c-ras-P21 and Gamma-glutamyltransferase (G-GT) activity and its isoenzymes in rat liver extracts were measured after partial hepatectomy. There were G-GT activity peaks at 12th and 36th hour after operation, while no ...c-ras-P21 and Gamma-glutamyltransferase (G-GT) activity and its isoenzymes in rat liver extracts were measured after partial hepatectomy. There were G-GT activity peaks at 12th and 36th hour after operation, while no distinct isoenzyme patterns were found. P21 protein expression occurred between 48 and 96 hours after partial hepatectomy. These results suggest that the temporary increase of G-GT and P21 protein level is involved in the prereplica-tive stage of liver regeneration.展开更多
This paper is devoted to identifying the biomarkers of rat liver regeneration via the adaptive logistic regression. By combining the adaptive elastic net penalty with the logistic regression loss, the adaptive logisti...This paper is devoted to identifying the biomarkers of rat liver regeneration via the adaptive logistic regression. By combining the adaptive elastic net penalty with the logistic regression loss, the adaptive logistic regression is proposed to adaptively identify the important genes in groups. Furthermore, by improving the pathwise coordinate descent algorithm, a fast solving algorithm is developed for computing the regularized paths of the adaptive logistic regression. The results from the experiments performed on the microarray data of rat liver regeneration are provided to illustrate the effectiveness of the proposed method and verify the biological rationality of the selected biomarkers.展开更多
To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1]...To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim of this study was to analyse the impact of terlipressin ver-展开更多
文摘c-ras-P21 and Gamma-glutamyltransferase (G-GT) activity and its isoenzymes in rat liver extracts were measured after partial hepatectomy. There were G-GT activity peaks at 12th and 36th hour after operation, while no distinct isoenzyme patterns were found. P21 protein expression occurred between 48 and 96 hours after partial hepatectomy. These results suggest that the temporary increase of G-GT and P21 protein level is involved in the prereplica-tive stage of liver regeneration.
基金supported by National Nature Science Foundation of China(No.61203293)Key Scientific and Technological Project of Henan Province(No.122102210131)+3 种基金Program for Science and Technology Innovation Talents in Universities of Henan Province(No.13HASTIT040)Foundation of Henan Educational Committee(No.13A120524)Henan Normal University Doctoral Topics(No.qd14156)Henan Higher School Funding Scheme for Young Teachers(No.2012GGJS-063)
文摘This paper is devoted to identifying the biomarkers of rat liver regeneration via the adaptive logistic regression. By combining the adaptive elastic net penalty with the logistic regression loss, the adaptive logistic regression is proposed to adaptively identify the important genes in groups. Furthermore, by improving the pathwise coordinate descent algorithm, a fast solving algorithm is developed for computing the regularized paths of the adaptive logistic regression. The results from the experiments performed on the microarray data of rat liver regeneration are provided to illustrate the effectiveness of the proposed method and verify the biological rationality of the selected biomarkers.
文摘To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim of this study was to analyse the impact of terlipressin ver-
