RNA interference(RNAi)targeting lethal genes in insects has great potential for sustainable crop protection.Compared with traditional double-stranded(ds)RNA delivery systems,nanoparticles such as chitosan,liposomes,an...RNA interference(RNAi)targeting lethal genes in insects has great potential for sustainable crop protection.Compared with traditional double-stranded(ds)RNA delivery systems,nanoparticles such as chitosan,liposomes,and cationic dendrimers offer advantages in delivering dsRNA/small interfering(si)RNA to improve RNAi efficiency,thus promoting the development and practice of RNAi-based pest management strategies.Here,we illustrate the limitations of traditional dsRNA delivery systems,reveal the mechanism of nanoparticle-mediated RNAi,summarize the recent progress and successful applications of nanoparticle-mediated RNAi in pest management,and finally address the prospects of nanoparticle-based RNA pesticides.展开更多
基金the Beijing Natural Science Foundation(6204043)National Natural Science Foundation of China(31900363).
文摘RNA interference(RNAi)targeting lethal genes in insects has great potential for sustainable crop protection.Compared with traditional double-stranded(ds)RNA delivery systems,nanoparticles such as chitosan,liposomes,and cationic dendrimers offer advantages in delivering dsRNA/small interfering(si)RNA to improve RNAi efficiency,thus promoting the development and practice of RNAi-based pest management strategies.Here,we illustrate the limitations of traditional dsRNA delivery systems,reveal the mechanism of nanoparticle-mediated RNAi,summarize the recent progress and successful applications of nanoparticle-mediated RNAi in pest management,and finally address the prospects of nanoparticle-based RNA pesticides.
