BACKGROUND Although total or subtotal colectomy for slow-transit constipation(STC)has been proven to be a definite treatment,the associated defecation function and quality of life(QOL)are rarely studied.AIM To evaluat...BACKGROUND Although total or subtotal colectomy for slow-transit constipation(STC)has been proven to be a definite treatment,the associated defecation function and quality of life(QOL)are rarely studied.AIM To evaluate the effectiveness of surgery for STC regarding defecation function and QOL.METHODS From March 2013 to September 2017,30 patients undergoing surgery for STC in our department were analyzed.Preoperative,intra-operative,and postoperative 3-mo,6-mo,1-year,and 2-year follow-up details were recorded.Defecation function was assessed by bowel movements,abdominal pain,bloating,straining,laxative,enema use,diarrhea,and the Wexner constipation and incontinence scales.QOL was evaluated using the gastrointestinal QOL index and the 36-item short form survey.RESULTS The majority of patients(93.1%,27/29)stated that they benefited from the operation at the 2-year follow-up.At each time point of the follow-up,the number of bowel movements per week significantly increased compared with that of the preoperative conditions(P<0.05).Similarly,compared with the preoperative values,a marked decline was observed in bloating,straining,laxative,and enema use at each time point of the follow-up(P<0.05).Postoperative diarrhea could be controlled effectively and notably improved at the 2-year follow-up.The Wexner incontinence scores at 6-mo,1-year,and 2-year were notably lower than those at the 3-mo follow-up(P<0.05).Compared with those of the preoperative findings,the Wexner constipation scores significantly decreased following surgery(P<0.05).Thus,it was reasonable to find that the gastrointestinal QOL index scores clearly increase(P<0.05)and that the 36-item short form survey results displayed considerable improvements in six spheres(role physical,role emotional,physical pain,vitality,mental health,and general health)following surgery.CONCLUSION Total or subtotal colectomy for STC is not only effective in alleviating constipation-related symptoms but also in enhancing patients’QOL.展开更多
AIM:To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life(QOL)in patients after allogeneic hematopoietic stem cell transplantation(ALLO-HSCT)....AIM:To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life(QOL)in patients after allogeneic hematopoietic stem cell transplantation(ALLO-HSCT).METHODS:Forty-four patients with severe hematopoietic disease were enrolled after ALLO-HSCT at our center from July 2018 to October 2020.They completed two questionnaires:the Ocular Surface Disease Index(OSDI)and the quality-of-life scale for Chinese patients with visual impairment(SQOL-DV1).Ocular conditions and systemic conditions were also assessed.RESULTS:Eye damage was correlated with total bilirubin(P=0.005),and gamma-glutamyl transferase(GGT)(P=0.021).There was no significant correlation between the overall QOL score and OSDI(P=0.8226)or SQOLDV1(P=0.9526)scores.The OSDI and the overall QOL score were not correlated with ocular conditions,including best-corrected visual acuity(BCVA),intraocular pressure,Schirmer tear test II,sodium fluorescein staining,tear film breakup time,and tear meniscus height.SQOLDV1 was correlated with BCVA(P=0.0007),sodium fluorescein staining(P=0.007),and tear film breakup time(P=0.0146).CONCLUSION:In some patients,early ocular symptoms are not evident after ALLO-HSCT,while ocular surface complications can be observed after a comprehensive ophthalmological examination.Especially for those with elevated total bilirubin or GGT,regular ophthalmic follow-up visits are essential to diagnose and treat ocular graft versus host disease(o GVHD),especially for patients with elevated total bilirubin or GGT.展开更多
目的:探讨超分子水杨酸联合凉血五花汤加减治疗玫瑰痤疮的效果及对皮肤病生活质量量表(Dermatosis quality of life scale,DLQI)评分、皮肤红斑指数的影响。方法:选择2021年6月-2022年6月在笔者医院接受治疗的60例玫瑰痤疮患者,采用随...目的:探讨超分子水杨酸联合凉血五花汤加减治疗玫瑰痤疮的效果及对皮肤病生活质量量表(Dermatosis quality of life scale,DLQI)评分、皮肤红斑指数的影响。方法:选择2021年6月-2022年6月在笔者医院接受治疗的60例玫瑰痤疮患者,采用随机数表法分为实验组(n=30)和对照组(n=30)。对照组给凉血五花汤治疗,实验组给予超分子水杨酸联合凉血五花汤治疗。比较两组临床疗效、DLQI评分、皮肤红斑指数、皮肤屏障相关指标水平变化情况、临床症状改善情况及不良反应发生情况。结果:治疗后,两组总有效率比较差异有统计学意义(P<0.05);治疗后,两组DLQI评分、皮肤红斑指数水平均降低,实验组降低更为明显(P<0.05);治疗后,两组经皮水分丢失水平均降低,实验组降低更为明显,角质层水含量水平均升高,实验组升高更为明显(P<0.05);治疗后,两组毛细血管扩张缓解、红斑变浅、皮肤潮红减退及皮肤敏感度降低时间比较差异有统计学意义(P<0.05);治疗期间,两组不良反应主要表现为面部刺激、恶心呕吐及头晕头痛,两组比较差异无统计学意义(P>0.05)。结论:超分子水杨酸联合凉血五花汤加减治疗玫瑰痤疮具有较好的效果,可有效改善DLQI评分、皮肤红斑指数水平。展开更多
目的:评价皮肤病生活质量指数(dermatology life quality index,DLQI)与非特异性生活质量量表(the short form-36 healthsurvey,SF-36)在评估手部湿疹患者生活质量时的效果。方法:采用简体中文版DLQI和SF-36量表同时对108例手部湿疹患者...目的:评价皮肤病生活质量指数(dermatology life quality index,DLQI)与非特异性生活质量量表(the short form-36 healthsurvey,SF-36)在评估手部湿疹患者生活质量时的效果。方法:采用简体中文版DLQI和SF-36量表同时对108例手部湿疹患者(病例组)及102例健康人群(对照组)的生活质量进行评估,并对评估结果进行统计学分析。结果:①DLQI研究结果:病例组评分远高于对照组(P<0.001),手部湿疹对患者的生理及社会活动影响最大(P<0.05),对人际关系影响最小(P<0.05),性别的差异对生活质量的影响无统计学意义(P>0.05)。②SF-36量表研究结果:病例组女性同对照组女性相比各个维度的分值均较低(P<0.05),而病例组男性同对照组男性相比仅在生理职能、躯体疼痛和躯体健康总评有较低的分数(P<0.001);多元方差分析结果表明在生理功能、活力、情感职能、心理健康、心理健康总评维度,性别差异均具有统计学意义(P<0.05),各维度在年龄方面,只有生理功能存在趋势性,年龄越大生理功能越低(P<0.05);在生理功能(PF)和躯体健康总评(PCS)维度,年龄和性别存在明显的交互作用(P<0.05)。结论:手部湿疹严重影响了患者的生活质量,SF-36量表较DLQI更适用于评估手部湿疹患者的生活质量。展开更多
基金Supported by the National Natural Science Foundation of China,No.81270461,No.81570483 and No.81770541.
文摘BACKGROUND Although total or subtotal colectomy for slow-transit constipation(STC)has been proven to be a definite treatment,the associated defecation function and quality of life(QOL)are rarely studied.AIM To evaluate the effectiveness of surgery for STC regarding defecation function and QOL.METHODS From March 2013 to September 2017,30 patients undergoing surgery for STC in our department were analyzed.Preoperative,intra-operative,and postoperative 3-mo,6-mo,1-year,and 2-year follow-up details were recorded.Defecation function was assessed by bowel movements,abdominal pain,bloating,straining,laxative,enema use,diarrhea,and the Wexner constipation and incontinence scales.QOL was evaluated using the gastrointestinal QOL index and the 36-item short form survey.RESULTS The majority of patients(93.1%,27/29)stated that they benefited from the operation at the 2-year follow-up.At each time point of the follow-up,the number of bowel movements per week significantly increased compared with that of the preoperative conditions(P<0.05).Similarly,compared with the preoperative values,a marked decline was observed in bloating,straining,laxative,and enema use at each time point of the follow-up(P<0.05).Postoperative diarrhea could be controlled effectively and notably improved at the 2-year follow-up.The Wexner incontinence scores at 6-mo,1-year,and 2-year were notably lower than those at the 3-mo follow-up(P<0.05).Compared with those of the preoperative findings,the Wexner constipation scores significantly decreased following surgery(P<0.05).Thus,it was reasonable to find that the gastrointestinal QOL index scores clearly increase(P<0.05)and that the 36-item short form survey results displayed considerable improvements in six spheres(role physical,role emotional,physical pain,vitality,mental health,and general health)following surgery.CONCLUSION Total or subtotal colectomy for STC is not only effective in alleviating constipation-related symptoms but also in enhancing patients’QOL.
基金Supported by Natural Science Foundation of Guangdong Province,China(No.2019A1515011212)Beijing Bethune Charitable Foundation(No.BJ-GY2021014J)。
文摘AIM:To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life(QOL)in patients after allogeneic hematopoietic stem cell transplantation(ALLO-HSCT).METHODS:Forty-four patients with severe hematopoietic disease were enrolled after ALLO-HSCT at our center from July 2018 to October 2020.They completed two questionnaires:the Ocular Surface Disease Index(OSDI)and the quality-of-life scale for Chinese patients with visual impairment(SQOL-DV1).Ocular conditions and systemic conditions were also assessed.RESULTS:Eye damage was correlated with total bilirubin(P=0.005),and gamma-glutamyl transferase(GGT)(P=0.021).There was no significant correlation between the overall QOL score and OSDI(P=0.8226)or SQOLDV1(P=0.9526)scores.The OSDI and the overall QOL score were not correlated with ocular conditions,including best-corrected visual acuity(BCVA),intraocular pressure,Schirmer tear test II,sodium fluorescein staining,tear film breakup time,and tear meniscus height.SQOLDV1 was correlated with BCVA(P=0.0007),sodium fluorescein staining(P=0.007),and tear film breakup time(P=0.0146).CONCLUSION:In some patients,early ocular symptoms are not evident after ALLO-HSCT,while ocular surface complications can be observed after a comprehensive ophthalmological examination.Especially for those with elevated total bilirubin or GGT,regular ophthalmic follow-up visits are essential to diagnose and treat ocular graft versus host disease(o GVHD),especially for patients with elevated total bilirubin or GGT.
文摘目的:探讨超分子水杨酸联合凉血五花汤加减治疗玫瑰痤疮的效果及对皮肤病生活质量量表(Dermatosis quality of life scale,DLQI)评分、皮肤红斑指数的影响。方法:选择2021年6月-2022年6月在笔者医院接受治疗的60例玫瑰痤疮患者,采用随机数表法分为实验组(n=30)和对照组(n=30)。对照组给凉血五花汤治疗,实验组给予超分子水杨酸联合凉血五花汤治疗。比较两组临床疗效、DLQI评分、皮肤红斑指数、皮肤屏障相关指标水平变化情况、临床症状改善情况及不良反应发生情况。结果:治疗后,两组总有效率比较差异有统计学意义(P<0.05);治疗后,两组DLQI评分、皮肤红斑指数水平均降低,实验组降低更为明显(P<0.05);治疗后,两组经皮水分丢失水平均降低,实验组降低更为明显,角质层水含量水平均升高,实验组升高更为明显(P<0.05);治疗后,两组毛细血管扩张缓解、红斑变浅、皮肤潮红减退及皮肤敏感度降低时间比较差异有统计学意义(P<0.05);治疗期间,两组不良反应主要表现为面部刺激、恶心呕吐及头晕头痛,两组比较差异无统计学意义(P>0.05)。结论:超分子水杨酸联合凉血五花汤加减治疗玫瑰痤疮具有较好的效果,可有效改善DLQI评分、皮肤红斑指数水平。
文摘目的:评价皮肤病生活质量指数(dermatology life quality index,DLQI)与非特异性生活质量量表(the short form-36 healthsurvey,SF-36)在评估手部湿疹患者生活质量时的效果。方法:采用简体中文版DLQI和SF-36量表同时对108例手部湿疹患者(病例组)及102例健康人群(对照组)的生活质量进行评估,并对评估结果进行统计学分析。结果:①DLQI研究结果:病例组评分远高于对照组(P<0.001),手部湿疹对患者的生理及社会活动影响最大(P<0.05),对人际关系影响最小(P<0.05),性别的差异对生活质量的影响无统计学意义(P>0.05)。②SF-36量表研究结果:病例组女性同对照组女性相比各个维度的分值均较低(P<0.05),而病例组男性同对照组男性相比仅在生理职能、躯体疼痛和躯体健康总评有较低的分数(P<0.001);多元方差分析结果表明在生理功能、活力、情感职能、心理健康、心理健康总评维度,性别差异均具有统计学意义(P<0.05),各维度在年龄方面,只有生理功能存在趋势性,年龄越大生理功能越低(P<0.05);在生理功能(PF)和躯体健康总评(PCS)维度,年龄和性别存在明显的交互作用(P<0.05)。结论:手部湿疹严重影响了患者的生活质量,SF-36量表较DLQI更适用于评估手部湿疹患者的生活质量。
