Objective To observe the clinical efficacy of the needling method for regulating wei qi and strengthening brain on insomnia.Method Two hundred patients with insomnia were randomly divided into a group of regulating we...Objective To observe the clinical efficacy of the needling method for regulating wei qi and strengthening brain on insomnia.Method Two hundred patients with insomnia were randomly divided into a group of regulating wei qi and strengthening brain（group A） and a group of normal acupuncture（group B）through random number table method,with 100 cases in each group.In group A,Baihui（百会 GV20）,Dazhui（大椎 GV 14）,Shenmai（申脉 BL62）,Zhaohai（照海 KI 6） and auricular points Yuanzhong（缘中 AT 2,3,4i）,and Shenmen（神门TF 4） were selected;and in group B,Sishencong（四神聪 EX-HN 1）,Shenmen（神门 HT 7）,and Sanyinjiao（三阴交 SP 6） were selected.Acupuncture was given on these points once daily for 15 days.Pittsburgh sleep quality index（PSQI） was used for scoring and curative effect was evaluated before and after treatment.Results The total effective rate was 89.0%（89/100） in group A and 65.0%（65/100） in group B with a very significant difference between the two groups（P〈0.01）;the difference of PSQI scores before and after treatment was（-9.15±5.68）in group A and（-5.64±5.73）in group B,with a very significant difference before and after treatment in the two groups（P〈0.01）.Conclusion The therapeutic effect of the needling method for regulating wei qi and strengthening brain on insomnia is superior to that of normal needling method.展开更多
目的观察针刺配合通络益气汤治疗脑小血管病致认知功能障碍的临床疗效及其对患者脑微循环、步态平衡和血清神经元PAS结构域蛋白4(neuronal PAS domain protein 4,NPAS4)、P-选择素(CD62P)表达的影响。方法将98例脑小血管病致认知功能障...目的观察针刺配合通络益气汤治疗脑小血管病致认知功能障碍的临床疗效及其对患者脑微循环、步态平衡和血清神经元PAS结构域蛋白4(neuronal PAS domain protein 4,NPAS4)、P-选择素(CD62P)表达的影响。方法将98例脑小血管病致认知功能障碍患者随机分为治疗组和对照组,每组49例。治疗组采用针刺配合通络益气汤治疗,对照组采用单纯通络益气汤治疗。观察两组治疗前后各项实验室指标[谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、晚期糖基化终末产物(advanced glycation end products,AGEs)、NPAS4、CD62P、一氧化氮(NO)、亲环素A(cyclophilin A,CyPA)、脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)、血管性血友病因子(von Willebrand factor,vFW)水平]、脑微循环指标[血脑屏障通透性、血管差压、临界压力(critical pressure,CP)、脑血管动态阻力(dynamic resistance,DR)]及各量表[Berg平衡量表(Berg balance scale,BBS)、Tinetti平衡与步态量表、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA]评分的变化情况,并比较两组临床疗效。结果两组治疗后GSH-Px、NO水平及CP、各量表评分均较同组治疗前显著上升,AGEs、NPAS4、CD62P、CyPA、Lp-PLA2、vFW水平及血脑屏障通透性、血管差压、DR显著下降,差异均具有统计学意义(P<0.05)。治疗组治疗后GSH-Px、NO水平及CP、各量表评分均明显高于对照组,AGEs、NPAS4、CD62P、CyPA、Lp-PLA2、vFW水平及血脑屏障通透性、血管差压、DR均明显低于对照组,两组比较差异均具有统计学意义(P<0.05)。治疗组总有效率为98.0%,明显高于对照组的87.8%,两组比较差异具有统计学意义(P<0.05)。结论针刺配合通络益气汤治疗脑小血管病致认知功能障碍疗效确切,可减少氧化应激反应及炎症反应,降低NPAS4、CD62P水平,减少血管内皮功能及认知功能损伤,改善血脑屏障通透性、脑微循环及步态平衡。展开更多
基金Supported by Project of State Administration of Traditional Chinese Medicine:2002 ZL 29
文摘Objective To observe the clinical efficacy of the needling method for regulating wei qi and strengthening brain on insomnia.Method Two hundred patients with insomnia were randomly divided into a group of regulating wei qi and strengthening brain（group A） and a group of normal acupuncture（group B）through random number table method,with 100 cases in each group.In group A,Baihui（百会 GV20）,Dazhui（大椎 GV 14）,Shenmai（申脉 BL62）,Zhaohai（照海 KI 6） and auricular points Yuanzhong（缘中 AT 2,3,4i）,and Shenmen（神门TF 4） were selected;and in group B,Sishencong（四神聪 EX-HN 1）,Shenmen（神门 HT 7）,and Sanyinjiao（三阴交 SP 6） were selected.Acupuncture was given on these points once daily for 15 days.Pittsburgh sleep quality index（PSQI） was used for scoring and curative effect was evaluated before and after treatment.Results The total effective rate was 89.0%（89/100） in group A and 65.0%（65/100） in group B with a very significant difference between the two groups（P〈0.01）;the difference of PSQI scores before and after treatment was（-9.15±5.68）in group A and（-5.64±5.73）in group B,with a very significant difference before and after treatment in the two groups（P〈0.01）.Conclusion The therapeutic effect of the needling method for regulating wei qi and strengthening brain on insomnia is superior to that of normal needling method.
