This study was conducted to explore the correlations between the expression,methylation,and various clinicopathological factors of purinergic P2X1 receptor(P2RX1)and the prognosis of patients with gastrointestinal tum...This study was conducted to explore the correlations between the expression,methylation,and various clinicopathological factors of purinergic P2X1 receptor(P2RX1)and the prognosis of patients with gastrointestinal tumors.The Cancer Genome Atlas(TCGA)and the Genotype-Tissue Expression(GTEx)databases were used to analyze the expression of P2RX1 in different types of gastrointestinal cancers.Kaplan-Meier analysis and univariate Cox regression analysis were used to analyze the correlations between P2RX1 expression and the prognosis of various gastrointestinal tumors.Correlations between P2RX1 expression and N6 methyladenine(m6A)-related genes as well as immune checkpoint genes were analyzed by R packages(R version:4.0.3)based on TCGA database.The association between P2RX1 methylation level and the prognosis of patients with gastrointestinal cancers was analyzed using the MethSurv database.In order to explore the biological functions of P2RX1 in hepatocellular carcinoma,the Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analysis were carried out using R software.In order to evaluate the correlations between P2RX1 and tumor immune infiltration,Spearman correlation test was performed.The correlations between P2RX1 expression and immune score as well as immune checkpoint genes were analyzed based on TCGA and Tumor Immune Estimation Resource(TIMER)databases.The expression of P2RX1 was found to be significantly downregulated in gastrointestinal tumors except in cholangiocarcinoma(P<0.05).High expression of P2RX1 tended to present better prognosis in hepatocellular carcinoma(P<0.05).It was noted that cg06475633 of P2RX1 presented a higher methylation level compared with other CpG sites in hepatocellular carcinoma.Overall,six CpGs of P2RX1 were associated with significant prognosis in patients with hepatocellular carcinoma(P<0.05).Among all the 20 m6A-related genes,Wilms'tumor 1-associating protein(WTAP)was the most strongly correlated with P2RX1 in hepatocellular carcinoma.Gene enrichment analysis showed that P2RX1 is widely involved in the proliferation,activation,organization,and differentiation of various immune cells.After investigating the TIMER database,P2RX1 was found to be tightly correlated with immune infiltrating cells in gastrointestinal tumors,especially with dendritic cells.Moreover,P2RX1 was found to be strongly positively associated with programmed cell death 1(PD1),programmed death-ligand 1(PD-L1),and cytotoxic T-lymphocyte-associated protein 4(CTLA4)in hepatocellular carcinoma(P<0.05).In conclusion,the dual role of P2RX1 in cancers and its involvement in the recruitment as well as regulation of tumor infiltrating cells in gastrointestinal cancers may be appreciated through this study.展开更多
Hard X-rays above 10 keV are detected from several anomalous X-ray pul- sars （AXPs） and soft gamma-ray repeaters （SGRs）, and different models have been proposed to explain the physical origin within the frame of e...Hard X-rays above 10 keV are detected from several anomalous X-ray pul- sars （AXPs） and soft gamma-ray repeaters （SGRs）, and different models have been proposed to explain the physical origin within the frame of either a magnetar model or a fallback disk system. Using data from Suzaku and INTEGRAL, we study the soft and hard X-ray spectra of four AXPs/SGRs： 1RXS J 170849-400910, 1E 1547.0- 5408, SGR 1806-20 and SGR 0501＋4516. It is found that the spectra could be well reproduced by the bulk-motion Comptonization （BMC） process as was first suggested by Triimper et al., showing that the accretion scenario could be compatible with X- ray emission from AXPs/SGRs. Simulated results from the Hard X-ray Modulation Telescope using the BMC model show that the spectra would have discrepancies from the power-law, especially the cutoff at -200 keV. Thus future observations will allow researchers to distinguish different models of the hard X-ray emission and will help us understand the nature of AXPs/SGRs.展开更多
RXS 1232953.9+062814 was identified as a cataclysmic variable by Wei et al. (1999). Four low-resolution spectra of 1RXS J232953.9+062814 were obtained with the 2.16-rn telescope of the National Astronomical Observator...RXS 1232953.9+062814 was identified as a cataclysmic variable by Wei et al. (1999). Four low-resolution spectra of 1RXS J232953.9+062814 were obtained with the 2.16-rn telescope of the National Astronomical Observatories, of which two were at outburst, and two were at quiescence. The system is about 16.8 B and 16.5 V at quiescence, and 12.6 B and 12.6 V at outburst. The quiescent spectra were dominated by double-peaked Balmer emissions, which indicates a hydrogen-rich system with a high-inclination accretion disc. MgH and TiO absorption bands appeared in the quiescent spectrum which implies a companion with a spectral type of early M dwarf. If we take it as a MO dwarf, then the system is located at a distance of 350 pc with a proper motion velocity 150 km s-1. The superhump period of 0.046311 days was confirmed by our V photometry. The short period and the hydrogen-rich nature reveal that this system is another SU Ursae Majoris-type dwarf nova below the period minimum after V485 Centauri. 1RXS J23 2953.9+062814 is one of the most important systems for studying the evolutionary scenario of cataclysmic variables since it is much brighter than V485 Cen.展开更多
The ROSAT X-ray source 1RXS J114003.0＋ 124112 was identified as a starburst galaxy at redshift 0.177 by He et al. The authors also noted that the source is almost two orders of magnitude brighter in X-ray than the X-...The ROSAT X-ray source 1RXS J114003.0＋ 124112 was identified as a starburst galaxy at redshift 0.177 by He et al. The authors also noted that the source is almost two orders of magnitude brighter in X-ray than the X-ray-brightest starburst galaxy and it seems to be in a merging system, making this source an enigmatic system demanding further observations. Here we report a re-identification of 1RXS J114003.0＋124112 using observations on the 2.6 m telescope at Byurakan Astrophysical Observatory, Armenia and the SDSS data. The results indicate that the starburst activity is associated with the brighter object of the system, while the fainter object is a typical Seyfert 1 galaxy at a different redshift （0.282）. Therefore, the two objects are not in a merging system, and the Seyfert 1 galaxy naturally accounts for the high X-ray flux. Three more objects reside in the vicinity, but they are all too faint to be responsible for the high X-ray flux.展开更多
基金supported by the Startup Fund for Scientific Research,Binzhou Medical University(Project Number:BY2019KJ43).
文摘This study was conducted to explore the correlations between the expression,methylation,and various clinicopathological factors of purinergic P2X1 receptor(P2RX1)and the prognosis of patients with gastrointestinal tumors.The Cancer Genome Atlas(TCGA)and the Genotype-Tissue Expression(GTEx)databases were used to analyze the expression of P2RX1 in different types of gastrointestinal cancers.Kaplan-Meier analysis and univariate Cox regression analysis were used to analyze the correlations between P2RX1 expression and the prognosis of various gastrointestinal tumors.Correlations between P2RX1 expression and N6 methyladenine(m6A)-related genes as well as immune checkpoint genes were analyzed by R packages(R version:4.0.3)based on TCGA database.The association between P2RX1 methylation level and the prognosis of patients with gastrointestinal cancers was analyzed using the MethSurv database.In order to explore the biological functions of P2RX1 in hepatocellular carcinoma,the Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analysis were carried out using R software.In order to evaluate the correlations between P2RX1 and tumor immune infiltration,Spearman correlation test was performed.The correlations between P2RX1 expression and immune score as well as immune checkpoint genes were analyzed based on TCGA and Tumor Immune Estimation Resource(TIMER)databases.The expression of P2RX1 was found to be significantly downregulated in gastrointestinal tumors except in cholangiocarcinoma(P<0.05).High expression of P2RX1 tended to present better prognosis in hepatocellular carcinoma(P<0.05).It was noted that cg06475633 of P2RX1 presented a higher methylation level compared with other CpG sites in hepatocellular carcinoma.Overall,six CpGs of P2RX1 were associated with significant prognosis in patients with hepatocellular carcinoma(P<0.05).Among all the 20 m6A-related genes,Wilms'tumor 1-associating protein(WTAP)was the most strongly correlated with P2RX1 in hepatocellular carcinoma.Gene enrichment analysis showed that P2RX1 is widely involved in the proliferation,activation,organization,and differentiation of various immune cells.After investigating the TIMER database,P2RX1 was found to be tightly correlated with immune infiltrating cells in gastrointestinal tumors,especially with dendritic cells.Moreover,P2RX1 was found to be strongly positively associated with programmed cell death 1(PD1),programmed death-ligand 1(PD-L1),and cytotoxic T-lymphocyte-associated protein 4(CTLA4)in hepatocellular carcinoma(P<0.05).In conclusion,the dual role of P2RX1 in cancers and its involvement in the recruitment as well as regulation of tumor infiltrating cells in gastrointestinal cancers may be appreciated through this study.
基金Supported by the National Natural Science Foundation of China
文摘Hard X-rays above 10 keV are detected from several anomalous X-ray pul- sars （AXPs） and soft gamma-ray repeaters （SGRs）, and different models have been proposed to explain the physical origin within the frame of either a magnetar model or a fallback disk system. Using data from Suzaku and INTEGRAL, we study the soft and hard X-ray spectra of four AXPs/SGRs： 1RXS J 170849-400910, 1E 1547.0- 5408, SGR 1806-20 and SGR 0501＋4516. It is found that the spectra could be well reproduced by the bulk-motion Comptonization （BMC） process as was first suggested by Triimper et al., showing that the accretion scenario could be compatible with X- ray emission from AXPs/SGRs. Simulated results from the Hard X-ray Modulation Telescope using the BMC model show that the spectra would have discrepancies from the power-law, especially the cutoff at -200 keV. Thus future observations will allow researchers to distinguish different models of the hard X-ray emission and will help us understand the nature of AXPs/SGRs.
基金This work was funded bythe National Natural Science Foundation of China No. 11973014.
文摘RXS 1232953.9+062814 was identified as a cataclysmic variable by Wei et al. (1999). Four low-resolution spectra of 1RXS J232953.9+062814 were obtained with the 2.16-rn telescope of the National Astronomical Observatories, of which two were at outburst, and two were at quiescence. The system is about 16.8 B and 16.5 V at quiescence, and 12.6 B and 12.6 V at outburst. The quiescent spectra were dominated by double-peaked Balmer emissions, which indicates a hydrogen-rich system with a high-inclination accretion disc. MgH and TiO absorption bands appeared in the quiescent spectrum which implies a companion with a spectral type of early M dwarf. If we take it as a MO dwarf, then the system is located at a distance of 350 pc with a proper motion velocity 150 km s-1. The superhump period of 0.046311 days was confirmed by our V photometry. The short period and the hydrogen-rich nature reveal that this system is another SU Ursae Majoris-type dwarf nova below the period minimum after V485 Centauri. 1RXS J23 2953.9+062814 is one of the most important systems for studying the evolutionary scenario of cataclysmic variables since it is much brighter than V485 Cen.
基金Supported by the National Natural Science Foundation of China.
文摘The ROSAT X-ray source 1RXS J114003.0＋ 124112 was identified as a starburst galaxy at redshift 0.177 by He et al. The authors also noted that the source is almost two orders of magnitude brighter in X-ray than the X-ray-brightest starburst galaxy and it seems to be in a merging system, making this source an enigmatic system demanding further observations. Here we report a re-identification of 1RXS J114003.0＋124112 using observations on the 2.6 m telescope at Byurakan Astrophysical Observatory, Armenia and the SDSS data. The results indicate that the starburst activity is associated with the brighter object of the system, while the fainter object is a typical Seyfert 1 galaxy at a different redshift （0.282）. Therefore, the two objects are not in a merging system, and the Seyfert 1 galaxy naturally accounts for the high X-ray flux. Three more objects reside in the vicinity, but they are all too faint to be responsible for the high X-ray flux.
