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"Three Rare Mineral Resources" and Crystalline Graphite Have Become Prospecting Focuses in China 被引量:4
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作者 HAO Ziguo FEI Hongcai +1 位作者 HAO Qingqing LIU Lian 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第5期1905-1906,共2页
With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, tradit... With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, traditional metal materials cannot meet the functional requirements. Consequently, "three rare mineral resources", regarded as the best altemative for current and future new industries, have received much attention among industrial circles and have become a new focus during the present geological prospecting in China. 展开更多
关键词 Be and Crystalline Graphite Have Become Prospecting Focuses in China Three rare mineral Resources Graphite
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Significance of Rare Mineral Resources to Strategic Emerging Industries
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作者 李鹏飞 杨丹辉 +1 位作者 渠慎宁 张艳芳 《China Economist》 2015年第3期100-113,共14页
As non-renewable natural resources, rare minerals' are extensively used as important raw materials in strategic emerging industries. As global consumption continues to increase over recent years, international compet... As non-renewable natural resources, rare minerals' are extensively used as important raw materials in strategic emerging industries. As global consumption continues to increase over recent years, international competition in the area of rare mineral minerals has been escalating. On the basis' of the identification of 22 rare mineral resources of six categories and analysis of their applications in strategic emerging industries, this paper has adopted a three-factor analytical framework and designed nine indicators from the three dimensions of supply risks, environmental impacts and economic impacts of restricted supply to conduct a quantitative evaluation of the strategic significance of rare mineral resources. The result indicates that the strategic significance of platinum-group metals is the highest and the strategic significance of cesium is the lowest. In order to further increase the reliability of evaluation results, this paper has employed the Monte Carlo simulation for uncertainty analysis'. Simulation result demonstrates that after the impacts" of individual indicators have been taken into account, the results' of this paper's evaluation of 22 rare mineral resources remain valid. Given the growing significance of rare mineral resources to strategic emerging industries, China should formulate a national strategy on rare mineral resources', strive to inerease the supply security of key raw materials for strategic emerging industries and achieve the sustainable development and utilization of rare mineral resources for national security of natural resources. 展开更多
关键词 rare mineral resources strategic significance supply risks environmentalimpacts economic impacts of restricted supply
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Rare-Element Pegmatites Rocks Rich and Li of the Aïr Massif of the Tchirozerine: Mineralogy and Chemical Composition Agadez Region-Northem Niger
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作者 Ntoumbé Mama Hamza Bassara +2 位作者 Amaya Adama Awona Paul Zéphyrin Nomenjanahary Limbisoa 《Open Journal of Applied Sciences》 2024年第1期171-181,共11页
The lithium potential in the Aïr massif is represented by mineral index of spodumene pegmatites and, lepidolite pegmatites. The mineral deposits of lithium occur in cluster or veins that cut the host rock or are ... The lithium potential in the Aïr massif is represented by mineral index of spodumene pegmatites and, lepidolite pegmatites. The mineral deposits of lithium occur in cluster or veins that cut the host rock or are located near the contact between the greenstone belt and granitic massif. The evidence of lithium is in the form of clusters or disseminated and stockwerk. Mineralogical characteristics show similarities between the Air Massif pegmatites and indicate the same homogenous source during the magma-generation process. The pegmatite rocks attracted the attention due to their wide exposure and composition, well appearance, and economically hosting of significant rare earth metals such as Sn and W. The mineralogical and petrographical investigations on the eight pegmatites rocks samples observed have a relative similarity, while a little difference in the shapes attributed to the ratio in the pegmatite rocks of the minerals. The occurrence of the kink band indicates the influence of the tectonic processes which affected the Aïr massif after the emplacement of late magmatic or post-magmatic pegmatites by injection into fractured rocks in the upper part of the crust. The Air Massif pegmatite has higher concentrations Li and of all trace elements except Hf and occasionally Zr, Ti, Sn and Mg of for the economic exploration. 展开更多
关键词 PEGMATITE Lithium rare Elements Hydrothermal Processes Aïr Massif
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Biomedical rare-earth magnesium alloy:Current status and future prospects 被引量:1
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作者 Mingli Yang Cheng Chen +5 位作者 Dongsheng Wang Yinjin Shao Wenhao Zhou Cijun Shuai Youwen Yang Xinghai Ning 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第4期1260-1282,共23页
Biomedical magnesium(Mg)alloys have garnered significant attention because of their unique biodegradability,favorable biocompatibility,and suitable mechanical properties.The incorporation of rare earth(RE)elements,wit... Biomedical magnesium(Mg)alloys have garnered significant attention because of their unique biodegradability,favorable biocompatibility,and suitable mechanical properties.The incorporation of rare earth(RE)elements,with their distinct physical and chemical properties,has greatly contributed to enhancing the mechanical performance,degradation behavior,and biological performance of biomedical Mg alloys.Currently,a series of RE-Mg alloys are being designed and investigated for orthopedic implants and cardiovascular stents,achieving substantial and encouraging research progress.In this work,a comprehensive summary of the state-of-the-art in biomedical RE-Mg alloys is provided.The physiological effects and design standards of RE elements in biomedical Mg alloys are discussed.Particularly,the degradation behavior and mechanical properties,including their underlying action are studied in-depth.Furthermore,the preparation techniques and current application status of RE-Mg alloys are reviewed.Finally,we address the ongoing challenges and propose future prospects to guide the development of high-performance biomedical Mg-RE alloys. 展开更多
关键词 Magnesium alloy rare earth elements Biodegradation behavior Mechanical performance Biological properties
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Study of the Electronic Structure and Optical Properties of Rare Earth Luminescent Materials
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作者 Chengxi Zhang 《Journal of Materials Science and Chemical Engineering》 2023年第10期8-18,共11页
Rare earth luminescent materials have attracted significant attention due to their wide-ranging applications in the field of optoelectronics. This study aims to delve into the electronic structure and optical properti... Rare earth luminescent materials have attracted significant attention due to their wide-ranging applications in the field of optoelectronics. This study aims to delve into the electronic structure and optical properties of rare earth luminescent materials, with the goal of uncovering their importance in luminescence mechanisms and applications. Through theoretical calculations and experimental methods, we conducted in-depth analyses on materials composed of various rare earth elements. Regarding electronic structure, we utilized computational techniques such as density functional theory to investigate the band structure, valence state distribution, and electronic density of states of rare earth luminescent materials. The results indicate that the electronic structural differences among different rare earth elements notably influence their luminescence performance, providing crucial clues for explaining the luminescence mechanism. In terms of optical properties, we systematically examined the material’s optical behaviors through fluorescence spectroscopy, absorption spectroscopy, and other experimental approaches. We found that rare earth luminescent materials exhibit distinct absorption and emission characteristics at different wavelengths, closely related to the transition processes of their electronic energy levels. Furthermore, we studied the influence of varying doping concentrations and impurities on the material’s optical properties. Experimental outcomes reveal that appropriate doping can effectively regulate the emission intensity and wavelength, offering greater possibilities for material applications. In summary, this study comprehensively analyzed the electronic structure and optical properties of rare earth luminescent materials, providing deep insights into understanding their luminescence mechanisms and potential value in optoelectronic applications. In the future, these research findings will serve as crucial references for the technological advancement in fields such as LEDs, lasers, and bioimaging. 展开更多
关键词 rare Earth Luminescent Materials Electronic Structure Optical Properties Luminescence Mechanism Prospects for Applications
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Soil properties and not plant factors affect both abundant and rare microbial taxa after thinning in a mixed stand of Cunninghamia lanceolata and Sassafras tzumu
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作者 Wanxia Peng Tongqing Song +5 位作者 Hu Du Feng Wang Fuping Zeng Yang Wang Shulin Chen Yinzhu Chen 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第2期81-94,共14页
Thinning is an effective management step for sustainable forest development,yet less attention is paid to the restoration of soil microbiota after thinning.In this study,both abundant and rare soil microbial communiti... Thinning is an effective management step for sustainable forest development,yet less attention is paid to the restoration of soil microbiota after thinning.In this study,both abundant and rare soil microbial communities(i.e.,bacterial,fungal),were evaluated under various thinning treatments in a mixed stand of Cunninghamia lanceolata and Sassafras tzumu using Mi Seq sequencing.Thinning did not significantly change either abundant or rare bacterial and fungal community composition,but affected their alpha diversity.The Shannon–Wiener indexes of rare fungal taxa under medium thinning were significantly lower than in the light thinning(P<0.05 level).Xanthobacteraceae dominated the abundant bacterial taxa,and Saitozyma and Mortierlla the abundant fungal taxa.The most common rare bacterial taxa varied;there was no prevalent rare fungal taxa under different thinnings.In addition,soil available nitrogen,total phosphorus,and p H had significant effects on rare bacterial taxa.Nutrients,especially available phosphorus,but not nitrogen,affected abundant and rare soil fungi.The results indicate that soil properties rather than plant factors affect abundant and rare microbial communities in soils of mixed stands.Thinning,through mediating soil properties,influences both abundant and rare bacterial and fungal communities in the mixed C.lanceolata and S.tzumu stand. 展开更多
关键词 Diversity Abundant taxa rare taxa THINNING Mixed stand
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Effect and Mechanism of Rare Earth Hydrotalcite Inhibiting Coal Spontaneous Combustion
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作者 张小娟 LIU Bo +1 位作者 罗振敏 SUN Lu 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第1期50-59,共10页
A hydrotalcite(layered double hydroxide, LDH) inhibitor which is suitable for the whole process of coal spontaneous combustion and a LDH inhibitor containing rare earth lanthanum elements were prepared. The inhibition... A hydrotalcite(layered double hydroxide, LDH) inhibitor which is suitable for the whole process of coal spontaneous combustion and a LDH inhibitor containing rare earth lanthanum elements were prepared. The inhibition effect and mechanism were analyzed by scanning electron microscopy(SEM),X-ray diffraction(XRD), thermal performance analysis, in-situ diffuse reflectance infrared spectroscopy and temperature-programmed experiment. The results have shown that the inhibitor containing lanthanum can play a good inhibitory role in every stage of coal oxidation. During the slow oxidation of coal samples, the inhibitor containing lanthanum ions can slow down the oxidation process of coal and increase the initial temperature of coal spontaneous combustion. At the same time, because the hydroxyl groups in LDHs are connected with-COO-groups on the coal surface through hydrogen bonds, the stability of coal is improved. With the increase of temperature, LDHs can remove interlayer water molecules and reduce the surface temperature of coal. CO release rate of coal samples decreases significantly after adding inhibitor containing lanthanum element, and the maximum inhibition rate of the inhibitor is 58.1%. 展开更多
关键词 rare earth HYDROTALCITE coal spontaneous combustion MECHANISM
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Effect of Rare-Earth Element Substitution in Superconducting R_(3)Ni_(2)O_(7) under Pressure
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作者 Zhiming Pan Chen Lu +1 位作者 Fan Yang Congjun Wu 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第8期77-81,共5页
Recently,high temperature(T_(c)≈80 K)superconductivity(SC)has been discovered in La_(3)Ni_(2)O_(7)(LNO)under pressure.This raises the question of whether the superconducting transition temperature T_(c) could be furt... Recently,high temperature(T_(c)≈80 K)superconductivity(SC)has been discovered in La_(3)Ni_(2)O_(7)(LNO)under pressure.This raises the question of whether the superconducting transition temperature T_(c) could be further enhanced under suitable conditions.One possible route for achieving higher T_(c) is element substitution.Similar SC could appear in the Fmmm phase of rare-earth(RE)R_(3)Ni_(2)O_(7)(RNO,R=RE element)material series under suitable pressure.The electronic properties in the RNO materials are dominated by the Ni 3d orbitals in the bilayer NiO_(2) plane.In the strong coupling limit,the SC could be fully characterized by a bilayer single 3d_(x^(2)−y^(2))-orbital t–J‖–J⊥ model.With RE element substitution from La to other RE element,the lattice constant of the Fmmm RNO material decreases,and the resultant electronic hopping integral increases,leading to stronger superexchanges between the 3d_(x^(2)−y^(2)) orbitals.Based on the slave-boson mean-field theory,we explore the pairing nature and the evolution of T_(c) in RNO materials under pressure.Consequently,it is found that the element substitution does not alter the pairing nature,i.e.,the inter-layer s-wave pairing is always favored in the superconducting RNO under pressure.However,the T_(c) increases from La to Sm,and a nearly doubled T_(c) could be realized in SmNO under pressure.This work provides evidence for possible higher T_(c) R_(3)Ni_(2)O_(7) materials,which may be realized in further experiments. 展开更多
关键词 ELEMENT SUBSTITUTION rare
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Primary unifocal penile follicular center non-Hodgkin lymphoma:Report of a rare case and review of the literature
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作者 Nikolaos Kostakopoulos Christos Masaoutis +4 位作者 Vasileios Argyropoulos Varvara Pantelaion Panagiotis Theodoropoulos Panagiotis Kouroupakis Athanasios Kostakopoulos 《Asian Journal of Urology》 CSCD 2024年第1期134-136,共3页
Dear Editor,We present a rare case of a primary penile follicular center non-Hodgkin lymphoma and a review of the available literature on this condition.A BCL2 gene transposition which was identified with fluorescent ... Dear Editor,We present a rare case of a primary penile follicular center non-Hodgkin lymphoma and a review of the available literature on this condition.A BCL2 gene transposition which was identified with fluorescent in situ hybridization(FISH)molecular analysis is a unique manifestation not previously reported to the best of our knowledge.A 67-year-old man presented with a 3-month history of a small nodule on the left side of the corona of glans penis.The patient had no significant medical or family history.The patient underwent excision and biopsy of the penile lesion with a 0.5 cm macroscopic margin under local anesthesia and sedation.He was discharged on the day of surgery,and there were no postoperative complications or adverse events.The informed consent was obtained from thepatient. 展开更多
关键词 ANESTHESIA LYMPHOMA rare
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Geochemical and petrological studies of high sulfur coal and overburden from Makum coalfield (Northeast India) towards understanding and mitigation of acid mine drainage
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作者 Angana Mahanta Debashis Sarmah +6 位作者 Nilotpol Bhuyan Monikankana Saikia Sarat Phukan K.S.V.Subramanyam Ajit Singh Prasenjit Saikia Binoy K.Saikia 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第1期133-147,共15页
Opencast coal mining produces trash of soil and rock containing various minerals,that are usually dumped nearby the abandoned sites which causes severe environmental concern including the production of acid mine drain... Opencast coal mining produces trash of soil and rock containing various minerals,that are usually dumped nearby the abandoned sites which causes severe environmental concern including the production of acid mine drainage(AMD)through oxidation pyrite minerals.The current study entailed assessing the potential production of AMD from an opencast coal mining region in Northeast part of India.In order to have a comprehensive overview of the AMD problem in Makum coalfield,the physico-chemical,geochemical,and petrological characteristics of the coal and overburden(OB)samples collected from the Makum coalfield(Northeast India)were thoroughly investigated.The maceral compositions reveal that coal features all three groups of macerals(liptinite,vitrinite,and inertinite),with a high concentration of liptinite indicating the coal of perhydrous,thereby rendering it more reactive.Pyrite(FeS_(2))oxidation kinetics were studied by conducting the aqueous leaching experiments of coal and(OB)samples to interpret the chemical weathering under controlled laboratory conditions of various temperature and time periods,and to replicate the actual mine site leaching.Inductively coupled plasma-optical emission spectroscopy(ICP-OES)was operated to detect the disposal of some precarious elements from coal and OB samples to the leachates during our controlled leaching experiment.The Rare earth element(REE)enrichment in the samples shows the anthropogenic incorporation of the REE in the coal and OB.These experiments reveal the change in conductivity,acid producing tendency,total dissolved solid(TDS),total Iron(Fe)and dissolved Sulfate(SO_(4)^(2−))ions on progress of the leaching experiments.Moreover,the discharge of FeS_(2) via atmospheric oxidation in laboratory condition undergoes a significant growth with the rise of temperature of the reaction systems in the environment and follows pseudo first order kinetics.A bio-remediative strategies is also reported in this paper to mitigate AMD water by employing size-segregated powdered limestone and water hyacinth plant in an indigenously developed site-specific prototype station.Apart from neutralisation of AMD water,this eco-friendly AMD remediation strategy demonstrates a reduction in PHEs concentrations in the treated AMD water. 展开更多
关键词 Opencast mining Pyrite oxidation Coal geochemistry Coal petrology rare earth elements AMD remediation
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Rare Earth Elements(La,Ce,Pr)Modified Co/NC Catalyst for Efficient and Stable Ammonia Decomposition to Hydrogen Production
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作者 ZHU Yi PAN Hongfei 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第6期1372-1378,共7页
Co/NC catalysts modified with rare earth elements(La,Ce,Pr)were prepared by pyrolysis of rare earth elements doped ZIF-67.The experimental results show that the modification of rare earth elements significantly improv... Co/NC catalysts modified with rare earth elements(La,Ce,Pr)were prepared by pyrolysis of rare earth elements doped ZIF-67.The experimental results show that the modification of rare earth elements significantly improves the ammonia decomposition activity and stability of the Co/NC catalyst.The La-Co/NC catalyst can achieve an 82.3%ammonia decomposition and 18.4 mmol hydrogen production rate at 550℃with a GHSV of 20000 cm^(3)·h^(-1).Furthermore,no obvious performance degradation is observed after 72 hours of reaction for all rare earth elements modified catalysts.It is shown that the modification of rare earth elements significantly improves the surface alkalinity and surface chemical state of the catalyst,and thus improves the ammonia decomposition activity of the catalyst.A new type of high-performance ammonia decomposition Co-based catalyst is proposed,and the promoting effect of rare earth elements on the activity of ammonia decomposition is revealed. 展开更多
关键词 hydrogen carrier hydrogen production ammonia decomposition rare earth elements cobalt-based catalysts
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Changes in Sediment Sources in the Southern Muddy Area of Weihai,China,Since the Late Pleistocene:A Record from Rare Earth Elements
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作者 ZHANG Zhichao LIU Jinqing +3 位作者 YIN Ping CAO Ke FENG Xiaokun WANG Shengyu 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第5期1221-1232,共12页
The small muddy areas developed in the southern Shandong Peninsula have attracted increasing attention from researchers because of complex changes in sediment sources driven by sea-level fluctuations and land-sea inte... The small muddy areas developed in the southern Shandong Peninsula have attracted increasing attention from researchers because of complex changes in sediment sources driven by sea-level fluctuations and land-sea interactions since the late Pleistocene.This study investigates the evolution of sediment sources and their responses to environmental changes since the late Pleistocene,using core WHZK01 collected from the nearshore muddy area in southern Weihai for rare earth element(REE)analysis.In doing so,this work highlights the changing patterns of material sources and the primary control factors.The results reveal that the sedimentary deposits in core WHZK01 exhibit distinct terrestrial characteristics.Discriminant function analysis(F_(D))and source discrimination dia-grams both suggest that the primary sources of these deposits are the Yellow River and adjacent small and medium-sized rivers,although the sources vary among different sedimentary units.Furthermore,the DU3 layer(17.82-25.10 m)displays typical riverine sedimentation,dominated by terrestrial detrital input,primarily from the local rivers,namely the Huanglei and Muzhu Rivers.The material in the DU2 layer(14.91-17.82 m)is mainly influenced by a mixture of the Qinglong and Yellow Rivers.The DU1 layer(0-14.91 m)is influenced by sea-level changes during the Holocene,with the Yellow River being the primary source,although there is also some input from local rivers.The changes in sea level during the Holocene and the input of Yellow River material carried by the coastal currents of the Yellow Sea are identified as the main controlling factors for the changes in material sources in the study area since the late Pleistocene,with small and mediumsized rivers also exerting some influence on the material sources.The above mentioned findings not only contribute to a better understanding of the source-sink systems of the Yellow River and adjacent small and mediumsized rivers but also deepen our understanding of the late Quaternary land-sea interactions in the Shandong Peninsula. 展开更多
关键词 rare earth element source identification environmental evolution muddy area southern Weihai
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Process engineering of demineralisation of moderate to high ash Indian coals through NaOH‑HCl leaching and HF leaching
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作者 Heena Dhawan D.K.Sharma 《International Journal of Coal Science & Technology》 EI CAS CSCD 2024年第2期111-122,共12页
Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective enough.This would also help in recovering Li and rare earth metals... Chemical leaching of coals would be required to produce cleaner coals for some special applications where physical benefi-ciation may not be effective enough.This would also help in recovering Li and rare earth metals besides in the sequestration of CO_(2).About 20 Indian coals having complexly distributed moderate to high ash contents were sequentially treated with various alkali–acid such as NaOH-HCl,HF,HCl,HCl-HF,and NaOH-HCl-HF leaching.This aimed to establish and design the best stepwise sequential process for the highest degree of demineralisation through a chemical leaching process.Kinetics and process intensification studies were carried out.More than 80%demineralisation of Madhaipur and Neemcha coals was observed using the best sequential treatment designed presently.The repeated stepwise treatment of the alkali and the acid was also studied,which was found to significantly enhance the degree of demineralisation of coals.The integrated process of alkali–acid leaching followed by solvent extraction(Organo-refining)and vice versa of the treated coal was also studied for producing cleaner coals. 展开更多
关键词 Alkali–acid leaching DEmineRALISATION Integrated process rare earth elements
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The Electrocatalytic Performance of Rare Earth Ion Doped Co_(0.2)Ni_(0.8)-MOF-74 Catalyst for Nitrogen Reduction
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作者 YUE Song GONG Lunjun +4 位作者 YANG Tonghui HU Weida LIU Xiaopan GAO Pengzhao XIAO Hanning 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第6期1337-1347,共11页
We took Co_(0.2)Ni_(0.8)-MOF-74 with bimetallic synergistic effect as the basic material,and selected rare earth ions Ho,Gd,and Er with ion radii close to Co and Ni as the research objects for doping.The influence of ... We took Co_(0.2)Ni_(0.8)-MOF-74 with bimetallic synergistic effect as the basic material,and selected rare earth ions Ho,Gd,and Er with ion radii close to Co and Ni as the research objects for doping.The influence of rare earth ion doping amount and doping type on the eNRR performance of the catalyst was explored.The experimental results show that the ammonia yield rate and Faraday efficiency doped with Co_(0.2)Ni_(0.8)-MOF-0.5Ho are the highest,reaching 1.28×10^(-10)mol·s^(-1)·cm^(-2)/39.8%,which is higher than the1.12×10^(-10)mol·s^(-1)·cm^(-2)/32.2%of Co_(0.2)Ni_(0.8)-MOF-74,and is about 14.3%/23.7%higher than that without doping,respectively.And the stability of Co_(0.2)Ni_(0.8)-MOF-0.5 Ho is good(after 80 hours of continuous testing,the current density did not significantly decrease).This is mainly due to doping,which gives Co_(0.2)Ni_(0.8)-MOF-74 a larger specific surface area and catalytic active sites.The catalyst doped at the same time has more metal cation centers,which increases the electron density of the metal centers and enhances the corresponding eNRR performance. 展开更多
关键词 electrocatalytic nitrogen reduction metal organic framework rare earth ions DOPING
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Exploiting fly models to investigate rare human neurological disorders
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作者 Tomomi Tanaka Hyung-Lok Chung 《Neural Regeneration Research》 SCIE CAS 2025年第1期21-28,共8页
Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological symptoms.Often attributed to genetic mutations that disrupt protein functio... Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological symptoms.Often attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted therapies.To investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary time.Genetic tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological diseases.Drosophila boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug candidates.Researchers can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical trials.In this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic implications.We discuss rare diseases associated with both neuron-expressed and glial-expressed genes.Specific cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal movements.And we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell syndrome.Loss-of-function mutations in ACOX1 result in ACOX1 deficiency,characterized by very-long-chain fatty acid accumulation and glial degeneration.Notably,this review highlights how modeling these diseases in Drosophila has provided valuable insights into their pathophysiology,offering a platform for the rapid identification of potential therapeutic interventions.Rare neurological diseases involve a wide range of expression systems,and sometimes common phenotypes can be found among different genes that cause abnormalities in neurons or glia.Furthermore,mutations within the same gene may result in varying functional outcomes,such as complete loss of function,partial loss of function,or gain-of-function mutations.The phenotypes observed in patients can differ significantly,underscoring the complexity of these conditions.In conclusion,Drosophila represents an indispensable and cost-effective tool for investigating rare neurological diseases.By facilitating the modeling of these conditions,Drosophila contributes to a deeper understanding of their genetic basis,pathophysiology,and potential therapies.This approach accelerates the discovery of promising drug candidates,ultimately benefiting patients affected by these complex and understudied diseases. 展开更多
关键词 ACOX1 Drosophila melanogaster GLIA lipid metabolism model organisms NEUROINFLAMMATION neurologic disorders NEURON rare disease VLCFA
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Association between Exposure of Rare Earth Elements and Outcomes of In Vitro Fertilization-Embryo Transfer in Beijing
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作者 Yutong Wang Jing Li +9 位作者 Shirong Xu Shengli Lin Zhenchen Hou Linlin Wang Yali Huang Yue Sun Wei Guo Lailai Yan Ying Wang Chan Tian 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第8期876-886,共11页
Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from spouses.Methods A total of 141 ... Objective The study aimed to investigate the impact of rare earth elements(REEs)exposure on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)by analyzing samples from spouses.Methods A total of 141 couples were included.Blood and follicular fluid from the wives and semen plasma from the husbands,were analyzed for REEs using inductively coupled plasma mass spectrometry(ICP-MS).Spearman's correlation coefficients and the Mann–Whitney U test were used to assess correlations and compare REE concentrations among three types of samples,respectively.Logistic models were utilized to estimate the individual REE effect on IVF-ET outcomes,while BKMR and WQS models explored the mixture of REE interaction effects on IVF-ET outcomes.Results Higher La concentration in semen(median 0.089 ng/mL,P=0.03)was associated with a lower fertilization rate.However,this effect was not observed after artificial selection intervention through intracytoplasmic sperm injection(ICSI)(P=0.27).In semen,the REEs mixture did not exhibit any significant association with clinical pregnancy.Conclusion Our study revealed a potential association between high La exposure in semen and a decline in fertilization rate,but not clinical pregnancy rate.This is the first to report REEs concentrations in follicular fluid with La,Ce,Pr,and Nd found at significantly lower concentrations than in serum,suggesting that these four REEs may not accumulate in the female reproductive system.However,at the current exposure levels,mixed REEs exposure did not exhibit reproductive toxicity. 展开更多
关键词 rare earth elements In vitro fertilization Pregnancy outcomes Mixture exposure analysis
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Improvement strategy on thermophysical properties of A_(2)B_(2)O_(7)-type rare earth zirconates for thermal barrier coatings applications:A review
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作者 Zijian Peng Yuhao Wang +8 位作者 Shuqi Wang Junteng Yao Qingyuan Zhao Enyu Xie Guoliang Chen Zhigang Wang Zhanguo Liu Yaming Wang Jiahu Ouyang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第5期1147-1165,共19页
The A_(2)B_(2)O_(7)-type rare earth zirconate compounds have been considered as promising candidates for thermal barrier coating(TBC) materials because of their low sintering rate,improved phase stability,and reduced ... The A_(2)B_(2)O_(7)-type rare earth zirconate compounds have been considered as promising candidates for thermal barrier coating(TBC) materials because of their low sintering rate,improved phase stability,and reduced thermal conductivity in contrast with the currently used yttria-partially stabilized zirconia (YSZ) in high operating temperature environments.This review summarizes the recent progress on rare earth zirconates for TBCs that insulate high-temperature gas from hot-section components in gas turbines.Based on the first principles,molecular dynamics,and new data-driven calculation approaches,doping and high-entropy strategies have now been adopted in advanced TBC materials design.In this paper,the solid-state heat transfer mechanism of TBCs is explained from two aspects,including heat conduction over the full operating temperature range and thermal radiation at medium and high temperature.This paper also provides new insights into design considerations of adaptive TBC materials,and the challenges and potential breakthroughs are further highlighted for extreme environmental applications.Strategies for improving thermophysical performance are proposed in two approaches:defect engineering and material compositing. 展开更多
关键词 rare earth zirconates thermal barrier coatings defect engineering doping and compositing thermal conductivity thermal expansion
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A rare case of cardiac and ophthalmic manifestations of meningococcal septicemia
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作者 Svetlana Rachina Anastasia Shchendrygina +13 位作者 Heshan Radeesha de Silva Svetlana Tarasenko Nadezhda Mukhina Irina Komarova Ludmila Fedina Elena Burmistrova Elvira Martens Sergey Sidorenko Vladimir Gostev Dmitry Polev Alina Saitova Lyudmila Kraeva Nikita Goncharov Irina Zvetkova 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第4期328-330,共3页
Acute pericarditis is usually a self-limiting disorder that commonly occurs due to viral etiology or unexplained causes.Meningococcal pericarditis(MP)is a remarkably uncommon clinical entity that manifests as a compli... Acute pericarditis is usually a self-limiting disorder that commonly occurs due to viral etiology or unexplained causes.Meningococcal pericarditis(MP)is a remarkably uncommon clinical entity that manifests as a complication during the acute or convalescent phase of meningococcal meningitis.However,its occurrence within the context of meningococcal septicemia has also been documented.We report a rare case of a previously healthy male patient who developed both acute pericarditis and uveitis as a presentation of meningococcal septicemia,with no characteristic skin rashes or meningeal signs. 展开更多
关键词 ACUTE ACUTE rare
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Response and assembly of abundant and rare taxa in Zaopei under different combination patterns of Daqu and pit mud:from microbial ecology to Baijiu brewing microecosystem
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作者 Yu Mu Jun Huang +5 位作者 Rongqing Zhou Suyi Zhang Hui Qin Hanlan Tang Qianglin Pan Huifang Tang 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1439-1452,共14页
The quality and aroma of strong-flavor Baijiu are mainly dependent on Daqu,pit mud(PM),and the interaction of both.However,little is known about how their combination patterns affect the microbiome and metabolome of Z... The quality and aroma of strong-flavor Baijiu are mainly dependent on Daqu,pit mud(PM),and the interaction of both.However,little is known about how their combination patterns affect the microbiome and metabolome of Zaopei,especially the metabolic function of rare taxa.Here,an experiment on industrial size was designed to assess the effects of 6 combinations(3 kinds of Daqu×2 kinds of PM)on the composition and assembly of different taxa,as well as the flavor profile.The results showed that Zaopei's microbiota was composed of a few abundant taxa and enormous rare taxa,and rare bacterial and abundant fungal subcommunities were significantly affected by combination patterns.The assembly processes of abundant/rare taxa and bacterial/fungal communities were distinct,and environmental changes mediated the balance between stochastic and deterministic processes in rare bacteria assembly.Furthermore,specific combination patterns improved the flavor quality of Zaopei by enhancing the interspecies interaction,which was closely related to rare taxa,especially rare bacteria.These findings highlighted that rare bacteria might be the keystone in involving community interaction and maintaining metabolic function,which provided a scientific foundation for better understanding and regulating the brewing microbiota from the viewpoint of microbial ecology. 展开更多
关键词 Bioaugmented Daqu Artificial pit mud Abundant and rare taxa Community assembly Metabolic function
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Wetting front migration model of ion-adsorption rare earth during the multi-hole unsaturated liquid injection
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作者 Yu Wang Xiaojun Wang +8 位作者 Yuchen Qiu Hao Wang Gang Li Kaijian Hu Wen Zhong Zhongqun Guo Bing Li Chunlei Zhang Guangxiang Ye 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第2期483-496,共14页
In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distanc... In the process of ion-adsorption rare earth ore leaching,the migration characteristics of the wetting front in multi-hole injection holes and the influence of wetting front intersection effect on the migration distance of wetting fronts are still unclear.Besides,wetting front migration distance and leaching time are usually required to optimize the leaching process.In this study,wetting front migration tests of ionadsorption rare earth ores during the multi-hole fluid injection(the spacing between injection holes was 10 cm,12 cm and 14 cm)and single-hole fluid injection were completed under the constant water head height.At the pre-intersection stage,the wetting front migration laws of ion-adsorption rare earth ores during the multi-hole fluid injection and single-hole fluid injection were identical.At the postintersection stage,the intersection accelerated the wetting front migration.By using the Darcy’s law,the intersection effect of wetting fronts during the multi-hole liquid injection was transformed into the water head height directly above the intersection.Finally,based on the Green-Ampt model,a wetting front migration model of ion-adsorption rare earth ores during the multi-hole unsaturated liquid injection was established.Error analysis results showed that the proposed model can accurately simulate the infiltration process under experimental conditions.The research results enrich the infiltration law and theory of ion-adsorption rare earth ores during the multi-hole liquid injection,and this study provides a scientific basis for optimizing the liquid injection well pattern parameters of ion-adsorption rare earth in situ leaching in the future. 展开更多
关键词 Ion-adsorption rare earth ore Multi-hole unsaturated liquid injection In situ leaching Intersection effect Calculation model
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