RS10-CLOUD快速开发平台,是RS10-CLOUD云平台的重要组成部分,其隶属于国家重大项目,是一个面向零散制造业管理市场,支撑企业生产管理类实现的低代码开发平台。主要描述了基于RS10-CLOUD快速开发平台模块优化的过程。出发点在于面对当今...RS10-CLOUD快速开发平台,是RS10-CLOUD云平台的重要组成部分,其隶属于国家重大项目,是一个面向零散制造业管理市场,支撑企业生产管理类实现的低代码开发平台。主要描述了基于RS10-CLOUD快速开发平台模块优化的过程。出发点在于面对当今中国企业跨界转产已涵盖到了各个不同的领域的形势,转产过程中工业生产管理环境的业务数据分类及含义的二义性无形中增加了生产管理换件人工控制的成本。因此在RS10-CLOUD工业管理软件中,引入了工业标签统一管理动态生效的逻辑,其在开发阶段统一定义工业术语、工业业务标签并注入到页面;在软件应用阶段可以持续维护,并且实现页面自动生效。在这种开发模式的考量下,创新性地在此类软件中采用加入先验知识的神经网络机器翻译NMT进行训练,同时基于训练可行性和翻译模型的准确性,运用TLA(target language lemmas)进行约束训练,得到了从中文到英文的翻译模型。为汇总对比国内外工业属性的含义,最终实现多语言翻译,从而减少合资企业,输出型产业的生产管理成本提供考量。展开更多
AIM To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus(HCV) infection(OCI).METHODS One hundred and three cases of seronegative OCI and 155...AIM To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus(HCV) infection(OCI).METHODS One hundred and three cases of seronegative OCI and 155 cases of seropositive chronic HCV infection(CHC) were diagnosed at five Liver Centers in Northeastern China, from 2012 to 2016. CXCL10 rs1439490, rs1440802, and IL-28 B rs12979860 were analyzed by sequencing. Serum CXCL10 was measured by ELISA. Intrahepatic CXCL10 was determined by quantitative PCR and immunohistochemical semi-quantitative scoring. Liver necroinflammation and fibrosis were scored according to the METAVIR system.RESULTS CXCL10 rs1439490 G/G was more prevalent in OCI patients(n = 93/103; 90.3%) than in CHC patients(n = 116/155; 74.8%; P = 0.008). OCI patients had lower serum CXCL10 levels than CHC patients(192.91 ± 46.50 pg/mL vs 354.78 ± 102.91 pg/mL, P < 0.0001). Of IL-28 B rs12979860 C/C patients, OCI patients with rs1439490 G/G had lower serum and liver levels of CXCL10 and lower levels of liver necroinflammation and fibrosis than non-G/G patients. OCI patients had higher alanine aminotransferase normalization rates after Peginterferon treatment than CHC patients(P < 0.05) and serum CXCL10 decreased significantly(P < 0.0001). Liver necroinflammation and fibrosis were alleviated in 8 OCI patients after treatment. Multivariate analysis indicated that rs1439490 G/G significantly influenced the occurrence of OCI in HCV infection(OR = 0.31, 95%CI: 0.15-0.66, P = 0.002).CONCLUSION CXCL10 rs1439490 G/G is positively associated with OCI in HCV infection and antiviral outcome.展开更多
目的本研究拟通过Meta分析来更好的阐明IL-10基因rs1800872多态性与慢性白血病(CL)易感性的关系。方法检索了从建库至2021年4月发表在PubMed,Cochrane library,Embase,Web of Science databases,万方和中国知网中的相关文献,最终纳人4...目的本研究拟通过Meta分析来更好的阐明IL-10基因rs1800872多态性与慢性白血病(CL)易感性的关系。方法检索了从建库至2021年4月发表在PubMed,Cochrane library,Embase,Web of Science databases,万方和中国知网中的相关文献,最终纳人4项病例对照研究,共涉及744名参与者。结果在杂合子共显性模型[CA us AA,OR 0.22(0.08~0.66),P=0.007]和超显性模型[CA vs CC+AA,OR 0.35(0.16~0.76),P=0.008]的结果中,观察到IL-10 rs1800872的CA基因型与慢性淋巴细胞白血病易感性降低的关系有统计学意义。此外,在这两个模型中,同样观察到IL-10 rs1800872的CA基因型也与亚洲人群CL易感性降低可能相关。结论当前的Meta分析表明IL-10基因rs1800872多态性可能作为CL早期临床筛查的一个潜在生物标志物,有助于提高临床CL患者的个体化预防及靶向药物的开发。展开更多
文摘RS10-CLOUD快速开发平台,是RS10-CLOUD云平台的重要组成部分,其隶属于国家重大项目,是一个面向零散制造业管理市场,支撑企业生产管理类实现的低代码开发平台。主要描述了基于RS10-CLOUD快速开发平台模块优化的过程。出发点在于面对当今中国企业跨界转产已涵盖到了各个不同的领域的形势,转产过程中工业生产管理环境的业务数据分类及含义的二义性无形中增加了生产管理换件人工控制的成本。因此在RS10-CLOUD工业管理软件中,引入了工业标签统一管理动态生效的逻辑,其在开发阶段统一定义工业术语、工业业务标签并注入到页面;在软件应用阶段可以持续维护,并且实现页面自动生效。在这种开发模式的考量下,创新性地在此类软件中采用加入先验知识的神经网络机器翻译NMT进行训练,同时基于训练可行性和翻译模型的准确性,运用TLA(target language lemmas)进行约束训练,得到了从中文到英文的翻译模型。为汇总对比国内外工业属性的含义,最终实现多语言翻译,从而减少合资企业,输出型产业的生产管理成本提供考量。
基金Supported by the National Natural Science Foundation of China,No.81670533the Jilin Provincial Science&Technology Department,No.2013 0102088JCthe Jilin Provincial Development and Reform Commission,No.2013C028-3
文摘AIM To examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus(HCV) infection(OCI).METHODS One hundred and three cases of seronegative OCI and 155 cases of seropositive chronic HCV infection(CHC) were diagnosed at five Liver Centers in Northeastern China, from 2012 to 2016. CXCL10 rs1439490, rs1440802, and IL-28 B rs12979860 were analyzed by sequencing. Serum CXCL10 was measured by ELISA. Intrahepatic CXCL10 was determined by quantitative PCR and immunohistochemical semi-quantitative scoring. Liver necroinflammation and fibrosis were scored according to the METAVIR system.RESULTS CXCL10 rs1439490 G/G was more prevalent in OCI patients(n = 93/103; 90.3%) than in CHC patients(n = 116/155; 74.8%; P = 0.008). OCI patients had lower serum CXCL10 levels than CHC patients(192.91 ± 46.50 pg/mL vs 354.78 ± 102.91 pg/mL, P < 0.0001). Of IL-28 B rs12979860 C/C patients, OCI patients with rs1439490 G/G had lower serum and liver levels of CXCL10 and lower levels of liver necroinflammation and fibrosis than non-G/G patients. OCI patients had higher alanine aminotransferase normalization rates after Peginterferon treatment than CHC patients(P < 0.05) and serum CXCL10 decreased significantly(P < 0.0001). Liver necroinflammation and fibrosis were alleviated in 8 OCI patients after treatment. Multivariate analysis indicated that rs1439490 G/G significantly influenced the occurrence of OCI in HCV infection(OR = 0.31, 95%CI: 0.15-0.66, P = 0.002).CONCLUSION CXCL10 rs1439490 G/G is positively associated with OCI in HCV infection and antiviral outcome.
文摘目的本研究拟通过Meta分析来更好的阐明IL-10基因rs1800872多态性与慢性白血病(CL)易感性的关系。方法检索了从建库至2021年4月发表在PubMed,Cochrane library,Embase,Web of Science databases,万方和中国知网中的相关文献,最终纳人4项病例对照研究,共涉及744名参与者。结果在杂合子共显性模型[CA us AA,OR 0.22(0.08~0.66),P=0.007]和超显性模型[CA vs CC+AA,OR 0.35(0.16~0.76),P=0.008]的结果中,观察到IL-10 rs1800872的CA基因型与慢性淋巴细胞白血病易感性降低的关系有统计学意义。此外,在这两个模型中,同样观察到IL-10 rs1800872的CA基因型也与亚洲人群CL易感性降低可能相关。结论当前的Meta分析表明IL-10基因rs1800872多态性可能作为CL早期临床筛查的一个潜在生物标志物,有助于提高临床CL患者的个体化预防及靶向药物的开发。
