A review on the Pharmacology and Adverse Drug Reaction of Chaihu Herbal Injection

The Chaihu herbal injection was the first herbal injection to be developed and used in China,which has been used in clinic for more than 70 years.This injection is widely used to treat fever caused by influenza or common cold and malaria.However,there is an ongoing debate about the safety of the clinical use of Chaihu herbal injection in view of the large number of adverse drug reaction reports and literature in China.On May 29,2018,the China Food and Drug Administration issued a notice requiring to revise the instruction manual of Chaihu herbal injection,list"prohibit for children"under the taboo item,and add the warning"adverse reactions of this product include anaphylactic shock".The purpose of this review is to provide updated,comprehensive information on the pharmacology and adverse drug reaction of Chaihu herbal injection based on scientific literatures in the past few decades.

Potential mechanism of Astragali radix-Angelicae sinensis radix in the treatment of spinal cord injury based on network pharmacology and molecular docking

Objective:Using network pharmacology and molecular docking technology to explore the possible mechanism of Huangqi(Astragali radix)-Danggui(Angelicae sinensis radix)on the treatment of spinal cord injury.Methods:The active components and the targets related to Astragali radix-Angelicae sinensis radix were screened out on the Traditional Chinese Medicine Systems Pharmacology database.Genes of spinal cord injury were searched by Genecards and the Online Mendelian Inheritance in Man databases.The intersection targets between herbs and diseases were obtained through online Venn diagrams.A components-targets-pathways network was established on Cytoscape 3.8.1 software.The STRING database was used to construct the intersection protein interaction network and screen out core targets.Gene Ontology biological processes and enrichment analysis based on the Kyoto Encyclopedia of Genes and Genes of intersection proteins were performed via DAVID database.Finally,the molecular docking with key components and core targets were performed in AutoDock software.Results:The 22 chemical components including quercetin,kaempferol were collected from Astragali radix-Angelicae sinensis radix.It acts on 110 targets,and interleukin-6,tumor necrosis factor,mitogen-activated protein kinase,tumor antigen p53 were considered as the major targets.50 pathways like Interleukin-17 signaling pathway,tumor necrosis factor signaling pathway and mitogen-activated protein kinase signaling pathway participate in biological processes such as positive transcription regulation and lipopolysacchanide response.The molecular docking revealed that the core targets had stronger binding activity with its corresponding active components.Conclusion:Astragali radix-Angelicae sinensis radix has the characteristics of multi-component,multi-target,and multi-pathway effects in treating spinal cord injury.Its potential mechanism may be related to preventing inflammation,improving microcirculation,inhibiting neuronal apoptosis,protecting damaged nerve cells and promoting nerve repair and regeneration.

A network pharmacology approach to investigate the mechanism of“Huangqi-Shanzhuyu”in the treatment of diabetic nephropathy

Background:To explore the action mechanism of Huangqi(Radix Astragali)and Shanzhuyu(Fructus Corni)in the treatment of diabetic nephropathy based on network pharmacology,aiming to provide a basis for clinical application.Methods:The main active components of Huangqi and Shanzhuyu were discerned through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),Traditional Chinese Medicine Integrated Database(TCMID).The targets related to diabetic nephropathy(DN)were obtained using Genecards,Therapeutic Target Database(TTD),and National Center for Biotechnology Information(NCBI)Gene.Subsequently,protein-protein interaction(PPI)networks were constructed with Cytoscape 3.7.2 and the STRING database.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were performed to analyze the intersection of targets via Database for Annotation,Visualization,and Integrated Discovery(DAVID)6.8.Built on the above analysis,we made a“Chinese medicine-chemical composition-target gene-disease”network.Results:Twenty-one active components were predicted from the Huangqi and Shanzhuyu herb pair,such as jaranol,mandenol and sitosterol.These components were applied to 41 targets mainly involved in many biological processes such as the PI3K-Akt signaling pathway,vascular endothelial growth factor(VEGF)signaling pathway,regulation of sodium ion transport and steroid-binding.Conclusion:This study proposes the network pharmacology method and identifies the potent combination therapeutic mechanism of Huangqi and Shanzhuyu for diabetic nephropathy(DN)through multiple targets and routes,this strategy will lay a good foundation for further in-depth study of the mechanism of action.

Study on mechanism and molecular docking verification of Angelicae Sinensis Radix and Astragali Radix in treating ischemic stroke

Background:Traditional Chinese medicine(TCM)has been shown to be effective in treating ischemic stroke(IS),and the combination of Angelicae Sinensis Radix(ASR)and Astragali Radix(AR)is a core TCM prescription that is widely acknowledged for its efficacy in IS treatment.This study utilized network pharmacology methods to explore the molecular mechanisms underlying the therapeutic effects of Angelicae Sinensis Radix and Astragali Radix in IS treatment,with preliminary validation conducted through molecular docking.Methods:Information on the structure,targets,main biological functions,and pathways of the active components in Angelicae Sinensis Radix and Astragali Radix was collected using databases such as PubChem,PharmMapper,UniProt,and GeneCards.The results were visualized using software such as Cytoscape 3.6.1,Ledock,and pymol.Results:We retrieved 20 active components and 149 targets associated with the compatibility of Angelicae Sinensis Radix and Astragali Radix from various databases,and GeneCards database was used to search 3350 IS-related gene targets,including 78 key targets of Angelicae Sinensis Radix and Astragali Radix for the treatment of IS.Enrichment analysis of these 78 targets using gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)revealed the involvement of 48 GO terms in the treatment of IS,mainly in biological processes such as metabolism,biological regulation,and stress response.The composition of biological devices such as supercavitary membrane,cell fluid,and extracellular space was also involved.The biological functions mainly included protein binding,ion binding,hydrolytic enzyme activity,and others.The identified pathways were estrogen signaling pathway,mitogen-activated protein kinase(MAPK)signaling pathway,PI3K-AKT signaling pathway,RAP1 signaling pathway,P53 signaling pathway,PPAR signaling pathway,FOXO signaling pathway,RAS signaling pathway,prolactin signaling pathway,HIF-1 signaling pathway,and TNF signaling pathway.Molecular docking analysis showed that the 17 key active components of Angelicae Sinensis Radix and Astragali Radix had strong binding activity with 13 IS key targets.Conclusion:Through the application of network pharmacology methods,it was found that the use of Angelicae Sinensis Radix and Astragali Radix for treating ischemic stroke mainly targets the MAPK and PI3K-AKT signaling pathways,involving several crucial compounds and genes.Nevertheless,additional in vitro and in vivo studies are needed to verify these findings.

Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali

Radix Astragali(RA),a traditional Chinese medicine from the dried root of Astragalus species,is widely distributed throughout the temperate regions of the world.The major bioactive constituents of RA are triterpene glycosides,flavonoids,saponins,and alkaloids,and these compounds mostly exert pharmacological activities on the cardiovascular,immune,respiratory,and hepatic systems.This review summarizes the recent studies on RA and provides a comprehensive summary regarding the status of resources,ethnopharmacology,phytochemistry,pharmacology,toxicology,clinical application,and patent release of RA.We hope this review can provide a guidance for further development of therapeutic agents from RA.

Protective Effects of Radix Astragali Injection on Multiple Organs of Rats with Obstructive Jaundice

Objective： To investigate the protective effects and mechanisms of Radix Astragali Injection on multiple organs of rats with obstructive jaundice（OJ）. Methods： A total of 180 rats were randomly divided into the sham-operated, model control and treated groups（60 in each group）. On 7, 14, 21 and 28 days after operation, the serum contents of alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, r-glutamyl transpeptidase（r-GT）, total bilirubin（TBil）, direct bilirubin（DBil）, blood urine nitrogen（BUN）, and creatinine（CREA） were determined. And the pathological changes of livers, kidneys and lungs, and protein expressions of toll-like receptor-4（TLR-4） of livers, intercellular adhesion molecule-1（ICAM-1） of lungs, Bax and nuclear factor-kappa B（NF-κB）, as well as apoptotic indexes of multiple organs were observed, respectively. Results： The pathological severity scores of multiple organs（including livers on 7, 14, 21 and 28 days, kidneys on 14 and 28 days, and lungs on 14 days）, serum contents of ALT（14 and 21 days）, AST（14 days）, TBil（7, 14, 21 and 28 days）, DBil（14 and 21 days）, BUN（28 days）, protein expressions of TLR-4（in livers, 28 days）, Bax（in livers and kidneys, 21 days）, and apoptotic indexes in livers（7 and 21 days） in the treated group were significantly lower than those in the model control group（P〈0.05 or P〈0.01）. Conclusion： Radix Astragali Injection exerts protective effects on multiple organs of OJ rats by improving the pathological changes of lung, liver and kidney, decreasing the serum index of hepatic and renal function as well as inhibiting the protein expression of TLR-4 and Bax in the livers and Bax in the kidneys.

Exploring the Molecular Mechanism of Radix Astragali on Colon Cancer Based on Integrated Pharmacology and Molecular Docking Technique

Objective:The objective of this study was to study the mechanism of Radix Astragali on colon cancer by integrated pharmacology and molecular docking technique.Methods:Integrative pharmacology-based research platform of traditional Chinese medicine(TCMIP)V2.0 was used to obtain the chemical components and corresponding targets of Radix Astragali and the target information of colon cancer to create the main target network of drugs and diseases.Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis was carried out using Hiplot website,and the interaction network of“Traditional Chinese Medicine-component-target-pathway”was established,and molecular docking with main targets was carried out for the key components.Results:Twenty-seven chemical constituents of Radix Astragali,their 254 corresponding targets,and 44 colon cancer-related targets were obtained.Through proteins interacting,70 nodes were obtained as core targets.GO analysis showed that it mainly acts on lipid metabolism,nuclear receptor activity,phagocytic cup,etc.KEGG pathway analysis showed that it was mainly enriched in the estrogen signaling pathway,C-type lectin receptor signaling pathway,PI3K-Akt signaling pathway,etc.The multidimensional network,quantitative estimate of the drug,and molecular docking showed that the main targets are AKT1,BCL2,and CDK6,and the key components involved are kumatakenin,astragaloside VIII,and choline.Conclusion:Kumatakenin,AstragalosideⅧ,Choline and other compounds of Radix Astragali may affect colon cancer by acting on AKT1,BCL2 and other targets,thereby regulating estrogen signaling pathway,C-type lectin receptor signaling pathway,PI3K-Akt signaling pathway and so on.Those will provide theoretical reference for future research on the material basis and mechanism of its pharmacodynamics.

组学技术在黄芪质量评价及药理作用机制研究中的应用

黄芪为补气之要药,临床应用广泛。但因各种因素导致黄芪质量参差不齐现象突出,且现行评价方法难以从整体上把控黄芪药材的质量优劣,未能有效的与不同复方中黄芪功效定向关联,严重影响其临床疗效及安全用药。针对上述问题,探索具有整体性和系统性特点的组学技术在中药材黄芪质量优劣性评价中的应用迫在眉睫。鉴于此本文查阅近年文献,对组学(代谢组学、转录组学、基因组学、蛋白组学)技术应用于中药材黄芪质量控制(品种、产地、种植方式、逆境、炮制加工)以及药理作用(抗疲劳、抗心衰、防治内分泌疾病、抗肿瘤)机制方面的研究进行综述,提出未来研究的方向与趋势,旨在为临床合理用药建立其全面系统的质量评价体系提供新的思路及方法。

黄芪黄酮类成分及其药理作用研究

黄芪是豆科黄芪属多年生草本植物。中药黄芪历史悠久,作为中国传统中药之一,具有应用范围广、药用价值高等特点。黄芪的化学成分主要包含黄芪甲苷、黄芪多糖、黄芪黄酮、氨基酸等。近年来药理研究表明黄芪中黄酮类成分具有抗肿瘤、抗炎、抗氧化、抗病毒、免疫调节、降血糖等多种药理作用,其抗肿瘤作用效果显著,成为近年来学者们广泛研究的热点。文章对黄芪黄酮的化学成分及其药理作用相关文献进行搜集、检索、查阅、归纳与整理,并进行系统概括与总结,以期为黄芪黄酮类成分进一步开发与利用提供理论依据。

基于网络药理学和分子对接探讨黄芪苦参配伍治疗结肠癌的作用机制

目的基于网络药理学及分子对接技术探讨黄芪苦参药对配伍治疗结肠癌的作用机制。方法根据中药系统药理学据库分析平台(TCMSP)筛选黄芪、苦参的所有活性成分;通过TCGA、GeneCards、OMIM得到结肠癌靶点基因;然后利用Cytoscape3.8.2等软件,建立“药-效物质-靶标”模型。利用PPI进行蛋白质交互作用的网络图谱;使用ClusterProfiler对靶点基因进行进一步GO、KEGG分析。对筛选出的黄芪和苦参的关键活性成分和主要靶点利用AutoDock Vina(1.1.2)进行分子对接验证。结果通过网络药理学、分子对接和生信分析,共筛选获得37个活性成分,167个药物治疗结肠癌的交互靶点基因,2616条GO条目;将涉及的排位前20的主要信号通路作图。分子对接结果显示核心成分与IL6、TNF、TP53、AKT1、IL1B靶点之间有较好的结合力。结论初步揭示了黄芪、苦参药对的物质基础及作用机制,为其治疗结肠癌的临床应用提供了理论基础。

基于网络药理学、分子对接技术及实验验证研究黄芪提取物治疗缺血缺氧性脑病的机制

运用网络药理学、分子对接技术探究黄芪提取物治疗缺血缺氧性脑病(hypoxic-ischemic encephalopathy,HIE)的机制,并进行实验验证。通过中药系统药理学数据库平台(TCMSP)、UniProt、GeneCards和OMIN数据库获得黄芪提取物的主要活性成分和基因靶点,通过GeneCards数据库获得HIE的相关靶点;利用Cytoscape软件构建黄芪提取物“活性成分-药物靶点”网络。应用PDB和TCMSP数据库获取分子结构,使用SYBYL-X2.1软件进行模拟分子对接。建立大鼠动物试验模型,采用Western blot法检测关键蛋白的表达情况。根据TCMSP数据库,共得到黄芪提取物的70个活性成分及其350个相关靶点,去除重复靶点和基因注释后,最终获得“黄芪提取物”有效成分的120个靶点。通过将黄芪提取物的120个靶点与HIE的前242个靶点(相关性分数>5)相映射,筛选出黄芪提取物治疗HIE的18个潜在靶点,发现4-羟基肉桂酸、顺式阿维酸、黄芪紫檀烷苷、常春藤皂苷元、华良姜素为关键活性成分。将18个潜在靶点输入STRING中进行蛋白相互作用分析,共发现3个核心靶点(degree值>30),分别为诱导型一氧化氮合酶2(nitric oxide synthase 2,NOS2)、前列腺素氧化环化酶2(prostaglandin-endoperoxide synthase 2,PTGS2)、超氧化物歧化酶1(superoxide dismutase 1,SOD1)。动物实验显示,黄芪提取物能够降低大鼠模型海马组织内的NOS2、PTGS2、MAPK4、CASP8蛋白表达。通过网络药理学分析和实验验证得出黄芪提取物能够通过多靶点、多通路起到抑制神经元凋亡、保护神经细胞的作用。

黄芪对脊髓损伤保护作用研究进展

脊髓损伤(spinal cord injury,SCI)是指由于多因素导致的脊髓与神经根的损伤,并在损害的相应节段出现各种运动、感觉和功能障碍,肌张力及病理反射等异常改变,如治疗不当会产生严重的并发症并遗留神经症状。目前治疗脊髓损伤尚缺乏统一有效的方法,手术减压和药物等治疗目前均具有一定的局限性。中药黄芪作为补益类药,具有补气生阳、固表止汗、利水消肿、托毒生肌等功效,其中的多糖类、黄酮类以及皂苷类等主要化学成分可通过发挥抑制神经炎症、抗神经元凋亡、抑制脂质过氧化、调节自噬、促进神经细胞再生、保护血管、改善微循环、增强机体免疫、抑制胶质瘢痕形成等作用而达到保护脊髓损伤的作用,且广泛应用于心、肺、脑等疾病中,近年来黄芪应用于脊髓损伤的保护作用及机制方面越来越引起众多学者的重视。该文通过梳理相关研究成果,为临床运用黄芪治疗脊髓损伤提供参考和借鉴。

黄芪在进展期胃癌的药理作用及作用机制研究进展

近年来胃癌发病趋于年轻化,并呈现快速进展、预后较差的特征,这一现象引起医学界对胃癌治疗策略的高度重视。早期胃癌症状不明显,临床上确诊的患者大部分为进展期胃癌,这不仅严重威胁患者的身心健康,也使治疗方案的探索变得尤为迫切。因此,寻求更加有效且安全的治疗手段成为研究的重点。本文综述和分析了近年来关于黄芪在进展期胃癌治疗中药理作用及其作用机制的文献,即在文中梳理和总结了黄芪的主要活性成分,包括多糖、黄酮、黄芪皂苷以及黄芪甲苷,并探讨了这些成分在进展期胃癌化疗、放疗和术后康复中的应用及其独特的治疗效果,讨论结果表明,黄芪具有潜在的辅助治疗作用,对进展期胃癌患者的康复过程具有积极影响。

黄芪抗非小细胞肺癌药理机制的研究进展

黄芪是一味应用广泛的传统中药,近年来,黄芪在抗癌研究领域引起了广泛关注。综述了黄芪在抗非小细胞肺癌方面的药理机制研究进展,发现黄芪可以通过多种途径干预肿瘤细胞,如减少肺癌细胞增殖、诱导凋亡、抑制侵袭和转移能力、调节免疫功能等,还能增强机体对肺癌的免疫监视和清除能力,以及诱导肺癌细胞自噬和逆转耐药性的潜力。黄芪多重的药理作用为它在未来的临床治疗中提供了理论依据,为开发新的治疗策略和药物提供了方向。然而,目前的研究大多停留在实验室水平,进一步的研究仍然需要在临床开展,以更全面地揭示黄芪在非小细胞肺癌治疗中的潜力。

网络药理学结合分子对接技术探讨黄芪-莪术促进肺癌肿瘤血管正常化的潜在机制

目的通过网络药理学联合分子对接技术探讨黄芪-莪术促进肺癌肿瘤血管正常化的潜在作用机制,为进一步研究寻找方向。方法利用公共数据库(TCMSP)检索并获取黄芪-莪术活性成分及相关靶点,通过基因卡、OMIM、TTD、药物GKB数据库和药物库数据,发现肺癌血管正常化的相关靶点,Met细胞景观插件ClueGO平台用于基因本体(GO)富集分析和京都基因组百科全书(KEGG)通路富集分析,最后利用AutoDock及Vina软件进行分子对接打分,Pymol软件进行对接结果的可视化展示。结果共筛选出486个黄芪-莪术生物活性成分和184个黄芪-莪术与肺癌肿瘤血管正常化相关的靶点;根据生物信息学分析,槲皮素、异鼠李素、山奈酚、7-O-甲基异脲醇、芒柄花黄素、毛芯异黄酮可能是黄芪-莪术调控肺癌肿瘤血管正常化的潜在活性成分,而RB1、MAPK1、EGFR、ESR1、AKT1、HIF1A、TP53、STAT1和CCND1是潜在的起效靶点;根据富集和分子对接结果显示异鼠李素与STAT1之间具有较高的结合亲和力,JAK2/STAT1通路可能是黄芪-莪术调控肺癌血管正常化的主要作用通路。结论黄芪-莪术促进肺癌肿瘤血管正常化作用的潜在机制可能是IFN-γ-JAK2/STAT1通路。

Quercetin,the key constituent of Astragali Radix,modulates ferroptosis in PASMCs and attenuates hypoxia pulmonary hypertension via the MAPK signaling pathway

This study delved into the mechanism by which the principal component of Astragali Radix regulated ferroptosis in the context of hypoxia-induced pulmonary hypertension,employing a combination of network pharmacology and experimental validation techniques.Active constituents of Astragali Radix and their corresponding targets were identified using the TCMSP database,while therapeutic targets associated with hypoxia-induced pulmonary hypertension were sourced from the GeneCards database.The Venn online tool facilitated the identification of overlapping targets between the active constituents of Astragali Radix and hypoxia-induced pulmonary hypertension.Interaction network diagrams depicting the relationship between Astragali Radix’s active constituents and their targets were constructed using Cytoscape software,with core targets and sub-networks identified using the CytoHubba plug-in.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were conducted using the DAVID database.Additionally,the FerrDb database was consulted to analyze genes implicated in regulating ferroptosis.The investigation revealed 18 active constituents selected from Astragali Radix,with quercetin emerging as the key component.A total of 35 potential targets associated with Astragali Radix in regulating ferroptosis and addressing hypoxia-induced pulmonary hypertension were predicted.Experimental validation demonstrated that quercetin could inhibit the MAPK signaling pathway,resulting in reduced Fe2+and lipid peroxide levels,increased GPX4 expression,and the reversal of ferroptosis.In summary,this study elucidated the fundamental constituents and pivotal signaling pathways through which Astragali Radix modulated ferroptosis and mitigated hypoxia-induced pulmonary hypertension.Specifically,quercetin,a core constituent of Astragali Radix,was observed to inhibit ferroptosis in pulmonary arterial smooth muscle cells via the MAPK pathway and alleviate hypoxia-induced pulmonary hypertension.

基于网络药理学和分子对接技术探究黄芪-淫羊藿治疗甲状腺功能减退症的机理

目的基于网络药理学和分子对接技术探究黄芪-淫羊藿治疗甲状腺功能减退症的可能机制。方法使用中药系统药理数据库(TCMSP)获取药物有效成分,并且预测靶点。获取2D结构图,并录入Phrammarpper数据库获得成分靶点。使用PharmGKb数据库、GeneCard数据库、DrugBank数据库、Therapeutic Target Database数据库预测疾病靶点。使用R 4.3.3获取药物疾病交集靶点。使用String数据库构建靶点蛋白互作网络(protein-protein interaction netuorks,PPI)。使用R 4.3.3和Cytoscape软件中Citispace获取核心靶点。通过R 4.3.3中BiocManager包和OrgDb包等和R Studio软件进行基因百科全书(kyoto encyclopedia of genes and genomes,KEGG)和基因本体(gene ontology,GO)富集分析。使用Cytoscape软件,建立“药物-成分-靶点-通路”网络关系图。结果获得药物核心成分10个,为槲皮素(quercetin)、山柰酚(kaempferol)、木犀草素(luteolin)、白桦脂酸(betulinic acid)等10个核心成分;PPI蛋白互作网络分析得到RAC-α丝氨酸/苏氨酸蛋白激酶(RAC-alphaserine/threonine-proteinkinase,AKT1)、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子(tumornecrosisfactor,TNF)、白细胞介素-1β(interleukin-1β,IL-1β)、细胞肿瘤抗原p53(cellular tumor antigen p 53,TP53)等16个淫羊藿-黄芪与甲减的关键靶点。GO富集主要是于质膜外侧、囊泡腔等组分上进行的细胞凋亡与增殖、对氧化应激的反应等过程。KEGG富集主要包括脂质和动脉粥样硬化通路、糖尿病并发症中的糖基化终末产物(advanced glycation end products,AGE)-糖基化终末产物受体(receptor for advanced glycation end products,RAGE)信号通路、磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)-蛋白激酶B(protein kinase B,AKT)信号通路等前30个信号通路。通过药物-成分-靶点-通路网络得到了槲皮素、AKT1、脂质与动脉粥样硬化通路3个关键节点。结论黄芪-淫羊藿可能通过多种成分共同作用于多个靶点形成多条信号通路来发挥对甲减的治疗作用,其中槲皮素-PI3K/AKT信号通路可能是其关键途径之一。

基于心肌重塑和心功能标志物NT-proBNP、H-FABP水平探讨黄芪注射液治疗慢性心力衰竭的作用

【目的】基于心肌重塑和心功能标志物N端脑钠肽前体(NT-proBNP)、心型脂肪酸结合蛋白(H-FABP)水平探讨黄芪注射液治疗慢性心力衰竭的作用。【方法】将80例心气虚型慢性心力衰竭患者随机分为对照组和研究组,每组各40例。对照组给予西医常规治疗,研究组在对照组的基础上给予黄芪注射液治疗,疗程为1周。观察2组患者治疗前后Lee氏心衰计分、中医证候积分、明尼苏达心力衰竭生活质量调查问卷(MLHFQ)评分及6 min步行距离的变化情况,检测2组患者治疗前后左室射血分数(LVEF)、每搏输出量(SV)和左室舒张末期内径(LVEDD)等心功能指标以及血清NT-proBNP、H-FABP的水平变化,并评估2组患者的临床疗效。【结果】(1)疗效方面,治疗1周后,研究组的总有效率为90.00%(36/40),对照组为62.50%(25/40),组间比较(χ^(2)检验),研究组的疗效明显优于对照组(P<0.01)。(2)结局指标方面,治疗后,2组患者的Lee氏心衰计分、中医证候积分及MLHFQ评分均较治疗前明显下降(P<0.01),且研究组的下降幅度均明显优于对照组(P<0.01)。(3)6 min步行距离方面,治疗后,2组患者的6 min步行距离均较治疗前明显增加(P<0.05或P<0.01),且研究组的增加幅度明显优于对照组(P<0.05)。(4)实验室指标方面,治疗后,2组患者的血清NT-proBNP、H-FABP水平均较治疗前明显下降(P<0.01),且研究组的下降幅度均明显优于对照组(P<0.01)。(5)心功能指标方面,治疗后,2组患者的LVEF、SV水平均较治疗前明显升高(P<0.01),且研究组的升高幅度均明显优于对照组(P<0.01);而2组患者的LVEDD治疗前后及治疗后组间比较,差异均无统计学意义(P>0.05)。【结论】在西医常规治疗基础上联合黄芪注射液治疗心气虚型慢性心力衰竭患者疗效确切,能有效缓解患者临床症状,改善患者心功能,提高患者生活质量。

黄芪化学成分及药理作用研究进展

黄芪为豆科植物蒙古黄芪或膜荚黄芪的干燥根,是临床上使用频率较高的中药材。近年来,随着国内外学者对黄芪研究的不断深入,发现了很多新的化学成分和药理作用,黄芪的化学成分主要有多糖、黄酮类化合物,三萜类化合物等,具有增强免疫功能,抗肿瘤,保护心脑血管系统,保护内脏,调节机体代谢,保护神经系统等作用,本次研究对近年来关于黄芪的相关文献进行综述分析,阐述其化学成分及药理作用的研究进展。

近5年黄芪化学成分及药理作用研究进展

黄芪是我国最古老的补益药之一,近年研究表明,其化学成分主要有黄芪多糖、皂苷类、黄酮类。本文对近5年黄芪的化学成分和药理作用的研究进展进行综述,以期为进一步研究和开发黄芪中药资源提供参考。