Assessing quinoline removal performances of an aerobic continuous moving bed biofilm reactor(MBBR) bioaugmented with Pseudomonas citronellolis LV1

This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculation of LV1 in aerobic continuous MBBR could substantially improve the quinoline removal performance with an improved removal efficiency of 34% averagely when quinoline was used as the sole carbon and nitrogen source. Additionally, efficient removal of quinoline in enhanced MBBR occurred at the influent p H of 7.0–8.0, hydraulic retention time(HRT) of 24–28 h and influent quinoline concentration of 100–700 mg·L^(-1). High-throughput sequencing analysis indicated that bioaugmentation could increase microbial diversity and shape the microbial community structure. Although the inoculant LV1 did not remain its dominance in stage Ⅲ, bioaugmentation indeed induced the formation of effective microbial community, and the indigenous microbes including Flavobacterium, Pseudoxanthomonas,Pseudomonas, Vermamoeba, Dyadobacter and Sphingomonas might play the key role in quinoline removal.According to the PICRUSt, the enhanced genes encoding aromatic ring-cleavage enzyme, especially for Nheterocyclic ring-cleavage enzymes, could lead to the improved removal performance of quinoline in bioaugmentation stage. Moreover, the enhanced MBBR treated well actual coking wastewater, as indicated by high removal performance of quinoline, phenol and COD.

Novel indole and quinoline alkaloids from Melodinus yunnanensis

6/7-Seco rearranged spiro-indolone alkaloids,meloyunines A(1)and B(2)and a monoterpenoid quinoline alkaloid meloyunine C(3)together with its possible intermediate 14,15-dehydromelohenine B(4),and their precursorΔ14-vincamenine(5)were isolated from Melodinus yunnanensis.All structures were elucidated based on NMR,FTIR,UV,and MS spectroscopic data.The isolation of monoterpenoid indole,quinoline,and its immediate from the same plant chemically supported the biosynthesis of quinoline from indole.Compound 2 was cytotoxic against several human cancer cell lines.

Bioaugmentation: a new strategy for removal of recalcitrant compounds in wastewater—a case study of quinoline

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Charge effects on quinoline hydrodenitrogenation catalyzed by Ni-Mo-S active sites-A theoretical study by DFT calculation

The charge distribution on Ni-Mo-S active sites can affect hydrodenitrogenation(HDN)activity.In this study,a series of model Ni-Mo-S were developed with various charge distributions.For comparison,the charge distribution effects on quinoline HDN were studied.The results show that a lack of electrons and extra protons can both lower the orbital eigenvalue of the Ni-Mo-S,leading to stronger adsorption of nitrogen-containing compounds and inhibition of ammonia desorption.Electron deficiency will improve the generation of active hydrogen on the active sites but inhibit hydrogen transfer to the nitrogen compounds;extra protons can provide H^(+)to the nitrogen compounds,which will flexibly transfer between the nitrogen compound and active sites,thus improving the cleavage of the C-N bond.

Magnetic Nano Cobalt Ferrite Catalyzed Synthesis of 4H-Pyrano[3,2-h]quinoline Derivatives under Microwave Irradiation

A microwave irradiated magnetically separable nano cobalt ferrite catalyzed green method for the synthesis of 4-phenyl-4H-pyrano[3,2-h]quinolin-2-amine and 2-amino-4-phenyl-4H-pyrano[3,2-h] quinoline-3-carbonitrile derivatives through cyclization of aromatic aldehyde, acetonitrile/malononitrile and 8-hydoxyquinoline is developed and presented in this paper. The cubic magnetic cobalt ferrite nano particles were synthesized by sol-gel citrate precursor method and characterized by FT-IR, XRD, SEM and TEM techniques and the structures of the synthesized pyranoquinoline derivatives were assigned by IR, MASS and 1H NMR techniques. The reaction is carried out in a domestic microwave oven with a heat-resistant microwave safe glass container with a lid.

THE SYNTHESES OF POLYQUINOLINES WITH 2,2'-PYRIDYLQUINOLINE AND 2,6-DIQUINOLYLPYRIDINE AS LIGAND AND THEIR APPLICATIONS IN SOME CATALYTIC REACTIONS

The polyquinolines with 2,2’-pyridylquinoline as bidentate and 2,6-diquinolylpyridine as tridentate ligand have been prepared from 4,4-dlamino- 3,3’-dibenzoyldiphenyl ether, 4,4’-diacetyldiphenyl ether and 1,4-bis (2-acetylpyridyl-6-oxy) benzene, 2,6-diacetylpyridine, respectively. These polyquinoline-supported ligands have been used in hydrogenation and hydroformylation of olefins with some transition metal complexes.

SYNTHESIS， COMPLEXATION PROPERTIES AND CRYSTAL STRUCTURE OF NEW DIOXOCYCLAM BEARING 8－METHYL QUINOLINE AS FUNCTIONAL PENDANT（S）

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Research on quinoline degradation in drinking water by a large volume strong ionization dielectric barrier discharge reaction system

Quinoline is widely used in the production of drugs as a highly effective insecticide,and its derivatives can also be used to produce dyes.It has a teratogenic carcinogen to wildlife and humans once entering into the aquatic environment.In this study,the degradation mechanism of quinoline in drinking water by a strong ionization dielectric barrier discharge(DBD)lowtemperature plasma with large volume was explored.High concentration of hydroxyl radical(·OH)(0.74 mmol l^(-1))and ozone(O3)(58.2 mg l^(-1))produced by strongly ionized discharge DBD system were quantitatively analyzed based on the results of electron spin resonance and O3 measurements.The influencing reaction conditions of input voltages,initial pH value,·OH inhibitors,initial concentration and inorganic ions on the removal efficiency of quinoline were systematically studied.The obtained results showed that the removal efficiency and TOC removal of quinoline achieved 94.8%and 32.2%,degradation kinetic constant was 0.050 min^(-1) at 3.8 k V and in a neutral pH(7.2).The proposed pathways of quinoline were suggested based on identified intermediates as hydroxy pyridine,fumaric acid,oxalic acid,and other small molecular acids by high-performance liquid chromatography/tandem mass spectrometry analysis.Moreover,the toxicity analysis on the intermediates demonstrated that its acute toxicity,bioaccumulation factor and mutagenicity were reduced.The overall findings provided theoretical and experimental basis for the application of a high capacity strong ionization DBD water treatment system in the removal of quinoline from drinking water.

SYNTHESIS AND COMPLEXATION PROPERTIES OF NEW DIOXO TETRAAMINE LIGANDS WITH 8－METHYL QUINOLINE AS FUNCTIONAL PENDANT（S）

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Ion-beam-assisted characterization of quinoline-insoluble particles in nuclear graphite

The irradiation behavior of graphite is essential for its applications in the nuclear industry.However,the behavioral differences of graphite remain obscure because of the very limited comprehension of its microstructural differences.One typical structure,the quinoline-insoluble(QI)particle,was investigated using IG-110 and NBG-18 graphite.After irradiation,the QI particles on the polished surface were proven to become hillocks,which were easily identifiable via scanning electron microscopy(SEM).Thus,a method that combined ion irradiation and SEM characterization was proposed to study the distribution and concentration of QI particles in graphite.During irradiation,the QI particles were found to evolve into densified spheres,which were weakly bonded with the surrounding graphite structures,thereby indicating that the densification of QI particles did not evidently contribute to graphite dimensional shrinkage.A much higher concentration of QI particles in NBG-18 than IG-110,which was suggested to be responsible for the smaller maximum dimensional shrinkage of former over the latter during irradiation,was characterized.

Biodegradation Kinetics and Mechanism of a Typical Coal Gasification Pollutant:Quinoline

A strain Pseudomonas sp.PP1 was isolated from activated sludge and characterized by morphological observation,biochemical and physiological identification as well as 16 S rRNA gene sequence analysis.It was a gram-negative,non-motile,rod-shaped with colonies which were white,opaque,small and wrinkled on solid quinoline-MSM.The strain was negative for catalase,gelatin liquefaction,M.R and V.P tests and was unable to reduce / restore nitrate.The 1406 bp 16 S rRNA gene fragment of PP1 was more than 99% identical to the Pseudomonas sp.Biodegradation of quinoline as single substrate was conducted in batch experiments at different temperatures( 15- 40 ℃) and p H values( 5- 10).The results indicate that the optimum conditions for the degradation of quinoline by PP1 were 30 ℃ and p H 7.Pseudomonas sp.PP1 was able to degrade 97.1%,95.4%,94.8%,63.6% and 40.4% quinoline when initial concentrations of quinoline were 50,100,200,300,and 400 mg / L,respectively,and lag phases were prolonged from 2 h to 10 h.The maximum degradation rate( q) was obtained at an initial quinoline concentration( S0) of about 100 mg/L with q of 0.082.The experimentally obtained q values at various initial S0 were fitted by Haldane model,Yano model,Aiba model,Edward model and Webb model,and the results demonstrated that Haldane model gives the best fit for strain PP1 with coefficient of determination,R2= 0.9124 and SDavg= 0.0113208.Five metabolic intermediates were identified by high performance liquid chromatograph( HPLC) and GC / MS.Finally,a possible pathway containing 5,6-dihydroxy-2-oxo-1,2-dihydroquinoline as an intermediate was proposed for the first time.

Synthesis and Photoelectrical Properties of D-A Type Carbazole-quinoline

The key issues concerning the design and synthesis of high fluorescent efficiency, good thermal stability of organic blue materials should be solved urgently in organic light emitting diodes. In this article, three D-A type blue emitters based on carbazole and phenylquinoline with flexible chains were prepared through Friedlander condensation reaction in relatively high yield. The photoelectric properties of all compounds were studied by UV-vis absorption, emission spectra and cyclic voltammograms. Density functional theory calculations(DFT) were performed to obtain a better understanding of the electronic structures. Interestingly, compound a3 with the highest fluorescence quantum yield of 0.53 can be applied into blue light emission materials on account of good thermal performance. Furthermore, a1～a3 with narrow band gap make them become potential candidates in the fields of OLED, solar cells and OFET.

Synthesis of New Mannich Products Bearing Quinoline Nucleous Using Reusable Ionic Liquid and Antitubercular Evaluation

A series of Mannich products bearing quinoline nucleus was synthesized, characterized, and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The results showed that compounds 4b, and 4d found most active with percentage inhibition of 95, and 96, respectively, at minimum inhibitory concentration (MIC) of >6.25 μg/mL, among the synthesized compounds. Whereas, compounds 4a, 4c, 4e, and 4f exhibited considerable antitubercular activity with percentage inhibition of 71, 79, 55, and 68, respectively, at MIC of >6.25 μg/mL. The structures of synthesized compounds were elucidated by various spectroscopic tools like IR, 1H NMR, 13C NMR, mass and elemental analysis.

Evaluation of the Antitumor and Radiosynthetizing Activity of a Novel Quinoline Sulfonamide Derivative (PIQSA) as a Histone Deacetylase Inhibitor

Inhibition of histone deacetylases (HDACs) is emerging as a new strategy in cancer therapy. In the present work a novel pyrimido-quinoline benzene sulfonamide (PIQSA compound) was designed and synthesized postulating its ability to inhibit HDAC enzyme in cancer cells. This study was designed to examine the in vitro anti-tumor efficacy of PIQSA against Ehrlich Ascite carcinoma cells (EAC) and three of the human cancer cell lines (H460), brain (U251) and liver (HepG2). The results of Cytotoxic assays showed that PIQSA exhibited in vitro antitumor activity in a dose dependant manner. The tumor growth delay studies indicating that PIQSA resulted in significant regression in tumor growth, which was more pronounced when PIQSA treatment accompanied with radiation exposure. Also, the efficacy of PIQSA to influence radiation response in Ehrlich solid carcinoma (ESC) tumors was estimated. The results suggest that PIQSA exhibited antitumor activities and strong radioenhancing properties associated with inhibition of HDAC activity, DNA fragmentation followed by apoptotic cell death, preferential cell loss of cells particularly in G1/G0 phase through an apoptotic pathway.

New and Facile Synthesis of Substituted Pyrrole, Pyridine, Pyrazolo[4,3-b] Pyridine, Pyrano[3,2-c] Quinoline, Napthopyran, Naphthodipyran and Coumarin Derivatives

Several new pyrazolo[4,3-b] pyridines 7a, b were prepared by reacting arylidenemalononitriles 1a, c or 1i, j with 4-nitrosoantipyrine 4. Reacting 1a, b, d with 4-azidomethylcarbonylantipyrine 8 give 2-aminopyrrole 14. Pyrano[3,2-c] quinolines 20a, b and 23 were obtained by reacting 4-hydroxyquinoline 15 with 1g, h, 2b respectively. Reaction of 1 with naphthalenediols 24, 27 and 29 yield naphthodipyrans 26a, b, 28a, b and 30a。

Anti-Cancer Activity and Molecular Docking of Some Pyrano[3,2‑c]quinoline Analogues

Quinoline analogues exhibited diversified biological activities depending on the structure type. A number of natural products with pyrano[3,2-c]quinolone structural motifs and patented chromenes were reported as promising cytotoxic agents. A molecular docking study was employed to investigate the binding and functional properties of 3-amino pyranoquinolinone 2a-c as anti-cancer agents. The three 3-amino pyranoquinolinone 2a-c showed an interesting ability to intercalate the DNA-topoisomerase complex and were able to obtain energetically favorable binding modes (−8.3 - −7.5 kcal/mol). Compound 2c containing butyl chain superiority over the other two compounds 2a-b which appeared to be involved in arene-H interactions with the two dG13 aromatic centers. The butyl chain also appeared to be immersed into a side subpocket formed by the side chains of Asn520 and Glu522 and the backbone amide of Arg503, Gly504, Lys505 and Ile506. Hence, the 3-amino pyranoquinolinone 2c used as starting material to prepare derivatives of pyrano[3,2-c]quinolone containing 1,2,4-triazine ring 4a-b which will enhance the anti-cancer activity. Pyrano[3,2-c]quinoline-2,5-diones 2a-c and 4a-b were evaluated in vitro on cell lines Ehrlich Ascites carcinoma cells (EAC), liver cancer cell line Hep-G2 and breast cancer cell line MCF-7 for the development of novel anticancer agents. The screening results revealed that compounds 4a-b were found most active candidates as anticancer agents.

Synthesis and Spectral Characterization of Novel 2-Pyrazoline and Bis-2-Pyrazoline Containing Quinoline Moiety

Eight new compounds containing in their structures substituted quinoline and pyrazole entity were synthesized in good to excellent yield by cyclocondensation reaction of chalcones and hydrazine hydrate. This reaction was conducted in formic acid in presence of BF3·Et2O or in acetic acid. These approaches were extended to bis-chalcones, which delivered functionalized bispyrazolines. The structures of the prepared compounds were confirmed by IR, 1HNMR, 13CNMR and mass spectral analysis.

DFT Studies on Molecular Structure, Thermodynamics Parameters, HOMO-LUMO and Spectral Analysis of Pharmaceuticals Compound Quinoline (Benzo[b]Pyridine)

Advances in computational chemistry have greatly increased its effectiveness and attractiveness as an emerging adjunct to experimental chemistry but also as an independent research field. This work studied some basic bonding Parameters, geometry, Uv-Visible spectra, HOMO-LUMO and harmonic vibrational frequencies of Quinoline were investigated by using density functional theory (DFT/6-31+ (d, p)) methods. The calculated wave numbers (B3LYP) agree properly with the determined wave numbers. The results obtained are then as compared with experimental statistics in which available. The structural parameters;thermochemistry, rotational constants, IR spectra and frequencies, bond distances, angles and dipole moment were obtained from the optimized stable geometries of the compound. The computed optimized geometric bond lengths and bond angles show good agreement with experimental data of the title compound. The calculated HOMO and LUMO energies indicate that charge transfer occurs within the molecule.

Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms

Methicillin-resistant Staphylococcus aureus (MRSA), the most common pathogen in hospital and community environments, can cause serious and even fatal infections. The antibiotics currently used for clinical treatment of MRSA have developed resistance, and there is an urgent need to develop new antimicrobials to treat infections caused by MRSA strains. Quinoline analogues play an important role in the development of antimicrobials. Herein, we discussed the current development of antibacterial activities of quinoline analogues, mainly for anti-MRSA activity, and their structure-activity relationships (SARs) from the perspective of using the quinoline nucleus to search for novel potential anti-MRSA candidates. Additionally, the mechanisms of some representative quinoline analogues against MRSA were clarified. Altogether, this review could provide further insights for the rational development of quinoline-based antibacterial drugs, especially against MRSA.