Strain in GaN/Si<111> by RBS/Channeling

GaN film grown on Si substrate was characterized by Rutherford backscattering/Channeling (RBS/C). The experimental results show that the thick- ness of GaN epilayer is about 2.5 μm and the GaN film has a good crystalline quality (Xmin=3.3%). By using channeling angular scanning. the 0.35% of average tetragonal distortion in GaN layer is observed. In addition, the depth profiles of strain in GaN film layer reveal that the strain in GaN film nonlinearly decreases with the increase of film thickness. The strain-free thickness (above 2.5 μm) of GaN film on Si substrate is far below that (150μm) of GaN film on Sapphire.

基于WBS-RBS法的肉类冷链运输风险识别

以肉类冷链运输为例,在梳理肉类冷链运输流程的基础上,采用工作分解结构法对肉类冷链运输的每个工作环节进行工作分解,得到工作分解结构图,采用风险分解结构从人员、环境、机械设备和管理4个方面对肉类冷链运输的每个工作环节进行风险分解,得到风险分解结构图;将每个工作环节的工作分解结构图和风险分解结构图进行矩阵耦合,形成每个工作环节的WBS-RBS耦合矩阵,对每个工作环节耦合矩阵中数值为1的元素进行分析,并对每个元素进行命名,通过合并、重组、修整等手段得到肉类冷链运输每个工作环节风险清单,针对肉类冷链运输每个工作环节风险清单提出相对应的风险防控措施,从源头上降低肉类冷链运输风险。

A Study of Microstructures in Helium-implanted 4H-SiC by RBS-channeling and TEM

Silicon carbide is a technologically important material due to its superior mechanical and electronic properties. The understanding of defect production in helium-implanted silicon carbide is important for the vise of this material in nuclear energy devices or for the proposed getting technique of electronic devices of silicon carbide. Much less is known about helium behavior in silicon carbide than in silicon and metals. Our recent study with transmission electron microscopy (TEM) indicated that the formation behavior of helium precipitates i.e.

基于WBS-RBS耦合矩阵法的水利工程洞室施工作业人因风险评估

为解决事故树分析法在复杂系统中识别风险时存在编制困难且容易遗漏风险的问题,本文提出了基于工作-风险分解(WBS-RBS)耦合矩阵法的水利工程洞室施工作业人因风险评估方法.首先,将水利工程洞室作业流程与风险进行细化分解,形成WBS-RBS耦合矩阵,识别出整个施工过程中的风险;其次,采用区间层次分析法计算风险因素权重,在此基础上通过专家调查法得到风险发生概率和损失后果的量化值,并用风险因素权重进行加权,得到修正的风险值;然后,将修正的风险值填入WBS-RBS耦合矩阵,得到各项风险因素和工作单元的风险值及占比情况.最后,以水利水电工程施工行业发生的多起洞室施工伤亡事故为例,验证了方法的科学性与有效性.

Influence of pore structure heterogeneity on channeling channels during hot water flooding in heavy oil reservoir based on CT scanning

Hot water flooding is an effective way to develop heavy oil reservoirs.However,local channeling channels may form,possibly leading to a low thermal utilization efficiency and high water cut in the reservoir.The pore structure heterogeneity is an important factor in forming these channels.This study proposes a method that mixes quartz sand with different particle sizes to prepare weakly heterogeneous and strongly heterogeneous models through which hot water flooding experiments are conducted.During the experiments,computer tomography(CT)scanning identifies the pore structure and micro remaining oil saturation distribution to analyze the influence of the pore structure heterogeneity on the channeling channels.The oil saturation reduction and average pore size are divided into three levels to quantitatively describe the relationship between the channeling channel distribution and pore structure heterogeneity.The zone where oil saturation reduction exceeds 20%is defined as a channeling channel.The scanning area is divided into 180 equally sized zones based on the CT scanning images,and threedimensional(3D)distributions of the channeling channels are developed.Four micro remaining oil distribution patterns are proposed,and the morphology characteristics of micro remaining oil inside and outside the channeling channels are analyzed.The results show that hot water flooding is more balanced in the weakly heterogeneous model,and the oil saturation decreases by more than 20%in most zones without narrow channeling channels forming.In the strongly heterogeneous model,hot water flooding is unbalanced,and three narrow channeling channels of different lengths form.In the weakly heterogeneous model,the oil saturation reduction is greater in zones with larger pores.The distribution range of the average pore size is larger in the strongly heterogeneous model.The network remaining oil inside the channeling channels is less than outside the channeling channels,and the hot water converts the network remaining oil into cluster,film,and droplet remaining oil.

秦岭造山带涝峪地区宽坪岩群变质作用温压条件及原位Rb-Sr年代学研究

秦岭造山带涝峪地区发育宽坪岩群的典型剖面,是研究宽坪岩群变质变形、构造热历史的重要区域。然而,由于缺乏对该地区宽坪岩群变质温压条件和年代学的约束,导致区域变质与多期变形事件的关系及地质意义认识仍不清楚。笔者以该地区宽坪岩群SN向剖面中的二云母石英片岩、含石榴子石二云母石英片岩、绿片岩和大理岩为研究对象,开展了详细的岩相学研究。在此基础上,重点对二云母石英片岩和含石榴子石二云母石英片岩进行了黑云母Ti温度计、多硅白云母地质压力计、变质相平衡模拟和原位LA–ICP–MS黑云母和白云母Rb–Sr年代学研究,进而探讨了涝峪地区宽坪岩群经历多期构造热事件的意义。野外和岩相学观察发现二云母石英片岩和绿片岩发生了强烈的变形,金云母大理岩经历了强烈的糜棱岩化作用。黑云母Ti温度计和多硅白云母压力计限定得到二云母石英片岩样品KP-3和KP-4的变质温压条件为300~500℃、2.0~8.0 kbar,对应的平均值为440℃、4.0 kbar。黑云母Ti温度计限定得到含石榴子石二云母石英片岩样品KP2202的变质温度为652~683℃。变质相平衡模拟P–T视剖面图计算得到二云母石英片岩样品KP-3和KP-4的变质温压条件为400~480℃和2.0~10 kbar;而含石榴子石二云母石英片岩样品KP2202的变质温压条件为645~680℃、8.0~9.0 kbar。综合地质温压计和相平衡模拟的结果,可以确定二云母石英片岩为绿片岩相变质作用的产物,而含石榴子石二云母石英片岩经历了低角闪岩相变质作用。原位LA–ICP–MS黑云母和白云母Rb–Sr分析显示二云母石英片岩记录两期等时线年龄,分别为~290 Ma和~155 Ma,而含石榴子石二云母石英片岩记录的等时线年龄为~110 Ma。因此涝峪地区宽坪岩群中的二云母石英片岩记录了3期等时线年龄,分别为~290 Ma、~155 Ma和~110 Ma。结合前人的研究结果,3期等时线年龄均代表了后期构造热事件的时代,其中~290 Ma的等时线年龄与古特提斯洋向北俯冲作用相对应,而~155 Ma和~110 Ma的等时线年龄可能与中生代时期北秦岭构造带发生强烈的变形和花岗岩岩浆活动导致的热重置有关。

Performance and enhanced oil recovery efficiency of an acid-resistant polymer microspheres of anti-CO_(2) channeling in low-permeability reservoirs

CO_(2) flooding is a vital development method for enhanced oil recovery in low-permeability reservoirs,However,micro-fractures are developed in low-permeability reservoirs,which are essential oil flow channels but can also cause severe CO_(2) gas channeling problems.Therefore,anti-gas channeling is a necessary measure to improve the effect of CO_(2) flooding.The kind of anti-gas channeling refers to the plugging of fractures in the deep formation to prevent CO_(2) gas channeling,which is different from the wellbore leakage.Polymer microspheres have the characteristics of controllable deep plugging,which can achieve the profile control of low-permeability fractured reservoirs.In acidic environments with supercritical CO_(2),traditional polymer microspheres have poor expandability and plugging properties.Based on previous work,a systematic evaluation of the expansion performance,dispersion rheological properties,stability,deep migration,anti-CO_(2) channeling and enhanced oil recovery ability of a novel acid-resistant polymer microsphere(DCNPM-A)was carried out under CQ oilifield conditions(salinity of85,000 mg/L,80℃,pH=3).The results show that the DCNPM-A microsphere had a better expansion performance than the traditional microsphere,with a swelling rate of 13.5.The microsphere dispersion with a concentration of 0.1%-0.5%had the advantages of low viscosity,high dispersion and good injectability in the low permeability fractured core.In the acidic environment of supercritical CO_(2),DCNPM-A microspheres showed excellent stability and could maintain strength for over 60 d with less loss.In core experiments,DCNPM-A microspheres exhibited delayed swelling characteristics and could effectively plug deep formations.With a plugging rate of 95%,the subsequent enhanced oil recovery of CO_(2) flooding could reach 21.03%.The experimental results can provide a theoretical basis for anti-CO_(2)channeling and enhanced oil recovery in low-permeability fractured reservoirs.

Predicting Turbidite Channel in Deep-Water Canyon Based on Grey Relational Analysis-Support Vector Machine Model:A Case Study of the Lingshui Depression in Qiongdongnan Basin,South China Sea

The turbidite channel of South China Sea has been highly concerned.Influenced by the complex fault and the rapid phase change of lithofacies,predicting the channel through conventional seismic attributes is not accurate enough.In response to this disadvantage,this study used a method combining grey relational analysis(GRA)and support vectormachine(SVM)and established a set of prediction technical procedures suitable for reservoirs with complex geological conditions.In the case study of the Huangliu Formation in Qiongdongnan Basin,South China Sea,this study first dimensionalized the conventional seismic attributes of Gas Layer Group I and then used the GRA method to obtain the main relational factors.A higher relational degree indicates a higher probability of responding to the attributes of the turbidite channel.This study then accumulated the optimized attributes with the highest relational factors to obtain a first-order accumulated sequence,which was used as the input training sample of the SVM model,thus successfully constructing the SVM turbidite channel model.Drilling results prove that the GRA-SVMmethod has a high drilling coincidence rate.Utilizing the core and logging data and taking full use of the advantages of seismic inversion in predicting the sand boundary of water channels,this study divides the sedimentary microfacies of the Huangliu Formation in the Lingshui 17-2 Gas Field.This comprehensive study has shown that the GRA-SVM method has high accuracy for predicting turbidite channels and can be used as a superior turbidite channel prediction method under complex geological conditions.

静息期精原前体细胞Rb1基因敲除致精原干细胞特化异常机制初探

目的探讨静息期精原前体细胞Rb1敲除致雄鼠精原干细胞(spermatogonial stem cells,SSCs)特化异常的调控机制。方法①用R对在基因表达综合数据库(gene expression omnibus,GEO)(GEO登记号:GSE124904)获取的出生后0.5 d(postnatal day 0.5,P0.5)雄鼠精原前体细胞单细胞测序数据进行分析。②用Vasa-Cre工具鼠与Rb1^(flox/flox)(或Id4-gfpTg;Rb1^(flox/flox))小鼠配繁构建静息期精原前体细胞Rb1条件性敲除(conditional knock out,cKO)雄鼠或带ID4绿色荧光(ID4-GFP)的Rb1 cKO雄鼠,通过PCR基因鉴定判断生殖细胞Rb1敲除情况以区分cKO雄鼠与对照(Con)。采集出生后数天内的小鼠(n=3~8)睾丸,利用流式细胞术基于细胞荧光强度将ID4‐GFP细胞均分为3个群落,检测各个群落细胞数量和细胞周期。③免疫荧光染色检测生殖细胞增殖(Ki67+)、SSCs特化(FOXO1胞核转换)和生殖细胞分化(STRA8+)情况。④TUNEL染色检测细胞凋亡。结果①单细胞测序数据分析显示:在P0.5精原前体细胞的2类细胞中,与细胞增殖相关的基因在将特化为精原干细胞的那一群细胞中富集表达。②生殖细胞增殖情况检测表明:P2.5时,对照[(11.22±3.27)%]与cKO小鼠[(46.10±6.21)%)]小鼠睾丸横切面生殖细胞Ki67+占比差异具有统计学意义(P<0.01)。③流式细胞术分析表明:P2.5对照[(5.05±1.46)%]与cKO[(12.05±2.22)%]小鼠睾丸ID4‐GFP荧光强度最强的那群细胞处于S期的占比差异具有统计学意义(P<0.05)。④TUNEL染色显示cKO组而非对照组小鼠睾丸横切面检测到细胞发生凋亡。⑤SSCs特化标志检测结果显示对照[(20.57±2.15)%]和cKO[(45.08±2.45)%]小鼠睾丸横切面生殖细胞FOXO1位于细胞质的占比差异具有统计学意义(P<0.01)。结论静息期精原前体细胞Rb1敲除使其出生后细胞周期恢复紊乱、凋亡发生,导致SSCs特化异常。

A Research Progress of CO_(2)-Responsive Plugging Channeling Gels

In the heterogeneous reservoirs,CO_(2) flooding easily leads to CO_(2) gas channeling,which can seriously affect sweeping efficiency and reduce oil recovery.After thoroughly investigating the advantages and shortcomings of various CO_(2) plugging technologies,this paper focuses on the feasibility of improving conventional water-alternating gas(WAG)through CO_(2)-responsive gel materials.Based on the different chemical reaction mechanisms between the unique chemical structure and CO_(2),changes in the material’s physical and chemical properties can respond to CO_(2).The feasibility of utilizing these property changes for CO_(2)-responsive plugging is explored.Various CO_(2)-responsive gels and gel nanoparticles have been extensively researched in different fields,such as energy,medicine,and biology.This paper surveys the molecular structures,chemical compositions,response mechanisms,and changes of these CO_(2)-responsive gels,aiming to draw insights into the carbon dioxide-enhanced oil recovery(CO_(2)-EOR)field.Finally,the key issues and future development direction of CO_(2)-responsive plugging gels were analyzed.

Comparison of Chinese LBs and English RBs

As English and Chinese belong to different language families,the left and right branching structures in the two languages are both similar and different.Generally speaking,Chinese has a predominance of left-branching structures and English has a predominance of right-branching structures.That is to say,Chinese is used to using left branches in its expressions,while English is used to using right branches in its expressions.

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.

基于WBS-RBS的预制构件施工过程质量风险管控

为有效识别预制构件施工过程中的质量风险,文中采用WBS-RBS法提取装配式施工全过程风险因素,建立预制构件施工全过程工作分解结构和基于风险要素的风险分解结构,并结合某大型公共建筑预制构件吊装实例,构建预制构件施工WBS-RBS风险矩阵,识别预制构件施工中的质量风险因素,依据风险因素提出针对性的方案与措施,为预制构件施工质量风险管控提供参考与思路。

LATTICE LOCATION DETERMINATION OF TRACE AMOUNT CARBON IN GALLIUM ARSENIDE BY THEORETICAL CALCULATION OF CPAA WITH CHANNELING

Combining the charged particle activation analysis (CPAA) and the (?)hanneling technique, partial concentrations of carbon on different crystal lattice locations of GaAs were calculated. The results show that at lower total concentration (≈0.3 ppm), carbon atoms occupy principally the octahedral and displaced octahedral interstitial positions, but at higher total concentration (≈2 ppm), the substitutional carbon plays a principal role.

Channeling of fast ions through the bent carbon nanotubes： The extended two-fluid hydrodynamic model

We investigate the interactions of charged particles with straight and bent single-walled carbon nanotubes （SWNTs） under channeling conditions in the presence of dynamic polarization of the valence electrons in carbon, This polarization is described by a cylindrical, two-fluid hydrodynamic model with the parameters taken from the recent modelling of several independent experiments on electron energy loss spectroscopy of carbon nano-structures. We use the hydrodynamic model to calculate the image potential for protons moving through four types of SWNTs at a speed of 3 atomic units. The image potential is then combined with the Doyle-Turner atomic potential to obtain the total potential in the bent carbon nanotubes. Using that potential, we also compute the spatial and angular distributions of protons channeled through the bent carbon nanotubes, and compare the results with the distributions obtained without taking into account the image potential.

北冰洋楚科奇边缘地北风深渊中碱性火山岩锆石U-Pb年龄与白云母原位Rb-Sr等时线年龄及其大地构造意义

楚科奇边缘地位于北冰洋美亚海盆的核心位置,作为水下高地,其从阿拉斯加-楚科奇大陆架延伸至美亚海盆中。楚科奇边缘地的研究对于重建北极地区的板块构造演化过程非常关键。目前关于其地壳性质、起源和演化过程仍不清晰。本次研究对楚科奇边缘地北风深渊平原斜坡上获取的碱性火山岩样品进行了详细分析,使用矿物自动定量分析(TIMA)方法研究了其岩性特征,运用LA-ICP-MS测定了样品中119颗锆石的U-Pb同位素年龄,同时使用LA-ICP-MS技术对样品薄片中的微晶白云母进行了原位Rb-Sr等时线年龄测定。结果表明, 119颗锆石的年龄可划分为94~636 Ma、929~1369 Ma、1655~2040 Ma和2439~2735 Ma四组。结合前人对在楚科奇边缘地获取的变质岩锆石U-Pb年龄和加拿大北极地区碎屑锆石年龄特征发现,第二组、第三组和第四组捕获锆石可能来源于加拿大北极群岛基底。第一组年轻锆石Th/U值较高,为典型的岩浆锆石,其中最年轻的6颗锆石的加权平均年龄为100.9±1.2 Ma,可能代表该碱性火山岩的形成年龄。白云母原位Rb-Sr等时线年龄为72±17 Ma,稍晚于样品中最年轻锆石年龄,能够与镜下白云母多呈脉状交代碱性岩的现象相对应,因此,样品中脉状白云母很可能是后期海底构造-热液活动的产物。本次研究所获得的锆石与白云母年龄从地质年代的角度证实了美亚海盆是由阿拉斯加-楚科奇微板块在早白垩世期间从北美板块边缘分离形成的,并且经历了后期的海底构造-热液叠加作用。

Hybrid channeling of Cu-Al cold plates for thermal management devices

Cu-Al cold plates,as a novel type of cold plate that combines the high thermal conductivity of copper with the low production cost of aluminum,are among the best options for enhancing the heat dissipation capacity of battery thermal management systems.Hybrid channeling of Cu-Al cold plates was proposed for thermal management devices with the combination of friction stir welding+channeling.The highest flexural strength of the Cu-Al interfaces reached 127.5 MPa with the optimized parameters.Due to the close-row welds adjacent to the channels,high-efficiency heat dissipation was realized with the fully bonded interfaces.No leakage of coolants occurred under the pressure of 0.85 MPa during the hydrostatic tests,indicating a sound sealing performance of the channels.Compared to the conventional Al cold plates,the heat sink capacity of the Cu-Al cold plates was enhanced by 16.3%.The results indicated that hybrid channeling not only en-hanced the interfacial strength of Cu-Al cold plates but also significantly improved the heat dissipation capacity,offering a new technical pathway for optimizing battery thermal management systems.

Flow and heat transfer characteristics of regenerative cooling parallel channel

Due to the complex high-temperature characteristics of hydrocarbon fuel,the research on the long-term working process of parallel channel structure under variable working conditions,especially under high heat-mass ratio,has not been systematically carried out.In this paper,the heat transfer and flow characteristics of related high temperature fuels are studied by using typical engine parallel channel structure.Through numeri⁃cal simulation and systematic experimental verification,the flow and heat transfer characteristics of parallel chan⁃nels under typical working conditions are obtained,and the effectiveness of high-precision calculation method is preliminarily established.It is known that the stable time required for hot start of regenerative cooling engine is about 50 s,and the flow resistance of parallel channel structure first increases and then decreases with the in⁃crease of equivalence ratio(The following equivalence ratio is expressed byΦ),and there is a flow resistance peak in the range ofΦ=0.5~0.8.This is mainly caused by the coupling effect of high temperature physical proper⁃ties,flow rate and pressure of fuel in parallel channels.At the same time,the cooling and heat transfer character⁃istics of parallel channels under some conditions of high heat-mass ratio are obtained,and the main factors affect⁃ing the heat transfer of parallel channels such as improving surface roughness and strengthening heat transfer are mastered.In the experiment,whenΦis less than 0.9,the phenomenon of local heat transfer enhancement and deterioration can be obviously observed,and the temperature rise of local structures exceeds 200℃,which is the risk of structural damage.Therefore,the reliability of long-term parallel channel structure under the condition of high heat-mass ratio should be fully considered in structural design.

基于WBS-RBS与AHP法的葠窝水库除险加固工程项目风险研究

针对大型水库除险加固工程项目管理的复杂性,本文运用WBS-RBS与AHP法对葠窝水库除险加固工程项目开展风险识别与评价。研究表明,施工组织设计、勘察设计偏差、项目管理人员的能力、现场人员的责任心及成本管理为主要风险因素,该研究可为大型混凝土重力坝水库除险加固工程的风险管理提供参考借鉴。

人参皂苷Rb1调节SIRT1/Nrf2信号通路对妊娠期糖尿病大鼠氧化应激损伤的影响

目的 分析人参皂苷Rb1调节沉默信息调节因子2相关酶1(SIRT1)/核因子E2相关因子2(Nrf2)信号通路对妊娠期糖尿病(GDM)大鼠氧化应激损伤的影响。方法 选取39只妊娠SD大鼠通过腹腔注射链脲佐菌素诱导制备GDM模型,将造模成功的36只大鼠随机分为模型组(腹腔注射10 mL/kg生理盐水)、人参皂苷Rb1低剂量组(腹腔注射1.4 mg/mL的人参皂苷Rb1溶液)、人参皂苷Rb1高剂量组(腹腔注射2.8 mg/mL的人参皂苷Rb1溶液)、人参皂苷Rb1高剂量+EX-527组(腹腔注射2.8 mg/mL的人参皂苷Rb1及5.0 mg/mL的EX-527混合溶液),每组9只。另取9只妊娠SD大鼠腹腔注射等剂量柠檬酸盐缓冲液设为对照组。检测各组大鼠血清空腹血糖(FBG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平及母体体质量、胎鼠存活率;采用原位末端凋亡法染色检测各组大鼠胎盘细胞凋亡率;检测各组大鼠血清与胎盘组织丙二醛(MDA)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)水平;采用免疫印迹法检测各组大鼠胎盘组织SIRT1/Nrf2信号通路相关蛋白表达水平。结果 与对照组比较,模型组大鼠血清FBG、TC、LDL-C及TG水平,母体体质量,胎盘细胞凋亡率,血清与胎盘组织MDA水平明显升高(P<0.05),血清HDL-C水平,胎鼠存活率,血清与胎盘组织GSH、SOD及CAT水平,胎盘组织SIRT、Nrf2及血红素加氧酶-1(HO-1)蛋白表达水平明显降低(P<0.05);与模型组比较,人参皂苷Rb1低剂量组、人参皂苷Rb1高剂量组大鼠血清FBG、TC、LDL-C及TG水平,母体体质量,胎盘细胞凋亡率,血清与胎盘组织MDA水平均降低(P<0.05),血清HDL-C水平,胎鼠存活率,血清与胎盘组织GSH、SOD及CAT水平,胎盘组织SIRT、Nrf2及HO-1蛋白表达水平均升高(P<0.05)。与人参皂苷Rb1低剂量组比较,人参皂苷Rb1高剂量组大鼠血清FBG、TC、LDL-C及TG水平,母体体质量,胎盘细胞凋亡率,血清与胎盘组织MDA水平均降低(P<0.05),血清HDL-C水平,胎鼠存活率,血清与胎盘组织GSH、SOD及CAT水平,胎盘组织SIRT、Nrf2及HO-1蛋白表达水平均升高(P<0.05)。与人参皂苷Rb1高剂量组比较,人参皂苷Rb1高剂量+EX-527组大鼠血清FBG、TC、LDL-C及TG水平,母体体质量,胎盘细胞凋亡率,血清与胎盘组织MDA水平明显升高(P<0.05),血清HDL-C水平,胎鼠存活率,血清与胎盘组织GSH、SOD及CAT水平,胎盘组织SIRT、Nrf2及HO-1蛋白表达水平明显降低(P<0.05)。结论 高剂量人参皂苷Rb1的干预效果优于低剂量人参皂苷Rb1,且EX-527可减弱高剂量人参皂苷Rb1对GDM大鼠的干预效果。人参皂苷Rb1可能通过激活SIRT1/Nrf2信号通路而增强GDM大鼠抗氧化功能,改善其糖脂代谢,进而抑制胎盘细胞凋亡并改善母体肥胖及不良妊娠结局,最终减轻其氧化应激损伤。