深圳湾北岸新民孔的Q_3~3-Q_4~1气候记录

对深圳湾北岸新民钻孔岩心沉积物中铁、钒元素、矿物鉴定的伊利石以及生物指标贝类介壳揭示的环境特征资料进行了分析，研究初步表明，该钻孔岩心沉积物理深12．12～10．91m层段的杂色花斑粘土中存有晚更新世晚期至早全新世气候波动的记录。钒元素和伊利石分析也得到了相应的证实。所记录的短期降温和升温事件可能表明，在第四纪末次冰期-冰消期中，气候曾强烈波动，并逐渐由晚冰期向冰后期过渡。这对研究晚武木冰期最低海面时期以来，海面回升及晚更新世晚期／早全新世的古环境方气候影响提供有价值的资料。

Cotton Spinning Industry Reports Continued Growth (Part B) Analysis of economic performance of China's cotton spinning industry in Q1-Q3 (Continued from Nov. 15, 2010)

Manufacturing and sales According to data collected from 11,934 statistics-worthy Chinese cotton spinning enterprises surveyed by National Bureau of Statistics of China, total industrial production value of the industry increased 27.39

Fixed-asset investment in textile industry slows in Q1-Q3 as cubs weigh on economy

Fixed asset investment growth in China’s textile industry slowed in the first three quarters this year, mainly resulting from the yuan appreciation, the rising material and labor costs, as well as dismal overseas market hit by the subprime lending crisis. From January to September, the total fixed-assets investment in the textile industry was up 10.15% to RMB 202.269 billion year-on-year,

曲安奈德益康唑乳膏处方及微观结构特性评价的比较研究

目的为曲安奈德益康唑乳膏一致性评价参比制剂(reference listed drug,RLD)的选择及质量等同性评价提供依据。方法采用逆向工程解析不同产地上市的原研产品、地产化产品派瑞松®和国产仿制药产品邦力®处方,比较处方(Q_(1))和关键功能性辅料的处方用量(Q_(2))的差异;并采用光学显微镜和冷镜露点法考察微观结构特性(Q_(3))差异。结果地产化产品派瑞松®与法国上市产品Pevisone®Q_(1)相同但Q_(2)不同;国产仿制药产品邦力®与地产化产品派瑞松®Q_(1)、Q_(2)及Q_(3)均不一致,两者产品Q_(3)的差异可能是由于Q_(1)和Q_(2)不同引起的。结论地产化产品派瑞松®不适宜作为本品一致性评价的RLD,建议国内生产企业选择Pevisone®为RLD,实现与参比制剂的Q_(1)、Q_(2)及Q_(3)一致,从而豁免生物等效性研究。

皮肤局部外用仿制药质量等同性评价的一般考虑

本文参考国内外相关技术指导原则及文献,针对皮肤局部外用仿制药研发和评价面临的复杂性与挑战,从与参比制剂质量等同性考虑,提出皮肤局部外用仿制药应与参比制剂保持最大程度的处方组成(Q1)、用量(Q2)和微观结构特性(Q3)等同的审评考虑,以期有助于该类药物的研发和评价。