The recent article by Liang et al. （2011）, pub- lished in Journal of Zhejiang University-SCIENCE B （Biomedicine ＆ Biotechnology）, is highly interesting. Interestingly, the past few years have seen the in- creasin...The recent article by Liang et al. （2011）, pub- lished in Journal of Zhejiang University-SCIENCE B （Biomedicine ＆ Biotechnology）, is highly interesting. Interestingly, the past few years have seen the in- creasing application of berbamine as an anti-cancer agent in other systemic malignancies besides chronic myeloid leukemia. For instance, berbamine administration alters the Bcl-2/Bax ratio and mitigates cell migration and thereby augments the anti-proliferative ability of trichostatin A in non-small cell lung cancers （Duan et al., 2010）. Similarly, berbamine inhibits p65 trans- location, up-regulates A20 and increases the activa- tion of the GADD45/c-Jun N-terminal kinase （JNK） pathway, thereby enhancing cellular apoptosis in multiple myelomas （Liang et al., 2009a; 2009b）. Similarly, alteration of the nuclear factor-kappa B （NF-~B） pathway results in enhanced apoptosis in lymphomas （Duet al., 2010）.展开更多
文摘The recent article by Liang et al. （2011）, pub- lished in Journal of Zhejiang University-SCIENCE B （Biomedicine ＆ Biotechnology）, is highly interesting. Interestingly, the past few years have seen the in- creasing application of berbamine as an anti-cancer agent in other systemic malignancies besides chronic myeloid leukemia. For instance, berbamine administration alters the Bcl-2/Bax ratio and mitigates cell migration and thereby augments the anti-proliferative ability of trichostatin A in non-small cell lung cancers （Duan et al., 2010）. Similarly, berbamine inhibits p65 trans- location, up-regulates A20 and increases the activa- tion of the GADD45/c-Jun N-terminal kinase （JNK） pathway, thereby enhancing cellular apoptosis in multiple myelomas （Liang et al., 2009a; 2009b）. Similarly, alteration of the nuclear factor-kappa B （NF-~B） pathway results in enhanced apoptosis in lymphomas （Duet al., 2010）.
