In recent years,the anti-tumor activity of Donglingeao(Rabdosiae Rubescentis Herba)has received much attention.The diterpenoid rubescensine A as its main anti-cancer active component has anti-tumor,anti-bacterial,anti...In recent years,the anti-tumor activity of Donglingeao(Rabdosiae Rubescentis Herba)has received much attention.The diterpenoid rubescensine A as its main anti-cancer active component has anti-tumor,anti-bacterial,anti-inflammatory pharmacological effects.At present,researches on the chemical composition,phar-macological effects and clinical application of Donglingeao(Rabdosiae Rubescentis Herba)have made impor-tant progress.The upstream key enzyme genes have basically been cloned in the biosynthesis pathway of diter-penoids.However,the synthetic route of rubescensine A is not clear,and there are few reports on the cyto-chrome P450 family that regulates the synthesis of rubescensine A.Therefore,it is necessary to further study the key enzyme genes that regulate the synthesis of rubescensine A to provide research basis for the in vitro synthesis of rubescensine A.展开更多
基金We thank for the funding support from the National Natural Science Foundation of China(00108028)。
文摘In recent years,the anti-tumor activity of Donglingeao(Rabdosiae Rubescentis Herba)has received much attention.The diterpenoid rubescensine A as its main anti-cancer active component has anti-tumor,anti-bacterial,anti-inflammatory pharmacological effects.At present,researches on the chemical composition,phar-macological effects and clinical application of Donglingeao(Rabdosiae Rubescentis Herba)have made impor-tant progress.The upstream key enzyme genes have basically been cloned in the biosynthesis pathway of diter-penoids.However,the synthetic route of rubescensine A is not clear,and there are few reports on the cyto-chrome P450 family that regulates the synthesis of rubescensine A.Therefore,it is necessary to further study the key enzyme genes that regulate the synthesis of rubescensine A to provide research basis for the in vitro synthesis of rubescensine A.
