Oxidative stability of two commercial olive oils of different specificity (green type and black type) has been studied during thermal and photochemical accelerated processes through the evolution of quality indices. I...Oxidative stability of two commercial olive oils of different specificity (green type and black type) has been studied during thermal and photochemical accelerated processes through the evolution of quality indices. It might help to assure a good utilisation of olive oil. In most of works described in literature, they are measured individually. In this study, a Principal Component Analysis (PCA) has been performed to emphasize their variation and describe in concise way the quality and the safety of extra-virgin olive oil after two oxidative stresses. No difference had been detected between both type oils when they are heated. Peroxides, aldehydes and conjugated dienes and trienes were formed but rapidly degraded into final oxidation compounds, mainly acid compounds. During the photochemical process, similar changes occurred slower and the green type oil had shown better stability because of its higher phenolic content. The fatty acids had been more impacted (higher disappearance of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA)) when the oils were heated than when irradiated. Saturated fatty acids (SFA), MUFA and PUFA were the most relevant indicators to characterize non-oxidized oils and PV characterized the early stage of oil oxidation.展开更多
Objective:To examine the physico-chemical parameters of commercially available local and multinational brands of paracetamol tablets in Nepal.Methods:Different five paracetamol brands were explored by testing various ...Objective:To examine the physico-chemical parameters of commercially available local and multinational brands of paracetamol tablets in Nepal.Methods:Different five paracetamol brands were explored by testing various parameters according to standard methods.The studied parameters included weight variation,friability,disintegration,dissolution and assay.The limits of the official test were referenced from official guidelines of Indian Pharmacopoeia(IP)and British Pharmacopoeia(BP).All brands were tested according to their pharmacopoeial claim and methods for these tests were successfully conducted to find out their qualities.Those methods were economic and authentic.Results:Requirements of weight variation and friability value were complied by all brands.Fifteen minutes of disintegration time were also complied by all the brands according to the BP/IP recommendation for uncoated tablets.All brands showed not less than 80%drug release in 45 min as per BP and not less than 85%in 30 min as per IP.Content of each brand was found to be within the range of 95%-105%.The present findings suggested that about every paracetamol brand which was accessible in Nepali market encountering the IP/BP requirements.Conclusions:Although the physico-chemical examinations such as weight variation,friability,disintegration,dissolution and assay were detected varying brand wise,but were found interior to defined limits.Being an over-the-counter drug,the consumption of paracetamol is too high.Therefore,it is important for each brand to be genuine,good manufactured and well marketed.So,additional exploration over the quality of paracetamol is compulsory for safe human consumption.展开更多
文摘Oxidative stability of two commercial olive oils of different specificity (green type and black type) has been studied during thermal and photochemical accelerated processes through the evolution of quality indices. It might help to assure a good utilisation of olive oil. In most of works described in literature, they are measured individually. In this study, a Principal Component Analysis (PCA) has been performed to emphasize their variation and describe in concise way the quality and the safety of extra-virgin olive oil after two oxidative stresses. No difference had been detected between both type oils when they are heated. Peroxides, aldehydes and conjugated dienes and trienes were formed but rapidly degraded into final oxidation compounds, mainly acid compounds. During the photochemical process, similar changes occurred slower and the green type oil had shown better stability because of its higher phenolic content. The fatty acids had been more impacted (higher disappearance of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA)) when the oils were heated than when irradiated. Saturated fatty acids (SFA), MUFA and PUFA were the most relevant indicators to characterize non-oxidized oils and PV characterized the early stage of oil oxidation.
文摘Objective:To examine the physico-chemical parameters of commercially available local and multinational brands of paracetamol tablets in Nepal.Methods:Different five paracetamol brands were explored by testing various parameters according to standard methods.The studied parameters included weight variation,friability,disintegration,dissolution and assay.The limits of the official test were referenced from official guidelines of Indian Pharmacopoeia(IP)and British Pharmacopoeia(BP).All brands were tested according to their pharmacopoeial claim and methods for these tests were successfully conducted to find out their qualities.Those methods were economic and authentic.Results:Requirements of weight variation and friability value were complied by all brands.Fifteen minutes of disintegration time were also complied by all the brands according to the BP/IP recommendation for uncoated tablets.All brands showed not less than 80%drug release in 45 min as per BP and not less than 85%in 30 min as per IP.Content of each brand was found to be within the range of 95%-105%.The present findings suggested that about every paracetamol brand which was accessible in Nepali market encountering the IP/BP requirements.Conclusions:Although the physico-chemical examinations such as weight variation,friability,disintegration,dissolution and assay were detected varying brand wise,but were found interior to defined limits.Being an over-the-counter drug,the consumption of paracetamol is too high.Therefore,it is important for each brand to be genuine,good manufactured and well marketed.So,additional exploration over the quality of paracetamol is compulsory for safe human consumption.
