Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) ...Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) to afford α,α'-bis(substituted benzylidene) cycloalkanones in good yields.展开更多
A very efficient and practical procedure for preparation of ( S)-( - )-ofloxacin has been developed (10 steps, overall yield ?45%). The key step of this approach is the regioselective nucleophilic substitution of 2-po...A very efficient and practical procedure for preparation of ( S)-( - )-ofloxacin has been developed (10 steps, overall yield ?45%). The key step of this approach is the regioselective nucleophilic substitution of 2-position fluorine atom of 2,3,4 tirfluoronitrobenzene by (S)-glycerol acetonide.展开更多
文摘Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) to afford α,α'-bis(substituted benzylidene) cycloalkanones in good yields.
文摘A very efficient and practical procedure for preparation of ( S)-( - )-ofloxacin has been developed (10 steps, overall yield ?45%). The key step of this approach is the regioselective nucleophilic substitution of 2-position fluorine atom of 2,3,4 tirfluoronitrobenzene by (S)-glycerol acetonide.
