Preoperative blood markers and intra-abdominal infection after colorectal cancer resection

BACKGROUND Colorectal cancer(CRC)has one of the highest morbidity and mortality rates among digestive tract tumors.Intra-abdominal infection(IAI)is a common postoperative complication that affects the clinical outcomes of patients with CRC and hinders their rehabilitation process.However,the factors influencing abdominal infection after CRC surgery remain unclear;further,prediction models are rarely used to analyze preoperative laboratory indicators and postoperative complications.AIM To explore the predictive value of preoperative blood markers for IAI after radical resection of CRC.METHODS The data of 80 patients who underwent radical resection of CRC in the Anorectal Surgery Department of Suzhou Hospital affiliated with Anhui Medical University were analyzed.These patients were categorized into IAI(n=15)and non-IAI groups(n=65)based on whether IAI occurred.Influencing factors were compared;general data and laboratory indices of both groups were identified.The relationship between the indicators was assessed.Further,a nomogram prediction model was developed and evaluated;its utility and clinical applic-ability were assessed.RESULTS The risk factors for IAI after radical resection of CRC were neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),systemic immune-inflammation index(SII),and carcinoembryonic antigen(CEA)levels.NLR was correlated with PLR and SII(r=0.604,0.925,and 0.305,respectively),while PLR was correlated with SII(r=0.787).The nomogram prediction model demonstrated an area under the curve of 0.968[95%confidence interval(CI):0.948-0.988]in the training set(n=60)and 0.926(95%CI:0.906-0.980)in the validation set(n=20).The average absolute errors of the calibration curves for the training and validation sets were 0.032 and 0.048,respectively,indicating a good model fit.The decision curve analysis curves demonstrated high net income above the 5%threshold,indicating the clinical practicality of the model.CONCLUSION The nomogram model constructed using NLR,PLR,SII,and CEA levels had good accuracy and reliability in predicting IAI after radical resection of CRC,potentially aiding clinical treatment decision-making.

Effect of dexmedetomidine on inflammatory factors and immune function in elderly patients undergoing laparoscopic radical resection of colorectal cancer

Objective:To investigate the effect of dexmedetomidine on inflammatory factors and immune function in elderly patients undergoing laparoscopic radical resection of colorectal cancer. Methods: From April 2016 to April 2017, 86 cases of elderly laparoscopic radical resection of colorectal cancer in our hospital were selected and randomly divided into the observation group and the control group. 2 groups of patients were open venous access, oxygen mask, monitoring heart rate (HR), blood pressure (BP), electrocardiogram (ECG), oxygen saturation (SpO2), bispectral index (BIS), after induction of anesthesia, the observation group was given dexmedetomidine 0.4 g/kg to 20 mL of normal saline control. Group of 20 mL saline, 15 min infusion is completed, and the observation group of dexmedetomidine in 0.4 g/kg - h continuous infusion of normal saline control group, continuous infusion, until the end of surgery. Before induction of anesthesia (T0), 2 h after operation beginning (T1), at the end of operation (T2), 24 h after operation (T3) in venous blood, using ELISA method for the determination of serum interleukin-2 receptor (sIL-2R) and interleukin-6 (IL-6), tumor necrosis factor alpha (the level of TNF-alpha);on preoperative and postoperative 4 h, 12 h, 24 h after operation in venous blood serum epinephrine ELISA method (E), norepinephrine (NE), endothelin-1 (ET-1) level;on preoperative and postoperative 4 h, 12 h after surgery, 24 h venous blood flow cytometry determination of CD3+, CD4+, CD8+, CD4+/CD8+.Results:compared with before operation, the observation group after 4 h, 12 h, 24 h NE, and the lower control group E, NE and ET-1 increased, the observation group after 4 h, 12 h, 24 h E, NE, ET-1 lower than that of the control group;compared with T0, 2 patients in group T2, T3 sIL-2R, IL-6, TNF-alpha were increased, the observation group T2, T3 sIL-2R, IL-6, TNF- were lower than that of the control group;compared with the preoperative, 2 group after 4 h, 12 h, 24 h CD3+, CD4+, CD8+ and CD4+/CD8+ decreased, the observation group after 4 h, 12 h, 24 h CD3+, CD4+, CD8+, CD4+/CD8+ higher than those in the control group.Conclusion: Dexmedetomidine has a good analgesic effect on elderly patients undergoing laparoscopic radical resection of colorectal cancer. It can effectively relieve the stress reaction and inflammatory reaction during perioperative period, and effectively improve the immune function of the patients.

Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA

BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment.

Correlation between invasive microbiota in margin-surrounding mucosa and anastomotic healing in patients with colorectal cancer

BACKGROUND Impaired anastomotic healing is one of the major complications resulting from radical resection in colorectal cancer(CRC).Accumulating evidence suggests that intestinal microbiota is correlated with anastomotic healing.AIM To explore the microbiota structural shift in margin-surrounding mucosa and evaluate the predictive ability of selected bacterial taxa for impaired anastomotic healing.METHODS Margin-surrounding mucosa samples derived from 37 patients were collected to characterize the microbial community structure by 16 s r RNA gene sequencing.The patients were divided into two groups according to the healing status of anastomoses:well-healing group(n=30)and impaired-healing group(n=7).Statistic differences in bacteria taxa were compared by Wilcoxon test and chisquared test.The predictive ability of the selected bacterial taxa for the healing status of anastomoses was evaluated by the area under the receiver operator characteristic curve.RESULTS Community structure shifts were observed in the impaired-healing group andwell-healing group.Six bacterial species were found to be significantly correlated with anastomotic healing,and among these species,Alistipes shahii,Dialister pneumosintes,and Corynebacterium suicordis were considered as the predictive factors.Taking the known risk factor age into consideration,Alistipes shahii,Dialister pneumosintes,and Corynebacterium suicordis improved predictive ability for the healing status of anastomoses.CONCLUSION These data show that Alistipes shahii,Dialister pneumosintes,and Corynebacterium suicordis could be considered as supplementary factors in the prediction of anastomosis healing status in patients after CRC radical resection.

STATUS OF SURGICAL TREATMENT OF RECTAL CANCER IN CHINA

The multimodality treatment methods of rectal cancer in China are presented. Extended radical excisions are used for Dukes’ B and C cases to reduce local recurrence. These include: high ligation with clearance of proximal lymph nodes at origin of inferior mesenteric artery, lateral pelvic lymphadenectomy, posterior or total pelvic exenterations in selected cases; but controversy exists. Radical sphincter-saving resections are advocated to improve the quality of life. Prerequisites of sphincter-saving resection are adequate resection of bowel and mesentery distal to the lesion, depending on the macroscopic type of lesion and degree of differentiation. The decisive factor in the choice of type of operation is the length of rectal stump above levator ani after resection. Bacon’s pull through resection was modified by preservation of levator ani and dentate margin, much better functional results were obtained postoperatively. Transanal full thickness local excision is advocated for small, protuberant, mobile, well differentiated lesions below the peritoneal reflection. Pre- or postoperative adjuvant radiation therapy is sometimes used for Dukes’ B and C cases. Adjuvant 5-Fu chemotherapy is usually used intraoperatively (intraluminal) or postoperatively (intravenous). The superiority of preoperative intrarectal 5-Fu emulsionover the conventional intravenous route has been demonstrated by experimental and clinical studies, which showed much higher and lasting concentration of 5-Fu in the rectal wall tissues and mesenteric lymph nodes, and a much lower concentration of 5-Fu in bone marrow after intrarectal administration. Several surgical groups employed varying techniques of sphincteric reconstruction of perineal colostomy after abdominoperineal excision, utilizing the gracilis or gluteus maximus sling, or intussusception of the colonic stump; with favorable late results in reported cases. However, controversy exists, so strict appropriate case selection is emphasized to avoid unnecessary sacrifice of the normal anus.

咪达唑仑对术前中重度焦虑老年患者结直肠癌根治术后谵妄的影响

目的探讨术前短期口服咪达唑仑对术前合并中重度焦虑老年患者结直肠癌根治术后谵妄的影响。方法选择择期行腹腔镜结直肠癌根治术的老年患者80例,男32例,女48例,年龄65~79岁,BMI 21~27 kg/m^(2),ASAⅡ或Ⅲ级,入院时状态特质焦虑量表(STAI-S)评分≥38分。采用随机数字表法将患者分为两组:对照组和咪达唑仑组,每组40例。咪达唑仑组予咪达唑仑7.5 mg每晚一次,连续服药3~4 d,直到术前1 d;对照组予外观相似的安慰剂半片。记录术前1 d STAI-S评分与术后3 d内谵妄的发生情况,记录入室时、麻醉诱导后30 min、1、2 h、拔管后30 min HR和MAP,记录术中丙泊酚、瑞芬太尼、右美托咪定用量及间羟胺使用情况,记录拔管后30 min、术后24、72 h视觉模拟评分(VAS)、曲马多使用情况以及拔管时间。结果与对照组比较,咪达唑仑组术前1 d STAI-S评分、术后谵妄发生率、术中间羟胺使用率、拔管后30 min、术后24 h VAS疼痛评分、曲马多使用率明显降低(P<0.05)。两组术中丙泊酚、瑞芬太尼、右美托咪定用量和拔管时间差异无统计学意义。结论术前口服咪达唑仑可有效降低合并术前中重度焦虑老年患者结直肠癌根治术后谵妄的发生。

CD64指数联合IL-1β、TLR4在诊断结直肠癌患者术后感染中的临床价值

目的探讨CD64指数联合血清白细胞介素-1β(IL-1β)、Toll样受体4(TLR4)在诊断结直肠癌患者术后切口感染中的临床应用价值。方法以2020年6月至2022年6月收治入院的113例行结直肠癌根治术患者作为研究对象,根据其术后是否发生切口感染,分为感染组与非感染组。分别于术前、术后3 d及术后5 d检测外周血CD64指数及血清IL-1β、TLR4水平,绘制ROC曲线并分析各指标单独及联合应用时诊断结直肠癌术后切口感染的临床应用价值,以及三者与患者切口感染严重程度之间的关系。结果术后3 d及术后5 d,感染组患者CD64指数以及血清IL-1β、TLR4水平均高于非感染组;术后3 d,感染组患者CD64指数、血清IL-1β及TLR4水平均较术前明显上升;术后5 d,感染组各指标均较术后3 d有所下降,但依旧高于术前水平,差异均具有统计学意义(P<0.05)。非感染组患者术前、术后3 d以及术后5 d CD64指数、IL-1β、TLR4水平差异均无统计学意义(P>0.05)。以术后3 d作为预测结直肠癌术后感染的时间点绘制各指标的ROC曲线,结果发现CD64指数、血清IL-1β、TLR4单独及三者联合应用预测结直肠癌术后感染的AUC^(ROC)分别为0.937、0.901、0.790及0.997(95%CI:0.992~1.000),各指标单独应用能较好地预测结直肠癌术后感染,三者联合应用的预测效能最高。结论外周血CD64指数、血清IL-1β、TLR4在预测结直肠癌术后切口感染中具有良好效能,三者联合应用的预测效能最高,可作为临床筛查术后感染的早期预测指标。

地佐辛静脉麻醉联合罗哌卡因局部浸润麻醉镇痛对腹腔镜结直肠癌根治术患者镇痛效果及围术期免疫和应激反应影响

目的探讨腹腔镜结直肠癌根治术患者使用地佐辛静脉麻醉联合罗哌卡因局部浸润麻醉镇痛效果及对围术期免疫和应激反应影响。方法选取2020年4月—2022年5月择期行腹腔镜结直肠癌根治术患者100例,据麻醉镇痛方式不同均分为观察组和对照组,观察组给予全麻及地佐辛静脉麻醉联合罗哌卡因局部浸润麻醉镇痛,对照组给予全麻及罗哌卡因局部浸润麻醉镇痛。记录2组麻醉诱导前5 min(T0)、术毕(T1)、拔管即刻(T2)、拔管后30 min(T3)、拔管后60 min(T4)时平均动脉压(MAP)、心率(HR)及血清皮质醇(Cor)、丙二醛(MDA)水平;比较术前、术后24 h 2组外周血CD4+、CD8+和CD4+/CD8+水平,术毕12、24、48 h视觉模拟评分法(VAS)评分,术前、术后3 d简易智力状态检查量表(MMSE)评分,以及2组麻醉恢复期间不良反应。结果T3时,2组MAP、HR高于T0时,且观察组低于对照组(P<0.05);T1、T2、T3、T4时,2组Cor、MDA均高于T0时,且观察组低于对照组(P<0.05)。术后24 h,2组CD4+、CD4+/CD8+降低,CD8+升高,且观察组CD4+、CD4+/CD8+较对照组升高,CD8+较对照组降低(P<0.05)。观察组术毕12、24、48 h VAS评分均较对照组降低(P<0.05)。术后3 d,2组MMSE评分均降低,且观察组低于对照组(P<0.05)。观察组麻醉恢复期间躁动发生率为6.00%(3/50)低于对照组的20.00%(10/50)(P<0.05)。结论全麻及地佐辛静脉联合罗哌卡因局部浸润麻醉镇痛对腹腔镜结直肠癌根治术患者免疫功能影响小,可减轻手术应激,镇痛效果好,且安全性高。

单次亚麻醉剂量艾司氯胺酮对全身麻醉下结直肠癌根治术患者术后早期情绪反应及恢复情况的影响

目的研究单次亚麻醉剂量艾司氯胺酮对全身麻醉下结直肠癌根治术患者术后早期情绪反应及恢复情况的影响。方法采用回顾性分析,选取2022年10月至2023年4月南京大学医学院附属鼓楼医院收治的120例全身麻醉下结直肠癌根治术患者为观察对象,按照麻醉方式不同分为研究组(n=60)与对照组(n=60)。研究组全身麻醉诱导之前给予0.3 mg/kg体重艾司氯胺酮一次性静脉推注,对照组正常麻醉;两组患者全身麻醉诱导、手术过程中麻醉维持、手术完成之后静脉镇痛药物及方式一致。比较两组患者手术前后焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分与术后(24、48 h)恢复质量评分量表(QOR40)评分、术后(1、3、6、18、24 h)视觉模拟评分法(VAS)评分、术后(24、48 h)改良警觉/镇静评分(MOAA/S)量表评分、术后苏醒时间、术后首次排气时间、术后下床时间及术后不良反应发生率。结果术后48 h,研究组患者SAS、SDS评分均明显低于术前,差异均有统计学意义(P<0.05);对照组手术前后SAS、SDS评分比较,差异均无统计学意义(P>0.05);研究组术后48 h SAS、SDS评分分别为(44.21±4.58)、(41.26±5.09)分,均低于对照组[(52.84±5.69)、(51.03±6.48)分],差异均有统计学意义(P<0.05)。研究组患者术后24、48 h QOR40评分分别为(142.51±4.86)、(150.84±5.73)分,均高于对照组[(134.06±5.17)、(142.49±5.52)分],差异均有统计学意义(P<0.05)。研究组患者术后1、3、6、18、24 h VAS评分分别为(2.49±0.74)、(2.27±0.68)、(2.11±0.64)、(1.97±0.63)、(1.86±0.65)分,均低于对照组[(2.97±0.81)、(2.71±0.75)、(2.58±0.69)、(2.47±0.65)、(2.33±0.67)分],差异均有统计学意义(P<0.05)。研究组患者术后24、48 h MOAA/S评分分别为(141.42±14.51)、(150.28±14.86)分,均低于对照组[(133.19±13.18)、(142.22±13.47)分],差异均有统计学意义(P<0.05)。研究组患者术后首次排气、下床时间分别为(39.01±4.73)、(33.31±4.57)h,均明显短于对照组[(43.86±5.25)、(37.65±5.19)h],差异均有统计学意义(P<0.05);两组患者术后苏醒时间比较,差异无统计学意义(P>0.05)。两组患者术后总不良反应发生率比较,差异无统计学意义(P>0.05)。结论单次亚麻醉剂量艾司氯胺酮用于全身麻醉下结直肠癌根治术麻醉可有效缓解患者情绪反应,提升术后早期镇痛、镇静效果,缓解疼痛程度,提高术后恢复质量及速度,且不良反应少。

腹腔镜结直肠癌术后吻合口瘘的原因分析与预防策略

目的研究分析腹腔镜结直肠癌手术后发生吻合口瘘的原因,并探讨相应的预防对策。方法选取2018年1月至2022年12月柳州市人民医院胃肠外科接受腹腔镜手术的676例结直肠癌患者作为研究对象,根据患者在手术后是否发生吻合口瘘将其分为研究组(发生吻合口瘘,49例)与对照组(未发生吻合口瘘,627例)。采取回顾性方式分析两组病例的临床资料,采用logistic回归分析方法分析腹腔镜结直肠癌手术后发生吻合口瘘的影响因素。结果单因素分析结果提示,研究组与对照组的性别、年龄、体重指数、糖尿病、术前血清白蛋白、手术时间比较,差异有统计学意义(P<0.05)。多因素分析结果提示,男性(β=0.335,OR=2.561,95%CI:1.489~3.082)、年龄≥60岁(β=0.361,OR=2.457,95%CI:1.193~3.107)、体重指数≥24.9 kg/m^(2)(β=0.329,OR=2.379,95%CI:1.140~3.278)、合并糖尿病(β=0.328,OR=2.369,95%CI:1.207~3.114)、术前血清白蛋白<35 g/L(β=0.357,OR=2.418,95%CI:1.245~3.098)、手术时间≥3.5 h(β=0.348,OR=2.406,95%CI:1.352~3.069)是腹腔镜结直肠癌手术后发生吻合口瘘的危险因素(P<0.05)。结论结直肠癌患者在腹腔镜手术后受到性别、年龄、体质量指数、糖尿病等因素的影响,易发生吻合口瘘。

益气固涩温脾汤加减辅助治疗结直肠癌根治术后吻合口瘘的临床研究

目的:探讨益气固涩温脾汤加减辅助治疗结直肠癌根治术后吻合口瘘患者的临床效果。方法:选取2022年1~12月期间某院收治的52例结直肠癌根治术后吻合口瘘患者作为研究对象,按照随机数字表法分为A组(n=24)和B组(n=28)。A组患者给予注射用头孢西丁钠等单纯常规对症治疗,B组在A组基础上给予益气固涩温脾汤加减治疗,共持续治疗3周。比较两组患者吻合口瘘愈合时间、恢复正常饮食时间、住院时间、症状评分(吻合口浊液、腹部剧痛、纳差、排便不畅)、临床疗效及不良反应发生情况。结果:治疗后,B组患者吻合口瘘愈合时间、恢复正常饮食时间、住院时间均短于A组(P<0.05);两组患者吻合口浊液、腹部剧痛、纳差、排便不畅症状评分均降低(P<0.05),且B组低于A组(P<0.05);B组患者治疗总有效率(96.43%)高于A组(70.83%,P<0.05);两组患者不良反应发生率比较无统计学差异(P=0.541)。结论:在单纯常规对症治疗基础上联合益气固涩温脾汤加减辅助治疗结直肠癌根治术后吻合口瘘患者临床疗效较好,可有效改善患者临床症状,降低症状评分,且未增加不良反应的发生风险。

单次注射亚麻醉剂量氯胺酮对腹腔镜结直肠癌根治术患者术后疲劳综合征的影响

目的探讨单次注射亚麻醉剂量氯胺酮对腹腔镜结直肠癌根治术患者术后疲劳综合征的影响。方法选取2020年1月—2022年9月就诊于苏州大学附属张家港医院行腹腔镜结直肠癌根治术的老年患者共计90例。纳入标准:年龄60~75岁,ASAⅡ—Ⅲ级,体重指数(BMI)18.5~27.9 kg/m^(2),术前1dChristensen疲劳评分≤4分,预期手术时间小于6 h,预期失血量低于800 mL。患者随机纳入氯胺酮组(K组)或安慰剂组(P组),每组各纳入45例患者。于术前1 d、术后3 d、术后5 d、术后7 d评估患者Christensen疲劳评分和简明围术期疲劳检测量表(ICFS-10)评分。于麻醉诱导前10 min(T0)、手术结束即刻(T1)、术后6 h(T2)、术后12 h(T3)、术后24 h(T4)抽取外周静脉血,检测白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。记录拔管时间、PACU停留时间以及苏醒延迟、躁动、恶心呕吐、复视发生情况。结果2组患者拔管时间、麻醉后监测治疗室(PACU)停留时间的比较差异无统计学意义(P>0.05)。2组患者苏醒延迟、躁动、恶心呕吐、复视发生率的比较差异无统计学意义(P>0.05)。K组患者术后3 d、术后5 d、术后7 d的Christensen疲劳评分和ICFS-10评分明显低于P组患者,差异有统计学意义(P<0.05)。2组患者术后3 d Christensen疲劳评分和ICFS-10评分明显高于同组其他时点,差异有统计学意义(P<0.05)。K组患者术后T1至T4时点的IL-6和TNF-α水平明显低于P组患者,差异有统计学意义(P<0.05)。2组患者T1时点IL-6和TNF-α水平明显高于同组其他时点,差异有统计学意义(P<0.05)。结论单次注射亚麻醉剂量氯胺酮能够改善腹腔镜结直肠癌根治术患者术后疲劳综合征,且对苏醒质量无明显不良影响。

不同麻醉方式在结直肠癌根治术中的应用效果对比

目的 对比全身麻醉和全身麻醉联合硬膜外麻醉在结直肠癌根治术中的应用效果。方法 180例结直肠癌根治术患者根据麻醉方式的不同分为全身麻醉组和全身麻醉联合硬膜外麻醉组,比较两组的麻醉苏醒时间、肠道恢复时间、下床活动时间、住院时间、疼痛程度及并发症。结果 全身麻醉联合硬膜外麻醉组的麻醉苏醒时间、肠道恢复时间、下床活动时间、住院时间均显著短于全身麻醉组,术后苏醒时、术后苏醒8 h时及术后苏醒24 h时的VAS评分均显著低于全身麻醉组(P <0.05)。全身麻醉联合硬膜外麻醉组的并发症总发生率为6.5%,显著低于全身麻醉组的17.1%(P <0.05)。结论 与全身麻醉相比,全身麻醉联合硬膜外麻醉可明显减轻结直肠癌根治术患者的术后疼痛程度,减少并发症的发生,促进患者预后恢复。

舒芬太尼与芬太尼靶控输注对结直肠癌根治术患者麻醉苏醒质量、肺内氧合及氧化抗氧化系统影响的对比研究

背景结直肠癌根治术是治疗结直肠癌的主要治疗手段.术中不同麻醉药物的使用,对手术的完成效果,以及术后患者的身体恢复状况均有较大的关系.目的对比研究舒芬太尼与芬太尼靶控输注对结直肠癌根治术患者麻醉苏醒质量、肺内氧合及氧化抗氧化系统影响.方法选取2020-07/2023-07期间鄞州第二医院78例行结直肠癌根治术患者,随机分为两组,各39例.舒芬太尼组予以舒芬太尼靶控输注复合麻醉,芬太尼予以芬太尼靶控输注复合麻醉.统计两组麻醉苏醒质量、不良反应发生率,比较两组麻醉诱导前(T0)、气管插管后即刻(T1)、气腹后30 min(T2)、手术拔管后5 min(T3)时刻心率(heart rate,HR)、动脉血氧分压(pressure of oxygen,PaO2)、平均动脉压(mean arterial pressure,MAP)、血氧饱和度(oxygen saturation,SpO2)及氧合指数(oxygenation index,OI)及T0、术后4 h(T4)、术后24 h(T5)、术后48 h(T6)时刻丙二醛(malondialdehyde,MDA)、谷胱甘肽(glutathione,GSH)、超氧化物歧化酶(superoxide dismutase,SOD)、神经生长因子(nerve growth factor,NGF)、前列腺素E2(prostaglandin E2,PGE2).结果重复测量分析显示,两组HR、PaO2、MAP、SpO2及OI主体内及主体间效应比较有统计学差异(P<0.05),简单效应LSD-t成对比较显示,T1、T2及T3时刻,舒芬太尼组HR、MAP均较芬太尼组低,PaO2、SpO2及OI均较芬太尼组高(P<0.05);重复测量分析显示,两组MDA、GSH、PGE2、NGF及SOD及主体内及主体间效应比较有统计学差异(P<0.05),简单效应LSD-t成对比较显示,T4、T5及T6时刻,舒芬太尼组MDA较芬太尼组高,GSH、PGE2、NGF、SOD均较芬太尼组低(P<0.05);舒芬太尼组苏醒、自主呼吸恢复及拔管时间较芬太尼组短,不良反应率较芬太尼组低(P<0.05).结论相较于芬太尼,在结直肠癌根治术中采用舒芬太尼靶控输注,可有效减轻应激反应,降低血清疼痛介质释放,对机体血流动力学、肺内氧合及氧化抗氧化系统影响较小,安全性高,有助于提高麻醉苏醒质量.

腹腔镜下结直肠癌根治术治疗效果及预后相关影响因素分析

目的:分析腹腔镜下结直肠癌根治术在结直肠癌患者中的治疗效果及预后的影响因素。方法:选取2019年2月—2021年2月烟台市北海医院收治的90例结直肠癌患者,所有患者均行腹腔镜下结直肠癌根治术,观察手术治疗效果。术后随访2年,依据患者的临床结局(生存或死亡)将其分为预后良好组与预后不良组,收集患者的年龄、性别等资料,以多因素logistic回归分析模型统计分析影响预后的因素。结果:90例患者中,完全缓解(CR)共50例(55.56%),部分缓解(PR)共34例(37.78%),疾病稳定(SD)共5例(5.56%),疾病进展(PD)共1例(1.11%),治疗总有效率为93.33%(84/90)。随访2年,90例患者中生存69例,生存率为76.67%(69/90)。单因素分析显示:预后不良组与预后良好组年龄、性别、体重指数(BMI)、文化程度、吸烟史、高血压史、肿瘤直径、肿瘤类型占比比较,差异均无统计学意义(P>0.05);预后不良组低分化、临床分期为Ⅲ~Ⅳ期、有脉管侵犯、有神经侵犯占比均高于预后良好组,差异均有统计学意义(P<0.05)。多因素logistic回归分析显示:低分化[β=2.059,OR=7.840,95%CI(2.530,24.291)]、临床分期为Ⅲ~Ⅳ期[β=2.485,OR=12.000,95%CI(3.203,44.956)]、有脉管侵犯[β=1.828,OR=6.223,95%CI(1.892,20.466)]、有神经侵犯[β=2.285,OR=9.821,95%CI(3.224,29.916)]为腹腔镜下结直肠癌根治术后患者预后不良的影响因素(P<0.05)。结论:腹腔镜下结直肠癌根治术治疗结直肠癌患者的效果显著,影响患者预后的因素众多,如低分化、临床分期为Ⅲ~Ⅳ期、有脉管侵犯、有神经侵犯等。

瑞芬太尼复合丙泊酚对腹腔镜结直肠癌根治术患者术中血流动力学及术后肠道运动功能的影响

目的:观察瑞芬太尼复合丙泊酚对腹腔镜结直肠癌根治术患者术中血流动力学及术后肠道运动功能的影响。方法:回顾性抽取上饶市人民医院于2021年6月—2023年6月收治的60例结直肠癌并行腹腔镜根治术患者,根据麻醉方式不同分为对照组与研究组,其中对照组29例使用芬太尼复合丙泊酚麻醉,研究组31例使用瑞芬太尼复合丙泊酚麻醉。对比两组围手术期指标、血流动力学、术后认知功能[简易智能精神状态检查量表(MMSE)评估]、肠道运动功能、不良反应。结果:两组手术时间比较,差异无统计学意义(P>0.05),研究组术后呼吸恢复时间、术后睁眼时间均短于对照组,丙泊酚用量少于于对照组,差异均有统计学意义(P<0.05);研究组麻醉10 min HR、MAP值及术后10 min HR值均高于对照组,差异均有统计学意义(P<0.05);术后1、3及6 h研究组MMSE评分均高于对照组,差异均有统计学意义(P<0.05);两组术后胃肠道运动功能比较,差异均无统计学意义(P>0.05);研究组不良反应发生率(9.68%)与对照组(24.14%)比较,差异无统计学意义(P>0.05)。结论:瑞芬太尼复合丙泊酚麻醉用于腹腔镜结直肠癌根治术患者有助于缩短术后呼吸恢复时间、术后睁眼时间,降低丙泊酚用量,且患者术后认知恢复更快,对血流动力学指标的影响更小,且安全可靠。

环泊酚与丙泊酚麻醉维持在老年腹腔镜结直肠癌根治术患者中的应用比较

目的探讨环泊酚与丙泊酚麻醉维持在老年腹腔镜结直肠癌根治术患者中的应用比较。方法共纳入医院收治的80例行腹腔镜结直肠癌根治术老年患者。随机分为观察组和对照组,每组40例。观察组采用环泊酚麻醉维持,对照组采用丙泊酚麻醉维持。比较两组患者不同时间点炎症因子水平、血流动力学指标、MMSE评分及不良反应。结果两组患者T1~T4时点心率(HR)、收缩压(SBP)及舒张压(DBP)均呈下降趋势,T4~T7时点呈上升趋势,组内比较差异有统计学意义(P<0.05)。组间比较,对照组T4、T5、T6及T7时点SBP及HR均高于观察组(P<0.05);观察组麻醉诱导时间、清醒时间、拔管时间均低于对照组(P<0.05);观察组术后24 h白细胞介素-6(IL-6)与肿瘤坏死因子-α(TNF-α)均低于对照组(P<0.05);观察组的并发症发生率为2.50%(1/40),显著低于对照组的25.00%(10/40),差异有统计学意义(P<0.05);两组不同时间点MMSE评分比较差异有统计学意义(P<0.05),观察组D1、D3、D5 MMSE评分均高于对照组(P<0.05)。结论环泊酚麻醉维持在老年腹腔镜结直肠癌根治术患者中的应用效果与丙泊酚比较,可对患者的血流动力学影响更小,降低术后24 h炎性因子水平差值、不良反应发生情况少,同时对患者术后MMSE评分影响小。

腹腔镜结直肠癌根治术在结直肠癌中的应用价值

目的:探讨腹腔镜结直肠癌根治术在结直肠癌中的应用价值。方法:选取2015年1月—2019年12月武汉市江夏区中医医院收治的100例结直肠癌患者。根据随机数表法将其分为观察组和对照组,各50例。对照组给予开腹结直肠癌根治术,观察组给予腹腔镜结直肠癌根治术。比较两组围手术期指标、并发症、生存指标。结果:观察组手术时间、住院时间均短于对照组,术中出血量少于对照组,下床活动时间早于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。两组无进展生存时间、总生存时间及3年生存率比较,差异无统计学意义(P>0.05)。结论:腹腔镜结直肠癌根治术具有手术时间短、出血量少、康复速度快的优势,相比于开腹手术来说,虽然远期疗效相当,但是腹腔镜手术可以降低术后并发症发生率,缩短患者的住院时间。

腹腔镜结直肠癌根治术联合微波消融术与联合腹腔镜肝切除术的疗效比较

目的 探讨腹腔镜结直肠癌根治联合术中微波消融与腹腔镜结直肠癌根治联合腹腔镜肝切除治疗结直肠癌肝转移的围手术期安全性和远期预后比较。方法 回顾性分析59例结直肠癌肝转移行腹腔镜手术患者资料,其中行腹腔镜结直肠癌根治术联合微波消融术组31例,腹腔镜结直肠癌根治术联合腹腔镜肝切除术组28例;对比两组患者术中与术后并发症、术后无瘤生存时间和总体生存时间,并分析影响患者生存的危险因素。结果 结肠癌肝转移行腹腔镜结直肠癌根治术联合腹腔镜肝切除术组对比腹腔镜结直肠癌根治联合术中微波消融术组,手术时间更长、术中出血更多(P <0.05);两组患者术后并发症比较,差异无统计学意义(P> 0.05);腹腔镜结直肠癌根治术联合腹腔镜肝切除术组具有更长的无瘤生存期时间和总体生存时间(P <0.05);多因素COX回归分析显示,联合腹腔镜微波射频、肝脏转移瘤多发、肝转移瘤直径> 3 cm是影响术后无瘤生存时间和总体生存时间的独立危险因素(P <0.05)。结论 腹腔镜结直肠癌根治联合腹腔镜肝切除治疗结直肠癌肝转移较腹腔镜结直肠癌根治联合术中微波消融术后并发症率相似,且具有更长的无瘤生存期时间和总体生存时间。

根治性切除与射频消融对化疗后最大径≤3 cm的结直肠癌肝转移灶的疗效对比:一项回顾性生存分析

目的研究结直肠癌肝转移(CRLM)瘤化疗后最大径≤3 cm患者接受手术或射频消融(RFA)治疗后复发和长期生存情况,探究CRLM患者化疗后≤3 cm的肝转移灶的最佳治疗方式。方法回顾性分析2012年1月至2022年12月浙江省肿瘤医院196例化疗后肝转移灶≤3 cm的CRLM患者,其中根治性切除组90例,射频消融组106例。采用Kaplan-Meier分析评估两组无复发生存率和总生存率,采用Cox回归模型评估影响生存的独立危险因素。结果患者的中位随访时间为21.5(13.0,40.0)个月。根治性切除组较射频消融组复发率低[53.3%vs 70.8%,χ^(2)=6.320,P=0.012],且根治性切除组未见治疗边缘复发,射频消融组9(8.5%)例患者出现局部治疗边缘复发。根治性切除组的3年无进展生存率明显优于射频消融组(42.4%vs 25.5%,P=0.031),两组3年总生存率差异无统计学意义(72.6%vs 67.3%,P=0.412)。多因素分析显示,手术切除是更好的无复发生存期的独立预测因素(OR=0.661,95%CI 0.459-0.952,P=0.026)。结论对于术前化疗后结直肠癌肝转移灶最大径≤3 cm的患者,手术治疗可以减少局部复发,延长无复发生存期。