Objective： To demonstrate the validity and reliability of volumetric quantitative computed tomography （vQCT） with multi-slice computed tomography （MSCT） and dual energy X-ray absorptiometry （DXA） for hip bone m...Objective： To demonstrate the validity and reliability of volumetric quantitative computed tomography （vQCT） with multi-slice computed tomography （MSCT） and dual energy X-ray absorptiometry （DXA） for hip bone mineral density （BMD） measurements, and to compare the differences between the two techniques in discriminating postmenopausal women with osteoporosis-related vertebral fractures from those without. Methods： Ninety subjects were enrolled and divided into three groups based on the BMD values of the lumbar spine and/or the femoral neck by DXA. Groups 1 and 2 consisted of postmenopausal women with BMD changes 〈-2SD, with and without radiographically confirmed vertebral fracture （n= 11 and 33, respectively）. Group 3 comprised normal controls with BMD changes 〉-ISD （n-46）. Post-MSCT （GE, LightSpeed16） scan reconstructed images of the abdominal-pelvic region, 1.25 mm thick per slice, were processed by OsteoCAD software to calculate the following parameters： volumetric BMD values of trabecular bone （TRAB）, cortical bone （CORT）, and integral bone （INTGL） of the left femoral neck, femoral neck axis length （NAL）, and minimum cross-section area （mCSA）. DXA BMD measurements of the lumbar spine （AP-SPINE） and the left femoral neck （NECK） also were performed for each subject. Results： The values of all seven parameters were significantly lower in subjects of Groups 1 and 2 than in normal postmenopausal women （P〈0.05, respectively）. Comparing Groups 1 and 2, 3D-TRAB and 3D-INTGL were significantly lower in postmenopausal women with vertebral fracture（s） [（109.8±9.61） and （243.3±33.0） mg/cm^3, respectively] than in those without [（148.9±7.47） and （285.4±17.8） mg/cm^3, respectively] （P〈0.05, respectively）, but no significant differences were evident in AP-SPINE or NECK BMD. Conclusion： the femoral neck-derived volumetric BMD parameters using vQCT appeared better than the DXA-derived ones in discriminating osteoporotic postmenopausal women with vertebral fractures from those without, vQCT might be useful to evaluate the effect of osteoporotic vertebral fracture status on changes in bone mass in the femoral neck.展开更多
目的运用定量CT研究老年女性腰椎间盘突出症患者和健康体检者腰椎骨密度(bone mineral density,BMD)的差异,探讨骨密度对腰椎间盘突出症的影响。方法选取腰椎间盘突出症患者64例,健康体检者60例作为对照,使用定量CT(quantitative CT,QCT...目的运用定量CT研究老年女性腰椎间盘突出症患者和健康体检者腰椎骨密度(bone mineral density,BMD)的差异,探讨骨密度对腰椎间盘突出症的影响。方法选取腰椎间盘突出症患者64例,健康体检者60例作为对照,使用定量CT(quantitative CT,QCT)测定两组人群腰椎相同部位骨密度,比较分析两组间、组内骨密度值。结果腰椎间盘突出症患者的骨密度值较对照组低,骨量减少及骨质疏松者在腰椎间盘突出症组所占比例较高,但差异无统计学意义(P>0.05)。腰椎间盘突出组中椎间盘邻近上下两椎体间骨密度有差异(P<0.05),而对照组则无明显差异。结论骨密度对腰椎间盘突出症有一定的影响,突出的椎间盘邻近两椎体骨密度存在某种特殊差异可能是造成椎间盘突出的一种原因。展开更多
目的：探讨不同腰椎椎体骨密度（ bone mineral density ，BMD）与年龄及同层面椎旁腰大肌、竖脊肌、腹部脂肪、血管钙化情况的关系。方法收集体检中心行腰椎检查的老年女性90名，采用定量CT（ quantitative CT ，QCT）及后处理软件测量...目的：探讨不同腰椎椎体骨密度（ bone mineral density ，BMD）与年龄及同层面椎旁腰大肌、竖脊肌、腹部脂肪、血管钙化情况的关系。方法收集体检中心行腰椎检查的老年女性90名，采用定量CT（ quantitative CT ，QCT）及后处理软件测量L2-L4椎体骨密度及三椎体同层面椎旁体质成分。统计学处理应用配对t检验、Pearson相关分析和多元逐步回归分析等。结果①3组椎体BMD均与年龄均呈负相关（P＜0.05），L2BMD、L3 BMD均与双侧腰大肌、竖脊肌密度成正相关（r＝0.233～0.301， P均＜0.05）。而L4 BMD显示与双侧竖脊肌密度及腹部脂肪面积有良好的相关性，均呈正相关。②多元逐步回归分析显示除年龄外，肌肉是影响BMD的重要因素。年龄是唯一全部进入3组腰椎BMD回归方程，并呈负相关，是影响腰椎BMD的重要因素。结论老年女性的腰椎骨密度与椎旁腰大肌、竖脊肌密度，腹部脂肪面积及年龄密切相关，除年龄外椎旁肌肉密度对骨密度影响最大。 QCT扫描更加直观、精确显示椎骨与椎旁体质成分情况，可作为测量诊断骨质疏松、体质成分的新手段。展开更多
文摘Objective： To demonstrate the validity and reliability of volumetric quantitative computed tomography （vQCT） with multi-slice computed tomography （MSCT） and dual energy X-ray absorptiometry （DXA） for hip bone mineral density （BMD） measurements, and to compare the differences between the two techniques in discriminating postmenopausal women with osteoporosis-related vertebral fractures from those without. Methods： Ninety subjects were enrolled and divided into three groups based on the BMD values of the lumbar spine and/or the femoral neck by DXA. Groups 1 and 2 consisted of postmenopausal women with BMD changes 〈-2SD, with and without radiographically confirmed vertebral fracture （n= 11 and 33, respectively）. Group 3 comprised normal controls with BMD changes 〉-ISD （n-46）. Post-MSCT （GE, LightSpeed16） scan reconstructed images of the abdominal-pelvic region, 1.25 mm thick per slice, were processed by OsteoCAD software to calculate the following parameters： volumetric BMD values of trabecular bone （TRAB）, cortical bone （CORT）, and integral bone （INTGL） of the left femoral neck, femoral neck axis length （NAL）, and minimum cross-section area （mCSA）. DXA BMD measurements of the lumbar spine （AP-SPINE） and the left femoral neck （NECK） also were performed for each subject. Results： The values of all seven parameters were significantly lower in subjects of Groups 1 and 2 than in normal postmenopausal women （P〈0.05, respectively）. Comparing Groups 1 and 2, 3D-TRAB and 3D-INTGL were significantly lower in postmenopausal women with vertebral fracture（s） [（109.8±9.61） and （243.3±33.0） mg/cm^3, respectively] than in those without [（148.9±7.47） and （285.4±17.8） mg/cm^3, respectively] （P〈0.05, respectively）, but no significant differences were evident in AP-SPINE or NECK BMD. Conclusion： the femoral neck-derived volumetric BMD parameters using vQCT appeared better than the DXA-derived ones in discriminating osteoporotic postmenopausal women with vertebral fractures from those without, vQCT might be useful to evaluate the effect of osteoporotic vertebral fracture status on changes in bone mass in the femoral neck.
文摘目的运用定量CT研究老年女性腰椎间盘突出症患者和健康体检者腰椎骨密度(bone mineral density,BMD)的差异,探讨骨密度对腰椎间盘突出症的影响。方法选取腰椎间盘突出症患者64例,健康体检者60例作为对照,使用定量CT(quantitative CT,QCT)测定两组人群腰椎相同部位骨密度,比较分析两组间、组内骨密度值。结果腰椎间盘突出症患者的骨密度值较对照组低,骨量减少及骨质疏松者在腰椎间盘突出症组所占比例较高,但差异无统计学意义(P>0.05)。腰椎间盘突出组中椎间盘邻近上下两椎体间骨密度有差异(P<0.05),而对照组则无明显差异。结论骨密度对腰椎间盘突出症有一定的影响,突出的椎间盘邻近两椎体骨密度存在某种特殊差异可能是造成椎间盘突出的一种原因。
文摘目的：探讨不同腰椎椎体骨密度（ bone mineral density ，BMD）与年龄及同层面椎旁腰大肌、竖脊肌、腹部脂肪、血管钙化情况的关系。方法收集体检中心行腰椎检查的老年女性90名，采用定量CT（ quantitative CT ，QCT）及后处理软件测量L2-L4椎体骨密度及三椎体同层面椎旁体质成分。统计学处理应用配对t检验、Pearson相关分析和多元逐步回归分析等。结果①3组椎体BMD均与年龄均呈负相关（P＜0.05），L2BMD、L3 BMD均与双侧腰大肌、竖脊肌密度成正相关（r＝0.233～0.301， P均＜0.05）。而L4 BMD显示与双侧竖脊肌密度及腹部脂肪面积有良好的相关性，均呈正相关。②多元逐步回归分析显示除年龄外，肌肉是影响BMD的重要因素。年龄是唯一全部进入3组腰椎BMD回归方程，并呈负相关，是影响腰椎BMD的重要因素。结论老年女性的腰椎骨密度与椎旁腰大肌、竖脊肌密度，腹部脂肪面积及年龄密切相关，除年龄外椎旁肌肉密度对骨密度影响最大。 QCT扫描更加直观、精确显示椎骨与椎旁体质成分情况，可作为测量诊断骨质疏松、体质成分的新手段。
