Objective:To analyze whether the European Organisation for Treatment and Research of Cancer(EORTC)Quality of Life Questionnaires(QLQ-C30 and QLQ-CR29)complement the low anterior resection of rectum syndrome(LARS)score...Objective:To analyze whether the European Organisation for Treatment and Research of Cancer(EORTC)Quality of Life Questionnaires(QLQ-C30 and QLQ-CR29)complement the low anterior resection of rectum syndrome(LARS)score in evaluating the quality of life of patients who underwent laparoscopic or robotic rectal cancer surgery.Methods:Initially,335 patients who underwent laparoscopic or robotic rectal cancer surgery were randomly selected at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine from June 2013 to September 2020.All the patients took the questionnaires of LARS score,QLQ-C30 and QLQ-CR29.Totally,questionnaires filled out by 224 patients were qualified after screening.Patients were divided into three groups according to LARS score:No LARS group(score 0-20),minor LARS group(score 21-29)and major LARS group(score 30-42).The scores of QLQ-C30 as well as QLQ-CR29 among the three groups were compared.Results:Major,minor and no LARS groups had 140 cases,40 cases and 44 cases respectively.In the scales of QLQ-C30,significant differences were discovered in global quality of life,physical function,role function,emotional function,cognitive function,social function,fatigue,pain,dyspnea,sleep disturbance,constipation and diarrhea between the no and major LARS groups(p<0.05).While the differences were only found in global quality of life and diarrhea between the minor and major LARS groups(p<0.05).In QLQ-CR29,scales of urinary frequency,blood and mucus in stool,body image,flatulence,fecal incontinence,sore skin,stool frequency,embarrassment,impotence,abdominal pain,buttock pain,bloating,dry mouth,hair loss,taste,anxiety and weight,had significant differences between the no and major LARS groups(p<0.05).Only six scales,ie blood and mucus in stool,flatulence,fecal incontinence,stool frequency,embarrassment and dysuria had significant differences between the minor and major LARS groups(p<0.05).Conclusion:For patients following laparoscopic or robotic low anal sphincter preserving surgery,LARS score,QLQ-C30 and QLQ-CR29 scores are consistent in overall trends.To guide disease evaluation and individualized treatment,as well as to evaluate efficacy,we suggest getting pre-and post-operative LARS scores incorporating QLQ-C30 and QLQ-CR29 scores as a comprehensive evaluation system.展开更多
目的探讨康复期锻炼对乳腺癌患者生命质量的影响。方法采用横断面研究方法,整群抽样上海癌症康复俱乐部1 956名女性乳腺癌康复期患者进行问卷调查,调查问卷采用欧洲癌症研究与治疗组织生命质量量表(quality of life questionnaire-core ...目的探讨康复期锻炼对乳腺癌患者生命质量的影响。方法采用横断面研究方法,整群抽样上海癌症康复俱乐部1 956名女性乳腺癌康复期患者进行问卷调查,调查问卷采用欧洲癌症研究与治疗组织生命质量量表(quality of life questionnaire-core 30,EORTC QLQ-C30)和乳腺癌生存质量量表(quality of life questionnaire-breast cancer module 23,QLQ-BR23)。结果 QLQ-BR23的信度和效度分别为0.898和0.904,EORTC QLQ-C30的信度和效度分别为0.988和0.989;对于QLQ-BR23量表,康复锻炼、锻炼次数和生命质量均无统计学意义。但是参与康复锻炼和锻炼次数≥5次/周患者的功能症状总得分高于未参加康复锻炼和康复锻炼<5次/周患者。对于EORTC QLQ-C30量表,通过调整社会人口学等因素,参加康复锻炼患者的躯体功能及总体健康状况得分均显著高于不参加体育锻炼患者(P<0.05,PAdjusted<0.05);康复锻炼≥5次/周患者的5个功能维度及总体健康状况得分均高于康复锻炼<5次/周患者,但只有躯体功能差异有统计学意义(P<0.05,PAdjusted<0.05)。结论参加康复锻炼的乳腺癌患者总体生命质量高于未参加锻炼者,康复锻炼对提高乳腺癌患者的生命质量有积极影响。展开更多
目的利用真实医疗环境中的电子病历系统临床资料和随访数据,评价中医药治疗食管癌的临床疗效。方法收集2014年1月至2018年12月河南省中医院、河南中医药大学第一附属医院、河南省肿瘤医院肿瘤科食管癌患者共计336例,通过建立数据库,根...目的利用真实医疗环境中的电子病历系统临床资料和随访数据,评价中医药治疗食管癌的临床疗效。方法收集2014年1月至2018年12月河南省中医院、河南中医药大学第一附属医院、河南省肿瘤医院肿瘤科食管癌患者共计336例,通过建立数据库,根据是否联合中医治疗分为两组,观察组接受西医治疗的基础上联合中医药治疗,对照组仅接受西医治疗,观察比较两组的临床疗效、患者Karnofsky功能状态评分、生命质量调查量表(QLQ-C30)评分及不良反应情况。结果观察组患者客观缓解率(objective response rate,ORR)与对照组比较,差异无统计学意义(P>0.05),但观察组疾病控制率(disease control rate,DCR)高于对照组,差异有统计学意义(P<0.05);观察组3年累积生存率显著高于对照组,差异具有统计学意义;治疗后两组患者KPS、QLQ-C30评分均较治疗前升高(P<0.05),且观察组上述评分升高较对照组更显著;消化道不良反应、神经毒性发生率观察组低于对照组,两组比较差异有统计学意义(P<0.05);而两组患者白细胞降低率、血小板减少率、血红蛋白减少率比较,差异均无统计学意义(P>0.05)。年龄、TNM分期、中医药干预及干预时间均为影响中晚期食管癌患者预后的独立危险因素(P<0.05)。结论中医药联合西医治疗可提高中晚期食管癌的临床疗效,同时可提高患者生活质量,减少西医治疗过程中不良反应的发生。展开更多
文摘Objective:To analyze whether the European Organisation for Treatment and Research of Cancer(EORTC)Quality of Life Questionnaires(QLQ-C30 and QLQ-CR29)complement the low anterior resection of rectum syndrome(LARS)score in evaluating the quality of life of patients who underwent laparoscopic or robotic rectal cancer surgery.Methods:Initially,335 patients who underwent laparoscopic or robotic rectal cancer surgery were randomly selected at Sir Run Run Shaw Hospital,Zhejiang University School of Medicine from June 2013 to September 2020.All the patients took the questionnaires of LARS score,QLQ-C30 and QLQ-CR29.Totally,questionnaires filled out by 224 patients were qualified after screening.Patients were divided into three groups according to LARS score:No LARS group(score 0-20),minor LARS group(score 21-29)and major LARS group(score 30-42).The scores of QLQ-C30 as well as QLQ-CR29 among the three groups were compared.Results:Major,minor and no LARS groups had 140 cases,40 cases and 44 cases respectively.In the scales of QLQ-C30,significant differences were discovered in global quality of life,physical function,role function,emotional function,cognitive function,social function,fatigue,pain,dyspnea,sleep disturbance,constipation and diarrhea between the no and major LARS groups(p<0.05).While the differences were only found in global quality of life and diarrhea between the minor and major LARS groups(p<0.05).In QLQ-CR29,scales of urinary frequency,blood and mucus in stool,body image,flatulence,fecal incontinence,sore skin,stool frequency,embarrassment,impotence,abdominal pain,buttock pain,bloating,dry mouth,hair loss,taste,anxiety and weight,had significant differences between the no and major LARS groups(p<0.05).Only six scales,ie blood and mucus in stool,flatulence,fecal incontinence,stool frequency,embarrassment and dysuria had significant differences between the minor and major LARS groups(p<0.05).Conclusion:For patients following laparoscopic or robotic low anal sphincter preserving surgery,LARS score,QLQ-C30 and QLQ-CR29 scores are consistent in overall trends.To guide disease evaluation and individualized treatment,as well as to evaluate efficacy,we suggest getting pre-and post-operative LARS scores incorporating QLQ-C30 and QLQ-CR29 scores as a comprehensive evaluation system.
文摘目的探讨康复期锻炼对乳腺癌患者生命质量的影响。方法采用横断面研究方法,整群抽样上海癌症康复俱乐部1 956名女性乳腺癌康复期患者进行问卷调查,调查问卷采用欧洲癌症研究与治疗组织生命质量量表(quality of life questionnaire-core 30,EORTC QLQ-C30)和乳腺癌生存质量量表(quality of life questionnaire-breast cancer module 23,QLQ-BR23)。结果 QLQ-BR23的信度和效度分别为0.898和0.904,EORTC QLQ-C30的信度和效度分别为0.988和0.989;对于QLQ-BR23量表,康复锻炼、锻炼次数和生命质量均无统计学意义。但是参与康复锻炼和锻炼次数≥5次/周患者的功能症状总得分高于未参加康复锻炼和康复锻炼<5次/周患者。对于EORTC QLQ-C30量表,通过调整社会人口学等因素,参加康复锻炼患者的躯体功能及总体健康状况得分均显著高于不参加体育锻炼患者(P<0.05,PAdjusted<0.05);康复锻炼≥5次/周患者的5个功能维度及总体健康状况得分均高于康复锻炼<5次/周患者,但只有躯体功能差异有统计学意义(P<0.05,PAdjusted<0.05)。结论参加康复锻炼的乳腺癌患者总体生命质量高于未参加锻炼者,康复锻炼对提高乳腺癌患者的生命质量有积极影响。
文摘目的利用真实医疗环境中的电子病历系统临床资料和随访数据,评价中医药治疗食管癌的临床疗效。方法收集2014年1月至2018年12月河南省中医院、河南中医药大学第一附属医院、河南省肿瘤医院肿瘤科食管癌患者共计336例,通过建立数据库,根据是否联合中医治疗分为两组,观察组接受西医治疗的基础上联合中医药治疗,对照组仅接受西医治疗,观察比较两组的临床疗效、患者Karnofsky功能状态评分、生命质量调查量表(QLQ-C30)评分及不良反应情况。结果观察组患者客观缓解率(objective response rate,ORR)与对照组比较,差异无统计学意义(P>0.05),但观察组疾病控制率(disease control rate,DCR)高于对照组,差异有统计学意义(P<0.05);观察组3年累积生存率显著高于对照组,差异具有统计学意义;治疗后两组患者KPS、QLQ-C30评分均较治疗前升高(P<0.05),且观察组上述评分升高较对照组更显著;消化道不良反应、神经毒性发生率观察组低于对照组,两组比较差异有统计学意义(P<0.05);而两组患者白细胞降低率、血小板减少率、血红蛋白减少率比较,差异均无统计学意义(P>0.05)。年龄、TNM分期、中医药干预及干预时间均为影响中晚期食管癌患者预后的独立危险因素(P<0.05)。结论中医药联合西医治疗可提高中晚期食管癌的临床疗效,同时可提高患者生活质量,减少西医治疗过程中不良反应的发生。
