Recently,a novel research led by Mallika Singh and Kenneth P.Olive^(1,2) published in Nature identified a highly selective inhibitor(RMC-7977)of the active GTP-bound forms of human RAS family(KRAS,HRAS and NRAS)with a...Recently,a novel research led by Mallika Singh and Kenneth P.Olive^(1,2) published in Nature identified a highly selective inhibitor(RMC-7977)of the active GTP-bound forms of human RAS family(KRAS,HRAS and NRAS)with affinity for both mutant and wild-type variants.Moreover,they assessed the therapeutic potential of RMC-7977 in a comprehensive range of human pancreatic ductal adenocarcinoma(PDAC)models and proved that RMC-7977 could induce apoptosis and sustained proliferative arrest,whereas normal tissues underwent only transient decreases in proliferation.Meanwhile.展开更多
文摘Recently,a novel research led by Mallika Singh and Kenneth P.Olive^(1,2) published in Nature identified a highly selective inhibitor(RMC-7977)of the active GTP-bound forms of human RAS family(KRAS,HRAS and NRAS)with affinity for both mutant and wild-type variants.Moreover,they assessed the therapeutic potential of RMC-7977 in a comprehensive range of human pancreatic ductal adenocarcinoma(PDAC)models and proved that RMC-7977 could induce apoptosis and sustained proliferative arrest,whereas normal tissues underwent only transient decreases in proliferation.Meanwhile.
