R-Factor Analysis of Data Based on Population Models Comprising R- and Q-Factors Leads to Biased Loading Estimates

Effects of performing an R-factor analysis of observed variables based on population models comprising R- and Q-factors were investigated. Although R-factor analysis of data based on a population model comprising R- and Q-factors is possible, this may lead to model error. Accordingly, loading estimates resulting from R-factor analysis of sample data drawn from a population based on a combination of R- and Q-factors will be biased. It was shown in a simulation study that a large amount of Q-factor variance induces an increase in the variation of R-factor loading estimates beyond the chance level. Tests of the multivariate kurtosis of observed variables are proposed as an indicator of possible Q-factor variance in observed variables as a prerequisite for R-factor analysis.

滇西官房铜矿床微量元素R型因子分析及其地质意义研究

官房铜矿床位于我国著名的三江成矿带南澜沧江火山岩段北段,属云县-景谷(火山弧)铜多金属成矿带,是该区最具代表性的玄武岩铜矿床,储量达中型规模。对矿区内矿石的33种微量元素进行聚类分析与R型因子分析,结果显示:经过聚类分析,33种微量元素可分为基性岩元素组合、中低温矿化元素组合、中酸性岩相关元素及中高温矿化元素组合;R型因子分析得到F_(1)、F_(2)、F_(3)、F_(4)四类元素组合因子。其中,聚类分析与R型因子分析的元素分类结果基本一致,能够代表矿床的成矿过程,即成矿分为热液成矿期和中低温地下水热液改造期两个阶段,成矿流体主要来源于深部,成矿物质具有壳幔混合来源的特征,该矿床属于隐伏岩体及岩浆作用有明显成因联系的浅成中-低温热液矿床。

The R2R3-MYB transcription factor GaPC controls petal coloration in cotton

Although a few cases of genetic epistasis in plants have been reported, the combined analysis of genetically phenotypic segregation and the related molecular mechanism remains rarely studied. Here, we have identified a gene(named GaPC) controlling petal coloration in Gossypium arboreum and following a heritable recessive epistatic genetic model. Petal coloration is controlled by a single dominant gene,GaPC. A loss-of-function mutation of GaPC leads to a recessive gene Gapc that masks the phenotype of other color genes and shows recessive epistatic interactions. Map-based cloning showed that GaPC encodes an R2R3-MYB transcription factor. A 4814-bp long terminal repeat retrotransposon insertion at the second exon led to GaPC loss of function and disabled petal coloration. GaPC controlled petal coloration by regulating the anthocyanin and flavone biosynthesis pathways. Expression of core genes in the phenylpropanoid and anthocyanin pathways was higher in colored than in white petals. Petal color was conferred by flavonoids and anthocyanins, with red and yellow petals rich in anthocyanin and flavonol glycosides, respectively. This study provides new insight on molecular mechanism of recessive epistasis,also has potential breeding value by engineering GaPC to develop colored petals or fibers for multifunctional utilization of cotton.

基于Tobit模型的河南省R&D投入产出影响因素分析

【目的】科技创新能力是地区综合实力的重要标志之一,科学地识别影响科技资源投入产出的因素,是实现经济跨越式发展和可持续发展的关键。【方法】基于Tobit模型对近十年河南省R&D投入产出面板数据进行相关检验,分析得出各变量对河南省R&D投入产出产生的不同影响。【结果】企业研发机构投入和高水平人才比例与河南省R&D投入产出效率呈显著正相关,而政府支持力度和对外开放程度则对R&D投入产出效率的作用不显著。【结论】建议河南省通过转换政府职能、注重人才引进、加强对外交流、改善区域环境等方式,优化R&D投入产出,更好地提升科技效能。

R环结合蛋白对肺腺癌患者预后的预测及药物敏感性分析

目的:研究R环结合蛋白对肺腺癌患者预后及抗肿瘤药物敏感性的影响,为R环在肿瘤生物学中的调控机制研究及临床决策提供科学依据。方法:从R环结合蛋白质组学研究文献及相关数据库中获取R环结合基因,以癌症基因组图谱数据库中的403例肺腺癌患者的数据作为训练集,以基因表达综合数据库中GSE14814与GSE31210两个数据集的数据作为验证集,采用加权基因共表达网络分析(WGCNA)、最小绝对收缩和选择算子(LASSO)、多因素Cox回归分析逐步筛选具有独立预后预测作用的临床变量及R环特征基因,maftools分析R环特征基因的突变特征,构建基于R环特征基因的风险评分和列线图模型,验证该模型对高、低风险患者预后预测的能力及其对抗肿瘤药物治疗敏感性的影响。最后采用实验验证R环特征基因表达对抗肿瘤药物敏感性的影响。结果:收集整理得到R环特征基因1551个,WGCNA筛选得到显著影响临床表型的R环基因78个,LASSO回归分析保留R环基因14个,多因素Cox回归分析筛选到3个与患者预后密切相关的R环特征基因(HEXIM1、GLI2、PLEC)和一个临床变量(肿瘤分级),根据各参数的回归系数构建预后模型和列线图模型。Kaplan-Meier生存分析显示,高风险组患者预后明显差于低风险组(P<0.01)。时间依赖受试者工作特征曲线表明,该模型在训练集和验证集列队中均具有较好的预测能力。抗肿瘤药物敏感性预测结果表明,高风险组患者对肺癌化疗和靶向治疗药物的敏感性更低。PLEC基因沉默实验表明抑制PLEC的表达能增强表皮生长因子受体野生型非小细胞肺腺癌细胞株对吉非替尼的敏感性。结论:R环结合蛋白是肺腺癌预后的风险因素,联合临床信息和R环特征基因可以有效预测肺腺癌患者的预后,靶向上述R环特征基因可能对提高患者存活率具有重要意义。

R程序包ForestStatTool在林学单木和林分因子统计中的应用

【目的】为了实现林学中单木和林分指标的快速、准确计算,开发了通用的R包ForestStatTool,并通过具体示例介绍其在单木和林分因子统计计算中的应用。【方法】在R语言环境中,编写了12个实用函数,涵盖重复标签处理、重复坐标处理、样地分割、空间结构指标计算、竞争指标计算、生物多样性指标计算和林分因子统计这7大类。以北京十三陵林场的侧柏纯林0.06 hm2圆形样地和吉林省汪清林业局金沟岭林场的云冷杉针阔混交林1 hm2方形大样地的数据为例,介绍了ForestStatTool包的主要功能及使用方法。【结果】ForestStatTool包通过分析各类样地数据,成功计算了林木的空间结构、竞争指数和生物多样性等指标。结果表明:ForestStatTool包可有效识别林木的空间分布特征,量化林木的竞争压力,并揭示了林分结构和多样性分布的特征;还能够满足大样地和复杂林分的快速统计分析需求,适用于多种林业应用场景。【结论】ForestStatTool包可方便、快速、准确地完成样地数据检查与预处理,并完成林学单木和林分因子的相关统计计算。ForestStatTool包可应用于森林经理、森林培育、森林生态等领域。

异质性FDI、R&D与海洋经济绿色全要素生产率

FDI是技术溢出的重要途径,其技术溢出效应的有效发挥受东道国吸收能力的制约,而东道国的吸收能力与一国的R&D息息相关。选取2004-2017年11个沿海省份的面板数据为样本,实证分析FDI、R&D以及二者交互项对海洋经济绿色全要素生产率的影响。结果表明:第一,不区分FDI来源的情况下,FDI水平的提高对海洋经济绿色全要素生产率具有反向抑制作用;第二,从整体上看,FDI与R&D的交互作用对海洋经济绿色全要素生产率具有积极的促进作用;第三,由于不同国家和地区在投资规模、投资结构、附带技术等方面有所不同,因此其对于海洋经济绿色全要素生产率的影响也会不同。

Comparative transcriptomic analysis of Rosa sterilis inflorescence branches with different trichome types reveals an R3-MYB transcription factor that negatively regulates trichome formation

Rosa sterilis S.D.Shi is an important economic tree in China that produces fruits with high nutritional and medicinal value.Many of R.sterills’organs are covered with different types of trichomes or prickles that directly affect fruit appearance and plant management.This study used RNA sequencing technology to analyze the transcriptomes of two parts of the inflorescence branch,namely inflorescence stems with flagellated trichomes and pedicels with both flagellated and glandular trichomes.Comparative transcriptomic analysis showed that many transcription factors(TFs)are potentially involved in the formation and development of trichomes.The accumulation of RsETC1,a TF of the R3-MYB family,was significantly higher in inflorescence stems than in pedicels;quantitative reverse transcription PCR(qRTPCR)verified that its expression was significantly higher in inflorescence stems than in pedicels during the first three development stages,indicating its inhibitory action on the initiation of glandular trichomes in R.sterilis.The mRNA level of RsETC1 accumulated to significantly higher levels in trichomeless tissues than in tissues with trichromes,suggesting that this gene may inhibit the formation of trichomes in R.sterilis.Over-expression of RsETC1 in Arabidopsis resulted in glabrous phenotypes,and the expression of trichome-related endogenous genes,except for TTG1,was markedly reduced.In addition,the contents of the phytohormones jasmonic acid(JA),gibberellin A3(GA_(3)),and cytokinins(CKs)in pedicels were significantly higher than those in inflorescence stems,and the expression patterns of the genes related to hormone biosynthesis and signal transduction presented consistent responses,suggesting that the transduction of these hormones might be crucial for trichome initiation and development.These data provide a new perspective for revealing the molecular mechanism of trichome formation in R.sterilis.

IMMUNOHISTOCHEMICAL OBSERVATION OF MACROPHAGE COLONY STIMULATING FACTOR AND ITS RECEPTOR IN BREAST CANCER AND HEPATOMA TISSUES

Objective: To study the potential role of cellular macrophage colony-stimulating factor (cM-CSF) and cellular macrophage colony-stimulating factor receptor (cM-CSF-R) with breast cancer and hepatoma and search the way for clinical application. Methods: Frozen surgical specimens from 48 breast cancer patients, including 29 cases of histological grade II and 19 eases of grade III, and 16 hepatoma patients were investigated by Avidin Biotin Complex (ABC) immunohistochemical assay with anti-M-CSF monoclonal antibody (Mab) and anti-M-CSF-R Mab. Pathohistological examination was performed as well. Results: cM-CSF and cM-CSF-R were detected in tested specimens. The expression levels of cM-CSF and cM-CSF-R in grade III group were higher than in grade II group and more higher than control group hyperplasia of breast. Hepatoma tissues also showed higher expression level of cM-CSF and cM-CSF-R than normal adult and fetal liver. Conclusion: Breast cancer and hepatoma tissues presented higher expression levels of cM-CSF and cM-CSF-R than control and expression level might be related with tumor’s process.

CO-EXPRESSION OF MACROPHAGE COLONY-STIMULATING FACTOR WITH ITS RECEPTOR IN HUMAN HEPATOMA CELLS AND ITS POTENTIAL ROLES

Objective: To investigate the potential role of macrophage colony-stimulating factor (M-CSF) and macrophage colony-stimulating factor receptor (M-CSF-R) on the growth of human hepatoma cells. Methods: Specimens of different origin, including tissues of human hepatocellular carcinoma (HCC), human fetal liver (FL) and normal liver (NL), the hepatoma cell lines, as well as the peripheral blood mononuclear cells (PBMC) from patients with HCC or liver metastatic tumor (LMT), were used to detect the expression levels of M-CSF and M-CSF-R by ABC immunohistochemistry staining and reverse transcription polymerase chain reaction methods the expression levels of M-CSF and M-CSF-R. Influence of monoclonal antibody against M-CSF (B5) or M-CSF-R (RE2) on proliferation ability of hepatoma cell linesin vitro was also studied. Results: The results showed that hepatoma tissues produced elevated levels of both M-CSF and M-CSF-R compared with those of fetal liver (P<0.001). The M-CSF/M-CSF-R expression levels of PBMC from hepatoma patients were higher than those of LMT patients (P<0.01,P<0.05) and the normal people (P<0.001). The hepatoma cell lines showed strong positive for M-CSF and M-CSF-R production. Both B5 and RE2 displayed a dose-dependent inhibitory effect on the growth and proliferation of hepatoma cells. Conclusion: The study indicates a co-expression model for M-CSF-R in hepatoma cells, suggesting an involvement of M-CSF/M-CSF-R in growth signaling of those malignant cells. The M-CSF/M-CSF-R seems to function through an autonomy mechanism in human hepatoma.

Lung adenocarcinoma harboring rare epidermal growth factor receptor L858R and V834L mutations treated with icotinib:A case report

BACKGROUND Epidermal growth factor receptor(EGFR)tyrosine-kinase inhibitors are widely used for the treatment of non-small-cell lung cancer with EGFR mutations.However,patients with rare,even compound EGFR mutations have different responses to EGFR-tyrosine-kinase inhibitors,which bring uncertainty to clinical treatment.CASE SUMMARY A 45-year-old female patient presented with a 3-mo history of cough and white sputum without chest pain.Chest computed tomography revealed lung spaceoccupying lesions and multiple lymphadenectasis.Bronchoscopy and pathology suggested lung adenocarcinoma.Compound variation of EGFR gene(exon 21 L858 R/V834 L)was detected in both tissue and circulating tumor deoxyribonucleic acid samples.As a result of next-generation sequencing and her family’s wishes,the patient was given oral treatment with icotinib hydrochloride(125 mg/d,tid)from March 21,2019 and has achieved stable disease for the last 1 year.CONCLUSION Non-small cell lung adenocarcinoma with EGFR L858 R/V834 L was treated successfully with icotinib,and it may be a new medication treatment option.

拉伸和弯曲载荷作用下含R槽方形壳角裂纹应力强度因子计算

为了求解拉伸和弯曲载荷作用下裂纹截面上多个不同的奇异应力场的应力强度因子,在断裂力学理论基础上,运用J2积分法和材料力学中平截面假设,以含R槽方形壳对称穿透角裂纹的应力强度因子为例进行分析研究。结果表明,J2积分法以及材料力学中平截面假设可用于确定拉伸和弯曲载荷作用下裂纹截面不同应力场对应的应力强度因子;提出的不同应力强度因子之间的关系式简化了具有复杂裂纹的含裂纹工程构件的应力强度因子求解,为解决复杂应力场所对应的应力强度因子问题提供了思路。同时将有限元解与本研究解进行了比较,两者吻合较好。

R型因子分析在福建邱村金矿原生晕样品数据处理中的运用

以福建邱村金矿矿区地质特征为基础,运用R型因子分析对原生晕样品进行数据处理,从元素异常组合及浓度分带等方面研究了原生晕地球化学特征,发现了As、Sb、Au、Ag、Mo元素代表成矿阶段金矿化元素组合、轴向存在明显且“反分带”现象、680 m至400 m标高存在另一期金矿化等认识。通过邱村金矿原生晕的地球化学特征,结合分析成矿地质背景和矿区的地质特征,认为该矿床属于典型的浅成低温热液型金矿。

Anisotropic Behavior of Cosmological Models with Exponential and Hyperbolic Scale Factors

In this paper, the cosmological models of the universe are constructed in gravity with choice of the functional in the form ?and . The space-time considered here is Bianchi Type I and the energy momentum tensor is in the form of perfect fluid. Two cosmological models are presented using a power form of exponential function and a hyperbolic form. The energy conditions along with the state finder diagnostic pair have been obtained and analyzed.

Diurnal and Seasonal Variations of CO2Fluxes and Their Climate Controlling Factors for a Subtropical Forest in Ningxiang

In this study, the diurnal and seasonal variations of CO2 fluxes in a subtropical mixed evergreen forest in Ningxiang of Hunan Province, part of the East Asian monsoon region, were quantified for the first time. The fluxes were based on eddy covariance measurements from a newly initiated flux tower. The relationship between the CO2 fluxes and climate factors was also analyzed. The results showed that the target ecosystem appeared to be a clear carbon sink in 2013, with integrated net ecosystem CO2exchange（NEE）, ecosystem respiration（RE）, and gross ecosystem productivity（GEP） of-428.8, 1534.8 and1963.6 g C m^-2yr^-1, respectively. The net carbon uptake（i.e. the-NEE）, RE and GEP showed obvious seasonal variability,and were lower in winter and under drought conditions and higher in the growing season. The minimum NEE occurred on12 June（-7.4 g C m^-2d^-1）, due mainly to strong radiation, adequate moisture, and moderate temperature; while a very low net CO2 uptake occurred in August（9 g C m^-2month^-1）, attributable to extreme summer drought. In addition, the NEE and GEP showed obvious diurnal variability that changed with the seasons. In winter, solar radiation and temperature were the main controlling factors for GEP, while the soil water content and vapor pressure deficit were the controlling factors in summer. Furthermore, the daytime NEE was mainly limited by the water-stress effect under dry and warm atmospheric conditions, rather than by the direct temperature-stress effect.

Grade Dependent Expression of Growth Factor Receptors and Signaling Molecules in Breast Cancer

Growth factor signaling plays a key role in the growth and development of breast. Aberrant expression and activation of growth factors like insulin like growth factor-I (IGF-I) and epidermal growth factor (EGF) and their downstream signaling has been implicated in breast cancer. The deregulation of growth factor signaling is associated with increased proliferation and cell survival, decreased apoptosis, invasion, angiogenesis and metastasis. The aim of the present study is to survey the different signaling molecules involved in the IGF and EGF signaling pathways, and to find if there are any relationship between breast cancer and their levels and activation. Thirty-nine samples of breast cancer tissues (24 Grade II and 15 Grade III tumours) and sixteen normal breast tissue samples were collected. The expression of the receptors and signaling molecules were investigated using Western blot. IGF-IRβ, AR, pAkt, IKK-α and p38 are upregulated in cancer tissues in a grade depended manner. Further, Akt and β-catenin were also upregulated in cancer samples. Correlation analysis of signaling molecules revealed a disruption in their expression in cancer tissues. The present study shows that various signaling molecules are upregulated or activated in cancer tissues involving IGF-IR and Akt pathway. The expression of signaling molecules in the cancer tissues were deregulated when compared to the control samples. Thus, flawed expression and over activation of Akt pathway is seen in the breast cancer tissues.

血清sFLT1、CTRP3水平与子宫内膜异位症的相关性

目的探究血清可溶性血管内皮生长因子受体1(soluble vascular endothelial growth factor receptor-1,sFLT1)、C1q/肿瘤坏死因子相关蛋白3(C1q/tumor necrosis factor related protein 3,CTRP3)与子宫内膜异位症(endometriosis,EMT)的相关性。方法回顾性分析江西省景德镇市妇幼保健院收治的80例EMT患者(EMT组),依据r-AFS分期分为Ⅰ-Ⅱ期43例,Ⅲ-Ⅳ期37例,按痛经程度分为轻度46例,中-重度34例;对照组为同时间段健康体检女性80例;检测并分析两组血清sFLT1、CTRP3水平,多因素logistic回归分析Ⅲ-Ⅳ期EMT影响因素,受试者工作特征曲线(receiver operating characteristic curve,ROC)评价血清s FLT1、CTRP3对Ⅲ-Ⅳ期EMT诊断价值。结果EMT组患者血清sFLT1、CTRP3水平低于对照组(P<0.05);中-重度痛经者血清sFLT1、CTRP3水平低于轻度者(P<0.05);r-AFS分期Ⅲ-Ⅳ期患者血清sFLT1、CTRP3水平低于Ⅰ-Ⅱ期者(P<0.05);EMT患者血清sFLT1、CTRP3分别与r-AFS分期、痛经程度呈负相关(P<0.05)。回归分析显示,sFLT1、CTRP3是Ⅲ-Ⅳ期EMT影响因素(P<0.05);血清sFLT1、CTRP3及联合诊断Ⅲ-Ⅳ期EMT的AUC为0.811、0.832、0.931,联合诊断效能优于sFLT1、CTRP3单独诊断。结论EMT患者血清sFLT1、CTRP3水平均降低,与痛经程度、r-AFS分期相关,是Ⅲ-Ⅳ期EMT影响因素,二者联合可辅助评估r-AFS分期。

花旗松素调控内质网应激PERK-ATF4通路减轻高血压大鼠心肌肥厚的机制研究

目的探讨花旗松素(TAX)对自发性高血压大鼠(SHR)心肌肥厚的影响及分子机制。方法24只SHR分为SHR对照组(SHR组)、TAX组(20 mg/kg)、TAX+PERK激活剂CCT020312(CCT)组(20 mg/kg TAX+2 mg/kg CCT),每组8只;另选8只正常血压Wistar-Kyoto(WKY)大鼠作为正常对照组(WKY组),给予相应的药物持续干预8周。实验过程中观察大鼠血压变化,并于干预结束后超声心动图检测大鼠舒张期室间隔厚度(IVSd)、收缩期室间隔厚度(IVSs)、左心室射血分数(LVEF)判断心肌肥厚程度和心脏功能,计算心脏指数、左心室指数,苏木精-伊红(HE)染色、小麦胚芽凝集素(WGA)染色和Masson染色评估心肌组织病理学变化,实时荧光定量PCR(qRT-PCR)检测心肌组织中心房钠尿肽(ANP)、B型利钠肽(BNP)、I型胶原蛋白α1链(COL1A1)和Ⅲ型胶原蛋白α1链(COL3A1)mRNA表达,Western blot检测心肌组织蛋白激酶R样内质网激酶(PERK)-转录激活因子4(ATF4)通路相关蛋白表达。结果干预结束后,与WKY组相比,SHR组收缩压(SBP)、舒张压(DBP)、IVSd、IVSs、心脏指数、左心室指数、心肌细胞横截面积、胶原容积分数(CVF)、心肌组织ANP、BNP、COL1A1和COL3A1 mRNA表达、葡萄糖调节蛋白78(GRP78)、ATF4、C/EBP同源蛋白(CHOP)蛋白水平和p-PERK/PERK比值升高(均P<0.05),LVEF降低(P<0.05);与SHR组相比,TAX组SBP、DBP、IVSd、IVSs、心脏指数、左心室指数、心肌细胞横截面积、CVF、心肌组织ANP、BNP、COL1A1和COL3A1 mRNA表达、GRP78、ATF4、CHOP蛋白水平和p-PERK/PERK比值降低(均P<0.05),LVEF升高(P<0.05);CCT020312可部分逆转TAX对心脏功能和心肌肥厚的保护作用。结论TAX可通过抑制内质网应激(ERS),改善高血压心肌肥厚,其作用机制可能与抑制PERK-ATF4通路有关。

Higher production of tumor necrosis factor alpha in hemozoin-fed human adherent monocytes is dependent on lipidic component of malarial pigment:new evidences on cytokine regulation in Plasmodium falciparum malaria

Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial pigment.Methods:Adherent human monocytes were fed for 3 hours with different meals(native hemozoin;lipid free hemozoin;and control latex particles),then tumor necrosis factor alpha was monitored in cell supernatants up to 48 hours through western blotting or specific enzyme-linked immunoadsorbent assay.In selected experiments,unfed monocytes were treated with different doses of 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid or 4-hydroxynonenal instead of phagocytosis.Results:Hemozoin-fed monocytes produced higher levels of tumor necrosis factor alpha than unstimulated and latex-fed cells, while lipid-free hemozoin did not reproduce these results.Additionally,hemozoin effects were mimicked dose-dependently by 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid,but not by 4-hydroxynonenal.Conclusions:Present data suggest an essential role for lipids in hemozoindependent enhanced release of tumor necrosis factor alpha from monocytes,and 15(S,R)hydroxy -6,8,11,13-eicosatetraenoic acid could be one possible specific mediator.

内质网应激通路相关蛋白IRE1、PERK、ATF6在舌鳞癌中的表达及其功能的生物信息学分析

目的:本研究旨在通过生物信息学方法系统分析肌醇需求酶1(Inositol-Requiring Enzyme 1,IRE1)、蛋白激酶R样内质网激酶(Protein Kinase R-like Endoplasmic Reticulum Kinase,PERK)、激活转录因子6(Activating Transcription Factor 6,ATF6)在舌鳞癌中的表达及意义。方法:使用GEO、Kaplan-Meier Plotter、GeneMANIA、DAVID等多个数据库对IRE1、PERK、ATF6在舌鳞癌中的表达与预后价值、相互蛋白作用网络及功能富集进行综合分析。结果:ATF6在舌鳞癌组织中表达高于癌旁正常组织,差异具有统计学意义(P <0.05)。IRE1及PERK高表达组患者总生存率(OS)高于低表达组,ATF6高表达组患者OS低于低表达组,差异均具有统计学意义(P <0.05)。本研究筛选出与IRE1、PERK、ATF6相互作用的蛋白质各20个并进行GO富集分析。IRE1及相关蛋白富集于内质网、线粒体等细胞组分中,具有蛋白质结合、蛋白磷酸酶结合等分子功能,参与内质网应激反应、泛素依赖性ERAD途径等生物学过程。PERK及相关蛋白富集于胞液、细胞膜等细胞组分中,具有翻译起始因子活性、RNA结合等分子功能,参与内质网未折叠蛋白反应、细胞对葡萄糖饥饿的反应等生物学过程。ATF6及其相关蛋白富集于内质网、细胞核等细胞组分中,具有转录调控区序列特异性DNA结合、蛋白质异二聚化活性等分子功能,参与RNA聚合酶Ⅱ启动子转录的正调控、内质网未折叠蛋白反应等生物学过程。结论:ATF6在舌鳞癌组织中呈现高表达,同IRE1、PERK与舌鳞癌患者不良预后相关。在未来抗肿瘤治疗中,IRE1、PERK、ATF6可能成为舌鳞癌的诊断和治疗的新选择。