A Set of Acupuncture Needles in the Late Qing Dynasty Collected by George Souliéde Morant

In the early 20th century,French vice-consul George Souliéde Morant encountered acupuncture during his visit to China,and then brought it back to France.After more than a century,his collection was transported from Paris,France to Kunming,China,and later recognized as a Chinese national third-class precious cultural heritage.Currently housed in the Museum of Western Studies on Chinese Medicine at Yunnan University of Chinese Medicine,this set of instruments includes one needle holder converted from a fan-shaped holder,ten acupuncture needles,and eleven paper tags handwritten in English with names of diseases and body parts.This article attempts to present the foundational information and historical significance of this collection of this set of late Qing dynasty acupuncture instruments by reviewing the collection and related research on acupuncture instruments,consulting acupuncture professionals,measuring the detailed information of the set of instruments,and employing a method of translating and summarizing the content of the attached tags.

Qingpu Folk Singing

TIANSHANGE is a unique form of folk tune in Wu dialect(spoken in Shanghai,Zhejiang Province,and in southeastern Jiangsu Province).The Tianshange in Qingpu District,Shanghai,boasts distinctive regional features.The earliest recorded reference to Qingpu Tianshange dates back to the Qing Dynasty(1644-1911),and in 2008,this form of art was included in the list of national intangible cultural heritage items of China.

Ancient DNA Study Reveals Population History of Western Qingzang Plateau

According to a study published in Current Biology on May 22,the genetic components of the ancient populations in the western Qingzang Plateau are closest to that of the ancient populations in the southern Qingzang Plateau,and have been maintained over the past 3,500 years.In addition,these ancient populations in the western Qingzang Plateau had complex and frequent interactions with ancient populations inside and outside the plateau.

Structural Carpentry in Qing Dynasty-A Framework for the Hierarchically Modularized Chinese Timber Structural Design

This article, by using mathematical expressions, offers a scientific framework for understanding how the grading system of Qing′s structural carpentry determines the design and construction in the grand style timber architecture.The Qing′s grand style timber structure, which is ready for prefabrication and assembly, is extremely hierarchical oriented and significantly standardized. The general procedure in designing a grand style timber structure is to start with the grade that defines the basic module (dou kou); next comes with the number of bracket set (cuan), the number of longitudinal bays and the number of purlins which affect its plan and cross section; thirdly choose a roof type that determines its longitudinal section and the facade as well. A series of formulae are conducted to help depict the layout, cross sectional roof curvature and special longitudinal treatments in 4 sloped and 9 spined roofs respectively.

稳幅范围、稳幅精度与De-Qing电路的设计

De—Qing电路的设计历来都是从它的稳定工作的必要条件出发,求得网络元件参数。本文从理论分析证明De-Qing工作有一限制的范围,这一范围既决定于所选元件参数,更大程度上取决于设计者所期望的稳幅精度。

管弦乐Qing-Diao(《清调》)研究——贾国平音乐创作的观念、技术与文化

20世纪90年代,十二音创作技术与序列思维依然对中国作曲家的创作产生着影响。他们在借用这种思维与技巧进行创作的同时,亦采用了各种方式来阐释民族文化。贾国平的管弦乐Qing-Diao(《清调》)便是这样一部作品。其中,无论是从作品“标签化”的标题、对传统音乐素材的处理、作品中单声思维的观念,还是整体音乐语言的组织与陈述方式,无不显示出作曲家在传承中国民族文化过程中观念的形成与技术的创新。

远红外FEL微波源调制器De-Qing稳幅电路设计

远红外自由电子激光(FEL)对微波源的幅度稳定度有特殊要求,因此,选用有突出优点的阻容振荡型[(De)22.7(-)]Qing电路作为微波源的脉间稳幅控制线路。电路设计采用新的设计路线,首先引入电压调整深度概念,用归一化设计,分析推导出与稳幅精度有关的各种因素和相互关系,然后以稳幅精度0.2%为条件求出电路各参数的限制范围,最后通过实验确定各元件参数的标称值。最终实现了微波源高压脉冲幅度稳定精度0.15%,满足了远红外自由电子激光实验需求。

关于de-Qing电路失灵保护

一、引言在电子直线加速器领域,基于能量稳定性的考虑,在雷达领域,由于信号稳定度要求,它们的功率脉冲发生器普遍采用脉间稳幅电路。而在电子直线加速器范围内,几乎无例外地采用de-Qing电路作为脉间稳幅手段。实践表明,任何电路都有失误的可能。

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation.

Traditional Chinese medicine “Qing Yi Tang” alleviates oxygen free radical injury in acute necrotizing pancreatitis

AIM To observe the changes in oxygen free radical (OFR) and the curative effect of traditional Chinese medicine 'Qing Yi Tang' in acute necrotizing pancreatitis (ANP).METHODS After induction of ANP by injection of sodium taurocholate into pancreatic duct, 16 dogs were randomly divided into control group and Chinese medicine group. Serum amylase, SOD and MDA were determined on postoperative day 1, 2, 4 and 7. The animals were sacrificed on day 7. SOD and MDA in organs were determined, and pathological changes in pancreas were observed.RESULTS As compared with control group, the serum level of amylase (734U/L vs 2783U/L) and MDA (7.8nmol/ml vs 14.8nmol/ml) in Chinese medicine group were decreased on day 7 (P＜0.05), while SOD increased significantly (281nU/ml vs 55nU/ml, P＜0.01), and similar changes occurred in MDA and SOD in organs, especially in the pancreas; the pathological changes in the pancreas were alleviated as well.CONCLUSION 'Qing Yi Tang' is effective in clearing OFRs and alleviating pathological changes in ANP.

Effect of Qing'e Formula on Circulating Sclerostin Levels in Patients with Postmenopausal Osteoporosis

Summary： Serum sclerostin is positively associated with serum 25 hydroxyvitamin D concentration. Our preliminary studies confirmed that Qing＇e formula （QEF） could effectively increase serum 25 hy- droxyvitamin D concentration in patients with postmenopausal osteoporosis （PMOP）, but the effect of supplementation with QEF on serum sclerostin is unknown. This study investigated the effects of sup- plementation of QEF on serum sclerostin levels in patients with PMOP. Totally 120 outpatients and in- patients with PMOP treated in our hospital between January and October 2012 were randomly divided into QEF＋calcium group, alfacalcidol＋calcium group, and placebo＋calcium group （n=40 each）, with a follow-up period of 2 years. The serum levels of sclerostin, 25 hydroxyvitamin D, and bone turnover markers （β-CTX, N-MID and T-PINP） at baseline and at the 6th month, 1st year, 1.5th year, and 2nd year after treatment were measured. The results showed that the levels of circulating sclerostin were in- creased significantly at the 6th month after treatment in QEF＋calcium group and alfacalcidol＋calcium group as compared with placebo＋calcium group （P〈0.05）, but there was no significant difference be- tween the former two groups （P〉0.05）. The levels of β-CTX, N-MID and T-PINP in serum were de- creased in both QEF＋calcium group and alfacalcidol＋calcium group at the 6th month after treatment, without significant difference between the two groups （P〉0.05）. BUt the levels were significantly lower than that in placebo＋calcium group （P〈0.05）. These results suggest that the mechanism by which QEF modulates bone metabolism in patients with PMOP might be related with the effect of QEF in increas- ing sclerostin expression. Our findings provide a scientific rationale for using QEF as an effective drug to prevent bone loss in PMOP.

阻容振荡型“De-Qing”电路参数的最佳设计

在调制器电压调整技术中,发展了阻容振荡型“De-Qing”电路最佳设计。当引入一个新的参数T_3/T后,则“De-Qing”电路参数的选择变得十分简捷,可以一次求出最佳参数。求出的“De-Qing”电路参数可以使电路在调整度由零到最大设计值的整个范围内均能工作。当“De-Qing”电路中时间常数选为3RC或5RC时,调整度极值分别为0.36或0.29。

Qingfei Paidu Decoction for COVID-19: A Bibliometric Analysis

Traditional Chinese medicine(TCM)has been used for thousands of years in fighting epidemics and has achieved remarkable therapeutic effects[1].The coronavirus disease 2019(COVID-19)pandemic has been effectively controlled in China under a series of policies.

Qing Dai, a traditional Chinese medicine for the treatment of chronic hemorrhagic radiation proctitis

Objective： To evaluate the efficacy and safety of Qing Dai （indigo naturalis）, a traditional Chinese medicine, in the treatment for chronic hemorrhagic radiation proctitis. Methods： Ten patients with chronic hemorrhagic radiation proctitis between January 2005 to January 2008 were treated with Qing Dai. Qing Dai was administered orally at a dose of 1.5 g, bid for 5 consecutive days, every 2 weeks for two courses. Patients were followed up every 3 months. The clinical response and side-effects were evaluated. Results： Six patients showed improvement of rectal bleeding to grade 0-1 after 1 course of Qing Dai therapy. Four patients had reduced rectal bleeding to grade 0-1 after 2 courses of the therapy. The median follow-up time was 10 months （range： 6-24）. During the follow-up period, 1 patient experienced recurrent rectal bleeding and was managed with topical formalin dabbing, which controlled the symptom. No treatment toxicity was observed. Conclusion： Qing Dai may be a safe and effective treatment for chronic hemorrhagic radiation proctitis.

Effects of Qing’E Formula on the Expression of Bone Metabolic Markers and VDR mRNA in Postmenopausal Osteoporosis Patients

Objectives: To study the partial mechanism of treating postmenopausal osteoporosis patients (POPs) using the ancient recipe of Qing’E Formula (QEF) by observing its effects on bone metabolic markers and VDR mRNA expression in primary POPs. Methods: Analysis was performed on 120 outpatient and inpatient POPs treated in our hospital between January and October 2013, where the patients were randomly divided into Qing’E group (QEF + Caltrate), Calcitriol group (Caltrate + Calcitriol soft capsules), and Compare group (Caltrate), each with a follow-up period of 1 year. Statistical analysis was then performed on bone mineral density, blood bone metabolic markers (β-CTX, N-MID, T-PINP) and changes in VDR mRNA expressions in the POPs before and after the treatments. Results: Prior to the treatments, bone mineral density and blood β-CTX, N-MID, T-PINP and VDR mRNA expression in the 3 groups of POPs exhibited no statistically significant differences, and the blood β-CTX, N-MID, T-PINP and VDR mRNA expression in the control group showed no statistically significant differences before and after the treatments. There were no significant differences in bone mineral density in the Qing’E group and the Calcitriol group before and after the treatments whereas the bone mineral density decreased in the control group after the treatments. As for blood β-CTX, N-MID, T-PINP and VDR mRNA expression, the measurements in POPs in the Qing’E group and the Calcitriol group were significantly higher than that of the control group. Conclusion: By adjusting the VDR mRNA expression, the QEF, a kidney-invigorating Chinese herbal formula, is capable of activating bone metabolism to prohibit further losses of bone mass, thereby preventing the deterioration of osteoporosis.

Effect of <i>Qing’e Pill</i>plus <i>Salvia</i>on Non-Traumatic Osteonecrosis of the Femoral Head of Idiopathic Type in Earlier Stage: A Case Report of a Twelve-Month of Period

Background: Compromised circulatory and bone/lipid metabolic dysfunction are two major contributors to non-traumatic osteonecrosis of the femoral head (ONFH). Qing’e pill plus Salvia has significant anti-inflammatory and anti-atherosclerotic action, and it could also regulate bone formation and remodeling by suppressing osteoclasts. Case Report: We describe a case of a 62-year- old man with ONFH of idiopathic type in earlier stage that could not be adequately controlled with oral non-steroidal analgesics and restoring bone loss agents for past 3 years. After six months treatment with Qing’e pill plus Salvia, the plasma low-density lipoprotein (LDL), high-density lipoprotein (HDL), apolipoprotein A1 (apo A1), apolipoprotein B (apo B), total cholesterol (TC), triglycerides (TG), and blood viscosity were measured on an empty stomach. The Harris scores were maintained during a six months follow-up after discontinuation of Qing’e pill plus Salvia. Discussion: Our case has shown that plasma levels of inflammatory and atherosclerotic relaxed factors and the Harris scores may be controlled with herbal medication in ONFH of idiopathic type in earlier stage that could not be adequately controlled with oral non-steroidal analgesics and restoring bone loss agents.

Composition of Pig Manures and Wastewaters under the Gan Qing Fen System in China

A large scale pig farm located in the North West of Beijing that applies the gan qing fen manure management system was selected and a continuous sampling of manures and wastewaters was performed from June to October 2009. Samples were collected once a week based on the pig production cycle, namely gestation, farrowing, weaning and fattening. Analysis of nutrients and heavy metals were determined by means of Inductively Coupled Plasma Atomic Emission Spectroscopy （ICP）. Total Nitrogen （TN） was determined by the Kjeldahl method. The main results showed that pig manures were characterized by high nutrients and heavy metals contents that might be due to the solid fraction separation from the liquid fraction under the gan qing fen manure management system. Further, piggery wastewaters were characterized by very low concentrations of nutrients and heavy metals as result of their dilution with flushing water mainly used for cleaning the pigsties. Manure and wastewaters samples from weaning pigs contained the highest concentrations of nutrients and heavy metals that could be due to high supplementation rates of these minerals in the weaner diets. In general, it seems that the manual daily collection of pig manures in the gan qing fen system is an efficient practice in order to maintain nutrient contents in pig manures but the use of flushing water should be reduced as it can lead to further environmental pollution.

Water Bath Extraction Optimization of Polyphenols from Qing Brick Tea and Raw Material Selection for Tea Polyphenol Extraction

In this paper,single-factor experiments and orthogonal experiment were conducted to optimize the water bath extraction of polyphenols from Qing Brick Tea,and the optimal extraction conditions obtained were as follows:solvent of 50%ethanol,solid/liquid ratio of 1∶30,temperature of 80℃,and time of 6 min.Under the optimal water bath extraction conditions,polyphenols in fresh tea leaves,fresh tea petioles,fresh tea blades,finished brick tea,finished tea petioles,finished tea blades,tea dregs after brewing and tea dregs after boiling were extracted,respectively.It was found that the quality fraction of polyphenols extracted from fresh tea leaves was the highest,with the best extraction effect.The extraction effect of leaf blades was better than that of leaf petioles,and the extraction effect of tea dregs after brewing was better than that of tea dregs after boiling.

The prevention and treatment of COVID-19 with Qingfei Paidu decoction in shanxi, China

Background In December 2019,Corona Virus Disease 2019(COVID-19)burst in Wuhan,China,and wreaked havoc over the country.On January 27,2020,the National Administration of Traditional Chinese Medicine urgently launched the special project,“research on screening effective prescriptions of traditional Chinese medicine(TCM)for prevention and treatment of COVID-19”.As the first pilot areas,Shanxi Province,Hebei Province,Heilongjiang Province and Shaanxi Province carried out clinical observation of Qingfei Paidu decoction in preventing and treating COVID-19.

THE UPLIFT PROCESS OF QING-ZANG PLATEAU

The uplift of Qing—Zang (Qinghai—Tibet) plateau was the most important event in the late Cenozoic, which deeply influenced the environments of the World, especially those of China. Since the uplift is so important and complex that it has been become the research focus of earth science. Nevertheless, the initial time and evolution process of the uplift is still controversial.1\ The initial time of the uplift\;Qing\|Zang plateau is a union geological\|geomorphic unit, which is composed of several geological\|structural units. Each geological\|structural unit has itself exchange history of sea\|continent (basin\|mountain); the exchange time of the different parts differs. Therefore, the initial time of some part of the plateau is not the uplift time of the whole plateau. The plateau is the highland with high height above sea level, little relief of the top, large area and steep boundary. The plateau plane is the paleo\|peneplain, which was formed by the uplift of the plateau after the peneplanation. Therefore, the initial time of the uplift should be counted from the time that the peneplain had been formed.