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Quantitative parameters in novel spectral computed tomography:Assessment of Ki-67 expression in patients with gastric adenocarcinoma 被引量:4
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作者 Li-Ting Mao Wei-Cui Chen +6 位作者 Jian-Ye Lu Han-Liang Zhang Yong-Song Ye Yu Zhang Bo Liu Wei-Wei Deng Xian Liu 《World Journal of Gastroenterology》 SCIE CAS 2023年第10期1602-1613,共12页
BACKGROUND The level of Ki-67 expression has served as a prognostic factor in gastric cancer.The quantitative parameters based on the novel dual-layer spectral detector computed tomography(DLSDCT)in discriminating the... BACKGROUND The level of Ki-67 expression has served as a prognostic factor in gastric cancer.The quantitative parameters based on the novel dual-layer spectral detector computed tomography(DLSDCT)in discriminating the Ki-67 expression status are unclear.AIM To investigate the diagnostic ability of DLSDCT-derived parameters for Ki-67 expression status in gastric carcinoma(GC).METHODS Dual-phase enhanced abdominal DLSDCT was performed preoperatively in 108 patients with gastric adenocarcinoma.Primary tumor monoenergetic CT attenuation value at 40-100 kilo electron volt(kev),the slope of the spectral curve(λ_(HU)),iodine concentration(IC),normalized IC(nIC),effective atomic number(Z^(eff))and normalized Z^(eff)(nZ^(eff))in the arterial phase(AP)and venous phase(VP)were retrospectively compared between patients with low and high Ki-67 expression in gastric adenocarcinoma.Spearman’s correlation coefficient was used to analyze the association between the above parameters and Ki-67 expression status.Receiver operating characteristic(ROC)curve analysis was performed to compare the diagnostic efficacy of the statistically significant parameters between two groups.RESULTS Thirty-seven and 71 patients were classified as having low and high Ki-67 expression,respectively.CT_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),and Z^(eff)-related parameters were significantly higher,but IC-related parameters were lower in the group with low Ki-67 expression status than the group with high Ki-67 expression status,and other analyzed parameters showed no statistical difference between the two groups.Spearman’s correlation analysis showed that CT_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),Z^(eff),and n Z^(eff) exhibited a negative correlation with Ki-67 status,whereas IC and nIC had positive correlation with Ki-67 status.The ROC analysis demonstrated that the multi-variable model of spectral parameters performed well in identifying the Ki-67 status[area under the curve(AUC)=0.967;sensitivity 95.77%;specificity 91.89%)].Nevertheless,the differentiating capabilities of singlevariable model were moderate(AUC value 0.630-0.835).In addition,the nZ_(VP)^(eff) and nIC_(VP)(AUC 0.835 and 0.805)showed better performance than CT_(40 kev-VP),CT_(70 kev-VP) and CT_(100 kev-VP)(AUC 0.630,0.631 and 0.662)in discriminating the Ki-67 status.CONCLUSION Quantitative spectral parameters are feasible to distinguish low and high Ki-67 expression in gastric adenocarcinoma.Z^(eff) and IC may be useful parameters for evaluating the Ki-67 expression. 展开更多
关键词 Spectral computer tomography quantitative parameters Gastric carcinoma Iodine concentration Effective atomic number Ki-67 expression
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Synthetically quantitative evaluation function of characteristic parameters on CO_2 arc welding process 被引量:4
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作者 俞建荣 蒋力培 +2 位作者 史耀武 孙振国 王军波 《China Welding》 EI CAS 2001年第1期19-26,共8页
The statistical probability and their variation regularity of the measurable characteristic parameters in the CO 2 arc welding droplet short circuiting transfer process have been studied. The statistical analysis sh... The statistical probability and their variation regularity of the measurable characteristic parameters in the CO 2 arc welding droplet short circuiting transfer process have been studied. The statistical analysis shows that the sensitivity of each characteristic parameter with regard to the variation of the short circuiting transfer process is different. The sensitivity of 4 kinds among these characteristic parameters is more intense than that of the short circuiting transfer frequency. In order to take account of the synthetic influence of these characteristic parameters, by means of the characteristic parameters synthetic value, a quantitative evaluation function is built up to describe and evaluate the short circuiting transfer process of CO 2 arc welding in real time. The testing shows that the evaluation function can give a suitable synthetic valuation for the short circuiting transfer process with a variety of welding variables. 展开更多
关键词 CO 2 arc welding process characteristic parameters quantitative evaluation function
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Quantitative determination of PFC3D microscopic parameters 被引量:3
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作者 LI Zhuo RAO Qiu-hua 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第3期911-925,共15页
It is important to calibrate micro-parameters for applying partied flow code(PFC)to study mechanical characteristics and failure mechanism of rock materials.Uniform design method is firstly adopted to determine the mi... It is important to calibrate micro-parameters for applying partied flow code(PFC)to study mechanical characteristics and failure mechanism of rock materials.Uniform design method is firstly adopted to determine the microscopic parameters of parallel-bonded particle model for three-dimensional discrete element particle flow code(PFC3D).Variation ranges of microscopic of the microscopic parameters are created by analyzing the effects of microscopic parameters on macroscopic parameters(elastic modulus E,Poisson ratio v,uniaxial compressive strengthσc,and ratio of crack initial stress to uniaxial compressive strengthσci/σc)in order to obtain the actual uniform design talbe.The calculation equations of the microscopic and macroscopic parameters of rock materials can be established by the actual uniform design table and the regression analysis and thus the PFC3D microscopic parameters can be quantitatively determined.The PFC3D simulated results of the intact and pre-cracked rock specimens under uniaxial and triaxial compressions(including the macroscopic mechanical parameters,stress−strain curves and failure process)are in good agreement with experimental results,which can prove the validity of the calculation equations of microscopic and macroscopic parameters. 展开更多
关键词 quantitative relationship of microscopic and macroscopic parameters uniform design method three-dimensional particle flow code(PFC3D) ROCK
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Variation on Wild Sunflower (Helianthus ruderalis L.) for Quantitative and Qualitative Parameters 被引量:2
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作者 S. A. Aliu S. Sh. Fetahu S. Xh. Kaqiu H. E. Bytyci 《Journal of Agricultural Science and Technology》 2010年第3期11-17,共7页
Our expedition have identified location in the central part of Kosovo where were collected a samples (accessions) at coordinates; Sub-Locality SL-1 (N42°34′36″, E21°07′45″), altitude 574 m, SL-2 (N4... Our expedition have identified location in the central part of Kosovo where were collected a samples (accessions) at coordinates; Sub-Locality SL-1 (N42°34′36″, E21°07′45″), altitude 574 m, SL-2 (N42°34′29″, E 21°07′45″altitude 591 m and SL-3 (N42°34′30″, E21°07′46″) on altitude 565 m. The aim of present investigation was carried out to study genetic variability of quantitative and qualitative parameters. The populations from SL-2 were characterized of higher significance on seed oil (23.74%) and protein content (16.74%). The estimation average value of seed protein and oil content was 15.52% and 23.48% respectively. The variability of plant height ranged from 182.33 cm to as much as 200.89 cm, while distinction's between them were + 18.56 cm which was a significant higher at P〈0.05 probability level. The SL-3 showed the higher value of HWK (34.6 g), head per plant (39.33) and head diameter (9.5 cm) but, was characterized significantly lowest on seed protein content (13.99%). The all traits included in our investigations showed a higher genetic variability with majority of extreme values. The sunflower populations differed significantly in several parameters measured, they have a different genetic and morphological backgrounds. Results from wild sunflower form indicated notable differences in dispersion of important genes for different traits and showed the potential for using in future for breeding program. 展开更多
关键词 SUNFLOWER ACCESSION quantitative parameters oil content protein content.
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The quantitative check-measure of the bend strain parameters of the rotating components
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作者 李文华 乔中涛 《Journal of Coal Science & Engineering(China)》 2002年第1期79-81,共3页
Based on the principle of the electric-magnetic check-measure, this paper puts forward a new technology and method that use the magnetic marks to check and measure the dynamic physical parameters such as angle speed, ... Based on the principle of the electric-magnetic check-measure, this paper puts forward a new technology and method that use the magnetic marks to check and measure the dynamic physical parameters such as angle speed, bending strain,stress and bending moment. The principles of the check-measure and the dealing and exchanging technology about signals have been demonstrated and the rotating components have been made up. The timely and quantitative check-measure of the dynamic physical parameters during the component in working has been realized by using computer control. 展开更多
关键词 rotating component dynamic parameter quantitative check-measure
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Quantitative evaluation methods for waterflooded layers of conglomerate reservoir based on well logging data 被引量:22
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作者 Tan Fengqi Li Hongqi +2 位作者 Xu Changfu Li Qingyuan Peng Shouchang 《Petroleum Science》 SCIE CAS CSCD 2010年第4期485-493,共9页
The rapid changing near source, multi-stream depositional environment of conglomerate reservoirs leads to severe heterogeneity, complex lithology and physical properties, and large changes of oil layer resistivity. Qu... The rapid changing near source, multi-stream depositional environment of conglomerate reservoirs leads to severe heterogeneity, complex lithology and physical properties, and large changes of oil layer resistivity. Quantitative evaluation of water-flooded layers has become an important but difficult focus for secondary development of oilfields. In this paper, based on the analysis of current problems in quantitative evaluation of water-flooded layers, the Kexia Group conglomerate reservoir of the Sixth District in the Karamay Oilfield was studied. Eight types of conglomerate reservoir lithology were identified effectively by a data mining method combined with the data from sealed coring wells, and then a multi-parameter model for quantitative evaluation of the water-flooded layers of the main oil-bearing lithology was developed. Water production rate, oil saturation and oil productivity index were selected as the characteristic parameters for quantitative evaluation of water-flooded layers of conglomerate reservoirs. Finally, quantitative evaluation criteria and identification rules for water-flooded layers of main oil-bearing lithology formed by integration of the three characteristic parameters of water-flooded layer and undisturbed formation resistivity. This method has been used in evaluation of the water-flooded layers of a conglomerate reservoir in the Karamay Oilfield and achieved good results, improving the interpretation accuracy and compliance rate. It will provide technical support for avoiding perforation of high water-bearing layers and for adjustment of developmental programs. 展开更多
关键词 Water-flooded layer quantitative evaluation conglomerate reservoir lithology identification decision tree characteristic parameters
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Measurement of Plasma Parameters of Calcium and Silicon in a Rock Sample Using Laser Induced Breakdown Spectroscopy 被引量:4
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作者 Uzma G M.Junaid +1 位作者 Khalid Alamgir T Samina 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2017年第10期3266-3269,共4页
Laser Induced Breakdown Spectroscopic(LIBS)technique was used to detect calcium and silicon in an unknown sample.In this method plasma was generated by Nd∶YAG laser of wavelength 1 064 nm with energy 400 mJ and pulse... Laser Induced Breakdown Spectroscopic(LIBS)technique was used to detect calcium and silicon in an unknown sample.In this method plasma was generated by Nd∶YAG laser of wavelength 1 064 nm with energy 400 mJ and pulse duration between 5~10ns.The method was applied for the qualitative as well as quantitative analysis.In the qualitative analysis,the electron number density(Ne)of plasma containing calcium and silicon is determined showing that Neof neutral particles is equivalent to 1016(cm-3)whereas for ionized particles it is 1017(cm-3).Plasma temperature is measured using Boltzmann plot method which must be greater than 10 000 k.Intensity ratio method is used for the quantitative analysis shows various elements in abundance with calcium and silicon in majority. 展开更多
关键词 LIBS Plasma parameter quantitative analysis Qualitative analysis
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Quantitative design of yield components to simulate yield formation for maize in China 被引量:3
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作者 HOU Hai-peng MA Wei +4 位作者 Mehmood Ali NOOR TANG Li-yuan LI Cong-feng DING Zai-song ZHAO Ming 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2020年第3期668-679,共12页
Maize(Zea mays L.) stands prominently as one of the major cereal crops in China as well as in the rest of the world.Therefore,predicting the growth and yield of maize for large areas through yield components under hig... Maize(Zea mays L.) stands prominently as one of the major cereal crops in China as well as in the rest of the world.Therefore,predicting the growth and yield of maize for large areas through yield components under high-yielding environments will help in understanding the process of yield formation and yield potential under different environmental conditions.This accurate early assessment of yield requires accuracy in the formation process of yield components as well.In order to formulate the quantitative design for high yields of maize in China,yield performance parameters of quantitative design for high grain yields were evaluated in this study,by utilizing the yield performance equation with normalization of planting density.Planting density was evaluated by parameters including the maximum leaf area index and the maximum leaf area per plant.Results showed that the variation of the maximum leaf area per plant with varying plant density conformed to the Reciprocal Model,which proved to have excellent prediction with root mean square error(RMSE) value of 5.95%.Yield model estimation depicted that the best optimal maximum leaf area per plant was 0.63 times the potential maximum leaf area per plant of hybrids.Yield performance parameters for different yield levels were quantitatively designed based on the yield performance equation.Through validation of the yield performance model by simulating high yields of spring maize in the Inner Mongolia Autonomous Region and Jilin Province,China,and summer maize in Shandong Province,the yield performance equation showed excellent prediction with the satisfactory mean RMSE value(7.72%) of all the parameters.The present study provides theoretical support for the formulation of quantitative design for sustainable high yield of maize in China,through consideration of planting density normalization in the yield prediction process,providing there is no water and nutrient limitation. 展开更多
关键词 MAIZE yield performance parameters high yield yield prediction process quantitative design
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Value of metabolic parameters in distinguishing primary mediastinal lymphomas from thymic epithelial tumors 被引量:1
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作者 Lei Zhu Xiaofeng Li +5 位作者 Jian Wang Qiang Fu Jianjing Liu Wenchao Ma Wengui Xu Wei Chen 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第2期468-477,共10页
Objective:A high rate of unnecessary thymectomies has been reported.This study aimed to distinguish primary mediastinal lymphomas(PMLs)from thymic epithelial tumors(TETs)by evaluating volumetric and metabolic paramete... Objective:A high rate of unnecessary thymectomies has been reported.This study aimed to distinguish primary mediastinal lymphomas(PMLs)from thymic epithelial tumors(TETs)by evaluating volumetric and metabolic parameters with l8F-FDG PET/CT.Methods:A total of 136 patients who were pathologically diagnosed with TETs or PMLs were enrolled,and 18F-FDG PET/CT was performed before therapy.Volumetric parameters,including the mean SUV(SUVmean),metabolic tumor volume(MTV),total lesion glycolysis(TLG),and SUVmax,were determined and compared between the 2 subtypes.The diagnostic performance of these parameters was evaluated with receiver operating characteristic(ROC)curve analysis.Results:All parameters significantly differed between patients with PMLs and TETs.Patients with lymphomas were younger and had higher SUVmean,SUVmax,TLG,and MTV values than patients with TETs.The MTV and TLG values had similar diagnostic performance.ROC analysis indicated that the areas under the curves of the SUVmean and SUVmax values performed similarly(approximately 0.76)in differentiating patients with PMLs from TETs,and both values were better than the MTV and TLG values.When age was included with the SUVmax in differentiating TETs from PMLs,the AUC was 0.91,and the sensitivity and specificity increased to 80%and 93%,respectively.Conclusions:The SUVmax and volumetric parameters of 18F-FDG PET/CT can be used to distinguish patients with PMLs versus TETs,and thus may aid in preventing unnecessary thymectomies or other invasive operations. 展开更多
关键词 FDG pet-ct LYMPHOMA metabolic tumor burden quantitative evaluation thymic epithelial tumors
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Quantitative feedback theory and zero phase error tracking control combined robust control for radar truck leveling simulator 被引量:1
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作者 凌轩 李晓辉 +1 位作者 朱玉泉 冯天麟 《Journal of Shanghai University(English Edition)》 2009年第5期384-390,共7页
Radar leveling system is the key equipment for improving the radar mobility and survival capability. A combined quantitative feedback theory (QFT) controller is designed for the radar truck leveling simulator in this ... Radar leveling system is the key equipment for improving the radar mobility and survival capability. A combined quantitative feedback theory (QFT) controller is designed for the radar truck leveling simulator in this paper, which suffers from strong nonlinearities and system parameter uncertainties. QFT can reduce the plant uncertainties and stabilize the system, but it fails to obtain high-precision tracking. This drawback can be solved by a robust QFT control scheme based on zero phase error tracking control (ZPETC) compensation. The combined controller not only possesses high robustness, but greatly improves the system performance. To verify the effiectiveness and the potential of the proposed controller, a series of experiments have been carried out. Experimental results have demonstrated its robustness against a large range of parameters variation and high tracking precision performance, as well as its capability of restraining the load coupling among channels. The combined QFT controller can drive the radar truck leveling platform accurately, quickly and stably. 展开更多
关键词 radar truck leveling simulator quantitative feedback theory (QFT) parameter uncertainties zero phase error tracking control (ZPETC) high robustness
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Quantitative comparison screening of seismological indexes and research on the integrated prediction method in North China
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作者 周翠英 朱元清 +3 位作者 王红卫 梁凯莉 李平 郭爱香 《Acta Seismologica Sinica(English Edition)》 CSCD 1999年第2期232-237,共6页
关键词 comparison screening method quantitative selecting SEISMOLOGY parameters INTEGRATED Prediction
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Quantitative Analysis of Glomeruli Lesions in Patients with Mesangial Proliferative Glomerulonephritis
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作者 孙建平 王韵琴 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1996年第2期106-110,共5页
By using computer imaging analysis system combined with light microscopy, the glomeruli lesions on biopsy specimens sections were quantitatively analysed. The patholoical changes of mesangial proliferative glomerulone... By using computer imaging analysis system combined with light microscopy, the glomeruli lesions on biopsy specimens sections were quantitatively analysed. The patholoical changes of mesangial proliferative glomerulonephritis (MsPGN) in children were quantitatively evaluated and the correlation between the mesangial matrix area (MA) and some clinical data were also analysed. The results indicated that the levels of various glomerular parameters in MsPGN group were higher than those of normal controls. No correlation was found between MA and 24 h urinary protein excretion, but a negative correlation was revealed between MA and estimated GFR. MA was also correlated with the duration of MsPGN recovery. It was suggested that the quantitative analysis of glomerular parameters by computer is a reproducible methods. The parameter of MA may be used for evaluation of the renal function, determination of the duration of therapy and evaluation of prognosis of MsPGN in children. 展开更多
关键词 quantitative analysis computer imaging analysis system glomerular parameters
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18F-氟代脱氧葡萄糖PET-CT定量参数与特发性间质性肺炎患者肺功能的关系探析
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作者 赵杰 梁琰 张晓 《哈尔滨医药》 2023年第1期14-16,共3页
目的探讨18F-氟代脱氧葡萄糖(18F-FDG)PET-CT定量参数与特发性间质性肺炎(IIP)患者肺功能的关系。方法回顾性分析25例在我院确诊并治疗的IIP患者为观察组,并选取同期健康体检肺功能正常患者25例为对照组,比较两组性别、年龄、病程等一... 目的探讨18F-氟代脱氧葡萄糖(18F-FDG)PET-CT定量参数与特发性间质性肺炎(IIP)患者肺功能的关系。方法回顾性分析25例在我院确诊并治疗的IIP患者为观察组,并选取同期健康体检肺功能正常患者25例为对照组,比较两组性别、年龄、病程等一般资料,比较不同肺功能水平患者的PET-CT定量参数水平,Pearson相关性分析PET-CT定量参数水平与肺功能严重程度关系。结果两组患者比较性别、年龄、病程、体质量指数(BMI)、吸烟史和文化程度一般资料差异无统计学意义(P>0.05);1秒用力呼气容积(FEV1%)降低,PaO_(2)越小,肺功能分级(GOLD)越高,病灶最大直径越大,最大标准摄取值(SUVmax)越小(P<0.05);Pearson相关性分析显示,病灶最大直径与PaO_(2)、FEV1%呈负相关,与GOLD呈正相关(P<0.05),SUVmax与FEV1%、PaO_(2)呈正相关,与GOLD呈负相关(P<0.05)。结论PET-CT定量参数病灶最大直径、SUVmax与IIP患者肺功能有关,临床医师可以此评估病情进展。 展开更多
关键词 18F-氟代脱氧葡萄糖 pet-ct定量参数
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DCE-MRI定量参数在乳腺癌分期及预后评估中的应用观察 被引量:1
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作者 饶德利 邱晓明 朱燕莉 《中国CT和MRI杂志》 2024年第4期89-91,共3页
目的观察动态增强磁共振成像(DCE-MRI)定量参数在乳腺癌分期及预后评估中的作用。方法选取2019年1月-2020年1月期间本院收治的女性乳腺癌患者共94例,为乳腺癌组。另选取同期入院诊治的女性良性乳腺变患者共92例,为良性病变组。两组患者... 目的观察动态增强磁共振成像(DCE-MRI)定量参数在乳腺癌分期及预后评估中的作用。方法选取2019年1月-2020年1月期间本院收治的女性乳腺癌患者共94例,为乳腺癌组。另选取同期入院诊治的女性良性乳腺变患者共92例,为良性病变组。两组患者分别于术前进行DCE-MRI定量参数检查,比较两组容量转移常数(K_(trans))、回流速率常数(K_(ep))和血管外细胞外间隙容积分数值(V_(e));分析K_(trans)、K_(ep)、V_(e)在乳腺癌不同分期中的差异;比较K_(trans)、K_(ep)、V_(e)在不同预后情况下的差异;绘制ROC曲线分析定量参数与乳腺癌预后的诊断效能。结果乳腺癌患者K_(trans)、K_(ep)值高于乳腺良性增生患者,而V_(e)值低于乳腺良性增生患者(P<0.05);乳腺癌不同分期K_(trans)、K_(ep)、V_(e)存在明显差异(P<0.05),随着病情进展K_(trans)、K_(ep)逐次增加,V_(e)逐次下降;Pearson相关性分析显示,术前乳腺癌分期与K_(trans)、K_(ep)呈正相关,与V_(e)值呈负相关(P<0.05);乳腺癌患者预后不良组K_(trans)、K_(ep)高于预后良好组(P<0.05);ROC曲线分析结果显示K_(trans)、预测乳腺癌预后不良AUC及特异度最高。结论DCE-MRI定量参数K_(trans)、K_(ep)、V_(e)在乳腺癌临床分期密切相关,且可用于乳腺癌预后评估。 展开更多
关键词 DCE-MRI定量参数 乳腺癌分期 预后评估
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混凝土振捣密实性研究进展 被引量:1
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作者 田正宏 马元山 李佳杰 《建筑材料学报》 EI CAS CSCD 北大核心 2024年第1期46-57,共12页
混凝土振捣工艺效果是影响成型质量的主要因素,但实践中仍以经验判断为主,缺乏可行的理论指导和科学量化的评价判据.针对拌和物振捣施工,从振捣密实理论、密实性影响因素、拌和物成型质量评价以及信息化工艺等方面,阐述了混凝土振捣施... 混凝土振捣工艺效果是影响成型质量的主要因素,但实践中仍以经验判断为主,缺乏可行的理论指导和科学量化的评价判据.针对拌和物振捣施工,从振捣密实理论、密实性影响因素、拌和物成型质量评价以及信息化工艺等方面,阐述了混凝土振捣施工的现状与技术进展,分析了振捣理论与应用存在的问题,展望了数字振捣技术的发展方向. 展开更多
关键词 振捣密实理论 振动设备 工艺参数 量化评价模型 信息化振捣
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定量CMR参数对急性心肌炎诊断的增量价值研究
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作者 牛永超 周芳 +2 位作者 赵丹丹 徐雅慧 张勇 《海南医学》 CAS 2024年第14期2056-2060,共5页
目的探究定量心脏磁共振(CMR)参数对急性心肌炎诊断的增量价值。方法选取2021年12月至2023年12月新乡市中心医院收治的120例急性心肌炎患者(急性心肌炎组)进行回顾性研究,另按2∶1比例选取本院体检健康者60例作为对照组,比较两组受检者... 目的探究定量心脏磁共振(CMR)参数对急性心肌炎诊断的增量价值。方法选取2021年12月至2023年12月新乡市中心医院收治的120例急性心肌炎患者(急性心肌炎组)进行回顾性研究,另按2∶1比例选取本院体检健康者60例作为对照组,比较两组受检者的定量CMR参数,通过受试者工作特征曲线(ROC)分析定量CMR参数诊断急性心肌炎的价值效能,并对定量CMR参数进行中位数划分,分析定量CMR参数增量诊断急性心肌炎的价值。结果急性心肌炎组患者T1弛豫时间、T2信号强度比、早期强化率明显高于对照组,差异均有统计学意义(P<0.05);ROC分析结果显示,T1弛豫时间、T2信号强度比、早期强化率诊断急性心肌炎的曲线下面积(AUC)分别为0.783、0.798、0.644。急性心肌炎组患者T1弛豫时间、T2信号强度比、早期强化率值的中位数分别为1310.5 ms、2%、3.51%。按中位数将其划分为T1弛豫时间≥1310.5 ms亚组,T1弛豫时间<1310.5 ms亚组;T2信号强度比≥2%亚组,T2信号强度比<2%亚组;早期强化率值≥3.51%亚组,早期强化率<3.51%亚组。ROC分析结果显示,在T1弛豫时间≥1310.5 ms亚组、T2信号强度比≥2%亚组、早期强化率值≥3.51%亚组中T1弛豫时间、T2信号强度比、早期强化率值诊断急性心肌炎的价值较好,AUC分别为0.979、0.959、0.999。结论定量CMR参数诊断急性心肌炎均具有一定价值,对定量CMR参数进行增量划分后其诊断急性心肌炎价值更高。 展开更多
关键词 急性心肌炎 定量心脏磁共振参数 增量 诊断价值
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血栓弹力图联合超声定量参数对胎儿生长受限的诊断效能研究
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作者 孙博 周斌 +1 位作者 王冠嘉 吕会娟 《南京医科大学学报(自然科学版)》 CAS 北大核心 2024年第8期1126-1133,共8页
目的:研究血栓弹力图联合超声定量参数对胎儿生长受限(fetal growth restriction,FGR)的诊断效能。方法:收集2021年7月—2023年5月郑州市妇幼保健院收治的50例FGR孕妇(FGR组),并选取同期同年龄段胎儿发育正常的50例孕妇作为对照(对照组... 目的:研究血栓弹力图联合超声定量参数对胎儿生长受限(fetal growth restriction,FGR)的诊断效能。方法:收集2021年7月—2023年5月郑州市妇幼保健院收治的50例FGR孕妇(FGR组),并选取同期同年龄段胎儿发育正常的50例孕妇作为对照(对照组)。比较两组血栓弹力图指标[最大振幅(maximum amplitude,MA)、α角(Angle)、凝血时间(coagulation time,K)、凝血反应时间(coagulation response time,R)]、脐动脉与大脑中动脉阻力指数(resistance index,RI)、搏动指数(pulsation index,PI)、血流收缩末期/舒张末期峰值(end-systolic/end-diastolic peak value,S/D)、脑胎盘率(cerebroplacental rate,CPR)、体重、腹围,二元相关分析、偏相关分析研究血栓弹力图、超声定量参数与体重、腹围的关系,受试者工作特征(receiver operating characteristic,ROC)曲线分析血栓弹力图、超声定量参数及联合诊断FGR价值。结果:FGR组孕中期、孕晚期、分娩前R、K均低于对照组,Angle、MA高于对照组(P<0.05);FGR组孕中期、孕晚期、分娩前脐动脉S/D、脐动脉PI、脐动脉RI高于对照组,大脑中动脉S/D、大脑中动脉PI、大脑中动脉RI、CRP低于对照组(P<0.05);FGR组孕中期、孕晚期、分娩前体重、腹围低于对照组(P<0.05);二元相关分析显示,分娩前各血栓弹力图、超声定量参数与体重、腹围相关性更强(P<0.05);偏相关分析显示,分娩前R、K、大脑中动脉RI、CRP与体重、腹围呈正相关,Angle、MA、脐动脉S/D、脐动脉PI、脐动脉RI仍与体重、腹围呈负相关(P<0.05);分娩前血栓弹力图、超声定量参数联合诊断FGR的ROC曲线下面积高于各单一指标(P<0.05)。结论:FGR孕妇接受血栓弹力图联合超声定量检测,可有效监测孕产妇在不同时期凝血功能变化和胎儿血流动力学变化,其联合诊断FGR具有较高价值。 展开更多
关键词 血栓弹力图 超声定量参数 胎儿生长受限 诊断效能
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紧凑型激光诱导击穿光谱仪的研制
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作者 王金梅 刘旭峰 +5 位作者 郑培超 陈光辉 刘少剑 李刚 杨志 孙志诚 《量子电子学报》 CAS CSCD 北大核心 2024年第3期437-445,共9页
基于煤质分析、冶金、水质检测等众多领域对激光诱导击穿光谱技术(LIBS)的需求,本研究设计了一台基于激光诱导击穿光谱原理的紧凑型快速检测装置,其具有良好的稳定性和较高的激光能量(0~100 mJ),可进行全自动化谱线对比与筛选,从而实现... 基于煤质分析、冶金、水质检测等众多领域对激光诱导击穿光谱技术(LIBS)的需求,本研究设计了一台基于激光诱导击穿光谱原理的紧凑型快速检测装置,其具有良好的稳定性和较高的激光能量(0~100 mJ),可进行全自动化谱线对比与筛选,从而实现多样品、多元素的LIBS快速检测。在参数优化的基础上,利用该装置对7个钢样所含的硅元素与碳元素进行了检测分析。实验结果表明,当延迟时间为1μs、离焦量为0 mm、激光能量为60 mJ时,可以获得最佳的硅、碳特征光谱数据。在最优实验条件下,对7个样品进行定量分析,利用内标法建立硅、碳元素的定标拟合曲线,其相关系数分别为0.986和0.999,相对强度比的相对标准误差不超过5%,预测值与实际值偏差较小。研究结果验证了该仪器具有良好的分析性能,对多元素检测、可移动式LIBS仪器的发展具有参考意义。 展开更多
关键词 光谱学 激光诱导击穿光谱 紧凑型LIBS光谱仪 定量分析 参数优化
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实时剪切波弹性成像联合超声造影参数在鉴别甲状腺实性结节良恶性的诊断价值研究
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作者 邵春晖 赵君智 +2 位作者 罗永科 吕品 史春玲 《安徽医药》 CAS 2024年第4期685-690,I0002,共7页
目的 评估实时剪切波弹性成像(SWE)杨氏模量联合超声造影(CEUS)参数在鉴别甲状腺结节良恶性中的诊断价值。方法 以2020年6月至2022年11月在宝鸡市人民医院经细针穿刺活检或手术病理证实的甲状腺结节病人为研究对象,按照研究目标设定的纳... 目的 评估实时剪切波弹性成像(SWE)杨氏模量联合超声造影(CEUS)参数在鉴别甲状腺结节良恶性中的诊断价值。方法 以2020年6月至2022年11月在宝鸡市人民医院经细针穿刺活检或手术病理证实的甲状腺结节病人为研究对象,按照研究目标设定的纳入/排除标准,最终纳入106例共106个结节,行常规超声及SWE检查,记录结节超声特征及弹性参数,后行CEUS检查,并对结节动态造影图像进行定量参数分析,获取造影时间-强度曲线(TIC)图及相关CEUS参数。比较SWE参数Еmax、Еmin、Еmean与CEUS参数PI、TTP、MTT、超声造影TIC曲线下面积(AUC)及联合参数在鉴别甲状腺结节良恶性中的诊断价值。结果 106例甲状腺结节中,甲状腺良性结节(TBN)组60例和恶性结节(TMN)组46例;两组结节一般资料比较中,病人年龄平均值TBN组(42.37±5.54)岁与TMN组(39.56±4.69)岁相比差异有统计学意义(P<0.05),结节血流分布差异有统计学意义(P<0.05);两组结节SWE杨氏模量Emax、Emin、Emean平均值中,TBN组平均值分别为(39.29±12.59)Kp、(14.19±4.60)Kp、(23.01±7.93)Kp,TMN组平均值分别为(104.35±35.62)Kp、(35.09±17.53)Kp、(62.13±22.94)Kp,两组相比差异有统计学意义(P<0.05);两组结节CEUS定性及定量各参数PI、TTP、AUC平均值中,TBN组各参数平均值分别为(45.88±4.22)dB、(22.02±1.97)s、(4177.58±426.29)dB·s,TMN组各参数平均值分别为(35.64±4.16)dB、(24.98±3.91)s、(3280.94±315.76)dB·s,TMN组PI、AUC均低于TBN组,而TMN组TTP长于TBN组,两组相比差异有统计学意义(P<0.05);SWE及CEUS参数联合诊断受试者操作特征(ROC)曲线下面积(AUC)、准确性及对应的灵敏度、特异度均高于各参数单独诊断,且均差异有统计学意义(P<0.05)。SWE各参数单独及联合诊断ROC曲线成对比较,Еmax比Еmin、Еmean比Еmin成对比较差异有统计学意义(Z=2.60、3.00,P<0.05)。CEUS各参数单独及联合诊断ROC曲线成对比较,TTP与联合诊断成对比较差异有统计学意义(Z=2.35,P<0.05)。Emean截断值为32.21 KPa时,SWE-Emean联合CEUS特征鉴别甲状腺结节良恶性的诊断效能均优于SWE-Emean或CEUS单独诊断。结论SWE杨氏模量联合CEUS参数可提高甲状腺结节诊断准确性。 展开更多
关键词 甲状腺结节 实时剪切波弹性成像 超声造影 定量参数 良恶性
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磁共振动态增强定量参数诊断乳腺癌的价值及其与恶性转化中血管生成的相关性
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作者 白丽 苏雪娟 陈体 《海南医学》 CAS 2024年第4期558-563,共6页
目的探究磁共振动态增强(DCE-MRI)定量参数对乳腺癌的诊断价值,并分析定量参数与恶性转化中血管生成的相关性。方法前瞻性选取2020年3月至2022年1月南阳市第二人民医院收治的160例乳腺病变患者,其中浸润性导管癌、导管内原位癌、非典型... 目的探究磁共振动态增强(DCE-MRI)定量参数对乳腺癌的诊断价值,并分析定量参数与恶性转化中血管生成的相关性。方法前瞻性选取2020年3月至2022年1月南阳市第二人民医院收治的160例乳腺病变患者,其中浸润性导管癌、导管内原位癌、非典型增生、单纯增生乳腺病变患者各40例。采用磁共振动态增强(DCE-MRI)扫描获取定量参数[细胞外血管外空间的体积分数(Ve)、转运常数(Ktrans)、速率常数(Kep)],比较各组患者DCE-MRI定量参数及血管生成相关因子[血管内生长因子(VEGF)、血管内皮细胞生长因子受体1(Flk-1/KDR)表达、微血管密度],并比较不同病变性质乳腺病变患者DCE-MRI定量参数,采用受试者工作特征曲线(ROC)分析DCE-MRI定量参数联合诊断乳腺癌的价值,采用Pearson相关性分析DCE-MRI定量参数与血管生成相关因子的关系。结果浸润性导管癌组患者的Ve、Ktrans、Kep分别为0.17±0.05、(0.18±0.06)min、(1.37±0.32)min,明显高于导管内原位癌组的0.14±0.04、(0.15±0.04)min、(1.22±0.27)min,非典型增生组的0.12±0.04、(0.05±0.02)min、(0.74±0.07)min和单纯增生组的0.10±0.03、(0.04±0.01)min、(0.53±0.02)min,差异均有统计学意义(P<0.05);浸润性导管癌组患者的Flk-1/KDR半定量积分、VEGF半定量评分及微血管密度分别为(7.44±2.18)分、(7.85±2.46)分、(51.88±3.07)个/100倍镜,明显高于导管内原位癌组的(5.33±1.30)分、(5.72±1.44)分、(31.53±6.51)个/100倍镜,非典型增生组的(3.26±1.65)分、(3.36±1.73)分、(28.74±4.05)个/100倍镜和单纯增生组的(1.06±0.71)分、(1.26±0.74)分、(19.03±4.02)个/100倍镜,差异均有统计学意义(P<0.05);恶性组患者的Ve、Ktrans、Kep分别为0.16±0.05、(0.17±0.05)min、(1.30±0.38)min,明显高于良性组的0.11±0.03、(0.05±0.02)min、(0.64±0.11)min,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,Ve、Ktrans、Kep与Flk-1/KDR、VEGF表达及微血管密度均呈正相关(P<0.05);经ROC分析结果显示,Ve、Ktrans、Kep诊断乳腺癌的AUC值均高于0.7,但各项参数联合预测恶性转化中血管生成的AUC值最大,为0.947(P<0.05)。结论DCE-MRI定量参数可显著提高乳腺癌患者阳性检出率,在一定程度上可反映癌前病变阶段组织血管生成趋势,临床应用价值较高。 展开更多
关键词 磁共振动态增强 乳腺癌 定量参数 恶性转化 血管生成相关因子
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