A traditional HPLC and a rapid resolution (RRLC) method coupled with triple Q MS was established to determine the di-methyl di-carbamidine in plasma.Result showed that RRLC-MS/MS obtained a low LOD at 0.14 pg on colum...A traditional HPLC and a rapid resolution (RRLC) method coupled with triple Q MS was established to determine the di-methyl di-carbamidine in plasma.Result showed that RRLC-MS/MS obtained a low LOD at 0.14 pg on column compared to 0.83 pg by conventional HPLC-MS/MS and thus increased sensitivity by 6 times,shortened analytical time by 3 times while maintaining a satisfactory testing result using Agilent LCQQQ.展开更多
文摘A traditional HPLC and a rapid resolution (RRLC) method coupled with triple Q MS was established to determine the di-methyl di-carbamidine in plasma.Result showed that RRLC-MS/MS obtained a low LOD at 0.14 pg on column compared to 0.83 pg by conventional HPLC-MS/MS and thus increased sensitivity by 6 times,shortened analytical time by 3 times while maintaining a satisfactory testing result using Agilent LCQQQ.
