The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the associations.We first comp...The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the associations.We first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc database.We then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA chain.In the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell transcriptomes.Additionally,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting carcinogenesis.In conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.展开更多
Two months into the year 2003 and one month into the Chinese lunar NewYear of goat,on behalf of the editorial board of the Chinese Journal of Integra-tive Medicine,I wish our readers,contributors and board members aro...Two months into the year 2003 and one month into the Chinese lunar NewYear of goat,on behalf of the editorial board of the Chinese Journal of Integra-tive Medicine,I wish our readers,contributors and board members around theworld a prosperous and successful new year.展开更多
Ayurveda is one of the most ancient medical prac-tice in the world with a history of 5000 years. Vajikaranais a branch of Ayurveda dealing with male potency andfertility. Almost all male diseases and therapeutic mea-s...Ayurveda is one of the most ancient medical prac-tice in the world with a history of 5000 years. Vajikaranais a branch of Ayurveda dealing with male potency andfertility. Almost all male diseases and therapeutic mea-sures have been described here. In the International Symposium on Ayurveda andOther Traditional Medicines, two scientific Sessions wereexclusively devoted to Rasayana (rejuvenation) and Va-jikarana, conducted on January 5- 6, 2000 at GujaratAyurved University, Jamnagar under the patronship ofthe Honorable Vice-Chancellor, Dr. P. N. V. Kurup.Besides the Indian specialists, scientists from Australia,展开更多
基金supported by the Medical Research Project of Jiangsu Commission of Health(Grant No.M2022015).
文摘The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the associations.We first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc database.We then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA chain.In the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell transcriptomes.Additionally,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting carcinogenesis.In conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.
文摘Two months into the year 2003 and one month into the Chinese lunar NewYear of goat,on behalf of the editorial board of the Chinese Journal of Integra-tive Medicine,I wish our readers,contributors and board members around theworld a prosperous and successful new year.
文摘Ayurveda is one of the most ancient medical prac-tice in the world with a history of 5000 years. Vajikaranais a branch of Ayurveda dealing with male potency andfertility. Almost all male diseases and therapeutic mea-sures have been described here. In the International Symposium on Ayurveda andOther Traditional Medicines, two scientific Sessions wereexclusively devoted to Rasayana (rejuvenation) and Va-jikarana, conducted on January 5- 6, 2000 at GujaratAyurved University, Jamnagar under the patronship ofthe Honorable Vice-Chancellor, Dr. P. N. V. Kurup.Besides the Indian specialists, scientists from Australia,
