibrosis remains the most serious consequence of S.japonicum chronic infection,with an incidence of nearly 20%in infected patients.5 Hence,nearly one million patients with chronic schistosomiasis are at risk of later developing liver fibrosis.
基金Supported by the Ministry of Education and Science of the Russian Federation,No.FWES-2024-0035.
文摘Parasitic liver diseases can be caused by trematodes,cestodes,nematodes,and protozoa.This pathology is significant because millions of people in different parts of the world have liver parasites,which can manifest themselves in the development of inflammation,liver cysts,cholecystitis,cholelithiasis,pancreatitis and liver cirrhosis that are often threatening their lives.The International Agency for Research on Cancer considers three species of trematodes,Schistosoma haematobium,Opisthorchis viverrini and Clonorchis sinensis,to be carcinogens.Complex modern examination methods,in some cases including extensive screening of large populations,are required for diagnosing liver parasites.Treatment of parasitic liver diseases is differentiated and can involve a combination of surgical and therapeutic measures.There is no doubt that the clinical and epidemiological scale allows one to regard parasitic liver diseases as a global healthcare problem.
