为解决自然条件下人脸表情识别易受角度、光线、遮挡物的影响以及人脸表情数据集各类表情数量不均衡等问题,提出基于Res2Net的人脸表情识别方法。使用Res2Net50作为特征提取的主干网络,在预处理阶段对图像随机翻转、缩放、裁剪进行数据...为解决自然条件下人脸表情识别易受角度、光线、遮挡物的影响以及人脸表情数据集各类表情数量不均衡等问题,提出基于Res2Net的人脸表情识别方法。使用Res2Net50作为特征提取的主干网络,在预处理阶段对图像随机翻转、缩放、裁剪进行数据增强,提升模型的泛化性。引入广义平均池化(generalized mean pooling, GeM)方式,关注图像中比较显著的区域,增强模型的鲁棒性;选用Focal Loss损失函数,针对表情类别不平衡和错误分类问题,提高较难识别表情的识别率。该方法在FER2013数据集上准确率达到了70.41%,相较于原Res2Net50网络提高了1.53%。结果表明,在自然条件下对人脸表情识别具有更好的准确性。展开更多
A novel image fusion network framework with an autonomous encoder and decoder is suggested to increase thevisual impression of fused images by improving the quality of infrared and visible light picture fusion. The ne...A novel image fusion network framework with an autonomous encoder and decoder is suggested to increase thevisual impression of fused images by improving the quality of infrared and visible light picture fusion. The networkcomprises an encoder module, fusion layer, decoder module, and edge improvementmodule. The encoder moduleutilizes an enhanced Inception module for shallow feature extraction, then combines Res2Net and Transformerto achieve deep-level co-extraction of local and global features from the original picture. An edge enhancementmodule (EEM) is created to extract significant edge features. A modal maximum difference fusion strategy isintroduced to enhance the adaptive representation of information in various regions of the source image, therebyenhancing the contrast of the fused image. The encoder and the EEM module extract features, which are thencombined in the fusion layer to create a fused picture using the decoder. Three datasets were chosen to test thealgorithmproposed in this paper. The results of the experiments demonstrate that the network effectively preservesbackground and detail information in both infrared and visible images, yielding superior outcomes in subjectiveand objective evaluations.展开更多
It is alarming for the fact that Wildfires number, severity and consequently impact have significantly increased during the last years, an aftermath of the Climate Change. One of the most affected areas worldwide is M...It is alarming for the fact that Wildfires number, severity and consequently impact have significantly increased during the last years, an aftermath of the Climate Change. One of the most affected areas worldwide is Mediterranean, due to the unique combination of its type of vegetation and demanding climatic conditions. This research is focused on the Region of Epirus in Greece, an area with significant natural vegetation and a range of geomorphological aspects. In order to estimate the Wildfire Risk Hazard, several factors have been used: geomorphological (slope, aspect, elevation, TWI, Hydrographic network), social (Settlements and landfils, roads, overhead lines and substations), environmental (land cover) and climatic (Fire Weather Index). Through a multi-criteria decision analysis (MCDA) and an analytic hierarchy process (AHP) in a GIS environment, the Wildfire Risk Hazard has been estimated not only for current conditions but also for future projections for the near future (2031-2060) and the far future (2071-2100). The selected case study includes the potential impact of the Wildfires to the installed (or targeted to be installed) RES projects in the studied region.展开更多
Considerable economic losses and ecological damage can be caused by forest fi res,and compared to suppression,prevention is a much smarter strategy.Accordingly,this study focuses on developing a novel framework to ass...Considerable economic losses and ecological damage can be caused by forest fi res,and compared to suppression,prevention is a much smarter strategy.Accordingly,this study focuses on developing a novel framework to assess forest fi re risks and policy decisions on forest fi re management in China.This framework integrated deep learning algorithms,geographic information,and multisource data.Compared to conventional approaches,our framework featured timesaving,easy implementation,and importantly,the use of deep learning that vividly integrates various factors from the environment and human activities.Information on 96,594 forest fi re points from 2001 to 2019 was collected on Moderate Resolution Imaging Spectroradiometer(MODIS)fi re hotspots from 2001 to 2019 from NASA’s Fire Information Resource Management System.The information was classifi ed into factors such as topography,climate,vegetation,and society.The prediction of forest fi re risk was generated using a fully connected network model,and spatial autocorrelation used to analyze the spatial aggregation correlation of active fi re hotspots in the whole area of China.The results show that high accuracy prediction of fi re risks was achieved(accuracy 87.4%,positive predictive value 87.1%,sensitivity 88.9%,area under curve(AUC)94.1%).Based on this,it was found that Chinese forest fi re risk shows signifi cant autocorrelation and agglomeration both in seasons and regions.For example,forest fi re risk usually raises dramatically in spring and winter,and decreases in autumn and summer.Compared to the national average,Yunnan Province,Guangdong Province,and the Greater Hinggan Mountains region of Heilongjiang Province have higher fi re risks.In contrast,a large region in central China has been recognized as having a long-term,low risk of forest fi res.All forest risks in each region were recorded into the database and could contribute to the forest fi re prevention.The successful assessment of forest fi re risks in this study provides a comprehensive knowledge of fi re risks in China over the last 20 years.Deep learning showed its advantage in integrating multiple factors in predicting forest fi re risks.This technical framework is expected to be a feasible evaluation tool for the occurrence of forest fi res in China.展开更多
Turkey has a high potential for wildfires along its Mediterranean coast because of its dense forest cover and mild climate.An average of 250 wildfires occurs every year with more than 10,000 hectares destroyed due to ...Turkey has a high potential for wildfires along its Mediterranean coast because of its dense forest cover and mild climate.An average of 250 wildfires occurs every year with more than 10,000 hectares destroyed due to natural and human-related causes.The study area is sensitive to fires caused by lightning,stubble burning,discarded cigarette butts,electric arcing from power lines,deliberate fire setting,and traffic accidents.However,52%of causes could not be identified due to intense wildfires occurring at the same time and insufficient equipment and personnel.Since wildfires destroy forest cover,ecosystems,biodiversity,and habitats,they should be spatially evaluated by separating them according to their causes,considering environmental,climatic,topographic and forest structure variables that trigger wildfires.In this study,wildfires caused by lightning,the burning of agriculture stubble,discarded cigarette butts and power lines were investigated in the provinces of Aydin,Mugla and Antalya,where 22%of Turkey’s wildfires occurred.The MaxEnt method was used to determine the spatial distribution of wildfires to identify risk zones for each cause.Wildfires were used as the species distribution and the probability of their occurrence estimated.Additionally,since the causes of many wildfires are unknown,determining the causes is important for fire prediction and prevention.The highest wildfire occurrence risks were 9.7%for stubble burning,30.2%for lightning,4.5%for power lines and 16.9%by discarded cigarette butts.In total,1,266 of the 1,714 unknown wildfire causes were identified by the analysis of the cause-based risk zones and these were updated by including cause-as signed unknown wildfire locations for verification.As a result,the Area under the ROC Curve(AUC)values were increased for susceptibility maps.展开更多
Cleaning up residual fires is an important part of forest fire management to avoid the loss of forest resources caused by the recurrence of a residual fire.Existing residual fire detection equipment is mainly infrared...Cleaning up residual fires is an important part of forest fire management to avoid the loss of forest resources caused by the recurrence of a residual fire.Existing residual fire detection equipment is mainly infrared temperature detection and smoke identification.Due to the isolation of ground,temperature and smoke characteristics of medium and large smoldering charcoal in some forest soils are not obvious,making it difficult to identify by detection equipment.CO gas is an important detection index for indoor smoldering fire detection,and an important identification feature of hidden smoldering ground fires.However,there is no research on locating smoldering fires through CO detection.We studied the diffusion law of CO gas directly above covered smoldering charcoal as a criterion to design a detection device equipped with multiple CO sensors.According to the motion decomposition search algorithm,the detection device realizes the function of automatically searching for smoldering charcoal.Experimental data shows that the average CO concentration over the covered smoldering charcoal decreases exponentially with increasing height.The size of the search step is related to the reliability of the search algorithm.The detection success corresponding to the small step length is high but the search time is lengthy which can lead to search failure.The introduction of step and rotation factors in search algorithm improves the search efficiency.This study reveals that the average ground CO concentration directly above smoldering charcoal in forests changes with height.Based on this law,a CO gas sensor detection device for hidden smoldering fires has been designed,which enriches the technique of residual fire detection.展开更多
Autonomous driving technology has made a lot of outstanding achievements with deep learning,and the vehicle detection and classification algorithm has become one of the critical technologies of autonomous driving syst...Autonomous driving technology has made a lot of outstanding achievements with deep learning,and the vehicle detection and classification algorithm has become one of the critical technologies of autonomous driving systems.The vehicle instance segmentation can perform instance-level semantic parsing of vehicle information,which is more accurate and reliable than object detection.However,the existing instance segmentation algorithms still have the problems of poor mask prediction accuracy and low detection speed.Therefore,this paper proposes an advanced real-time instance segmentation model named FIR-YOLACT,which fuses the ICIoU(Improved Complete Intersection over Union)and Res2Net for the YOLACT algorithm.Specifically,the ICIoU function can effectively solve the degradation problem of the original CIoU loss function,and improve the training convergence speed and detection accuracy.The Res2Net module fused with the ECA(Efficient Channel Attention)Net is added to the model’s backbone network,which improves the multi-scale detection capability and mask prediction accuracy.Furthermore,the Cluster NMS(Non-Maximum Suppression)algorithm is introduced in the model’s bounding box regression to enhance the performance of detecting similarly occluded objects.The experimental results demonstrate the superiority of FIR-YOLACT to the based methods and the effectiveness of all components.The processing speed reaches 28 FPS,which meets the demands of real-time vehicle instance segmentation.展开更多
Electronic properties of two-dimensional(2D) materials can be strongly modulated by localized strain. The typical spatial resolution of conventional Kelvin probe force microscopy(KPFM) is usually limited in a few hund...Electronic properties of two-dimensional(2D) materials can be strongly modulated by localized strain. The typical spatial resolution of conventional Kelvin probe force microscopy(KPFM) is usually limited in a few hundreds of nanometers, and it is difficult to characterize localized electronic properties of 2D materials at nanoscales. Herein, tip-enhanced Raman spectroscopy(TERS) is proposed to combine with KPFM to break this restriction. TERS scan is conducted on ReS2bubbles deposited on a rough Au thin film to obtain strain distribution by using the Raman peak shift. The localized contact potential difference(CPD) is inversely calculated with a higher spatial resolution by using strain measured by TERS and CPD-strain working curve obtained using conventional KPFM and atomic force microscopy. This method enhances the spatial resolution of CPD measurements and can be potentially used to characterize localized electronic properties of 2D materials.展开更多
BACKGROUND IFIH1 is a protein-coding gene.Disorders associated with IFIH1 include Aicardi-Goutières syndrome(AGS)type 7 and Singleton-Merten syndrome type 1.Related pathways include RIG-I/MDA5-mediated induction ...BACKGROUND IFIH1 is a protein-coding gene.Disorders associated with IFIH1 include Aicardi-Goutières syndrome(AGS)type 7 and Singleton-Merten syndrome type 1.Related pathways include RIG-I/MDA5-mediated induction of the interferon(IFN)-α/βpathway and the innate immune system.AGS type 7 is an autosomal dominant inflammatory disorder characterized by severe neurological impairment.In infancy,most patients present with psychomotor retardation,axial hypotonia,spasticity,and brain imaging changes Laboratory assessments showed increased IFN-αactivity with upregulation of IFN signaling and IFN-stimulated gene expression.Some patients develop normally in the early stage,and then have episodic neurological deficits.CASE SUMMARY The 5-year-old girl presented with postpartum height and weight growth retardation,language retardation,brain atrophy,convulsions,and growth hormone deficiency.DNA samples were obtained from peripheral blood from the child and her parents for whole-exome sequencing and test of genome-wide copy number variation.Heterozygous mutations in the IFIH1 gene were found.Physical examination at admission found that language development was delayed,the reaction to name calling was average,there was no communication with people,but there was eye contact,no social smile,and no autonomous language.However,the child had rich gesture language and body language,could understand instructions,had bad temper.When she wants to achieve something,she starts crying or shouting.Cardiopulmonary examination showed no obvious abnormality,and abdominal examination was normal.Bilateral muscle strength and muscle tone were symmetrical and slightly decreased.Physiological reflexes exist,but pathological reflexes were not elicited.CONCLUSION We reported the clinical characteristics of a Chinese child with a clinical diagnosis of AGS type 7,which expanded the mutational spectrum of the IFIH1 gene.展开更多
文摘为解决自然条件下人脸表情识别易受角度、光线、遮挡物的影响以及人脸表情数据集各类表情数量不均衡等问题,提出基于Res2Net的人脸表情识别方法。使用Res2Net50作为特征提取的主干网络,在预处理阶段对图像随机翻转、缩放、裁剪进行数据增强,提升模型的泛化性。引入广义平均池化(generalized mean pooling, GeM)方式,关注图像中比较显著的区域,增强模型的鲁棒性;选用Focal Loss损失函数,针对表情类别不平衡和错误分类问题,提高较难识别表情的识别率。该方法在FER2013数据集上准确率达到了70.41%,相较于原Res2Net50网络提高了1.53%。结果表明,在自然条件下对人脸表情识别具有更好的准确性。
文摘A novel image fusion network framework with an autonomous encoder and decoder is suggested to increase thevisual impression of fused images by improving the quality of infrared and visible light picture fusion. The networkcomprises an encoder module, fusion layer, decoder module, and edge improvementmodule. The encoder moduleutilizes an enhanced Inception module for shallow feature extraction, then combines Res2Net and Transformerto achieve deep-level co-extraction of local and global features from the original picture. An edge enhancementmodule (EEM) is created to extract significant edge features. A modal maximum difference fusion strategy isintroduced to enhance the adaptive representation of information in various regions of the source image, therebyenhancing the contrast of the fused image. The encoder and the EEM module extract features, which are thencombined in the fusion layer to create a fused picture using the decoder. Three datasets were chosen to test thealgorithmproposed in this paper. The results of the experiments demonstrate that the network effectively preservesbackground and detail information in both infrared and visible images, yielding superior outcomes in subjectiveand objective evaluations.
文摘It is alarming for the fact that Wildfires number, severity and consequently impact have significantly increased during the last years, an aftermath of the Climate Change. One of the most affected areas worldwide is Mediterranean, due to the unique combination of its type of vegetation and demanding climatic conditions. This research is focused on the Region of Epirus in Greece, an area with significant natural vegetation and a range of geomorphological aspects. In order to estimate the Wildfire Risk Hazard, several factors have been used: geomorphological (slope, aspect, elevation, TWI, Hydrographic network), social (Settlements and landfils, roads, overhead lines and substations), environmental (land cover) and climatic (Fire Weather Index). Through a multi-criteria decision analysis (MCDA) and an analytic hierarchy process (AHP) in a GIS environment, the Wildfire Risk Hazard has been estimated not only for current conditions but also for future projections for the near future (2031-2060) and the far future (2071-2100). The selected case study includes the potential impact of the Wildfires to the installed (or targeted to be installed) RES projects in the studied region.
文摘利用多尺度特征策略进行特征提取的有效性不足是多模态医学图像融合领域存在的问题。为了增加融合结果的多尺结构信息,提出了一种基于残差多尺度网络(residual multi-scale network,Res2Net)、交错稠密网络和空间通道融合算法的多模态医学图像融合算法。Res2Net的编码器在提取多尺度特征时能保留更多语义信息;交错稠密网络减少了解码器和编码器之间的语义差异,丰富了融合图像的结构和细节信息;掩码鉴别器约束了脑瘤病灶区域,进一步提高了融合图像的质量;特征图通过空间通道融合算法融合减少了多模态图像之间的信息冗余。该算法在信息熵(entropy of information,EN)、互信息(mutual information,MI)、结构相似性(structure similarity index measure,SSIM)、多尺度结构相似性(multi scale structural similarity index measure,MI_SSIM)指标上拥有较高水平的性能表现,EN提高了6%,MI提高了3%。结果显示,所提出的算法在视觉感知和指标评估上达到了较高的融合质量。
基金funded by the Key R&D Projects in Hainan Province (ZDYF2021SHFZ256)Natural Science Foundation of Hainan University,grant numbers KYQD (ZR)21,115
文摘Considerable economic losses and ecological damage can be caused by forest fi res,and compared to suppression,prevention is a much smarter strategy.Accordingly,this study focuses on developing a novel framework to assess forest fi re risks and policy decisions on forest fi re management in China.This framework integrated deep learning algorithms,geographic information,and multisource data.Compared to conventional approaches,our framework featured timesaving,easy implementation,and importantly,the use of deep learning that vividly integrates various factors from the environment and human activities.Information on 96,594 forest fi re points from 2001 to 2019 was collected on Moderate Resolution Imaging Spectroradiometer(MODIS)fi re hotspots from 2001 to 2019 from NASA’s Fire Information Resource Management System.The information was classifi ed into factors such as topography,climate,vegetation,and society.The prediction of forest fi re risk was generated using a fully connected network model,and spatial autocorrelation used to analyze the spatial aggregation correlation of active fi re hotspots in the whole area of China.The results show that high accuracy prediction of fi re risks was achieved(accuracy 87.4%,positive predictive value 87.1%,sensitivity 88.9%,area under curve(AUC)94.1%).Based on this,it was found that Chinese forest fi re risk shows signifi cant autocorrelation and agglomeration both in seasons and regions.For example,forest fi re risk usually raises dramatically in spring and winter,and decreases in autumn and summer.Compared to the national average,Yunnan Province,Guangdong Province,and the Greater Hinggan Mountains region of Heilongjiang Province have higher fi re risks.In contrast,a large region in central China has been recognized as having a long-term,low risk of forest fi res.All forest risks in each region were recorded into the database and could contribute to the forest fi re prevention.The successful assessment of forest fi re risks in this study provides a comprehensive knowledge of fi re risks in China over the last 20 years.Deep learning showed its advantage in integrating multiple factors in predicting forest fi re risks.This technical framework is expected to be a feasible evaluation tool for the occurrence of forest fi res in China.
文摘Turkey has a high potential for wildfires along its Mediterranean coast because of its dense forest cover and mild climate.An average of 250 wildfires occurs every year with more than 10,000 hectares destroyed due to natural and human-related causes.The study area is sensitive to fires caused by lightning,stubble burning,discarded cigarette butts,electric arcing from power lines,deliberate fire setting,and traffic accidents.However,52%of causes could not be identified due to intense wildfires occurring at the same time and insufficient equipment and personnel.Since wildfires destroy forest cover,ecosystems,biodiversity,and habitats,they should be spatially evaluated by separating them according to their causes,considering environmental,climatic,topographic and forest structure variables that trigger wildfires.In this study,wildfires caused by lightning,the burning of agriculture stubble,discarded cigarette butts and power lines were investigated in the provinces of Aydin,Mugla and Antalya,where 22%of Turkey’s wildfires occurred.The MaxEnt method was used to determine the spatial distribution of wildfires to identify risk zones for each cause.Wildfires were used as the species distribution and the probability of their occurrence estimated.Additionally,since the causes of many wildfires are unknown,determining the causes is important for fire prediction and prevention.The highest wildfire occurrence risks were 9.7%for stubble burning,30.2%for lightning,4.5%for power lines and 16.9%by discarded cigarette butts.In total,1,266 of the 1,714 unknown wildfire causes were identified by the analysis of the cause-based risk zones and these were updated by including cause-as signed unknown wildfire locations for verification.As a result,the Area under the ROC Curve(AUC)values were increased for susceptibility maps.
基金funded by Natural Science Foundation of Heilongjiang Province(TD2020C001)National Forestry Science and Technology Promotion Project(2019[10])。
文摘Cleaning up residual fires is an important part of forest fire management to avoid the loss of forest resources caused by the recurrence of a residual fire.Existing residual fire detection equipment is mainly infrared temperature detection and smoke identification.Due to the isolation of ground,temperature and smoke characteristics of medium and large smoldering charcoal in some forest soils are not obvious,making it difficult to identify by detection equipment.CO gas is an important detection index for indoor smoldering fire detection,and an important identification feature of hidden smoldering ground fires.However,there is no research on locating smoldering fires through CO detection.We studied the diffusion law of CO gas directly above covered smoldering charcoal as a criterion to design a detection device equipped with multiple CO sensors.According to the motion decomposition search algorithm,the detection device realizes the function of automatically searching for smoldering charcoal.Experimental data shows that the average CO concentration over the covered smoldering charcoal decreases exponentially with increasing height.The size of the search step is related to the reliability of the search algorithm.The detection success corresponding to the small step length is high but the search time is lengthy which can lead to search failure.The introduction of step and rotation factors in search algorithm improves the search efficiency.This study reveals that the average ground CO concentration directly above smoldering charcoal in forests changes with height.Based on this law,a CO gas sensor detection device for hidden smoldering fires has been designed,which enriches the technique of residual fire detection.
基金supported by the Natural Science Foundation of Guizhou Province(Grant Number:20161054)Joint Natural Science Foundation of Guizhou Province(Grant Number:LH20177226)+1 种基金2017 Special Project of New Academic Talent Training and Innovation Exploration of Guizhou University(Grant Number:20175788)The National Natural Science Foundation of China under Grant No.12205062.
文摘Autonomous driving technology has made a lot of outstanding achievements with deep learning,and the vehicle detection and classification algorithm has become one of the critical technologies of autonomous driving systems.The vehicle instance segmentation can perform instance-level semantic parsing of vehicle information,which is more accurate and reliable than object detection.However,the existing instance segmentation algorithms still have the problems of poor mask prediction accuracy and low detection speed.Therefore,this paper proposes an advanced real-time instance segmentation model named FIR-YOLACT,which fuses the ICIoU(Improved Complete Intersection over Union)and Res2Net for the YOLACT algorithm.Specifically,the ICIoU function can effectively solve the degradation problem of the original CIoU loss function,and improve the training convergence speed and detection accuracy.The Res2Net module fused with the ECA(Efficient Channel Attention)Net is added to the model’s backbone network,which improves the multi-scale detection capability and mask prediction accuracy.Furthermore,the Cluster NMS(Non-Maximum Suppression)algorithm is introduced in the model’s bounding box regression to enhance the performance of detecting similarly occluded objects.The experimental results demonstrate the superiority of FIR-YOLACT to the based methods and the effectiveness of all components.The processing speed reaches 28 FPS,which meets the demands of real-time vehicle instance segmentation.
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China (Grant No. LZ22A040003)the National Natural Science Foundation of China (Grant No. 52027809)。
文摘Electronic properties of two-dimensional(2D) materials can be strongly modulated by localized strain. The typical spatial resolution of conventional Kelvin probe force microscopy(KPFM) is usually limited in a few hundreds of nanometers, and it is difficult to characterize localized electronic properties of 2D materials at nanoscales. Herein, tip-enhanced Raman spectroscopy(TERS) is proposed to combine with KPFM to break this restriction. TERS scan is conducted on ReS2bubbles deposited on a rough Au thin film to obtain strain distribution by using the Raman peak shift. The localized contact potential difference(CPD) is inversely calculated with a higher spatial resolution by using strain measured by TERS and CPD-strain working curve obtained using conventional KPFM and atomic force microscopy. This method enhances the spatial resolution of CPD measurements and can be potentially used to characterize localized electronic properties of 2D materials.
文摘BACKGROUND IFIH1 is a protein-coding gene.Disorders associated with IFIH1 include Aicardi-Goutières syndrome(AGS)type 7 and Singleton-Merten syndrome type 1.Related pathways include RIG-I/MDA5-mediated induction of the interferon(IFN)-α/βpathway and the innate immune system.AGS type 7 is an autosomal dominant inflammatory disorder characterized by severe neurological impairment.In infancy,most patients present with psychomotor retardation,axial hypotonia,spasticity,and brain imaging changes Laboratory assessments showed increased IFN-αactivity with upregulation of IFN signaling and IFN-stimulated gene expression.Some patients develop normally in the early stage,and then have episodic neurological deficits.CASE SUMMARY The 5-year-old girl presented with postpartum height and weight growth retardation,language retardation,brain atrophy,convulsions,and growth hormone deficiency.DNA samples were obtained from peripheral blood from the child and her parents for whole-exome sequencing and test of genome-wide copy number variation.Heterozygous mutations in the IFIH1 gene were found.Physical examination at admission found that language development was delayed,the reaction to name calling was average,there was no communication with people,but there was eye contact,no social smile,and no autonomous language.However,the child had rich gesture language and body language,could understand instructions,had bad temper.When she wants to achieve something,she starts crying or shouting.Cardiopulmonary examination showed no obvious abnormality,and abdominal examination was normal.Bilateral muscle strength and muscle tone were symmetrical and slightly decreased.Physiological reflexes exist,but pathological reflexes were not elicited.CONCLUSION We reported the clinical characteristics of a Chinese child with a clinical diagnosis of AGS type 7,which expanded the mutational spectrum of the IFIH1 gene.