Effect of Huangqi Xiaoke Recipe combined with alprostadil on qi and yin deficiency type diabetic nephropathy and its effect on vascular endothelium and oxidative stress

Objective: To observe the clinical efficacy of Huangqi Xiaoke Decoction combined with alprostadil on qi and yin deficiency type diabetic nephropathy (DN) and its effect on vascular endothelium and oxidative stress. Methods: A total of 72 patients with qi and yin deficiency type DN who were admitted to the diabetes specialist ward and outpatient department of Baoan District Hospital of Shenzhen from January 2017 to July 2018 were enrolled. The patients were divided into the control group and the observation group according to the random number method. 36 cases in each group. Both groups were treated with conventional treatments such as hypoglycemic, hypotensive, lipid-lowering and anti-platelet aggregation. The control group was treated with alprostadil on the basis of conventional treatment. The observation group was given orally on the basis of the control group. Both groups were treated once a day for a total of 4 weeks. Compare the clinical syndrome scores and clinical efficacy of the two groups before and after treatment;fasting blood glucose (FPG), glycosylated hemoglobin (HbA1C), blood lipids (TC, TG, LDL, HDL), serum creatinine (SCr), blood urea nitrogen (BUN Endothelin-1 (ET-1), nitric oxide (NO), von Willebrand factor (vWF);glutathione peroxidase (GSH-Px), superoxide disproportionation The level of enzyme (SOD), malondialdehyde (MDA). Results:The total effective rate of TCM syndromes in observation group was 94.44%, which was significantly different from 72.22% in the control group. The scores of TCM syndromes in the observation group were significantly lower than those in the control group;Compared with the control group, the HDL-C of the observation group did not change much, there was no statistical difference;FBG, HbA1C, SCr, BUN, TC, TG, LDL-C, ET-1, vWF, MDA Significantly decreased, NO, GSH-Px, SOD increased significantly, with significant difference. Conclusion: Huangqi Xiaoke Decoction combined with alprostadil in the treatment of qi and yin deficiency type DN has significant curative effect, which can not only lower blood sugar, regulate blood lipids, improve renal function and clinical symptoms, but also inhibit oxidative stress and protect endothelial function.

Media, Redemption, and Myth Superscription in Zhang Yimou＇s Riding Alone for Thousands of Miles

This article analyzes scenes of media and redemption in Zhang Yimou＇s 张艺谋 film Qianli zou danqi 千里走单骑（Riding Alone for Thousands of Miles, 2005） as a critique of Romantic Orientalism. Whereas in Western Romantic poetry, the themes of retreating to nature and journeying abroad are strengthened by imagining the Orient and appropriating the local voice, Riding Alone negates that motif by depicting the divided subjectivities of Kenichi, a historian of Oriental Art at Tokyo University, and his failed redemption during his journey to China. The film offers his father Takata＇s alternative journey, which involves the foreign traveler losing his subject position before asserting his own, leading to the revival of the Lord Guan story. Much of the historical myth-making of Lord Guan in Buddhist, Daoist, and Confucian religious practices involves a reinvention of a cultural tradition as a response to foreign threat; all share the features of what Prasenjit Duara calls ＂the apotheosization of a hero and his role as guardian＂ in a process of the ＂superscription of symbols.＂ By contrast, Riding Alone is secular and forward-thinking while reenacting several meanings of the Lord Guan myth such as repentance, sacrifice, redemption, and guardianship. The film interpolates the Japanese into a new ＂Oriental＂ subject position that has to lose its Western Orientalism as well as the negative impact of industrialism while retaining democratic subjectivity, and the Chinese into a new democratic subject position that maintains autonomy.