Introduction: Degenerative aortic stenosis is the most common valvulopathy in developed countries. The implantation of a percutaneous aortic valve (TAVI) has taken an important place in the management of this valvulop...Introduction: Degenerative aortic stenosis is the most common valvulopathy in developed countries. The implantation of a percutaneous aortic valve (TAVI) has taken an important place in the management of this valvulopathy. The objective of this work is to report the results of patients treated by TAVI by the team of Sainte Clotilde Hospital (Reunion Island). Patients and?Methods: This was a descriptive retrospective study conducted from 01/10/2014?to 01/10/ 2017 in the Sainte Clotilde Hospital, Reunion Island. All patients who received TAVI for degenerative aortic stenosis were included in the study. Follow-up was completed until 31/08/19. Results: Forty-six (46) patients were included (sex ratio 0.53). The age was 82 (±7.5). Respectively,?56.5%, 21.7% and 6.5% of patients were diabetic [n = 26 (56.5%)], severe renal impairment [n = 10 (21.7%)] and hemodialysis [n = 3 (6.5%)]. All procedures were performed by femoral route under consious sedation. Edwards’ prostheses were used more often (93%), 100% Sapien 3, 6% of which were size 23. The primary success rate was 97.8% and the failure rate was 2% (deaths per procedure). The TAVI range of 0.66 ± 0.14 and 46.8 ± 15.5 against 1.48 ± 4.3 and 13.8 ± 5 in post TAVI. Severe pulmonary arterial?hypertension (>60 mmHg) was observed in 21.7% of pre-TAVI patients?compared to 4% in post TAVI patients. The overall rate of complications was 17% (n = 8). They were related to conductive disorders [6.5% (n = 3)], paraprosthetic leakage [2% (n = 1)], tamponade [2% (n = 1)], and hemorrhagic complications [6.5% (n = 3)]. Mean follow-up was 946 days (median = 1007.5 days), mean follow-up death rate was 30.4% (n = 14). The causes of death were non-cardiac in 57% (n = 8) of the cases. Conclusion: The TAVI results of the Sainte Clotilde Hospital Clinic are comparable to those observed in the literature.展开更多
Liquid metal(LM) micro-droplets have been widely used in microfluidics, drug-loaded nano-system and micro-nano machine due to its excellent properties. However,there still exist difficulties in succinctly dispersing a...Liquid metal(LM) micro-droplets have been widely used in microfluidics, drug-loaded nano-system and micro-nano machine due to its excellent properties. However,there still exist difficulties in succinctly dispersing a bulk of LM into micro-droplets due to the large interfacial tension.Besides, the controllable switching between droplet dispersion and reunion is yet to be realized. Herein, a practical and efficient method for dispersing LM was proposed and the controllable switching between dispersion and reunion of LM droplets was achieved. LM micro-droplets were produced by vibrating the LM immersed in a mixture of N,N-dimethylformamide(DMF) and polyvinyl chloride(PVC). The experimental results show that the size distribution of LM micro-droplets could be tuned by controlling the vibration frequency. More intriguingly, the dispersion and reunion of LM droplets can be switched intelligently through tuning the vibration frequency and amplitude. Furthermore, optical properties of the LM micro-droplet coating were evaluated to display potential applications. A self-driven motion of PVCcoated LM could be achieved by utilizing the produced LM micro-droplets based on the Marangoni effect, which holds promising value for developing future transport tool of LM droplets. The present work suggests an entirely feasible method for dispersing and utilizing LM droplets, which is of great significance for promoting the development of LM micro-droplet science and technology.展开更多
According to the last World Malaria Report,there were an estimated 584 000 malaria deaths worldwide in 2013.The problem of parasite resistance towards available medicines is increasing.Natural products could play an i...According to the last World Malaria Report,there were an estimated 584 000 malaria deaths worldwide in 2013.The problem of parasite resistance towards available medicines is increasing.Natural products could play an important role to discover new antimalarial drug.The aim of the study was to highlight the anti-plasmodial properties of plants used in traditional medicine on the Mascarene Islands.85展开更多
文摘Introduction: Degenerative aortic stenosis is the most common valvulopathy in developed countries. The implantation of a percutaneous aortic valve (TAVI) has taken an important place in the management of this valvulopathy. The objective of this work is to report the results of patients treated by TAVI by the team of Sainte Clotilde Hospital (Reunion Island). Patients and?Methods: This was a descriptive retrospective study conducted from 01/10/2014?to 01/10/ 2017 in the Sainte Clotilde Hospital, Reunion Island. All patients who received TAVI for degenerative aortic stenosis were included in the study. Follow-up was completed until 31/08/19. Results: Forty-six (46) patients were included (sex ratio 0.53). The age was 82 (±7.5). Respectively,?56.5%, 21.7% and 6.5% of patients were diabetic [n = 26 (56.5%)], severe renal impairment [n = 10 (21.7%)] and hemodialysis [n = 3 (6.5%)]. All procedures were performed by femoral route under consious sedation. Edwards’ prostheses were used more often (93%), 100% Sapien 3, 6% of which were size 23. The primary success rate was 97.8% and the failure rate was 2% (deaths per procedure). The TAVI range of 0.66 ± 0.14 and 46.8 ± 15.5 against 1.48 ± 4.3 and 13.8 ± 5 in post TAVI. Severe pulmonary arterial?hypertension (>60 mmHg) was observed in 21.7% of pre-TAVI patients?compared to 4% in post TAVI patients. The overall rate of complications was 17% (n = 8). They were related to conductive disorders [6.5% (n = 3)], paraprosthetic leakage [2% (n = 1)], tamponade [2% (n = 1)], and hemorrhagic complications [6.5% (n = 3)]. Mean follow-up was 946 days (median = 1007.5 days), mean follow-up death rate was 30.4% (n = 14). The causes of death were non-cardiac in 57% (n = 8) of the cases. Conclusion: The TAVI results of the Sainte Clotilde Hospital Clinic are comparable to those observed in the literature.
基金partially supported by the Key Project of National Natural Science Foundation of China (91748206)Dean’s Research Funding and the Frontier Project of the Chinese Academy of Sciences
文摘Liquid metal(LM) micro-droplets have been widely used in microfluidics, drug-loaded nano-system and micro-nano machine due to its excellent properties. However,there still exist difficulties in succinctly dispersing a bulk of LM into micro-droplets due to the large interfacial tension.Besides, the controllable switching between droplet dispersion and reunion is yet to be realized. Herein, a practical and efficient method for dispersing LM was proposed and the controllable switching between dispersion and reunion of LM droplets was achieved. LM micro-droplets were produced by vibrating the LM immersed in a mixture of N,N-dimethylformamide(DMF) and polyvinyl chloride(PVC). The experimental results show that the size distribution of LM micro-droplets could be tuned by controlling the vibration frequency. More intriguingly, the dispersion and reunion of LM droplets can be switched intelligently through tuning the vibration frequency and amplitude. Furthermore, optical properties of the LM micro-droplet coating were evaluated to display potential applications. A self-driven motion of PVCcoated LM could be achieved by utilizing the produced LM micro-droplets based on the Marangoni effect, which holds promising value for developing future transport tool of LM droplets. The present work suggests an entirely feasible method for dispersing and utilizing LM droplets, which is of great significance for promoting the development of LM micro-droplet science and technology.
文摘According to the last World Malaria Report,there were an estimated 584 000 malaria deaths worldwide in 2013.The problem of parasite resistance towards available medicines is increasing.Natural products could play an important role to discover new antimalarial drug.The aim of the study was to highlight the anti-plasmodial properties of plants used in traditional medicine on the Mascarene Islands.85
