Plasma is an ionized gas.It is typically formed at high temperature.As a result of both the development of bow-temperature plasma sources and a better understanding of complex plasma phenomena over the last decade,&qu...Plasma is an ionized gas.It is typically formed at high temperature.As a result of both the development of bow-temperature plasma sources and a better understanding of complex plasma phenomena over the last decade,"plasma medicine"has become a booming interdisciplinary research topic of growing importance that explores enormous opportunities at the interface of chemistry,plasma physics,and biomedical sciences with engineering.This review presents the latest development in plasma medicine in the area of the central nervous system and aims to introduce cutting-edge plasma medicine to clinical and translational medical researchers and practitioners.展开更多
Gastric cancer is one of common malignant tumors from a global perspective, and its morbidity ranks the forth and also the second largest cause of cancer-related death worldwide. Many factors can cause gastric cancer,...Gastric cancer is one of common malignant tumors from a global perspective, and its morbidity ranks the forth and also the second largest cause of cancer-related death worldwide. Many factors can cause gastric cancer, including helicobacter pylori infection, chronic inflammation, genetic factors et al. Among all of these, helicobacter pylori infection can significantly increase the production of reactive oxygen species（ROS） and reactive nitrogen species（RNS） in human stomach, which can cause the oxidative stress. Oxidative stress plays an important role in the pathogenesis of gastro-intestinal diseases such as mucosal damage, gastro-intestinal ulcers and cancer. Modern therapeutic treatments such as surgery and chemotherapy have undesired side effects, so the antioxidant therapy gains more and more attentions. Antioxidant therapy system comprises of various antioxidants（SOD, catalase, glutathione peroxidase and carnosine） and Chinese herbal medicine, which is mainly focused on the chemoprevention. Natural products and their derivatives, such as tea polyphenol, resveratrol and vitamins, have some potential benefits on their chemoprevention. Besides, much work has been done to understand the role of dietary factors playing in the prevention of gastrointestinal cancers. In this review based on some valuable studies, we aim to make some brief summaries about risk factors, pathogenic mechanism of oxidative stress and antioxidants therapy in gastric cancer.展开更多
Oxidative stress leads to chondrocyte apoptosis and extracellular matrix(ECM)degradation,thus contributing to the pathogenesis of osteoarthritis(OA).Herein,curcumin with remarkable antioxidant and anti-inflammatory ac...Oxidative stress leads to chondrocyte apoptosis and extracellular matrix(ECM)degradation,thus contributing to the pathogenesis of osteoarthritis(OA).Herein,curcumin with remarkable antioxidant and anti-inflammatory activities has been employed as an organic ligand to coordinate ferric ions for enhancing the water-solubility and biocompatibility of natural product curcumin.The obtained iron-curcumin-based coordination nanoparticles(Fe-Cur NPs)exhibit great water-solubility and efficient reactive oxygen/nitrogen species(ROS/RNS)scavenging ability.In vitro chondrocyte evaluation experiments indicated that the intracellular ROS/RNS induced by interleukin 1β(IL-1β)could be efficiently scavenged by these Fe-Cur NPs and oxidative-stressinduced cell death could be preserved as well.In addition,post intra-articular(i.a.)injection into OA rat joints,Fe-Cur NPs could greatly inhibit OA progression via activating the nuclear factor-erythroid 2 related factor-2(Nrf2)and inhibiting nod-like receptor protein-3(NLRP3)inflammasome activation in primary rat chondrocytes,as well as decrease the production of matrix degrading proteases and other inflammatory mediators.The efficient antioxidation and anti-inflammation performance of Fe-Cur NPs endow them as a promising nanoplatform for treatment of various inflammatory diseases,and more detailed researches will be conducted in the future.展开更多
Homeostasis of gut microbiota is extremely essential for maintaining nutrient metabolism and regulating immunological function.The increasing evidence suggests that inflammatory bowel disease(IBD)is strongly associate...Homeostasis of gut microbiota is extremely essential for maintaining nutrient metabolism and regulating immunological function.The increasing evidence suggests that inflammatory bowel disease(IBD)is strongly associated with dysregulation of gut microbiota.During activated inflammation,excessive reactive oxygen species(ROS)and reactive nitrogen species(RNS)produced by inflammatory cells play a detrimental role in regulating IBD and gut microbiota.ROS/RNS cause damage to the surrounding tissues,including nutrient absorption disorders,intestinal dysmotility and barrier dysfunction.Meanwhile,ROS/RNS provide terminal electron receptors for anaerobic respiration and support the bloom of facultative anaerobes,eventually causing gut microbiota dysbiosis.Redox-active nanoparticles(NPs)with catalytic properties or enzyme-like activities can effectively scavenge ROS/RNS,and selectively target inflamed sites via ultrasmall size-mediated enhanced permeation and retention(EPR)effect,showing great potential to regulate IBD and maintain the homeostasis of gut microbiota.In addition,the widespread application of NPs in commercial products 1 has increased their accumulation in healthy organisms,and the biological effects on normal microbiota resulting from long-term exposure of NPs to gastrointestinal tract also need attention.展开更多
基金the National Natural Science Foundation of China(nos.51707012 and 11475019).
文摘Plasma is an ionized gas.It is typically formed at high temperature.As a result of both the development of bow-temperature plasma sources and a better understanding of complex plasma phenomena over the last decade,"plasma medicine"has become a booming interdisciplinary research topic of growing importance that explores enormous opportunities at the interface of chemistry,plasma physics,and biomedical sciences with engineering.This review presents the latest development in plasma medicine in the area of the central nervous system and aims to introduce cutting-edge plasma medicine to clinical and translational medical researchers and practitioners.
基金National Natural Science Foundation of China(Grant Nos.31471338,81260338)
文摘Gastric cancer is one of common malignant tumors from a global perspective, and its morbidity ranks the forth and also the second largest cause of cancer-related death worldwide. Many factors can cause gastric cancer, including helicobacter pylori infection, chronic inflammation, genetic factors et al. Among all of these, helicobacter pylori infection can significantly increase the production of reactive oxygen species（ROS） and reactive nitrogen species（RNS） in human stomach, which can cause the oxidative stress. Oxidative stress plays an important role in the pathogenesis of gastro-intestinal diseases such as mucosal damage, gastro-intestinal ulcers and cancer. Modern therapeutic treatments such as surgery and chemotherapy have undesired side effects, so the antioxidant therapy gains more and more attentions. Antioxidant therapy system comprises of various antioxidants（SOD, catalase, glutathione peroxidase and carnosine） and Chinese herbal medicine, which is mainly focused on the chemoprevention. Natural products and their derivatives, such as tea polyphenol, resveratrol and vitamins, have some potential benefits on their chemoprevention. Besides, much work has been done to understand the role of dietary factors playing in the prevention of gastrointestinal cancers. In this review based on some valuable studies, we aim to make some brief summaries about risk factors, pathogenic mechanism of oxidative stress and antioxidants therapy in gastric cancer.
基金This research was supported by the National Research Program of China(No.2016YFA0201200)the National Natural Science Foundation of China(Nos.U20A20254 and 52072253)+2 种基金the China Postdoctoral Science Foundation(No.2021TQ0229)the Collaborative Innovation Center of Suzhou Nano Science and Technology,the Preponderant Discipline Supporting Project of the Second Affiliated Hospital of Soochow University(No.XKTJXK202003)the Suzhou Special Foundation for the Key Diseases Diagnosis and Treatment(Nos.LCZX201904 and LCZX201708).
文摘Oxidative stress leads to chondrocyte apoptosis and extracellular matrix(ECM)degradation,thus contributing to the pathogenesis of osteoarthritis(OA).Herein,curcumin with remarkable antioxidant and anti-inflammatory activities has been employed as an organic ligand to coordinate ferric ions for enhancing the water-solubility and biocompatibility of natural product curcumin.The obtained iron-curcumin-based coordination nanoparticles(Fe-Cur NPs)exhibit great water-solubility and efficient reactive oxygen/nitrogen species(ROS/RNS)scavenging ability.In vitro chondrocyte evaluation experiments indicated that the intracellular ROS/RNS induced by interleukin 1β(IL-1β)could be efficiently scavenged by these Fe-Cur NPs and oxidative-stressinduced cell death could be preserved as well.In addition,post intra-articular(i.a.)injection into OA rat joints,Fe-Cur NPs could greatly inhibit OA progression via activating the nuclear factor-erythroid 2 related factor-2(Nrf2)and inhibiting nod-like receptor protein-3(NLRP3)inflammasome activation in primary rat chondrocytes,as well as decrease the production of matrix degrading proteases and other inflammatory mediators.The efficient antioxidation and anti-inflammation performance of Fe-Cur NPs endow them as a promising nanoplatform for treatment of various inflammatory diseases,and more detailed researches will be conducted in the future.
基金supported by the National Natural Science Foundation of China(Nos.91859101,81971744,U1932107,and 81471786)the National Natural Science Foundation of Tianjin(No.19JCZDJC34000)the Innovation Foundation of Tianjin University.
文摘Homeostasis of gut microbiota is extremely essential for maintaining nutrient metabolism and regulating immunological function.The increasing evidence suggests that inflammatory bowel disease(IBD)is strongly associated with dysregulation of gut microbiota.During activated inflammation,excessive reactive oxygen species(ROS)and reactive nitrogen species(RNS)produced by inflammatory cells play a detrimental role in regulating IBD and gut microbiota.ROS/RNS cause damage to the surrounding tissues,including nutrient absorption disorders,intestinal dysmotility and barrier dysfunction.Meanwhile,ROS/RNS provide terminal electron receptors for anaerobic respiration and support the bloom of facultative anaerobes,eventually causing gut microbiota dysbiosis.Redox-active nanoparticles(NPs)with catalytic properties or enzyme-like activities can effectively scavenge ROS/RNS,and selectively target inflamed sites via ultrasmall size-mediated enhanced permeation and retention(EPR)effect,showing great potential to regulate IBD and maintain the homeostasis of gut microbiota.In addition,the widespread application of NPs in commercial products 1 has increased their accumulation in healthy organisms,and the biological effects on normal microbiota resulting from long-term exposure of NPs to gastrointestinal tract also need attention.
