Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl gr...Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl group in the isopropyl side chain of propofol,constructs a new type of chiral molecule,which significantly enhances the spatial effect,and improves the affinity for GABA receptors.Its pharmacological properties are characterized by high potency,rapid onset of action,rapid recovery,low accumulation,and minimal adverse reactions.Therefore,it has a wide range of applications in various endoscopic diagnostic and therapeutic operations,ICU sedation,and general anesthesia.In this paper,the related knowledge of ciprofol and the development of clinical application research are comprehensively sorted out and synthesized,to provide a solid theoretical basis for the rational application of ciprofol in clinical practice.At the same time,the future research direction of ciprofol will also be prospected to provide valuable references for research in related fields.展开更多
Postpartum fatigue is an important issue that threatens women’s health.The incidence of postpartum fatigue is high.Failure to intervene in time may lead to adverse outcomes such as postpartum depression,premature ter...Postpartum fatigue is an important issue that threatens women’s health.The incidence of postpartum fatigue is high.Failure to intervene in time may lead to adverse outcomes such as postpartum depression,premature termination of breastfeeding,child abuse,and low infant development.This article reviews the concepts,characteristics,related factors,adverse effects,and interventions of postpartum fatigue.The aim is to improve doctors’and nurses’awareness of on postpartum fatigue in pregnant women,enrich the research content and methods,stimulate the interest of nurses,and actively carry out targeted intervention research to prevent or reduce the occurrence of adverse outcomes.展开更多
Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease, leading toa great number of death and a huge disease burden to China. Recently, as the promulgation of a series of nation...Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease, leading toa great number of death and a huge disease burden to China. Recently, as the promulgation of a series of national healthpolicies, the diagnosis and treatment of COPD has gradually gained attention. The prevention and treatment capacity ofCOPD in China has been greatly improved, but there are still problems of insufficient diagnosis and irregular treatment. Theproblem is mainly related to the lack of universal pulmonary function test, insufficient number and level of doctors, and thenonstandard use of drugs. The prevention and treatment of COPD in primary medical institutions is particularly lacking. Inorder to promote the prevention and treatment of COPD, China has innovatively adopted a number of measures, including"Happy Breathing" project, standardized diagnosis and treatment system and capacity building for respiratory diseases inprimary medical institutions, el at. Effective progress has been made through these methods, and great improvement of theprevention, diagnosis and treatment of COPD has been achieved.展开更多
It is of strategical significance to exploit new medicines with Chinese features and with their patented rights phytechemistry will have great prospects in this aspect. This article briefly introduces the main researc...It is of strategical significance to exploit new medicines with Chinese features and with their patented rights phytechemistry will have great prospects in this aspect. This article briefly introduces the main research fields on phytochemistry and their significance, the present research situation in China, and suggests some concrete proposals on the development of the discipline in China.展开更多
Objective:To investigate the effect of psychological education combined with progressive muscle relaxation training on the symptom cluster and rehospitalization of elderly patients with coronary heart disease.Methods:...Objective:To investigate the effect of psychological education combined with progressive muscle relaxation training on the symptom cluster and rehospitalization of elderly patients with coronary heart disease.Methods:This study is a longitudinal randomized controlled study involving 140 elderly patients with coronary heart disease.The patients were divided into two groups:an intervention group and a control group,with 70 cases in each group,via random number table.The patients in the control group received routine nursing,whereas those in the intervention group received psychological education combined with progressive muscle relaxation training for 4 weeks on the basis of routine nursing.The effect of the intervention was evaluated before intervention,at the end of 1 month,3 months,and 6 months after intervention.Results:At the end of 1 month,3 months,and 6 months,the sleep,fatigue,anxiety,and functional status of the patients in the intervention group were significantly better than those of the control group,with statistical significance difference(P<0.05).The rehospitalization rate of the intervention group was lower than that of the control group,and the difference was statistically significant(X2=10.685,P=0.001).Conclusion:Psychological education combined with progressive muscle relaxation training is effective in alleviating the symptom cluster of elderly patients with coronary heart disease and reducing their rehospitalization rate;thus,it should be popularized.展开更多
This paper summarizes the typical models,construction theory and development status of modern agricultural science and technology parks at home and abroad,in order to provide a reference for the sustainable developmen...This paper summarizes the typical models,construction theory and development status of modern agricultural science and technology parks at home and abroad,in order to provide a reference for the sustainable development of modern agricultural science and technology parks in China.It is found that at present,the agricultural science and technology park in China is in the stage of quantitative development,neglecting the qualitative construction of the park.This paper points out that the balanced relationship among ecology,economy and society should be adjusted to promote the sustainable development of the park.展开更多
Fructus Ligustri Lucidi （ FLL）, a well-known and commonly used Chinese herbal medicine in clinical practice, is often applied in animal husbandry in the form of monomer or compound. The chemical composition, pharmac...Fructus Ligustri Lucidi （ FLL）, a well-known and commonly used Chinese herbal medicine in clinical practice, is often applied in animal husbandry in the form of monomer or compound. The chemical composition, pharmacological effects of FLL and its application progress in animal husbandry are reviewed.展开更多
Objective To analyze the development status of precision medicine in China and summarize the problems so as to put forward some countermeasures to promote its high-quality development.Methods Literature research and c...Objective To analyze the development status of precision medicine in China and summarize the problems so as to put forward some countermeasures to promote its high-quality development.Methods Literature research and comparative research were used to study the development status of precision medicine in China from the perspectives of market environment,product research and development(R&D)and policy environment.Results and Conclusion There are some problems in the field of precision medicine in China,such as technical barriers,less investment in new drug R&D,and imperfect regulatory measures.Therefore,some solutions are put forward.First,enterprises should be encouraged to strengthen their cooperation with innovative R&D.Second,the compensation system of drug patent protection period must be established as soon as possible.Lastly,overseas experience should be learned with scientific supervision.展开更多
Following a thorough examination and appraisal by the Awards jury and after ratification by the CAS President’s Working Conference, a total of 15 R&D projects were granted special-grade prizes and 13 first-grade ...Following a thorough examination and appraisal by the Awards jury and after ratification by the CAS President’s Working Conference, a total of 15 R&D projects were granted special-grade prizes and 13 first-grade prizesrespectively at the 1994 CAS Awards for S&T Progress.A brief introduction of them is given as follows:展开更多
In the wake of examination,appraisal and recommendation by the jury of the CAS Awards for S&T Progress and ratified by the CAS President’s Working Conference, 29 R&D projects was confered one special-grade pr...In the wake of examination,appraisal and recommendation by the jury of the CAS Awards for S&T Progress and ratified by the CAS President’s Working Conference, 29 R&D projects was confered one special-grade prize and 28 first-grade prizes of the 1993 CAS Awards for S&T Progress respectively. A brief introduction to them is as follows: SPECIAL PRIZE (1 ITEM)展开更多
The 1990s is a key historical decade in the process of China’s on-going modernization drive.When reviewing the overall picture of the socio-economic trend and S&T development around the world during the last two ...The 1990s is a key historical decade in the process of China’s on-going modernization drive.When reviewing the overall picture of the socio-economic trend and S&T development around the world during the last two decades,we may reach the conclusion that a new technological revolution is taking shape.For both the developed and the developing countries,challenges and opportunities are close at hand.In the Decision to Speed up China’s S&T Progress Jointly Issued by the CPC Central Committee and the State Council.a developmen-展开更多
High myopia, is a condition of the diopter over -6.00D, accompanied by axial extension and fundus changes, suchas temporal arc plaque, pigment epithelium thinning, leopard-shaped fundus, fuchs spot, retina choroidal a...High myopia, is a condition of the diopter over -6.00D, accompanied by axial extension and fundus changes, suchas temporal arc plaque, pigment epithelium thinning, leopard-shaped fundus, fuchs spot, retina choroidal atrophy,progressive decline in vision, as well as amblyopia, glaucoma, cataract, vitreous opacity, retinal detachment andother ophthalmic diseases. High myopia is one of the common causes of blindness in China. It is necessary toreview these cases in order to better guide the clinical and improve the level of vision of patients.展开更多
The practice of evidence-based medicine （EBM） in recent years has spurred the increased study of the peri-operative period （POP） and has won acclaim. At present, surgeons fully recognize the importance of the POP ...The practice of evidence-based medicine （EBM） in recent years has spurred the increased study of the peri-operative period （POP） and has won acclaim. At present, surgeons fully recognize the importance of the POP and are enthusiastically immersing themselves actively into itsresearch.展开更多
Background:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events.This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target le...Background:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events.This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.Methods:Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included.All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures.Patients were grouped into non-smokers,quitters,and smokers according to their smoking status.Clinical outcomes including rapid lesion progression,lesion re-vascularization,and myocardial infarction were recorded at second coronary angiography.Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.Results:A total of 1255 patients and 1670 lesions were included.Smokers were younger and more likely to be male compared with nonsmokers.Increase in percent diameter stenosis was significantly lower(2.7[0.6,7.1]%vs.3.5[0.9,8.9]%)and 3.4[1.1,7.7]%,P=0.020)in quitters than those in smokers and non-smokers.Quitters tended to have a decreased incidence of rapid lesions progression(15.8%[76/482]vs.21.6%[74/342]and 20.6%[89/431],P=0.062),lesion re-vascularization(13.1%[63/482]vs.15.5%[53/432]and 15.5%[67/431],P=0.448),lesion-related myocardial infarction(0.8%[4/482]vs.2.6%[9/342]and 1.4%[6/431],P=0.110)and all-cause myocardial infarction(1.9%[9/482]vs.4.1%[14/342]and 2.3%[10/431],P=0.128)compared with smokers and non-smokers.In multivariable analysis,smoking status was not an independent predictor for rapid lesion progression,lesion re-vascularization,and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers(hazards ratio:3.00,95%confidence interval:1.04-8.62,P=0.042).Conclusion:Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions,meanwhile,smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers.展开更多
文摘Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl group in the isopropyl side chain of propofol,constructs a new type of chiral molecule,which significantly enhances the spatial effect,and improves the affinity for GABA receptors.Its pharmacological properties are characterized by high potency,rapid onset of action,rapid recovery,low accumulation,and minimal adverse reactions.Therefore,it has a wide range of applications in various endoscopic diagnostic and therapeutic operations,ICU sedation,and general anesthesia.In this paper,the related knowledge of ciprofol and the development of clinical application research are comprehensively sorted out and synthesized,to provide a solid theoretical basis for the rational application of ciprofol in clinical practice.At the same time,the future research direction of ciprofol will also be prospected to provide valuable references for research in related fields.
文摘Postpartum fatigue is an important issue that threatens women’s health.The incidence of postpartum fatigue is high.Failure to intervene in time may lead to adverse outcomes such as postpartum depression,premature termination of breastfeeding,child abuse,and low infant development.This article reviews the concepts,characteristics,related factors,adverse effects,and interventions of postpartum fatigue.The aim is to improve doctors’and nurses’awareness of on postpartum fatigue in pregnant women,enrich the research content and methods,stimulate the interest of nurses,and actively carry out targeted intervention research to prevent or reduce the occurrence of adverse outcomes.
基金CAMS Innovation Fund for Medical Sciences (CIFMS)(No. 2018-I2M-1-001)National Key R&D Program of China, Ministry ofScience and Technology of China(No. 2016YFC1303901)。
文摘Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease, leading toa great number of death and a huge disease burden to China. Recently, as the promulgation of a series of national healthpolicies, the diagnosis and treatment of COPD has gradually gained attention. The prevention and treatment capacity ofCOPD in China has been greatly improved, but there are still problems of insufficient diagnosis and irregular treatment. Theproblem is mainly related to the lack of universal pulmonary function test, insufficient number and level of doctors, and thenonstandard use of drugs. The prevention and treatment of COPD in primary medical institutions is particularly lacking. Inorder to promote the prevention and treatment of COPD, China has innovatively adopted a number of measures, including"Happy Breathing" project, standardized diagnosis and treatment system and capacity building for respiratory diseases inprimary medical institutions, el at. Effective progress has been made through these methods, and great improvement of theprevention, diagnosis and treatment of COPD has been achieved.
文摘It is of strategical significance to exploit new medicines with Chinese features and with their patented rights phytechemistry will have great prospects in this aspect. This article briefly introduces the main research fields on phytochemistry and their significance, the present research situation in China, and suggests some concrete proposals on the development of the discipline in China.
文摘Objective:To investigate the effect of psychological education combined with progressive muscle relaxation training on the symptom cluster and rehospitalization of elderly patients with coronary heart disease.Methods:This study is a longitudinal randomized controlled study involving 140 elderly patients with coronary heart disease.The patients were divided into two groups:an intervention group and a control group,with 70 cases in each group,via random number table.The patients in the control group received routine nursing,whereas those in the intervention group received psychological education combined with progressive muscle relaxation training for 4 weeks on the basis of routine nursing.The effect of the intervention was evaluated before intervention,at the end of 1 month,3 months,and 6 months after intervention.Results:At the end of 1 month,3 months,and 6 months,the sleep,fatigue,anxiety,and functional status of the patients in the intervention group were significantly better than those of the control group,with statistical significance difference(P<0.05).The rehospitalization rate of the intervention group was lower than that of the control group,and the difference was statistically significant(X2=10.685,P=0.001).Conclusion:Psychological education combined with progressive muscle relaxation training is effective in alleviating the symptom cluster of elderly patients with coronary heart disease and reducing their rehospitalization rate;thus,it should be popularized.
文摘This paper summarizes the typical models,construction theory and development status of modern agricultural science and technology parks at home and abroad,in order to provide a reference for the sustainable development of modern agricultural science and technology parks in China.It is found that at present,the agricultural science and technology park in China is in the stage of quantitative development,neglecting the qualitative construction of the park.This paper points out that the balanced relationship among ecology,economy and society should be adjusted to promote the sustainable development of the park.
文摘Fructus Ligustri Lucidi （ FLL）, a well-known and commonly used Chinese herbal medicine in clinical practice, is often applied in animal husbandry in the form of monomer or compound. The chemical composition, pharmacological effects of FLL and its application progress in animal husbandry are reviewed.
文摘Objective To analyze the development status of precision medicine in China and summarize the problems so as to put forward some countermeasures to promote its high-quality development.Methods Literature research and comparative research were used to study the development status of precision medicine in China from the perspectives of market environment,product research and development(R&D)and policy environment.Results and Conclusion There are some problems in the field of precision medicine in China,such as technical barriers,less investment in new drug R&D,and imperfect regulatory measures.Therefore,some solutions are put forward.First,enterprises should be encouraged to strengthen their cooperation with innovative R&D.Second,the compensation system of drug patent protection period must be established as soon as possible.Lastly,overseas experience should be learned with scientific supervision.
文摘Following a thorough examination and appraisal by the Awards jury and after ratification by the CAS President’s Working Conference, a total of 15 R&D projects were granted special-grade prizes and 13 first-grade prizesrespectively at the 1994 CAS Awards for S&T Progress.A brief introduction of them is given as follows:
文摘In the wake of examination,appraisal and recommendation by the jury of the CAS Awards for S&T Progress and ratified by the CAS President’s Working Conference, 29 R&D projects was confered one special-grade prize and 28 first-grade prizes of the 1993 CAS Awards for S&T Progress respectively. A brief introduction to them is as follows: SPECIAL PRIZE (1 ITEM)
文摘The 1990s is a key historical decade in the process of China’s on-going modernization drive.When reviewing the overall picture of the socio-economic trend and S&T development around the world during the last two decades,we may reach the conclusion that a new technological revolution is taking shape.For both the developed and the developing countries,challenges and opportunities are close at hand.In the Decision to Speed up China’s S&T Progress Jointly Issued by the CPC Central Committee and the State Council.a developmen-
文摘High myopia, is a condition of the diopter over -6.00D, accompanied by axial extension and fundus changes, suchas temporal arc plaque, pigment epithelium thinning, leopard-shaped fundus, fuchs spot, retina choroidal atrophy,progressive decline in vision, as well as amblyopia, glaucoma, cataract, vitreous opacity, retinal detachment andother ophthalmic diseases. High myopia is one of the common causes of blindness in China. It is necessary toreview these cases in order to better guide the clinical and improve the level of vision of patients.
文摘The practice of evidence-based medicine （EBM） in recent years has spurred the increased study of the peri-operative period （POP） and has won acclaim. At present, surgeons fully recognize the importance of the POP and are enthusiastically immersing themselves actively into itsresearch.
基金a grant from National Nature Science Foundation of China(No.81370327).
文摘Background:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events.This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.Methods:Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included.All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures.Patients were grouped into non-smokers,quitters,and smokers according to their smoking status.Clinical outcomes including rapid lesion progression,lesion re-vascularization,and myocardial infarction were recorded at second coronary angiography.Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.Results:A total of 1255 patients and 1670 lesions were included.Smokers were younger and more likely to be male compared with nonsmokers.Increase in percent diameter stenosis was significantly lower(2.7[0.6,7.1]%vs.3.5[0.9,8.9]%)and 3.4[1.1,7.7]%,P=0.020)in quitters than those in smokers and non-smokers.Quitters tended to have a decreased incidence of rapid lesions progression(15.8%[76/482]vs.21.6%[74/342]and 20.6%[89/431],P=0.062),lesion re-vascularization(13.1%[63/482]vs.15.5%[53/432]and 15.5%[67/431],P=0.448),lesion-related myocardial infarction(0.8%[4/482]vs.2.6%[9/342]and 1.4%[6/431],P=0.110)and all-cause myocardial infarction(1.9%[9/482]vs.4.1%[14/342]and 2.3%[10/431],P=0.128)compared with smokers and non-smokers.In multivariable analysis,smoking status was not an independent predictor for rapid lesion progression,lesion re-vascularization,and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers(hazards ratio:3.00,95%confidence interval:1.04-8.62,P=0.042).Conclusion:Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions,meanwhile,smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers.
