Inositol phospholipids are concentrated in the cytosolic surface of membranes. Phosphatidylinositol （PtdIns）, the precursor of phosphoinositides, is synthesized primarily in the endoplasmic reticulum. Reversible pho...Inositol phospholipids are concentrated in the cytosolic surface of membranes. Phosphatidylinositol （PtdIns）, the precursor of phosphoinositides, is synthesized primarily in the endoplasmic reticulum. Reversible phosphorylation in the inositol ring of PtdIns at positions 3, 4 and 5 results in the generation of seven phosphoinositide species： PtdIns（3）P, PtdIns（4）P, PtdIns（5）P, PtdIns（3,4）P2, PtdIns（3,5）P2, PtdIns（4,5）P2, PtdIns（3,4,5）P3. Phos- phoinositides can be rapidly interconverted from one species to another by strategically localized kinases and phosphatases [1]. Phosphoinositides play a fundamental role in controlling membrane-cytosol interfaces [2]. They are essential regulators of many cellular functions, including classical signal transduction, membrane trafficking, cytoskeletal organization, nuclear events, cell survival versus apoptosis, motility and the permeability and transport of membranes [1, 3].展开更多
文摘Inositol phospholipids are concentrated in the cytosolic surface of membranes. Phosphatidylinositol （PtdIns）, the precursor of phosphoinositides, is synthesized primarily in the endoplasmic reticulum. Reversible phosphorylation in the inositol ring of PtdIns at positions 3, 4 and 5 results in the generation of seven phosphoinositide species： PtdIns（3）P, PtdIns（4）P, PtdIns（5）P, PtdIns（3,4）P2, PtdIns（3,5）P2, PtdIns（4,5）P2, PtdIns（3,4,5）P3. Phos- phoinositides can be rapidly interconverted from one species to another by strategically localized kinases and phosphatases [1]. Phosphoinositides play a fundamental role in controlling membrane-cytosol interfaces [2]. They are essential regulators of many cellular functions, including classical signal transduction, membrane trafficking, cytoskeletal organization, nuclear events, cell survival versus apoptosis, motility and the permeability and transport of membranes [1, 3].
