Objective:This study aimed to explore the efficacy and safety of Qingxin Fupi Jieyu formula(the herbal formula has the function of clear away the heart fire,tonify spleen,and relieve depression,QXFPJYF)in treating dig...Objective:This study aimed to explore the efficacy and safety of Qingxin Fupi Jieyu formula(the herbal formula has the function of clear away the heart fire,tonify spleen,and relieve depression,QXFPJYF)in treating digestive tract cancer-related cognitive impairment(CRCI).Methods:28 subjects with digestive tract CRCI were treated with QXFPJYF for 6 weeks.The scores of Montreal Cognitive Assessment and Mini-Mental State Examination were observed at four-time points(baseline,week 2,week 4,week 6).Besides,anxiety and depression scores and tumor markers were measured.Results:The scores of Montreal Cognitive Assessment and various fields were elevated steadily after treatment,such as visuospatial/executive,attention,language,delayed recall,and orientation.The differences were statistically significant(P<0.05)besides language score.The scores of Mini-Mental State Examination and various factors were elevated gradually at week 2,week 4 and week 6,including language and praxis,attention and calculation,recall and orientation,and the differences were statistically significant(P<0.05)except for recall score.The results also showed the change of tumor markers were not obvious,but anxious and depressed emotions were improved.More importantly,no subjects developed with obvious adverse reactions during the study.Conclusion:The finding indicated that QXFPJYF treated digestive tract CRCI with great efficacy and safety,which improved cognitive function from several fields.Nevertheless,the current study was limited by sample and medical ethics,and which was a self-control trial,some limitations needed to be acknowledged,further high-quality research is required to explore and verify it.展开更多
[Objectives] To observe the clinical effect and safety of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets for patients with ventricular premature beat.[Methods] 126 patients were divided randomly int...[Objectives] To observe the clinical effect and safety of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets for patients with ventricular premature beat.[Methods] 126 patients were divided randomly into the control group (62 cases) and the treatment group (64 cases). The control group was treated with routine western medicine, and the treatment group was treated with routine western medicine combined with Huangku Qingxin Mixture, both for one month. Then, observed the changes of Myerburg score, SAS score, symptom score and dynamic electrocardiogram in the two groups before and after treatment.[Results] The total effective rate of clinical symptoms was 82.81% in the treatment group and 64.52% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). The total effective rate of dynamic electrocardiogram was 84.38% in the treatment group and 58.06% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). Before treatment, there was no significant difference being found in the comparison of the scores of Myerburg and SAS in the two groups ( P >0.05). After treatment, Myerburg score and SAS score in the two groups were lower than those before treatment ( P <0.05);Myerburg score and SAS score in the treatment group were both better than those in the control group ( P <0.05). Before treatment, there was no significant difference in the comparison of the QT interval dispersion (QTd) and the corrected QT interval dispersion (QTcd) by Bazette formula ( P >0.05). After treatment, the results of QTd and QTcd in the two groups were lower than those before treatment ( P <0.05);the results of QTd and QTcd in the treatment group were better than those in the control group ( P <0.05).[Conclusions] The application of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets can effectively reduce Myerburg scores and SAS scores in patients with ventricular premature beat, shorten QTd and QTcd, and improve the life quality of patients. It has no adverse clinical reaction.展开更多
目的:观察清心莲子饮加减方治疗糖尿病肾脏病(DKD)Ⅲ~Ⅳ期气阴两虚证患者的临床疗效。方法:选取2021年10月—2024年3月福建中医药大学附属人民医院收治的DKDⅢ~Ⅳ期气阴两虚证患者60例,随机分为两组,每组各30例。对照组予西医常规治疗...目的:观察清心莲子饮加减方治疗糖尿病肾脏病(DKD)Ⅲ~Ⅳ期气阴两虚证患者的临床疗效。方法:选取2021年10月—2024年3月福建中医药大学附属人民医院收治的DKDⅢ~Ⅳ期气阴两虚证患者60例,随机分为两组,每组各30例。对照组予西医常规治疗如降压、降糖等,治疗组同时加服清心莲子饮加减方。连续治疗8周后,比较两组患者的临床疗效、肾功能、空腹血糖(FBG)、24 h尿蛋白定量(24 h UTP)、糖基化终末产物(AGEs)、白细胞介素6(IL-6)及中医证候积分等的影响。结果:(1)治疗后,治疗组总有效率优于对照组(P<0.05);(2)两组FBG、血尿酸(UA)及证候积分均较治疗前明显降低(P<0.05,P<0.01);治疗组Scr、eGFR、BUN、24 h UTP、AGEs及IL-6均较治疗前明显改善(P<0.01),而对照组上述指标较治疗前无明显变化(P>0.05);(3)治疗后,治疗组AGEs、IL-6、FBG、24 h UTP及中医证候积分明显低于对照组(P<0.05),而两组Scr、eGFR、BUN及UA差异无统计学意义(P>0.05)。结论:清心莲子饮加减方可有效减轻DKDⅢ~Ⅳ期气阴两虚证患者症状,平稳控制血糖,减少尿蛋白,减轻氧化应激和炎症反应,改善肾功能,提高临床疗效,延缓DKD进展。展开更多
文摘Objective:This study aimed to explore the efficacy and safety of Qingxin Fupi Jieyu formula(the herbal formula has the function of clear away the heart fire,tonify spleen,and relieve depression,QXFPJYF)in treating digestive tract cancer-related cognitive impairment(CRCI).Methods:28 subjects with digestive tract CRCI were treated with QXFPJYF for 6 weeks.The scores of Montreal Cognitive Assessment and Mini-Mental State Examination were observed at four-time points(baseline,week 2,week 4,week 6).Besides,anxiety and depression scores and tumor markers were measured.Results:The scores of Montreal Cognitive Assessment and various fields were elevated steadily after treatment,such as visuospatial/executive,attention,language,delayed recall,and orientation.The differences were statistically significant(P<0.05)besides language score.The scores of Mini-Mental State Examination and various factors were elevated gradually at week 2,week 4 and week 6,including language and praxis,attention and calculation,recall and orientation,and the differences were statistically significant(P<0.05)except for recall score.The results also showed the change of tumor markers were not obvious,but anxious and depressed emotions were improved.More importantly,no subjects developed with obvious adverse reactions during the study.Conclusion:The finding indicated that QXFPJYF treated digestive tract CRCI with great efficacy and safety,which improved cognitive function from several fields.Nevertheless,the current study was limited by sample and medical ethics,and which was a self-control trial,some limitations needed to be acknowledged,further high-quality research is required to explore and verify it.
文摘[Objectives] To observe the clinical effect and safety of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets for patients with ventricular premature beat.[Methods] 126 patients were divided randomly into the control group (62 cases) and the treatment group (64 cases). The control group was treated with routine western medicine, and the treatment group was treated with routine western medicine combined with Huangku Qingxin Mixture, both for one month. Then, observed the changes of Myerburg score, SAS score, symptom score and dynamic electrocardiogram in the two groups before and after treatment.[Results] The total effective rate of clinical symptoms was 82.81% in the treatment group and 64.52% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). The total effective rate of dynamic electrocardiogram was 84.38% in the treatment group and 58.06% in the control group. Through comparison of two groups, the difference was statistically significant ( P <0.05). Before treatment, there was no significant difference being found in the comparison of the scores of Myerburg and SAS in the two groups ( P >0.05). After treatment, Myerburg score and SAS score in the two groups were lower than those before treatment ( P <0.05);Myerburg score and SAS score in the treatment group were both better than those in the control group ( P <0.05). Before treatment, there was no significant difference in the comparison of the QT interval dispersion (QTd) and the corrected QT interval dispersion (QTcd) by Bazette formula ( P >0.05). After treatment, the results of QTd and QTcd in the two groups were lower than those before treatment ( P <0.05);the results of QTd and QTcd in the treatment group were better than those in the control group ( P <0.05).[Conclusions] The application of Huangku Qingxin Mixture combined with Metoprolol Tartrate Tablets can effectively reduce Myerburg scores and SAS scores in patients with ventricular premature beat, shorten QTd and QTcd, and improve the life quality of patients. It has no adverse clinical reaction.
文摘目的:观察清心莲子饮加减方治疗糖尿病肾脏病(DKD)Ⅲ~Ⅳ期气阴两虚证患者的临床疗效。方法:选取2021年10月—2024年3月福建中医药大学附属人民医院收治的DKDⅢ~Ⅳ期气阴两虚证患者60例,随机分为两组,每组各30例。对照组予西医常规治疗如降压、降糖等,治疗组同时加服清心莲子饮加减方。连续治疗8周后,比较两组患者的临床疗效、肾功能、空腹血糖(FBG)、24 h尿蛋白定量(24 h UTP)、糖基化终末产物(AGEs)、白细胞介素6(IL-6)及中医证候积分等的影响。结果:(1)治疗后,治疗组总有效率优于对照组(P<0.05);(2)两组FBG、血尿酸(UA)及证候积分均较治疗前明显降低(P<0.05,P<0.01);治疗组Scr、eGFR、BUN、24 h UTP、AGEs及IL-6均较治疗前明显改善(P<0.01),而对照组上述指标较治疗前无明显变化(P>0.05);(3)治疗后,治疗组AGEs、IL-6、FBG、24 h UTP及中医证候积分明显低于对照组(P<0.05),而两组Scr、eGFR、BUN及UA差异无统计学意义(P>0.05)。结论:清心莲子饮加减方可有效减轻DKDⅢ~Ⅳ期气阴两虚证患者症状,平稳控制血糖,减少尿蛋白,减轻氧化应激和炎症反应,改善肾功能,提高临床疗效,延缓DKD进展。
