Objective: To explore the clinical application effect of formulating the operating room nursing work procedure sheet for elderly lung cancer patients in thoracoscopic radical surgery. Methods: A total of 85 elderly pa...Objective: To explore the clinical application effect of formulating the operating room nursing work procedure sheet for elderly lung cancer patients in thoracoscopic radical surgery. Methods: A total of 85 elderly patients with lung cancer treated in our hospital from May 2022 to May 2023 were included as the study population for this research. They were divided into a study group of 42 cases and a regular group of 43 cases. The regular group of elderly patients received routine nursing care, while the study group of elderly patients was provided with the operating room nursing care work procedure sheet. The surgical duration, intraoperative blood loss, time to mobilization, and postoperative complication rate were compared and analyzed between the two groups. Results: Compared to the regular group, the study group had significantly shorter surgical duration and time to mobilization, as well as less intraoperative blood loss (P < 0.05). The overall incidence of postoperative complications in the study group (4.76%) was significantly lower than that in the regular group (19.05%) (P Conclusion: Formulating the operating room nursing work procedure sheet for elderly lung cancer patients can effectively improve surgical efficiency, reduce the incidence of postoperative complications, and promote patient prognosis in thoracoscopic radical surgery. Therefore, this model is worth promoting and adopting in clinical practice.展开更多
Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent...Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.展开更多
Objective: To investigate the effect of different anesthesia methods on immune function, oxidative stress and related cytokines in elderly patients undergoing radical mastectomy. Methods: The 90 elderly patients who u...Objective: To investigate the effect of different anesthesia methods on immune function, oxidative stress and related cytokines in elderly patients undergoing radical mastectomy. Methods: The 90 elderly patients who underwent radical surgery for lung cancer from March 2016 to March 2018 were randomly divided into two groups, 45 cases each. One group was given sevoflurane inhalation anesthesia (sevoflurane group), and the other group was given propofol anesthesia (propofol group). The immune function, oxidative stress and related cytokine levels in immediately before induction of anesthesia (T0), 1 hour of surgery (T1), 2 hours of surgery(T2) and 2 hours after surgery (T3) were compared between the two groups. Result: At T1, T2 and T3, the levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were significantly lower, and the levels of CD8+ were significantly higher those in T0 (P<0.05), and the levels of CD3+, CD4+ and CD4+/CD8+ in the sevoflurane group were significantly lower ,the level of CD8+ was significantly higher than those in the propofol group (P<0.05). There was no significant difference in VEGF and COX-2 levels between propofol groups at each time point (P>0.05), but at T3, VEGF and COX-2 levels in sevoflurane group were (415.12±60.23) pg/mL and (23.14±2.19) ng/mL respectively, which were significantly lower than those in T0 (P<0.05), and significantly lower than propofol group (P<0.05). There was no significant difference in MMP-2 and MMP-9 levels between propofol groups at each time point (P>0.05). The levels of MMP-2 and MMP-9 in the sevoflurane group at T2 and T3 were (324.83±26.81) ng/L, (352.05±31.96) ng/L, (313.19±27.32) ng/L and (345.21±33.04) ng/L respectively, which were significantly lower than those in T0, and significantly lower than propofol group (P<0.05). At T1 and T2, the MDA levels of the two groups were significantly higher than those in T0, and the SOD were significantly lower than those in T0 (P<0.05). At T2, the MDA level in the sevoflurane group was significantly lower than that in the propofol group (P<0.05), and the SOD level was significantly higher than that in the propofol group (P<0.05). Conclusion:Propofol intravenous anesthesia can protect the immune function of elderly patients undergoing radical lung cancer surgery, but sevoflurane can weaken the oxidative stress response and inhibit the expression of VEGF, COX-2, MMP-2 and MMP-9.展开更多
To evaluate the efficacy of adjuvantchemotherapy after radical surgery for non-small-celllung cancer (NSCLC). Methods Seventy patients with NSCLC (stages Ⅰ -Ⅲ ) undergoing radical surgery were randomized intotwo ...To evaluate the efficacy of adjuvantchemotherapy after radical surgery for non-small-celllung cancer (NSCLC). Methods Seventy patients with NSCLC (stages Ⅰ -Ⅲ ) undergoing radical surgery were randomized intotwo groups. Group 1 (n = 35): combination group,which received adjuvant chemotherapy withcyclophosphamide 300 mg/m 2, vincristine 1. 4 mg/m 2,adriamycin 50 mg/m 2, and lomustine 50 mg/m 2 on day1, and cisplatin 20 mg/m 2 on days 1-5. Thetreatment was repeated every 4-6 weeks for 4 cycles,followed by oral administration of ftorafur (FT-207) 600-900 mg/d for 1 year. Group 2 (n = 35): surgerygroup, which received surgical treatment only. Results The overall 5-year survival rate was 48.6%in the combination group versus 31 .4% in the surgerygroup, and difference between the two groups was notStatistically significant (x 2 = 3.09, P > 0.05). The year survival rate for patients with stage Ⅲ diseasewas 44% and 20.8% in the combination and surgerygroups, respectively, showing a statistically significantdifference (x 2 = 5.28, P < 0.025). The 5-yearsurvival rates of patients in stages Ⅰ -Ⅱ in the twogroups were 60.0% and 54.5%, respectively, andwere not significantly different (x 2 = 0. 03, P > 0. 75). Conclusion Postoperative adjuvant chemotherapy provides statistically significant improvement in the 5 year survival rate only in patients with stage ⅢNSCLC.展开更多
文摘Objective: To explore the clinical application effect of formulating the operating room nursing work procedure sheet for elderly lung cancer patients in thoracoscopic radical surgery. Methods: A total of 85 elderly patients with lung cancer treated in our hospital from May 2022 to May 2023 were included as the study population for this research. They were divided into a study group of 42 cases and a regular group of 43 cases. The regular group of elderly patients received routine nursing care, while the study group of elderly patients was provided with the operating room nursing care work procedure sheet. The surgical duration, intraoperative blood loss, time to mobilization, and postoperative complication rate were compared and analyzed between the two groups. Results: Compared to the regular group, the study group had significantly shorter surgical duration and time to mobilization, as well as less intraoperative blood loss (P < 0.05). The overall incidence of postoperative complications in the study group (4.76%) was significantly lower than that in the regular group (19.05%) (P Conclusion: Formulating the operating room nursing work procedure sheet for elderly lung cancer patients can effectively improve surgical efficiency, reduce the incidence of postoperative complications, and promote patient prognosis in thoracoscopic radical surgery. Therefore, this model is worth promoting and adopting in clinical practice.
文摘Objective: To explore the nursing effect of evidence-based PDCA cycle management mode in accelerated rehabilitation of patients undergoing thoracoscopic lung cancer radical surgery. Methods: 104 patients who underwent thoracoscopic lung cancer radical surgery in our hospital from June 2022 to February 2023 were randomly divided into control group and intervention group, with 52 cases in each group. The control group implemented evidence-based ERAS clinical pathway management, while the intervention group implemented evidence-based PDCA cycle quality management. The postoperative recovery of the two groups of patients was compared. Results: The postoperative recovery of the intervention group was significantly better than that of the control group. The first time to get out of bed, the first time to eat, the duration of chest drainage tube placement, and the length of hospital stay were significantly shorter than those of the control group. The incidence of postoperative chest complications and hospitalization costs were significantly lower than those of the control group, and patient satisfaction was significantly higher than that of the control group (P Conclusion: Evidence-based PDCA cycle quality management mode can effectively improve the implementation quality of accelerated rehabilitation nursing for patients undergoing thoracoscopic lung cancer radical surgery, and it is worthy of clinical promotion.
文摘Objective: To investigate the effect of different anesthesia methods on immune function, oxidative stress and related cytokines in elderly patients undergoing radical mastectomy. Methods: The 90 elderly patients who underwent radical surgery for lung cancer from March 2016 to March 2018 were randomly divided into two groups, 45 cases each. One group was given sevoflurane inhalation anesthesia (sevoflurane group), and the other group was given propofol anesthesia (propofol group). The immune function, oxidative stress and related cytokine levels in immediately before induction of anesthesia (T0), 1 hour of surgery (T1), 2 hours of surgery(T2) and 2 hours after surgery (T3) were compared between the two groups. Result: At T1, T2 and T3, the levels of CD3+, CD4+ and CD4+/CD8+ in the two groups were significantly lower, and the levels of CD8+ were significantly higher those in T0 (P<0.05), and the levels of CD3+, CD4+ and CD4+/CD8+ in the sevoflurane group were significantly lower ,the level of CD8+ was significantly higher than those in the propofol group (P<0.05). There was no significant difference in VEGF and COX-2 levels between propofol groups at each time point (P>0.05), but at T3, VEGF and COX-2 levels in sevoflurane group were (415.12±60.23) pg/mL and (23.14±2.19) ng/mL respectively, which were significantly lower than those in T0 (P<0.05), and significantly lower than propofol group (P<0.05). There was no significant difference in MMP-2 and MMP-9 levels between propofol groups at each time point (P>0.05). The levels of MMP-2 and MMP-9 in the sevoflurane group at T2 and T3 were (324.83±26.81) ng/L, (352.05±31.96) ng/L, (313.19±27.32) ng/L and (345.21±33.04) ng/L respectively, which were significantly lower than those in T0, and significantly lower than propofol group (P<0.05). At T1 and T2, the MDA levels of the two groups were significantly higher than those in T0, and the SOD were significantly lower than those in T0 (P<0.05). At T2, the MDA level in the sevoflurane group was significantly lower than that in the propofol group (P<0.05), and the SOD level was significantly higher than that in the propofol group (P<0.05). Conclusion:Propofol intravenous anesthesia can protect the immune function of elderly patients undergoing radical lung cancer surgery, but sevoflurane can weaken the oxidative stress response and inhibit the expression of VEGF, COX-2, MMP-2 and MMP-9.
文摘To evaluate the efficacy of adjuvantchemotherapy after radical surgery for non-small-celllung cancer (NSCLC). Methods Seventy patients with NSCLC (stages Ⅰ -Ⅲ ) undergoing radical surgery were randomized intotwo groups. Group 1 (n = 35): combination group,which received adjuvant chemotherapy withcyclophosphamide 300 mg/m 2, vincristine 1. 4 mg/m 2,adriamycin 50 mg/m 2, and lomustine 50 mg/m 2 on day1, and cisplatin 20 mg/m 2 on days 1-5. Thetreatment was repeated every 4-6 weeks for 4 cycles,followed by oral administration of ftorafur (FT-207) 600-900 mg/d for 1 year. Group 2 (n = 35): surgerygroup, which received surgical treatment only. Results The overall 5-year survival rate was 48.6%in the combination group versus 31 .4% in the surgerygroup, and difference between the two groups was notStatistically significant (x 2 = 3.09, P > 0.05). The year survival rate for patients with stage Ⅲ diseasewas 44% and 20.8% in the combination and surgerygroups, respectively, showing a statistically significantdifference (x 2 = 5.28, P < 0.025). The 5-yearsurvival rates of patients in stages Ⅰ -Ⅱ in the twogroups were 60.0% and 54.5%, respectively, andwere not significantly different (x 2 = 0. 03, P > 0. 75). Conclusion Postoperative adjuvant chemotherapy provides statistically significant improvement in the 5 year survival rate only in patients with stage ⅢNSCLC.
