目的:研究子宫内膜异位症(EMS)患者中性粒细胞与淋巴细胞比值(NLR)、人附睾蛋白4(HE4)水平及动态监测临床意义。方法:选取我院2018年7月至2019年11月收治的135例EMS患者为研究对象,采用全自动血细胞分析仪检测计算NLR,酶联免疫吸附法检...目的:研究子宫内膜异位症(EMS)患者中性粒细胞与淋巴细胞比值(NLR)、人附睾蛋白4(HE4)水平及动态监测临床意义。方法:选取我院2018年7月至2019年11月收治的135例EMS患者为研究对象,采用全自动血细胞分析仪检测计算NLR,酶联免疫吸附法检测HE4水平。比较术前不同美国生育协会(rAFS)分期、术后7 d复发与未复发EMS患者NLR、HE4水平,分析术前NLR、HE4水平与rAFS分期的关联性,NLR、HE4对复发的影响及术后7 d联合检测对复发的预测价值。结果:随着rAFS分期提高,NLR、HE4水平呈逐渐升高趋势(P<0.05);经Spearman相关性分析,EMS患者NLR、HE4水平与rAFS分期呈正相关(P<0.05);EMS患者术后7 d NLR、HE4水平低于术前(P<0.05);复发患者术后7 d NLR、HE4水平高于未复发患者(P<0.05);经Cox回归分析将年龄、性别、病程、术后辅助药物治疗等其他因素调整后,NLR、HE4仍为复发的重要影响因素(P<0.01);经ROC曲线分析,联合检测AUC值0.831、敏感度82.49%、特异度86.25%高于NLR值单一检测0.762、78.56%、75.29%,HE4单一检测0.748、74.59%、78.67%(P<0.05)。结论:EMS患者NLR、HE4水平明显异常升高,与临床分期具有密切关联性,且动态监测可预测复发情况的发生,具有重要临床意义。展开更多
In this paper, we analyze and design a new type of servo system with noninteger voltage controlled crystal oscillator （VCXO） for rubidium atomic frequency standard （RAFS）, which does not require fractional frequen...In this paper, we analyze and design a new type of servo system with noninteger voltage controlled crystal oscillator （VCXO） for rubidium atomic frequency standard （RAFS）, which does not require fractional frequency synthesizer. By the estab- lishment of the loop equations with noises and drifts, we prove that all the components of the loop can affect its performance in- dex, and in which, RAFS long-term frequency stability is mainly determined by frequency multiplier, quantum system, and servo amplifier; the short-term one is mostly decided by VCXO. Owing to the elimination of the frequency synthesizer and its additive mixing unit, we can reduce phase noise and stray of the servo sys- tem, and it is favorable for miniaturizing the RAFS system. In addition, we adopt some targeted optimization measures to im- prove the frequency stability index. The good short-term fre- quency stability index is also validated by the test results.展开更多
文摘目的:研究子宫内膜异位症(EMS)患者中性粒细胞与淋巴细胞比值(NLR)、人附睾蛋白4(HE4)水平及动态监测临床意义。方法:选取我院2018年7月至2019年11月收治的135例EMS患者为研究对象,采用全自动血细胞分析仪检测计算NLR,酶联免疫吸附法检测HE4水平。比较术前不同美国生育协会(rAFS)分期、术后7 d复发与未复发EMS患者NLR、HE4水平,分析术前NLR、HE4水平与rAFS分期的关联性,NLR、HE4对复发的影响及术后7 d联合检测对复发的预测价值。结果:随着rAFS分期提高,NLR、HE4水平呈逐渐升高趋势(P<0.05);经Spearman相关性分析,EMS患者NLR、HE4水平与rAFS分期呈正相关(P<0.05);EMS患者术后7 d NLR、HE4水平低于术前(P<0.05);复发患者术后7 d NLR、HE4水平高于未复发患者(P<0.05);经Cox回归分析将年龄、性别、病程、术后辅助药物治疗等其他因素调整后,NLR、HE4仍为复发的重要影响因素(P<0.01);经ROC曲线分析,联合检测AUC值0.831、敏感度82.49%、特异度86.25%高于NLR值单一检测0.762、78.56%、75.29%,HE4单一检测0.748、74.59%、78.67%(P<0.05)。结论:EMS患者NLR、HE4水平明显异常升高,与临床分期具有密切关联性,且动态监测可预测复发情况的发生,具有重要临床意义。
文摘In this paper, we analyze and design a new type of servo system with noninteger voltage controlled crystal oscillator （VCXO） for rubidium atomic frequency standard （RAFS）, which does not require fractional frequency synthesizer. By the estab- lishment of the loop equations with noises and drifts, we prove that all the components of the loop can affect its performance in- dex, and in which, RAFS long-term frequency stability is mainly determined by frequency multiplier, quantum system, and servo amplifier; the short-term one is mostly decided by VCXO. Owing to the elimination of the frequency synthesizer and its additive mixing unit, we can reduce phase noise and stray of the servo sys- tem, and it is favorable for miniaturizing the RAFS system. In addition, we adopt some targeted optimization measures to im- prove the frequency stability index. The good short-term fre- quency stability index is also validated by the test results.
