The Yaounde Group(YG),representing the southern edge of the North Equatorial PanAfrican Belt,consists of quartzites,schists,micaschists,amphibolites,gneisses and migmatites.Tectonism has formed a landscape characteriz...The Yaounde Group(YG),representing the southern edge of the North Equatorial PanAfrican Belt,consists of quartzites,schists,micaschists,amphibolites,gneisses and migmatites.Tectonism has formed a landscape characterized by the development of linear and folded valleys and ridges,fault scarps,V-shaped valleys,incised rivers and knickpoints.These landforms constitute important markers of the regional tectonic activity,which have been computed from spatial sources such as SRTM,DEM,hydrographical networks and geomorphic indices such as AF,T,Smf,Vf,Bs,Hi,U,SI and Li.The results highlighted a mature relief consisting of asymmetric basins generated by tilting and uplift phenomena.The relative index of active tectonics(RIAT)has been estimated from an average of eight geomorphic indices evaluated on 24 subbasins,in the study area.Four classes have been defined:class 1(1.38),very high active(1.0≤RIAT<1.5);class 2(1.50-1.88),high active(1.5≤RIAT<2.0);and class 3(2.00-2.13)moderate active(2.0≤RIAT<2.5).These three classes,respectively covering 10.20%(458 km2),80.10%(3595 km2)and 9.69%(435 km2)of the study area,have shown a highly active tectonic zone,and imply the existence of a neotectonic event in the YG.This tectonic unit(YG)was also affected by the dextral NW-SE strike-slip faulting,which cross-cut the Sanaga Shear Zone(SSZ)at Ebebda and the foliation oriented NW-SE.The tilting and uplift of rocks related to Moho ascending are responsible for crustal thinning in the Cameroon basement,more important to the Adamawa Plateau from the Cretaceous age and the reactivation of existing tectonic accidents.The presence of hills,fault scarps,reverse faults,knickpoints,V and U shaped valleys and rounded mountains testify to the interaction between tectonic uplift,lithology,climate,weathering and erosion.展开更多
The present study area,Dadra and Nagar Haveli,contains several lineaments and traces of active faults.The various aspect of the geomo rphic analysis,i.e.,stream length(SL) gradient,hypsometric integral(HI),basin shape...The present study area,Dadra and Nagar Haveli,contains several lineaments and traces of active faults.The various aspect of the geomo rphic analysis,i.e.,stream length(SL) gradient,hypsometric integral(HI),basin shape(BS),valley floor(VF),have been applied to evaluate the relative index of active tectonics(RIAT) of the Damanganga watershed.The high and low zones of tectonic activity have been identified based on the geomorphic analysis of the watershed.After evaluation of all indices,three classes,class IIhigh(1.3 ≤RIAT <1.5),class Ⅲ-moderate(1.5 ≤RIAT <1.8),and class Ⅳ-low(1.8 ≤RIAT),have been obtained to outline the degree/gradation of comparative tectonic activities in the study area.The appraised outcome of the RIAT dispersal is also well reinforced by the geomorphic evidence in the field.The collective outcomes of geomorphic evidence,such as stream deflection and analysis of lineament,deflection of streams,and geomorphic indices,conceal that the Damanganga watershed is affected by tectonic activity.展开更多
AIM: To examine the association of hepatoma-derived growth factor(HDGF) expression with the prognosis of patients with cervical cancer of the uterus(CC). METHODS: HDGF is a unique nuclear growth factor, and it may pla...AIM: To examine the association of hepatoma-derived growth factor(HDGF) expression with the prognosis of patients with cervical cancer of the uterus(CC). METHODS: HDGF is a unique nuclear growth factor, and it may play an important role in the development and progression of carcinoma. HDGF expression in 88 CC patients aged 23 to 76 years(median, 54 years) was analyzed by immunohistochemistry. A rabbit polyclonal antibody against the C-terminal amino acids(aa 231-240) of the human HDGF sequence was used as primary antibody at a dilution of 1:5000. This specific anti-HDGF antibody was purified using C-terminal peptide-conjugated Sepharose columns. Staining of endothelial cells in the noncancerous areas of each specimen was used as an internal positive control. Samples with more than 80% of tumor cells showing positive immunoreactivity in both the nucleus and cytoplasm were regarded as HDGF index level 2, more than 80% positive immunoreactivity in either the nucleus or cytoplasm as level 1, and less than 80% in both the nucleus and cytoplasm as level 0. The chisquare test and Fisher's exact probability test were used to examine the relationship between HDGF expression and clinicopathologic parameters, and statistical significance was examined by the log-rank test. Multivariate analysis of factors related to survival was performed using Cox's proportional hazards regression model. Statistical significance was set at P < 0.05. RESULTS: The five-year overall survival rate was 82.9%. Fourteen patients died due to tumors, nine of whom had tumor recurrence at 2-21 mo(median, 10 mo) after surgery. Tumor recurrence in five patients was determined at the time of the patients' deaths. Nineteen cases were regarded as HDGF index level 0, 11 as level 1, and 58 as level 2. Patients with level 2 expression showed higher rates of histological classification of keratinized squamous cell carcinomaand adenosquamous carcinoma(44.8% of level 2 patients and 13.3% in levels 0 and 1), deep invasion(p T2-4 in 65.5% of level 2 patients, and 30.0% in levels 0 and 1), the presence of lymphatic invasion(50.0% in level 2, and 20.0% in levels 0 and 1), and the presence of lymph node metastasis(37.9% in level 2, and 6.7% in levels 0 and 1). Patients with an HDGF index of level 2 CC showed poorer 5-year overall survival rates than those with level 0 or 1 CC(74.0% and 100%, respectively, P = 0.0036). Univariate analysis revealed that histological classification(P = 0.04), depth of tumor invasion(P = 0.0001), vascular invasion(P = 0.004), and lymph node metastasis(P = 0.0001) were significant factors affecting overall survival in addition to HDGF expression. Multivariate analysis revealed HDGF expression level and lymph node metastasis as independent prognostic factors for overall survival(P = 0.0148 and P = 0.0197, respectively). The prognostic significance of HDGF was further analyzed in p T1 and p T2-4 patient groups, respectively. Among patients with p T1 CC, one the 39 analyzed patients died during the study, and no difference was observed among patients with HDGF index level 0, 1, or 2 CC. However, prognostic significance of the HDGF index was observed in the p T2-4 patient group, in which the mortality rates of patients with HDGF index level 2 CC and those with level 0 or 1 CC significantly differed(P = 0.0463). CONCLUSION: The HDGF expression level is of prognostic significance in CC.展开更多
A novel portable analyzer for raw milk quality control during the material purchase at dairy plants was developed, by which the percentages（mass fraction） of main components including total protein, fat, and lactose...A novel portable analyzer for raw milk quality control during the material purchase at dairy plants was developed, by which the percentages（mass fraction） of main components including total protein, fat, and lactose of an unhomogenized milk sample could be determinated in 1 min with the help of non-dispersive short-wave near-infrared （NDSWNIR） spectrometry in a wavelength range from 600 nm to 1100 nm and multivariate calibration. The analyzer was designed with a single-beam optical system, which comprised a temperature control module, a multi-channel narrow-band light source（16 wavelengths）, a glass absorption cell with 15 mm sample thickness, a silicon photodiode detector, several compound lenses and a recorder module. A total of 80 raw milk samples were collected at a dairy farm twice a month for 4 months. The samples were scanned with a common UV-Vis-NIR spectrometer and analyzed according to China GB standard methods. The uninformative variables elimination（UVE） method was carried out on the spectrum data and the percentages of main components of all the samples to choose the peak emitting wavelength of each channel of the light source. Another 90 raw milk samples were collected from the same dairy farm thrice a month for 3 months. The samples were analyzed according to China GB standard methods and with the proposed analyzer. The percentages of the main components and the NDSWNIR absorption data of the samples were used for the construction and validation of the multivariate calibration model with partial least squares（PLS） method. The root-mean-square errors of prediction（RMSEP） of total protein, fat and lactose were 0.201, 0.172 and 0.247 and the coefficients of correlation（R） were 0.932, 0.981 and 0.933, respectively.展开更多
文摘The Yaounde Group(YG),representing the southern edge of the North Equatorial PanAfrican Belt,consists of quartzites,schists,micaschists,amphibolites,gneisses and migmatites.Tectonism has formed a landscape characterized by the development of linear and folded valleys and ridges,fault scarps,V-shaped valleys,incised rivers and knickpoints.These landforms constitute important markers of the regional tectonic activity,which have been computed from spatial sources such as SRTM,DEM,hydrographical networks and geomorphic indices such as AF,T,Smf,Vf,Bs,Hi,U,SI and Li.The results highlighted a mature relief consisting of asymmetric basins generated by tilting and uplift phenomena.The relative index of active tectonics(RIAT)has been estimated from an average of eight geomorphic indices evaluated on 24 subbasins,in the study area.Four classes have been defined:class 1(1.38),very high active(1.0≤RIAT<1.5);class 2(1.50-1.88),high active(1.5≤RIAT<2.0);and class 3(2.00-2.13)moderate active(2.0≤RIAT<2.5).These three classes,respectively covering 10.20%(458 km2),80.10%(3595 km2)and 9.69%(435 km2)of the study area,have shown a highly active tectonic zone,and imply the existence of a neotectonic event in the YG.This tectonic unit(YG)was also affected by the dextral NW-SE strike-slip faulting,which cross-cut the Sanaga Shear Zone(SSZ)at Ebebda and the foliation oriented NW-SE.The tilting and uplift of rocks related to Moho ascending are responsible for crustal thinning in the Cameroon basement,more important to the Adamawa Plateau from the Cretaceous age and the reactivation of existing tectonic accidents.The presence of hills,fault scarps,reverse faults,knickpoints,V and U shaped valleys and rounded mountains testify to the interaction between tectonic uplift,lithology,climate,weathering and erosion.
基金DG ISR and DST (GoG) for providing required supportDMC Dadra and Nagar Haveli (DNH/1255) for providing financial support。
文摘The present study area,Dadra and Nagar Haveli,contains several lineaments and traces of active faults.The various aspect of the geomo rphic analysis,i.e.,stream length(SL) gradient,hypsometric integral(HI),basin shape(BS),valley floor(VF),have been applied to evaluate the relative index of active tectonics(RIAT) of the Damanganga watershed.The high and low zones of tectonic activity have been identified based on the geomorphic analysis of the watershed.After evaluation of all indices,three classes,class IIhigh(1.3 ≤RIAT <1.5),class Ⅲ-moderate(1.5 ≤RIAT <1.8),and class Ⅳ-low(1.8 ≤RIAT),have been obtained to outline the degree/gradation of comparative tectonic activities in the study area.The appraised outcome of the RIAT dispersal is also well reinforced by the geomorphic evidence in the field.The collective outcomes of geomorphic evidence,such as stream deflection and analysis of lineament,deflection of streams,and geomorphic indices,conceal that the Damanganga watershed is affected by tectonic activity.
基金Supported by The Japan Society for the Promotion of Science,No.21590412The Osaka Foundation for the Prevention of Cancer and Cardiovascular Diseases
文摘AIM: To examine the association of hepatoma-derived growth factor(HDGF) expression with the prognosis of patients with cervical cancer of the uterus(CC). METHODS: HDGF is a unique nuclear growth factor, and it may play an important role in the development and progression of carcinoma. HDGF expression in 88 CC patients aged 23 to 76 years(median, 54 years) was analyzed by immunohistochemistry. A rabbit polyclonal antibody against the C-terminal amino acids(aa 231-240) of the human HDGF sequence was used as primary antibody at a dilution of 1:5000. This specific anti-HDGF antibody was purified using C-terminal peptide-conjugated Sepharose columns. Staining of endothelial cells in the noncancerous areas of each specimen was used as an internal positive control. Samples with more than 80% of tumor cells showing positive immunoreactivity in both the nucleus and cytoplasm were regarded as HDGF index level 2, more than 80% positive immunoreactivity in either the nucleus or cytoplasm as level 1, and less than 80% in both the nucleus and cytoplasm as level 0. The chisquare test and Fisher's exact probability test were used to examine the relationship between HDGF expression and clinicopathologic parameters, and statistical significance was examined by the log-rank test. Multivariate analysis of factors related to survival was performed using Cox's proportional hazards regression model. Statistical significance was set at P < 0.05. RESULTS: The five-year overall survival rate was 82.9%. Fourteen patients died due to tumors, nine of whom had tumor recurrence at 2-21 mo(median, 10 mo) after surgery. Tumor recurrence in five patients was determined at the time of the patients' deaths. Nineteen cases were regarded as HDGF index level 0, 11 as level 1, and 58 as level 2. Patients with level 2 expression showed higher rates of histological classification of keratinized squamous cell carcinomaand adenosquamous carcinoma(44.8% of level 2 patients and 13.3% in levels 0 and 1), deep invasion(p T2-4 in 65.5% of level 2 patients, and 30.0% in levels 0 and 1), the presence of lymphatic invasion(50.0% in level 2, and 20.0% in levels 0 and 1), and the presence of lymph node metastasis(37.9% in level 2, and 6.7% in levels 0 and 1). Patients with an HDGF index of level 2 CC showed poorer 5-year overall survival rates than those with level 0 or 1 CC(74.0% and 100%, respectively, P = 0.0036). Univariate analysis revealed that histological classification(P = 0.04), depth of tumor invasion(P = 0.0001), vascular invasion(P = 0.004), and lymph node metastasis(P = 0.0001) were significant factors affecting overall survival in addition to HDGF expression. Multivariate analysis revealed HDGF expression level and lymph node metastasis as independent prognostic factors for overall survival(P = 0.0148 and P = 0.0197, respectively). The prognostic significance of HDGF was further analyzed in p T1 and p T2-4 patient groups, respectively. Among patients with p T1 CC, one the 39 analyzed patients died during the study, and no difference was observed among patients with HDGF index level 0, 1, or 2 CC. However, prognostic significance of the HDGF index was observed in the p T2-4 patient group, in which the mortality rates of patients with HDGF index level 2 CC and those with level 0 or 1 CC significantly differed(P = 0.0463). CONCLUSION: The HDGF expression level is of prognostic significance in CC.
文摘A novel portable analyzer for raw milk quality control during the material purchase at dairy plants was developed, by which the percentages（mass fraction） of main components including total protein, fat, and lactose of an unhomogenized milk sample could be determinated in 1 min with the help of non-dispersive short-wave near-infrared （NDSWNIR） spectrometry in a wavelength range from 600 nm to 1100 nm and multivariate calibration. The analyzer was designed with a single-beam optical system, which comprised a temperature control module, a multi-channel narrow-band light source（16 wavelengths）, a glass absorption cell with 15 mm sample thickness, a silicon photodiode detector, several compound lenses and a recorder module. A total of 80 raw milk samples were collected at a dairy farm twice a month for 4 months. The samples were scanned with a common UV-Vis-NIR spectrometer and analyzed according to China GB standard methods. The uninformative variables elimination（UVE） method was carried out on the spectrum data and the percentages of main components of all the samples to choose the peak emitting wavelength of each channel of the light source. Another 90 raw milk samples were collected from the same dairy farm thrice a month for 3 months. The samples were analyzed according to China GB standard methods and with the proposed analyzer. The percentages of the main components and the NDSWNIR absorption data of the samples were used for the construction and validation of the multivariate calibration model with partial least squares（PLS） method. The root-mean-square errors of prediction（RMSEP） of total protein, fat and lactose were 0.201, 0.172 and 0.247 and the coefficients of correlation（R） were 0.932, 0.981 and 0.933, respectively.
