Turbulent flow through a trash rack of bars of rectangular and biconvex shapes is considered. A trash rack is composed of an array of bars fitted into a hydro-electric power station to prevent debris and fish to enter...Turbulent flow through a trash rack of bars of rectangular and biconvex shapes is considered. A trash rack is composed of an array of bars fitted into a hydro-electric power station to prevent debris and fish to enter the waterway towards the turbine. The work is directed towards modeling a large number of bars for which the flow turn out to have a periodic structure. It is here shown that this case can be simplified with the flow past a single bar together with periodic boundary conditions. Using this approach the head loss is derived for different angles of attack α and blockages P for two shapes of the rack, a rectangular bar and an aerodynamically shaped biconvex bar. It is found that overall loss of the biconvex bars is in general about 15% of the loss for the rectangular case for small angles of attack. For large angle of attack this difference diminishes. Of interest for the biconvex bars is also a local minimum in the head loss for angles approximately greater than 20°and for a blockage P around 0.35. This combination of parameters gives a low loss together with an efficient barrier for debris and fishes.展开更多
The concept of base isolation for storage racks is still a developing subject and has not been addressed in the recently updated seismic codes for storage racks.The friction pendulum bearing system(FPS)generates a nat...The concept of base isolation for storage racks is still a developing subject and has not been addressed in the recently updated seismic codes for storage racks.The friction pendulum bearing system(FPS)generates a natural period independent of the structure's seismic mass.This property makes FPS an ideal choice for isolating rack structures since merchandise may be placed on the racks in several possible arrangements.The results of a comprehensive parametric study aimed at evaluating the seismic performance of a four-shelf,two-bay selective pallet rack isolated with FPS is presented in this paper.The influence of radius of curvature of the FPS,seismic mass,and mass irregularity on the rack's seismic response is examined.The effect of variation of the coefficient of friction due to axial loading is studied by choosing friction values from two distinct friction characterization studies.The coefficient of friction calculated from these studies shows mild and significant variations,respectively,for the whole range of static axial loads expected on the isolator,and from different pallet mass arrangements considered.The optimum radius of curvature and the appropriate range of friction coefficient,for the defined range of static axial loads,to attain a desirable seismic performance are determined.展开更多
Large-module rack of the Three Gorges shiplift is manufactured by casting and machining, which is unable to avoid slag inclusions and surface cracks. To ensure its safety in the future service, studying on crack propa...Large-module rack of the Three Gorges shiplift is manufactured by casting and machining, which is unable to avoid slag inclusions and surface cracks. To ensure its safety in the future service, studying on crack propagation rule and the residual life estimation method of large-module rack is of great significance. The possible crack distribution forms of the rack in the Three Gorges shiplift were studied. By applying moving load on the model in FRANC3 D and ANSYS, quantitative analyses of interference effects on double cracks in both collinear and offset conditions were conducted. The variation rule of the stress intensity factor(SIF) influence factor, RK, of double collinear cracks changing with crack spacing ratio, RS, was researched. The horizontal and vertical crack spacing threshold of double cracks within the design life of the shiplift were obtained, which are 24 and 4 times as large as half of initial crack length, c0, respectively. The crack growth rates along the length and depth directions in the process of coalescence on double collinear cracks were also studied.展开更多
The receptor for activated C kinase 1(RACK1)is a protein that plays a crucial role in various signaling pathways and is involved in the pathogenesis of Alzheimer's disease(AD),a prevalent neurodegenerative disease...The receptor for activated C kinase 1(RACK1)is a protein that plays a crucial role in various signaling pathways and is involved in the pathogenesis of Alzheimer's disease(AD),a prevalent neurodegenerative disease.RACK1 is highly expressed in neuronal cells of the central nervous system and regulates the pathogenesis of AD.Specifically,RACK1 is involved in regulation of the amyloid-β precursor protein processing through α-or β-secretase by binding to different protein kinase C isoforms.Additionally,RACK1 promotes synaptogenesis and synaptic plasticity by inhibiting N-methyl-D-aspartate receptors and activating gamma-aminobutyric acid A receptors,thereby preventing neuronal excitotoxicity.RACK1 also assembles inflammasomes that are involved in various neuroinflammatory pathways,such as nuclear factor-kappa B,tumor necrosis factor-alpha,and NOD-like receptor family pyrin domain-containing 3 pathways.The potential to design therapeutics that block amyloid-β accumulation and inflammation or precisely regulate synaptic plasticity represents an attractive therapeutic strategy,in which RACK1 is a potential target.In this review,we summarize the contribution of RACK1 to the pathogenesis of AD and its potential as a therapeutic target.展开更多
This short survey contains some recent developments of the algebraic theory of racks and quandles.We report on some elements of representation theory of quandles and ring theoretic approach to quandles.
基金The Swedish Agency of Energy and Stand Up for Energy
文摘Turbulent flow through a trash rack of bars of rectangular and biconvex shapes is considered. A trash rack is composed of an array of bars fitted into a hydro-electric power station to prevent debris and fish to enter the waterway towards the turbine. The work is directed towards modeling a large number of bars for which the flow turn out to have a periodic structure. It is here shown that this case can be simplified with the flow past a single bar together with periodic boundary conditions. Using this approach the head loss is derived for different angles of attack α and blockages P for two shapes of the rack, a rectangular bar and an aerodynamically shaped biconvex bar. It is found that overall loss of the biconvex bars is in general about 15% of the loss for the rectangular case for small angles of attack. For large angle of attack this difference diminishes. Of interest for the biconvex bars is also a local minimum in the head loss for angles approximately greater than 20°and for a blockage P around 0.35. This combination of parameters gives a low loss together with an efficient barrier for debris and fishes.
文摘The concept of base isolation for storage racks is still a developing subject and has not been addressed in the recently updated seismic codes for storage racks.The friction pendulum bearing system(FPS)generates a natural period independent of the structure's seismic mass.This property makes FPS an ideal choice for isolating rack structures since merchandise may be placed on the racks in several possible arrangements.The results of a comprehensive parametric study aimed at evaluating the seismic performance of a four-shelf,two-bay selective pallet rack isolated with FPS is presented in this paper.The influence of radius of curvature of the FPS,seismic mass,and mass irregularity on the rack's seismic response is examined.The effect of variation of the coefficient of friction due to axial loading is studied by choosing friction values from two distinct friction characterization studies.The coefficient of friction calculated from these studies shows mild and significant variations,respectively,for the whole range of static axial loads expected on the isolator,and from different pallet mass arrangements considered.The optimum radius of curvature and the appropriate range of friction coefficient,for the defined range of static axial loads,to attain a desirable seismic performance are determined.
基金Project(0722018)supported by the China Three Gorges CorporationProject(2012KJX01)supported by the Hubei Key Laboratory of Hydroelectric Machinery Design&Maintenance,China
文摘Large-module rack of the Three Gorges shiplift is manufactured by casting and machining, which is unable to avoid slag inclusions and surface cracks. To ensure its safety in the future service, studying on crack propagation rule and the residual life estimation method of large-module rack is of great significance. The possible crack distribution forms of the rack in the Three Gorges shiplift were studied. By applying moving load on the model in FRANC3 D and ANSYS, quantitative analyses of interference effects on double cracks in both collinear and offset conditions were conducted. The variation rule of the stress intensity factor(SIF) influence factor, RK, of double collinear cracks changing with crack spacing ratio, RS, was researched. The horizontal and vertical crack spacing threshold of double cracks within the design life of the shiplift were obtained, which are 24 and 4 times as large as half of initial crack length, c0, respectively. The crack growth rates along the length and depth directions in the process of coalescence on double collinear cracks were also studied.
基金supported by grants from the National Natural Science Foundation of China(Grant No.82071395)the Natural Science Foundation of Chongqing(Grant Nos.cstc2021ycjh-bgzxm0186,cstc2020jcyj-zdxmX0004,and cstc2021jcyj-bsh0023)the CQMU Program for Youth Innovation in Future Medicine(Grant No.W0044).
文摘The receptor for activated C kinase 1(RACK1)is a protein that plays a crucial role in various signaling pathways and is involved in the pathogenesis of Alzheimer's disease(AD),a prevalent neurodegenerative disease.RACK1 is highly expressed in neuronal cells of the central nervous system and regulates the pathogenesis of AD.Specifically,RACK1 is involved in regulation of the amyloid-β precursor protein processing through α-or β-secretase by binding to different protein kinase C isoforms.Additionally,RACK1 promotes synaptogenesis and synaptic plasticity by inhibiting N-methyl-D-aspartate receptors and activating gamma-aminobutyric acid A receptors,thereby preventing neuronal excitotoxicity.RACK1 also assembles inflammasomes that are involved in various neuroinflammatory pathways,such as nuclear factor-kappa B,tumor necrosis factor-alpha,and NOD-like receptor family pyrin domain-containing 3 pathways.The potential to design therapeutics that block amyloid-β accumulation and inflammation or precisely regulate synaptic plasticity represents an attractive therapeutic strategy,in which RACK1 is a potential target.In this review,we summarize the contribution of RACK1 to the pathogenesis of AD and its potential as a therapeutic target.
文摘This short survey contains some recent developments of the algebraic theory of racks and quandles.We report on some elements of representation theory of quandles and ring theoretic approach to quandles.
