The Gouméré region is located in the North-East of Côte d’Ivoire and is located in the South-West of the Bui furrow. In order to highlight the geology of the area studied, 14 samples were taken for stu...The Gouméré region is located in the North-East of Côte d’Ivoire and is located in the South-West of the Bui furrow. In order to highlight the geology of the area studied, 14 samples were taken for studies using petrographic, geochemical and metallogenic methods. The study of macroscopic and microscopic petrography made it possible to highlight two major lithological units: 1) a volcano-plutonic unit, formed of gabbros, basalt, volcaniclastics and rhyodacite;2) a sedimentary unit (microconglomerate). From a geochemical point of view, the results obtained indicate that the plutonites are gabbro and gabbro diorite while the volcanics have compositions of basaltic andesites, rhyolite and dacites. The sediments have a litharenitic to sublitharenitic character. The metallogenic study made it possible to highlight hydrothermal alterations and metalliferous paragenesis on the formations studied. Hydrothermal alteration is characterized by the presence of carbonation, silicification, sericitization, sulfidation and to a lesser degree chloritization. Metalliferous paragenesis consists of pyrite, chalcopyrite, hematite and magnetite.展开更多
This study aims to compare the quality of family and social relationships and Type D personality in cardiovascular patients with normal people. In this research, 300 individuals (n = 150 male, 150 female) are divided ...This study aims to compare the quality of family and social relationships and Type D personality in cardiovascular patients with normal people. In this research, 300 individuals (n = 150 male, 150 female) are divided in two groups of patient (n = 150) and non-patients (n = 150) were selected as samples from the author’s offices (both private and his office in Mazandaran Heart Center). They attended in this study filling the questionnaires of “Pierce Quality relations” and “Personality Inventory (DS14)”. In order to analyze data, First observations were described by the help of descriptive statistics methods including tables, graphs, and indices of central tendency and distribution. Then, observations were described by inferential statistics methods such as univariate and multivariate analysis of variance and then were analyzed by SPSS. Out of the 300 participants, 108 patients (36%) had the mean age of 52 to 63 years old and 30 patients (10%) were 30 to 40 years old. This study showed that there is a significant difference between cardiovascular patients and control group in terms of quality of family and social relationships and Type D personality (P < 0.01). Cardiovascular patients have lower quality of family and social relationships, social support, as well as lower depth of relationships, and also higher relationship conflict than normal people. Also cardiovascular patients have higher type D personality than normal people (P < 0.01). In general, research findings indicate the importance of psychological factors associated with coronary artery disease.展开更多
3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon ...3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production.展开更多
Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized countries.Knowledge of IBD pathogenesis is still incomplete,and the ...Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized countries.Knowledge of IBD pathogenesis is still incomplete,and the most widely-accepted interpretation considers genetic factors,environmental stimuli,uncontrolled immune responses and altered intestinal microbiota composition as determinants of IBD,leading to dysfunction of the intestinal epithelial functions.In vitro models commonly used to study the intestinal barrier do not fully reflect the proper intestinal architecture.An important innovation is represented by organoids,3D in vitro cell structures derived from stem cells that can self-organize into functional organ-specific structures.Organoids may be generated from induced pluripotent stem cells or adult intestinal stem cells of IBD patients and therefore retain their genetic and transcriptomic profile.These models are powerful pharmacological tools to better understand IBD pathogenesis,to study the mechanisms of action on the epithelial barrier of drugs already used in the treatment of IBD,and to evaluate novel target-directed molecules which could improve therapeutic strategies.The aim of this review is to illustrate the potential use of organoids for therapy personalization by focusing on the most significant advances in IBD research achieved through the use of adult stem cells-derived intestinal organoids.展开更多
The present paper evaluated Friedman’s and Rosenman’s Type A and Type B personality theory.According to the authors,Type A personality has been linked to coronary heart disease and other heart problems.After discuss...The present paper evaluated Friedman’s and Rosenman’s Type A and Type B personality theory.According to the authors,Type A personality has been linked to coronary heart disease and other heart problems.After discussing the basic concepts of the theory,it was important to analyze different research papers that utilized the theory in different domains.Then the discussion moved forward to new personality types that have been discovered throughout the years(Types C,D,T).Then a summary of the criticism that the theory has received is included.Finally,future research ideas and limitations of the theory were included.展开更多
BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predicti...BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment.METHODS A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumornode-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131 H/R and FcγRIIIa-158 V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze sera.Genetic study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems".RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth factor beta(TGFβ) with Trx1, whereas males had one with TGFβ and RTrx1. Trx1/CD30 controls the redox immune homeostasis, and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor. This event happens through different gender-specific cytokine pathways. Our study demonstrated that the serum levels ofTrx1/RTrx1, TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγ and IL2 combination constitute a predictive gender specific biomarker system. This is relevant for clinical screening to detect the risk of the potential development or progression of a tumor.CONCLUSION Oxidative stress on Trx1/CD30 is a trigger of cancer disease, and the selected oxidation and immune products are a biomarker system for aging and cancer.展开更多
J. D. Salinger, American novelist and short story writer, is recognized by critics and readers alike as one of the most popular and influential of contemporary writers.His only novel,"The Catcher in the Rye"...J. D. Salinger, American novelist and short story writer, is recognized by critics and readers alike as one of the most popular and influential of contemporary writers.His only novel,"The Catcher in the Rye",so vividly captured the spirit of the fifties and early sixties that those years have been called"The Age of Holden Caulfield."Salinger draws a rich psychological portrait of Holden Caulfield through vivid, colloquial style,using slang and ungrammatical or sloppy pattern of speech. Drawing on an analysis of Salinger's life and his age,this paper seeks to explore Salinger's portrayal of a disillusioned youth and the exposure of the fraudulence of contemporary America in combination with his manipulation of colloquial style and dramatization of interior monologue.展开更多
文摘The Gouméré region is located in the North-East of Côte d’Ivoire and is located in the South-West of the Bui furrow. In order to highlight the geology of the area studied, 14 samples were taken for studies using petrographic, geochemical and metallogenic methods. The study of macroscopic and microscopic petrography made it possible to highlight two major lithological units: 1) a volcano-plutonic unit, formed of gabbros, basalt, volcaniclastics and rhyodacite;2) a sedimentary unit (microconglomerate). From a geochemical point of view, the results obtained indicate that the plutonites are gabbro and gabbro diorite while the volcanics have compositions of basaltic andesites, rhyolite and dacites. The sediments have a litharenitic to sublitharenitic character. The metallogenic study made it possible to highlight hydrothermal alterations and metalliferous paragenesis on the formations studied. Hydrothermal alteration is characterized by the presence of carbonation, silicification, sericitization, sulfidation and to a lesser degree chloritization. Metalliferous paragenesis consists of pyrite, chalcopyrite, hematite and magnetite.
文摘This study aims to compare the quality of family and social relationships and Type D personality in cardiovascular patients with normal people. In this research, 300 individuals (n = 150 male, 150 female) are divided in two groups of patient (n = 150) and non-patients (n = 150) were selected as samples from the author’s offices (both private and his office in Mazandaran Heart Center). They attended in this study filling the questionnaires of “Pierce Quality relations” and “Personality Inventory (DS14)”. In order to analyze data, First observations were described by the help of descriptive statistics methods including tables, graphs, and indices of central tendency and distribution. Then, observations were described by inferential statistics methods such as univariate and multivariate analysis of variance and then were analyzed by SPSS. Out of the 300 participants, 108 patients (36%) had the mean age of 52 to 63 years old and 30 patients (10%) were 30 to 40 years old. This study showed that there is a significant difference between cardiovascular patients and control group in terms of quality of family and social relationships and Type D personality (P < 0.01). Cardiovascular patients have lower quality of family and social relationships, social support, as well as lower depth of relationships, and also higher relationship conflict than normal people. Also cardiovascular patients have higher type D personality than normal people (P < 0.01). In general, research findings indicate the importance of psychological factors associated with coronary artery disease.
基金This work was supported by the National Natural Science Foundation of China(No.82073793)the National Major Science and Technology Projects of China(No.2018ZX09721003-007/No.2018ZX09J18107).
文摘3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production.
文摘Inflammatory bowel diseases(IBDs)are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized countries.Knowledge of IBD pathogenesis is still incomplete,and the most widely-accepted interpretation considers genetic factors,environmental stimuli,uncontrolled immune responses and altered intestinal microbiota composition as determinants of IBD,leading to dysfunction of the intestinal epithelial functions.In vitro models commonly used to study the intestinal barrier do not fully reflect the proper intestinal architecture.An important innovation is represented by organoids,3D in vitro cell structures derived from stem cells that can self-organize into functional organ-specific structures.Organoids may be generated from induced pluripotent stem cells or adult intestinal stem cells of IBD patients and therefore retain their genetic and transcriptomic profile.These models are powerful pharmacological tools to better understand IBD pathogenesis,to study the mechanisms of action on the epithelial barrier of drugs already used in the treatment of IBD,and to evaluate novel target-directed molecules which could improve therapeutic strategies.The aim of this review is to illustrate the potential use of organoids for therapy personalization by focusing on the most significant advances in IBD research achieved through the use of adult stem cells-derived intestinal organoids.
文摘The present paper evaluated Friedman’s and Rosenman’s Type A and Type B personality theory.According to the authors,Type A personality has been linked to coronary heart disease and other heart problems.After discussing the basic concepts of the theory,it was important to analyze different research papers that utilized the theory in different domains.Then the discussion moved forward to new personality types that have been discovered throughout the years(Types C,D,T).Then a summary of the criticism that the theory has received is included.Finally,future research ideas and limitations of the theory were included.
文摘BACKGROUND Identifying biomarkers for the risk of developing degenerative processes linked to aging and colorectal cancer(CRC) onset that could improve clinical strategies.AIM To determine valid targets and a predictive biomarker's system of chronicization of inflammation for cancer treatment.METHODS A group of 147 CRC patients was studied. Clinical diagnosis was confirmed histopathologically, and patients were sub-typed using the pathological tumornode-metastasis classification. Thirteen colon adenoma patients and 219 healthy subjects were also studied. A system biology study on Thioredoxin1/CD30 redox-immune systems(Trx1/CD30), T helper cytokines and polymorphisms of killer immunoglobulin-like receptors, FcγRIIa-131 H/R and FcγRIIIa-158 V/F was carried out. Enzyme-linked immunosorbent assay was performed to analyze sera.Genetic study was executed by polymerase chain reaction sequence-specific primers and sequence-based typing method. Statistical analysis was performed by using the "Statgraphics software systems".RESULTS We found a positive increase between Trx1/RTrx1 levels and sCD30 level and increased age. With respect to the gender relationships, there were distinct differences. Females showed a primary relationship between transforming growth factor beta(TGFβ) with Trx1, whereas males had one with TGFβ and RTrx1. Trx1/CD30 controls the redox immune homeostasis, and an imbalance in the relationship between the Trx1/RTrx1 and sCD30 levels is linked to the onset and progression of tumor. This event happens through different gender-specific cytokine pathways. Our study demonstrated that the serum levels ofTrx1/RTrx1, TGFβ/interleukin(IL)6 and TGFβ/IL4 combinations and the sCD30,IFNγ and IL2 combination constitute a predictive gender specific biomarker system. This is relevant for clinical screening to detect the risk of the potential development or progression of a tumor.CONCLUSION Oxidative stress on Trx1/CD30 is a trigger of cancer disease, and the selected oxidation and immune products are a biomarker system for aging and cancer.
文摘J. D. Salinger, American novelist and short story writer, is recognized by critics and readers alike as one of the most popular and influential of contemporary writers.His only novel,"The Catcher in the Rye",so vividly captured the spirit of the fifties and early sixties that those years have been called"The Age of Holden Caulfield."Salinger draws a rich psychological portrait of Holden Caulfield through vivid, colloquial style,using slang and ungrammatical or sloppy pattern of speech. Drawing on an analysis of Salinger's life and his age,this paper seeks to explore Salinger's portrayal of a disillusioned youth and the exposure of the fraudulence of contemporary America in combination with his manipulation of colloquial style and dramatization of interior monologue.