Acute toxicity of 21 quinolone antibiotics was monitored using photobacterium Vibriofischeri assay. The minimum IC20 （inhibitory concentration for 20% luminescence elimination） was obtained at the least 18.86 μmol/...Acute toxicity of 21 quinolone antibiotics was monitored using photobacterium Vibriofischeri assay. The minimum IC20 （inhibitory concentration for 20% luminescence elimination） was obtained at the least 18.86 μmol/L for the tested quinolones. A quantitative structure-activity relationship model was established to investigate the possible mechanism for the acute toxicity. The critical physicochemical descriptors, describing a and atom electronegativity, implied that the electron transfer might occur between the quinolones and photobacterium V. fischeri. Although the quinolones exhibited limited acute toxicity to photobacterium, toxicity elevation was detected after their chlorination. Hence, chlorination disinfection treatment of quinolone-containing water should be of concerns.展开更多
基金supported by the National Natural Science Foundation of China (Nos.21377143, 21077123)the National High Technology Research and Development Program (863) of China (No.2013AA0652051)
文摘Acute toxicity of 21 quinolone antibiotics was monitored using photobacterium Vibriofischeri assay. The minimum IC20 （inhibitory concentration for 20% luminescence elimination） was obtained at the least 18.86 μmol/L for the tested quinolones. A quantitative structure-activity relationship model was established to investigate the possible mechanism for the acute toxicity. The critical physicochemical descriptors, describing a and atom electronegativity, implied that the electron transfer might occur between the quinolones and photobacterium V. fischeri. Although the quinolones exhibited limited acute toxicity to photobacterium, toxicity elevation was detected after their chlorination. Hence, chlorination disinfection treatment of quinolone-containing water should be of concerns.
