Three parallel anaerobic-anoxic/anaerobic-aerobic (AN/AO) processes were developed to enrich denitrifying phosphorus removal bacteria (DPB) for low strength wastewater treatment. The main body of the parallel AN/A...Three parallel anaerobic-anoxic/anaerobic-aerobic (AN/AO) processes were developed to enrich denitrifying phosphorus removal bacteria (DPB) for low strength wastewater treatment. The main body of the parallel AN/AO process consists of an AN (anaerobic-anoxic) process and an AO (anaerobic-aerobic) process. In the AO process, the common phosphorus accumulating organisms (PAOs) was dominate, while in the AN process, DPB was dominate, The volume of anaerobic zone(Vana):anoxie zone(Vano) : aerobic zone (Vaer) for the parallel AN/AO process is 1:1:1 in contrast with a Vana:Vaer and Vano:Vaer of 1:2 and 1:4 for a traditional biological nutrient removal process (BNR). Process 3 excels in the 3 processes on the basis of COD, TN and TP removal. For 4 month operation, the effluent COD concentration of process 3 did not exceed 60 mg/L; the effluent TN concentration of process 3 was lower than 15 mg/L; and the effluent TP concentration of process 3 was lower than 1 mg/L.展开更多
Absorption and catalytic oxidation of nitric oxide can be achieved by using cobalt(Ⅲ) ethylenediamine (Co(en)3^3+. When simultaneous absorbing SO2 and NO, the precipitation of Co2(SO3)3 will be yielded and th...Absorption and catalytic oxidation of nitric oxide can be achieved by using cobalt(Ⅲ) ethylenediamine (Co(en)3^3+. When simultaneous absorbing SO2 and NO, the precipitation of Co2(SO3)3 will be yielded and the NO removal will be decreased. A new catalyst system using Co(en)3^3+ coupled with urea has been developed to simultaneous remove NO and SO2 in the flue gas. NO is absorbed and catalytically oxidized to nitrite and nitrate by Co(en)3^3+. The dissolved oxygen in scrubbing solution from the feed stream acts as oxidant. Urea restrains the precipitation of Co2(SO3)3 by oxidizing SO3^2-to SO4^2- as COSO4 is more soluble in water. The experimental results proved that nearly all SO3^2- can be oxidized to SO4^2- and the high NO and SO2 removal could be obtained with the new system. The NO removal is influenced by gas flow rate, the concentration of Co(en)3^3+ and urea in the absorption solution, the temperature of the scrubbing solution and the content of oxygen in the flue gas. The low gas flow rate is favorable to increase the NO removal. The experiments proved that the NO removal could be maintained at more than 95% by the system of 0.02 mol/L Co(en)3^3+ and 1% urea at 50℃ with 10% O2 in the flue gas.展开更多
This paper is concerned with the relation between the parameters of nonwoven filter and removing of white cells. Melt-blown polypropylene nonwovens are used as filtration materials of white cells filter. According to ...This paper is concerned with the relation between the parameters of nonwoven filter and removing of white cells. Melt-blown polypropylene nonwovens are used as filtration materials of white cells filter. According to the combination of different fiber diameter, different product density and different weight, optimized combination of parameters of nonwoven filter with more effective removing of white cells is obtained. The result is that removing of white cells is 96.90 percent; recovery of red cells is 92.27 percent.展开更多
A new permanent magnetic separator was introduced to treat the ores with the characteristics of weak magnetic iron minerals and in a fine size range. The new machine was applied to the iron removal from potash feldspa...A new permanent magnetic separator was introduced to treat the ores with the characteristics of weak magnetic iron minerals and in a fine size range. The new machine was applied to the iron removal from potash feldspar. The effects of the magnetic field intensity, pulp density and grinding fineness on the iron removal were investigated. The optimized operation parameters were achieved and listed as follows: the -0.074 mm content is 85%, the pulp density is 45% and the magnetic field strength is 2T. A close test of middles regrinding was also carried out to improve concentrate yield. The data show that the grade of TFe(total iron) in potash feldspar product decreased from 1.31% to 0.21% and the concentrate yield reached 85.32%. All the results indicated that the traditonal high-intensity electromagnetic separators can be betterly substituted by the new permanent magnetic separator. This study may provide the theoretical evidence for iron removal from potash feldspar.展开更多
In this study,a patch removing based Isogeometric analysis(PR-IGA)method is proposed to conduct the holed structural analysis with only one parametric domain,in which there are also no trimmed elements.The theoretical...In this study,a patch removing based Isogeometric analysis(PR-IGA)method is proposed to conduct the holed structural analysis with only one parametric domain,in which there are also no trimmed elements.The theoretical foundation of this novel patch removing approach is that any holed structure can be obtained by removing sub-patches(i.e.,the holes)from an intact base patch.Since the parametric domains of these patches are all meshed by rectangular grids,the elements in the resulted holed structural parametric domain could all be untrimmed rectangles under certain mapping conditions.To achieve the special condition,a systematic technique consisting of T-spline local refinement and control points substitution/adjustment is provided.Due to the intactness of parametric elements,the analysis procedure of holed structures based on the proposed PRIGA is quite simplified and efficient compared to traditional multi-patch and trimming schemes.Moreover,after the deduction of analytical sensitivities related to structural mass and mechanical responses,the PR-IGA is directly employed in the holed structural shape optimization to successfully eliminate the need for model transformation during modeling,analysis and optimization processes.Numerical examples involving analysis and shape optimization of complex holed structures are presented to demonstrate the effectiveness of the proposed method.展开更多
Great advances in retinal ganglion cells survival(RGCs),optic nerve preservation and regeneration have been made in the past 15years.Nowadays,we know that RGCs are capable of regenerating the full length of the opti...Great advances in retinal ganglion cells survival(RGCs),optic nerve preservation and regeneration have been made in the past 15years.Nowadays,we know that RGCs are capable of regenerating the full length of the optic nerve,cross the chiasm,enter the brain and reinnervate visual targets.展开更多
The non-operative treatment of ectopicpregnancy with traditional Chinese medicine(TCM)combined with western medicine hasbeen widely used clinically.The therapeuticresults are satisfactory.Although there areminor varia...The non-operative treatment of ectopicpregnancy with traditional Chinese medicine(TCM)combined with western medicine hasbeen widely used clinically.The therapeuticresults are satisfactory.Although there areminor variations among different medical institutions,the general principles of thetherapy are the same,i.e.promoting bloodcirculation and removing blood stasis.展开更多
The black cubic boron nitride(cBN)single crystal is synthesized by using hBN-LiH and hBN-Li_(3)N-B as the raw materials at high temperature and high pressure(HTHP).The colors of the cBN crystal synthesized in an hBN-L...The black cubic boron nitride(cBN)single crystal is synthesized by using hBN-LiH and hBN-Li_(3)N-B as the raw materials at high temperature and high pressure(HTHP).The colors of the cBN crystal synthesized in an hBN-Li_(3)N-B system vary from transparent yellow,half-transparent and then opaque black with the increasing B content in the raw materials.It is worth noting that a trigonal shadow is presented at the center of the cBN crystal synthesized in the hBN-Li_(3)N-B system but can not be found in the hBN-LiH system.Analyzing the Raman spectrum,we find that the darkening and the trigonal shadow in the cBN crystal may be due to the presence of excess B atoms.The above-mentioned phenomenon can be determined by removing impurity capacity and growth environment of the cBN crystal.展开更多
On December 28,2020 the project on R&D of guard catalyst for removing carbonyl iron/carbonyl nickel undertaken by the SINOPEC Nanjing Chemical Research Institute(NCRI)has passed the research achievements appraisal...On December 28,2020 the project on R&D of guard catalyst for removing carbonyl iron/carbonyl nickel undertaken by the SINOPEC Nanjing Chemical Research Institute(NCRI)has passed the research achievements appraisal organized by the Sinopec Science and Technology Division.The experts attending the appraisal meeting have suggested speeding up the commercial application tests as soon as possible.展开更多
Objective: To observe the effect and clinical significance of circulating endothelial cells (CEC) in the pathogenesis of coronary heart disease with unstable angina pectoris (CHD-UAP), and to explore the protective ef...Objective: To observe the effect and clinical significance of circulating endothelial cells (CEC) in the pathogenesis of coronary heart disease with unstable angina pectoris (CHD-UAP), and to explore the protective effect of Chinese herbs for activating blood circulation, removing stasis and supplementing Qi (CH) on CHD-UAP patient's CEC. Methods: Sixty patients with diagnosis of CHD-UAP confirmed and differentiated to be Qi-deficiency and blood stasis by TCM were randomly divided into two groups and treated, on the basis of Western drug-therapy, with Tongxinluo capsule (通心络胶囊, TXL) and Huoxue Tongmai capsule (活血通脉胶囊, HXTM) respectively by way of oral taking three times a day, 3 capsules every time, with 1 month as one therapeutic course. The number of CEC in patients' blood circulation was counted before and after treatment. Besides, the number of CEC in 30 healthy persons was also counted for control. Results: The number of CEC in CHD-UAP patients was significantly higher than that in the healthy persons (P<0.01). After the patients were treated with CH, either TXL or HXTM, it significantly decreased (P<0.01)with insignificant difference between the two treated groups. Conclusion: CEC in CHD-UAP patients is severely damaged and endothelial function in disorder, Chinese herbs have protective effect on patients' CEC.展开更多
It is important to identify and remove the wastes not only from manufacturing process, but also from nonmanufacturing process. In the last several decades, significant research achievements and practice benefits have ...It is important to identify and remove the wastes not only from manufacturing process, but also from nonmanufacturing process. In the last several decades, significant research achievements and practice benefits have been achieved about removing wastes from manufacturing process. Since the1990 s, some researchers and lean practitioners have paid more attention to removing waste from non-manufacturing process.Based on the authors' research work and industrial practice, the paper introduces a kind of lean approach for removing waste from non-manufacturing process. In its case study, the order handling process in a value chain is described with respect to a factory and its downstream distribution centers(DCs). The paper proposes a lean approach solution for creating the improved order handling process, and analyze how great improvements in performance can be achieved. As a result, the significant achievement has created a win-win scenario for both the nonmanufacturing process in a factory and non-manufacturing facilities(like DCs) across the value chain. It demonstrates that improvements have been made by removing waste from the non-manufacturing process that takes place within a factory as well as with external participants through the whole value chain. Likewise, the proposed lean approach has helped the case companies to achieve greater levels of efficiency and more benefits. Finally, some conclusions are drawn.展开更多
Chronic kidney disease is a general term for various types of renal diseases characterized by a long course of disease and difficulty in early detection.It is one of the social diseases that need to be solved urgently...Chronic kidney disease is a general term for various types of renal diseases characterized by a long course of disease and difficulty in early detection.It is one of the social diseases that need to be solved urgently and its pathogenesis and treatment have always been a hotspot for researchers.Studies have shown that traditional Chinese medicine(TCM)can effectively delay the progress of chronic kidney disease.According to the clinical experience of national famous TCM physicians,based on its pathogenesis of"kidney deficiency as the foundation and poison as the target",chronic kidney disease can be treated by invigorating the kidney and removing toxic.Based on the above background,this paper summarizes the research progress of invigorating the kidney and removing toxic in delaying chronic kidney disease from multiple mechanisms and pathways in modern research.展开更多
Developing autonomous mobile robot system has been a hot topic in AI area. With recent advances in technology, autonomous robots are attracting more and more attention worldwide, and there are a lot of ongoing researc...Developing autonomous mobile robot system has been a hot topic in AI area. With recent advances in technology, autonomous robots are attracting more and more attention worldwide, and there are a lot of ongoing research and development activities in both industry and academia. In complex ground environment, obstacles positions are uncertain. Path finding for robots in such environment is very hot issues currently. In this paper, we present the design and implementation of a multi-sensor based object detecting and moving autonomous robot exploration system, 4RE, with the VEX robotics design system. With the goals of object detecting and removing in complex ground environment with different obstacles, a novel object detecting and removing algorithms is proposed and implemented. Experimental results indicate that our robot system with our object detecting and removing algorithm can effectively detect the obstacles on the path and remove them in complex ground environment and avoid collision with the obstacles.展开更多
Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibro...Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibrosis,and these bodies have become the synthesis and storage sites of vW factor,ET-1 and other factors of liver fibrosis;during pathological stimulation,W-P bodies will excrete the above factors into the cytoplasm,which can make the structure and function of HSEC maladjusted,cause the disturbance of liver microcirculation,and aggravate the process of liver fibrosis.However,previous studies have found that Plumbagin,the active ingredient of Guangxi specialty ethnic medicine,has the definite function of promoting blood circulation and removing blood stasis and anti-liver fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived from it as follows:the role of Plumbagin in promoting blood circulation and removing blood stasis and anti-liver fibrosis is produced by affecting the formation quantity of W-P bodies,affecting the synthesis and storage of the contents of W-P bodies,and interfering with their exocytosis ability.展开更多
Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Data...Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Database(TCMSP),and the drug targets were searched in the Swiss Target Prediction database;in the Disease-Gene Database(DisGeNET))Search for angiogenesis-promoting and inhibiting angiogenesis targets;use the protein interaction database(STRING)database and Cytoscape software to analyze the network core targets;use the DAVID database to enrich the drug-disease target intersection for GO and KEGG;RT-qPCR experiments verified the effect of luteolin on MMP9 gene expression;in vitro tube formation experiments analyzed the effect of luteolin on endothelial cell neovascularization.Results:After analysis,it is concluded that Danshen has 10 active ingredients and 50 angiogenesis targets;Chuanxiong has 2 active ingredients and 4 angiogenesis targets.The intersection of drug-taking targets yielded 9 targets,including AR,PARP1,MMP9,MMP2,MMP12,AKR1B10,ABCC1,CDK6,and STAT3.After analyzing the active ingredient-target network graph of Danshen/Chuanxiong,it was concluded that luteolin is the key chemical ingredient.After protein interaction(PPI)analysis,the results showed that MMP9 is the core target.The KEGG pathway is mainly enriched in 5 signaling pathways,the most important pathway is cancer-related pathways.There are 22 main biological processes of GO,which mainly involve collagen catabolism,protein extracellular matrix,metal endopeptidase activity,etc.The preliminary analysis of tubule formation experiment shows that luteolin inhibits angiogenesis and down-regulates the expression of MMP9 gene.Conclusion:Luteolin,the key chemical component of the Danshen-Ligusticum chuanxiong drug pair,inhibits angiogenesis by regulating the MMP9 target,and develops the reverse regulation of angiogenesis for the traditional Chinese medicine for promoting blood circulation and removing blood stasis on the basis of the known treatment of ischemic diseases.Provide a new perspective and theoretical basis for the use of Danshen and Chuanxiong medicine in clinical cancer patients.Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.展开更多
Hepatic fibrosis is a reversible pathological phenomenon in the early and middle stages,but but no satisfactory intervention drugs have been available so far.Recent studies have suggested that microcirculation disturb...Hepatic fibrosis is a reversible pathological phenomenon in the early and middle stages,but but no satisfactory intervention drugs have been available so far.Recent studies have suggested that microcirculation disturbance of liver is one of the important pathogenesis of chronic liver disease,the improvement of microcirculation is beneficial to the recovery of liver function and the delay of liver fibrosis.Hepatic stellate cells are the core cells of hepatic fibrosis,and also the most critical cells that affect the microcirculation of the liver.While TLR4/MyD88/NF-κB and TLR4/MyD88/MAPKs which are based on the action of hepatic stellate cells are two pathways that have very important influence on the inflammatory response of liver,the proliferation and apoptosis of hepatic stellate cells,and the secretion of fibrogenic cytokines.It was found that Plumbapin,the active ingredient of Guangxi specialty ethnic medicine,has the definite effect of promoting blood circulation and removing blood stasis and anti-hepatic fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived as follows:the pharmacological effect of Plumbapin on anti-hepatic fibrosis,promoting blood circulation and removing stasis was based on the influence of TLR4/MyD88/NF-κB and MAPKs signal pathway.展开更多
:This article first analyzes the problems existing in the teaching about diagnosing and removing automobile’s failure,and then discusses some specific teaching strategies on diagnosing and removing automobile’s fail...:This article first analyzes the problems existing in the teaching about diagnosing and removing automobile’s failure,and then discusses some specific teaching strategies on diagnosing and removing automobile’s failure to provide some effective reference for the related staff.展开更多
AS environmental preservation takes a more prominent role in global planning, China is making massive investments in African forestry, helping the continent to improve governance of its timber trade and sustainable fo...AS environmental preservation takes a more prominent role in global planning, China is making massive investments in African forestry, helping the continent to improve governance of its timber trade and sustainable forest management,展开更多
基金The Shuguang Program of Shanghai Education Committee (No. 03SG20)
文摘Three parallel anaerobic-anoxic/anaerobic-aerobic (AN/AO) processes were developed to enrich denitrifying phosphorus removal bacteria (DPB) for low strength wastewater treatment. The main body of the parallel AN/AO process consists of an AN (anaerobic-anoxic) process and an AO (anaerobic-aerobic) process. In the AO process, the common phosphorus accumulating organisms (PAOs) was dominate, while in the AN process, DPB was dominate, The volume of anaerobic zone(Vana):anoxie zone(Vano) : aerobic zone (Vaer) for the parallel AN/AO process is 1:1:1 in contrast with a Vana:Vaer and Vano:Vaer of 1:2 and 1:4 for a traditional biological nutrient removal process (BNR). Process 3 excels in the 3 processes on the basis of COD, TN and TP removal. For 4 month operation, the effluent COD concentration of process 3 did not exceed 60 mg/L; the effluent TN concentration of process 3 was lower than 15 mg/L; and the effluent TP concentration of process 3 was lower than 1 mg/L.
文摘Absorption and catalytic oxidation of nitric oxide can be achieved by using cobalt(Ⅲ) ethylenediamine (Co(en)3^3+. When simultaneous absorbing SO2 and NO, the precipitation of Co2(SO3)3 will be yielded and the NO removal will be decreased. A new catalyst system using Co(en)3^3+ coupled with urea has been developed to simultaneous remove NO and SO2 in the flue gas. NO is absorbed and catalytically oxidized to nitrite and nitrate by Co(en)3^3+. The dissolved oxygen in scrubbing solution from the feed stream acts as oxidant. Urea restrains the precipitation of Co2(SO3)3 by oxidizing SO3^2-to SO4^2- as COSO4 is more soluble in water. The experimental results proved that nearly all SO3^2- can be oxidized to SO4^2- and the high NO and SO2 removal could be obtained with the new system. The NO removal is influenced by gas flow rate, the concentration of Co(en)3^3+ and urea in the absorption solution, the temperature of the scrubbing solution and the content of oxygen in the flue gas. The low gas flow rate is favorable to increase the NO removal. The experiments proved that the NO removal could be maintained at more than 95% by the system of 0.02 mol/L Co(en)3^3+ and 1% urea at 50℃ with 10% O2 in the flue gas.
文摘This paper is concerned with the relation between the parameters of nonwoven filter and removing of white cells. Melt-blown polypropylene nonwovens are used as filtration materials of white cells filter. According to the combination of different fiber diameter, different product density and different weight, optimized combination of parameters of nonwoven filter with more effective removing of white cells is obtained. The result is that removing of white cells is 96.90 percent; recovery of red cells is 92.27 percent.
基金Funded by the National High-tech R&D Program of China(No.2007AA06Z123)the Hubei Provincial Key Laboratory of Pollutant Analysis and Recycling Project(KY2010G19)the Independent Innovation Research Fund of Wuhan University of Technology(2010-YB-16)
文摘A new permanent magnetic separator was introduced to treat the ores with the characteristics of weak magnetic iron minerals and in a fine size range. The new machine was applied to the iron removal from potash feldspar. The effects of the magnetic field intensity, pulp density and grinding fineness on the iron removal were investigated. The optimized operation parameters were achieved and listed as follows: the -0.074 mm content is 85%, the pulp density is 45% and the magnetic field strength is 2T. A close test of middles regrinding was also carried out to improve concentrate yield. The data show that the grade of TFe(total iron) in potash feldspar product decreased from 1.31% to 0.21% and the concentrate yield reached 85.32%. All the results indicated that the traditonal high-intensity electromagnetic separators can be betterly substituted by the new permanent magnetic separator. This study may provide the theoretical evidence for iron removal from potash feldspar.
基金This work is supported by National Natural Science Foundation of China(Project No.11702254,SC,www.nsfc.gov.cn)Postdoctoral Science Foundation of China(Project No.2016M592306,SC,www.chinapostdoctor.org.cn)Key Scientific Research Project in Higher Education Institutions of Henan Province(Project No.17A130001,SC,www.haedu.gov.cn).
文摘In this study,a patch removing based Isogeometric analysis(PR-IGA)method is proposed to conduct the holed structural analysis with only one parametric domain,in which there are also no trimmed elements.The theoretical foundation of this novel patch removing approach is that any holed structure can be obtained by removing sub-patches(i.e.,the holes)from an intact base patch.Since the parametric domains of these patches are all meshed by rectangular grids,the elements in the resulted holed structural parametric domain could all be untrimmed rectangles under certain mapping conditions.To achieve the special condition,a systematic technique consisting of T-spline local refinement and control points substitution/adjustment is provided.Due to the intactness of parametric elements,the analysis procedure of holed structures based on the proposed PRIGA is quite simplified and efficient compared to traditional multi-patch and trimming schemes.Moreover,after the deduction of analytical sensitivities related to structural mass and mechanical responses,the PR-IGA is directly employed in the holed structural shape optimization to successfully eliminate the need for model transformation during modeling,analysis and optimization processes.Numerical examples involving analysis and shape optimization of complex holed structures are presented to demonstrate the effectiveness of the proposed method.
文摘Great advances in retinal ganglion cells survival(RGCs),optic nerve preservation and regeneration have been made in the past 15years.Nowadays,we know that RGCs are capable of regenerating the full length of the optic nerve,cross the chiasm,enter the brain and reinnervate visual targets.
文摘The non-operative treatment of ectopicpregnancy with traditional Chinese medicine(TCM)combined with western medicine hasbeen widely used clinically.The therapeuticresults are satisfactory.Although there areminor variations among different medical institutions,the general principles of thetherapy are the same,i.e.promoting bloodcirculation and removing blood stasis.
文摘The black cubic boron nitride(cBN)single crystal is synthesized by using hBN-LiH and hBN-Li_(3)N-B as the raw materials at high temperature and high pressure(HTHP).The colors of the cBN crystal synthesized in an hBN-Li_(3)N-B system vary from transparent yellow,half-transparent and then opaque black with the increasing B content in the raw materials.It is worth noting that a trigonal shadow is presented at the center of the cBN crystal synthesized in the hBN-Li_(3)N-B system but can not be found in the hBN-LiH system.Analyzing the Raman spectrum,we find that the darkening and the trigonal shadow in the cBN crystal may be due to the presence of excess B atoms.The above-mentioned phenomenon can be determined by removing impurity capacity and growth environment of the cBN crystal.
文摘On December 28,2020 the project on R&D of guard catalyst for removing carbonyl iron/carbonyl nickel undertaken by the SINOPEC Nanjing Chemical Research Institute(NCRI)has passed the research achievements appraisal organized by the Sinopec Science and Technology Division.The experts attending the appraisal meeting have suggested speeding up the commercial application tests as soon as possible.
文摘Objective: To observe the effect and clinical significance of circulating endothelial cells (CEC) in the pathogenesis of coronary heart disease with unstable angina pectoris (CHD-UAP), and to explore the protective effect of Chinese herbs for activating blood circulation, removing stasis and supplementing Qi (CH) on CHD-UAP patient's CEC. Methods: Sixty patients with diagnosis of CHD-UAP confirmed and differentiated to be Qi-deficiency and blood stasis by TCM were randomly divided into two groups and treated, on the basis of Western drug-therapy, with Tongxinluo capsule (通心络胶囊, TXL) and Huoxue Tongmai capsule (活血通脉胶囊, HXTM) respectively by way of oral taking three times a day, 3 capsules every time, with 1 month as one therapeutic course. The number of CEC in patients' blood circulation was counted before and after treatment. Besides, the number of CEC in 30 healthy persons was also counted for control. Results: The number of CEC in CHD-UAP patients was significantly higher than that in the healthy persons (P<0.01). After the patients were treated with CH, either TXL or HXTM, it significantly decreased (P<0.01)with insignificant difference between the two treated groups. Conclusion: CEC in CHD-UAP patients is severely damaged and endothelial function in disorder, Chinese herbs have protective effect on patients' CEC.
基金supported in part by the National Natural Science Foundation of China (61773381,61773382,61533019,91520301)Finnish TEKES’s Project "SoMa2020:Social Manufacturing" (211560)+1 种基金Chinese Guangdong’s S&T Project (2015B010103001,2016B090910001,2017B090912001)Dongguan’s Innovation Talents Project (Gang Xiong)
文摘It is important to identify and remove the wastes not only from manufacturing process, but also from nonmanufacturing process. In the last several decades, significant research achievements and practice benefits have been achieved about removing wastes from manufacturing process. Since the1990 s, some researchers and lean practitioners have paid more attention to removing waste from non-manufacturing process.Based on the authors' research work and industrial practice, the paper introduces a kind of lean approach for removing waste from non-manufacturing process. In its case study, the order handling process in a value chain is described with respect to a factory and its downstream distribution centers(DCs). The paper proposes a lean approach solution for creating the improved order handling process, and analyze how great improvements in performance can be achieved. As a result, the significant achievement has created a win-win scenario for both the nonmanufacturing process in a factory and non-manufacturing facilities(like DCs) across the value chain. It demonstrates that improvements have been made by removing waste from the non-manufacturing process that takes place within a factory as well as with external participants through the whole value chain. Likewise, the proposed lean approach has helped the case companies to achieve greater levels of efficiency and more benefits. Finally, some conclusions are drawn.
基金National Natural Science Foundation of China(No.81873270)"Six Talent Peaks"High-level Talent Project of Jiangsu Province(No.WSN-012)+2 种基金International Joint Research and Development Project of Nanjing Science and Technology Bureau for Medical and Health Care(No.202002051)PhaseⅢProject of TCM Advantaged Discipline in Nanjing University of Traditional Chinese Medicine(No.ZYX03KF076)"Peak Academic"Talent Project of Jiangsu Hospital of Traditional Chinese Medicine(No.Y2018RC17)。
文摘Chronic kidney disease is a general term for various types of renal diseases characterized by a long course of disease and difficulty in early detection.It is one of the social diseases that need to be solved urgently and its pathogenesis and treatment have always been a hotspot for researchers.Studies have shown that traditional Chinese medicine(TCM)can effectively delay the progress of chronic kidney disease.According to the clinical experience of national famous TCM physicians,based on its pathogenesis of"kidney deficiency as the foundation and poison as the target",chronic kidney disease can be treated by invigorating the kidney and removing toxic.Based on the above background,this paper summarizes the research progress of invigorating the kidney and removing toxic in delaying chronic kidney disease from multiple mechanisms and pathways in modern research.
文摘Developing autonomous mobile robot system has been a hot topic in AI area. With recent advances in technology, autonomous robots are attracting more and more attention worldwide, and there are a lot of ongoing research and development activities in both industry and academia. In complex ground environment, obstacles positions are uncertain. Path finding for robots in such environment is very hot issues currently. In this paper, we present the design and implementation of a multi-sensor based object detecting and moving autonomous robot exploration system, 4RE, with the VEX robotics design system. With the goals of object detecting and removing in complex ground environment with different obstacles, a novel object detecting and removing algorithms is proposed and implemented. Experimental results indicate that our robot system with our object detecting and removing algorithm can effectively detect the obstacles on the path and remove them in complex ground environment and avoid collision with the obstacles.
基金Supported by the Research Project of National Natural Science Foundation of China(No.81960761,81960751,81680705)Basic Ability Improvement Project for Young and Middle-aged Teachers in Colleges and Universities of Guangxi(No.2018KY1149)。
文摘Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibrosis,and these bodies have become the synthesis and storage sites of vW factor,ET-1 and other factors of liver fibrosis;during pathological stimulation,W-P bodies will excrete the above factors into the cytoplasm,which can make the structure and function of HSEC maladjusted,cause the disturbance of liver microcirculation,and aggravate the process of liver fibrosis.However,previous studies have found that Plumbagin,the active ingredient of Guangxi specialty ethnic medicine,has the definite function of promoting blood circulation and removing blood stasis and anti-liver fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived from it as follows:the role of Plumbagin in promoting blood circulation and removing blood stasis and anti-liver fibrosis is produced by affecting the formation quantity of W-P bodies,affecting the synthesis and storage of the contents of W-P bodies,and interfering with their exocytosis ability.
基金Fund Project:Outstanding Doctoral Graduates of Shanxi University of Traditional Chinese Medicine Come to Shanxi to Work,Reward Funds,Scientific Research Start-Up Fund Project(No.2020BKS06)。
文摘Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Database(TCMSP),and the drug targets were searched in the Swiss Target Prediction database;in the Disease-Gene Database(DisGeNET))Search for angiogenesis-promoting and inhibiting angiogenesis targets;use the protein interaction database(STRING)database and Cytoscape software to analyze the network core targets;use the DAVID database to enrich the drug-disease target intersection for GO and KEGG;RT-qPCR experiments verified the effect of luteolin on MMP9 gene expression;in vitro tube formation experiments analyzed the effect of luteolin on endothelial cell neovascularization.Results:After analysis,it is concluded that Danshen has 10 active ingredients and 50 angiogenesis targets;Chuanxiong has 2 active ingredients and 4 angiogenesis targets.The intersection of drug-taking targets yielded 9 targets,including AR,PARP1,MMP9,MMP2,MMP12,AKR1B10,ABCC1,CDK6,and STAT3.After analyzing the active ingredient-target network graph of Danshen/Chuanxiong,it was concluded that luteolin is the key chemical ingredient.After protein interaction(PPI)analysis,the results showed that MMP9 is the core target.The KEGG pathway is mainly enriched in 5 signaling pathways,the most important pathway is cancer-related pathways.There are 22 main biological processes of GO,which mainly involve collagen catabolism,protein extracellular matrix,metal endopeptidase activity,etc.The preliminary analysis of tubule formation experiment shows that luteolin inhibits angiogenesis and down-regulates the expression of MMP9 gene.Conclusion:Luteolin,the key chemical component of the Danshen-Ligusticum chuanxiong drug pair,inhibits angiogenesis by regulating the MMP9 target,and develops the reverse regulation of angiogenesis for the traditional Chinese medicine for promoting blood circulation and removing blood stasis on the basis of the known treatment of ischemic diseases.Provide a new perspective and theoretical basis for the use of Danshen and Chuanxiong medicine in clinical cancer patients.Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.
基金the Research Project of National Natural Science Foundation of China(81960761,81960751,81680705)Basic Ability Improvement Project for Young and Middle-aged Teachers in Colleges and Universities of Guangxi(2018KY1149)Natural Science Foundation of Guangxi Province(2020JJA140257).
文摘Hepatic fibrosis is a reversible pathological phenomenon in the early and middle stages,but but no satisfactory intervention drugs have been available so far.Recent studies have suggested that microcirculation disturbance of liver is one of the important pathogenesis of chronic liver disease,the improvement of microcirculation is beneficial to the recovery of liver function and the delay of liver fibrosis.Hepatic stellate cells are the core cells of hepatic fibrosis,and also the most critical cells that affect the microcirculation of the liver.While TLR4/MyD88/NF-κB and TLR4/MyD88/MAPKs which are based on the action of hepatic stellate cells are two pathways that have very important influence on the inflammatory response of liver,the proliferation and apoptosis of hepatic stellate cells,and the secretion of fibrogenic cytokines.It was found that Plumbapin,the active ingredient of Guangxi specialty ethnic medicine,has the definite effect of promoting blood circulation and removing blood stasis and anti-hepatic fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived as follows:the pharmacological effect of Plumbapin on anti-hepatic fibrosis,promoting blood circulation and removing stasis was based on the influence of TLR4/MyD88/NF-κB and MAPKs signal pathway.
文摘:This article first analyzes the problems existing in the teaching about diagnosing and removing automobile’s failure,and then discusses some specific teaching strategies on diagnosing and removing automobile’s failure to provide some effective reference for the related staff.
文摘AS environmental preservation takes a more prominent role in global planning, China is making massive investments in African forestry, helping the continent to improve governance of its timber trade and sustainable forest management,