Rockfall is one of severe natural hazards that are frequently reported in northeast region of India. It carries rock block falling from the cliff with high velocities and energies which can result in damages to vehicl...Rockfall is one of severe natural hazards that are frequently reported in northeast region of India. It carries rock block falling from the cliff with high velocities and energies which can result in damages to vehicles, disruption to transportation, injuries and fatalities. The massive rockfall event which occurred in April 2017 on the highway NH-44 A, near Lengpui Airport, blocked the traffic for 1 d, and fortunately,no casualties were reported as the event occurred in the night. This is the only highway connecting the Aizawl city to the airport and the region is highly prone to rockfall events. Hence assessment of rockfall along this highway is necessary. In the current study, rockfall hazard assessment has been carried out on three locations by rockfall hazard rating system(RHRS). During pre-failure analysis, the result shows that most hazardous slopes have RHRS score of 639. The slopes were found to be vulnerable and later on the rockfall activity occurred. Three-dimensional(3 D) stability analysis has been carried out using 3 DEC software package to analyze the failure behavior and to decide the rockfall-prone zone(unstable blocks)for slope. The total displacement of 2.24 cm and velocity of 2,25 mm/s of the failed block have been observed in the numerical analysis. Further, the rockfall vulnerable zone(unstable blocks) is considered to determine the parameters such as run-out distance, bounce height and energies of the falling rock blocks. The maximum total kinetic energy of 5047 kJ has been observed in the numerical analysis with the maximum run-out distance up to 18 m.展开更多
Hazard and risk assessment procedures of different types of rockfall were analyzed to compare their outcomes when they are applied to the same case study.Although numerous methodologies are available in literature,roc...Hazard and risk assessment procedures of different types of rockfall were analyzed to compare their outcomes when they are applied to the same case study.Although numerous methodologies are available in literature,rockfall hazard and risk analyses are often limited to standard estimations,affected by a margin of uncertainty,especially when relevant engineering projects are about to be realized.Based on the design purpose,different types of approaches can be chosen among the qualitative and quantitative ones available in literature,which allow different levels of analysis.One of the main criticisms related to rockfall events is the risk affecting linear structures,such as road or railways,due both to their strategic relevance for trade and communications and to the great entity of the exposed value(traffic units)traveling along them.In this perspective,a comparison between the qualitative method known as Evolving Rockfall Hazard Assessment(EHRA),the semi-quantitative modified Rockfall Hazard Rating System(RHRS)and the quantitative Rockfall Risk Management(RoMa)approach is herein commented according to a practical application to a case study.It is the case of the rockfall threat along slopes crossed by a strategic road connecting two of the most known spots of eastern Sicily(Italy),at the Taormina tourist complex.Data were retrieved from both recent literature and technical surveys on field.Achieved results highlight how the approaches are affected by a different level of detail and uncertainty,arising also by some necessary assumption that must be taken into account,especially when mitigation measures or territory planning have to be designed.Achieved results can be also taken into account for similar studies worldwide,in order to choose the most suitable procedure based on the design purpose.This is indeed crucial in the perspective of the optimization of time and economic resources in the territorial planning practice.展开更多
Objective To investigate the alteration and its significanc e of left atrium enlargment in patients with coronary heart diseaes(CHD). Me thods 286 CHD patients, average age 63 16±11 21 years, male 171 case s and ...Objective To investigate the alteration and its significanc e of left atrium enlargment in patients with coronary heart diseaes(CHD). Me thods 286 CHD patients, average age 63 16±11 21 years, male 171 case s and female 115 cases, were examined of left atrium diameter(LAD), left ventric ular systolic and diastolic diameter(LVS d and LVD d),septal thickness(IVST),l eft ventricular ejection fraction(EF),E/A ratio, resting heart rate(RHR), an d coronary arteriography. Res ults LAD and RHR were increased in CHD patients, and even more in CHD p atients with LVH.Correlation analysis showed that the LAD of CHD patients corre lated negatively to EF( P <0 05), and positively to the level of coronary artery s tenosis. Otherwise, LAD correlated positively to RHR in CHD patients. C onclusions Left atrium enlargment may be a mark of development of CHD a nd decrease of cardiac function.展开更多
BACKGROUND： High incidence of stroke at interchange period of autumn and winter was demonstrated by epidemiological survey, and the specific causes should be further investigated. OBJECTIVE： To investigate the influ...BACKGROUND： High incidence of stroke at interchange period of autumn and winter was demonstrated by epidemiological survey, and the specific causes should be further investigated. OBJECTIVE： To investigate the influence of artificial cold exposure on the incidence of stroke in renovascular hypertensive rats （RHR）, and analyze the association with blood pressure and cold-inducible RNA binding protein （CIRP） mRNA expression in brain tissue. DESIGN： A completely randomized grouping design, a randomized control animal trial. SETTINGS： Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University; Department of Chemistry, Open laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong. MATERIALS： Male SD rats （n=460）, weighing 80 - 100 g were obtained from Guangdong Province Health Animal Unit. A modified RXZ-300A intelligent artificial climate cabinet （Ningbo Jiangnan Instrument Co. ,Ltd., China）. METHODS： The experiment were processed in the Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University and the Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong from October 2004 to November 2005. Rats （n = 400） were operated to establish 2-kidney 2-clip RHR model as described previously. The sham-operated rats （n =60） served as normotensive controls. Eight weeks later, 300 of RHR were randomly selected according to their systolic blood pressure （SBP） and divided into 3 sub-groups （n =100 per group）： mild hypertensive group （SBP of 160 - 200 mm Hg）, moderate hypertensive group （SBP of 200 - 220 mm Hg） and severe hypertensive group （SBP 〉 220 mm Hg）. Each group was further divided into two groups （n =50） under ACE and non-ACE. Normal sham-operated SD rats （n =60）, SBP 〈 140 mm Hg, were randomly divided into two groups： Sham-operated control group （n =30） under ACE and non-ACE. To establish the ACE and non-ACE treatment, rats were housed individually in artificial climate cabinet, and ACE was designed as three cycles of 12-hour light of 22℃ （7 ： 00 - 19 ： 00） and 12-hour dark of 4℃（19 ： 00 - 7 ： 00）. The non-ACE group was kept at 22℃ throughout the experiment. MAIN OUTCOME MEASURES： Blood Pressure changes were measured and stroke symptom were observed; Expression of the CIRP were examined by reverse transcription-polymerase chain reaction. RESULTS： Finally 360 rats were involved in the analysis of results. ①Incidence of stroke： The incidence of stroke in 2k2c RHR was significantly higher after a three-day intermittent （12-hour） ACE （29.3%） as compared with that in non-ACE （17.3%） （P 〈 0.05）. Furthermore, the severe hypertensive 2k2c RHR （BP 〉 220 mm Hg） was found to have much higher incidence of stroke （66%, 33/50） than the mild （8%, 4/50） and moderate （18%） hypertensive 2k2c RHR. ②CIRP mRNA in brain tissue： ACE treatment stimulated the mRNA expression of CIRP in non-stroke 2k2c RHR but not in stroke 2k2c RHR （P 〈 0.05）. CONCLUSION： High blood pressure and low expression of CIRP are associated with ACE induced stroke.展开更多
基金the Ministry of Earth Sciences,Government of India(MoES/P.O(Geosci)/42/2015)for the grant to carry out this study
文摘Rockfall is one of severe natural hazards that are frequently reported in northeast region of India. It carries rock block falling from the cliff with high velocities and energies which can result in damages to vehicles, disruption to transportation, injuries and fatalities. The massive rockfall event which occurred in April 2017 on the highway NH-44 A, near Lengpui Airport, blocked the traffic for 1 d, and fortunately,no casualties were reported as the event occurred in the night. This is the only highway connecting the Aizawl city to the airport and the region is highly prone to rockfall events. Hence assessment of rockfall along this highway is necessary. In the current study, rockfall hazard assessment has been carried out on three locations by rockfall hazard rating system(RHRS). During pre-failure analysis, the result shows that most hazardous slopes have RHRS score of 639. The slopes were found to be vulnerable and later on the rockfall activity occurred. Three-dimensional(3 D) stability analysis has been carried out using 3 DEC software package to analyze the failure behavior and to decide the rockfall-prone zone(unstable blocks)for slope. The total displacement of 2.24 cm and velocity of 2,25 mm/s of the failed block have been observed in the numerical analysis. Further, the rockfall vulnerable zone(unstable blocks) is considered to determine the parameters such as run-out distance, bounce height and energies of the falling rock blocks. The maximum total kinetic energy of 5047 kJ has been observed in the numerical analysis with the maximum run-out distance up to 18 m.
文摘Hazard and risk assessment procedures of different types of rockfall were analyzed to compare their outcomes when they are applied to the same case study.Although numerous methodologies are available in literature,rockfall hazard and risk analyses are often limited to standard estimations,affected by a margin of uncertainty,especially when relevant engineering projects are about to be realized.Based on the design purpose,different types of approaches can be chosen among the qualitative and quantitative ones available in literature,which allow different levels of analysis.One of the main criticisms related to rockfall events is the risk affecting linear structures,such as road or railways,due both to their strategic relevance for trade and communications and to the great entity of the exposed value(traffic units)traveling along them.In this perspective,a comparison between the qualitative method known as Evolving Rockfall Hazard Assessment(EHRA),the semi-quantitative modified Rockfall Hazard Rating System(RHRS)and the quantitative Rockfall Risk Management(RoMa)approach is herein commented according to a practical application to a case study.It is the case of the rockfall threat along slopes crossed by a strategic road connecting two of the most known spots of eastern Sicily(Italy),at the Taormina tourist complex.Data were retrieved from both recent literature and technical surveys on field.Achieved results highlight how the approaches are affected by a different level of detail and uncertainty,arising also by some necessary assumption that must be taken into account,especially when mitigation measures or territory planning have to be designed.Achieved results can be also taken into account for similar studies worldwide,in order to choose the most suitable procedure based on the design purpose.This is indeed crucial in the perspective of the optimization of time and economic resources in the territorial planning practice.
文摘Objective To investigate the alteration and its significanc e of left atrium enlargment in patients with coronary heart diseaes(CHD). Me thods 286 CHD patients, average age 63 16±11 21 years, male 171 case s and female 115 cases, were examined of left atrium diameter(LAD), left ventric ular systolic and diastolic diameter(LVS d and LVD d),septal thickness(IVST),l eft ventricular ejection fraction(EF),E/A ratio, resting heart rate(RHR), an d coronary arteriography. Res ults LAD and RHR were increased in CHD patients, and even more in CHD p atients with LVH.Correlation analysis showed that the LAD of CHD patients corre lated negatively to EF( P <0 05), and positively to the level of coronary artery s tenosis. Otherwise, LAD correlated positively to RHR in CHD patients. C onclusions Left atrium enlargment may be a mark of development of CHD a nd decrease of cardiac function.
基金the National Natural Science Foundation of China, No. 30471917the Hong Kong Research Grant Council,No. HKU 7198/01
文摘BACKGROUND： High incidence of stroke at interchange period of autumn and winter was demonstrated by epidemiological survey, and the specific causes should be further investigated. OBJECTIVE： To investigate the influence of artificial cold exposure on the incidence of stroke in renovascular hypertensive rats （RHR）, and analyze the association with blood pressure and cold-inducible RNA binding protein （CIRP） mRNA expression in brain tissue. DESIGN： A completely randomized grouping design, a randomized control animal trial. SETTINGS： Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University; Department of Chemistry, Open laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong. MATERIALS： Male SD rats （n=460）, weighing 80 - 100 g were obtained from Guangdong Province Health Animal Unit. A modified RXZ-300A intelligent artificial climate cabinet （Ningbo Jiangnan Instrument Co. ,Ltd., China）. METHODS： The experiment were processed in the Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University and the Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong from October 2004 to November 2005. Rats （n = 400） were operated to establish 2-kidney 2-clip RHR model as described previously. The sham-operated rats （n =60） served as normotensive controls. Eight weeks later, 300 of RHR were randomly selected according to their systolic blood pressure （SBP） and divided into 3 sub-groups （n =100 per group）： mild hypertensive group （SBP of 160 - 200 mm Hg）, moderate hypertensive group （SBP of 200 - 220 mm Hg） and severe hypertensive group （SBP 〉 220 mm Hg）. Each group was further divided into two groups （n =50） under ACE and non-ACE. Normal sham-operated SD rats （n =60）, SBP 〈 140 mm Hg, were randomly divided into two groups： Sham-operated control group （n =30） under ACE and non-ACE. To establish the ACE and non-ACE treatment, rats were housed individually in artificial climate cabinet, and ACE was designed as three cycles of 12-hour light of 22℃ （7 ： 00 - 19 ： 00） and 12-hour dark of 4℃（19 ： 00 - 7 ： 00）. The non-ACE group was kept at 22℃ throughout the experiment. MAIN OUTCOME MEASURES： Blood Pressure changes were measured and stroke symptom were observed; Expression of the CIRP were examined by reverse transcription-polymerase chain reaction. RESULTS： Finally 360 rats were involved in the analysis of results. ①Incidence of stroke： The incidence of stroke in 2k2c RHR was significantly higher after a three-day intermittent （12-hour） ACE （29.3%） as compared with that in non-ACE （17.3%） （P 〈 0.05）. Furthermore, the severe hypertensive 2k2c RHR （BP 〉 220 mm Hg） was found to have much higher incidence of stroke （66%, 33/50） than the mild （8%, 4/50） and moderate （18%） hypertensive 2k2c RHR. ②CIRP mRNA in brain tissue： ACE treatment stimulated the mRNA expression of CIRP in non-stroke 2k2c RHR but not in stroke 2k2c RHR （P 〈 0.05）. CONCLUSION： High blood pressure and low expression of CIRP are associated with ACE induced stroke.
