Urinary tract infection(UTI) is one of the most commonchildhood infections.Permanent renal cortical scarring may occur in affected children,especially with recurrent UTIs,leading to long-term complications such as hyp...Urinary tract infection(UTI) is one of the most commonchildhood infections.Permanent renal cortical scarring may occur in affected children,especially with recurrent UTIs,leading to long-term complications such as hypertension and chronic renal failure.To prevent such damage,several interventions to prevent UTI recurrences have been tried.The most established and accepted prevention at present is low dose long-term antibiotic prophylaxis.However it has a risk of break through infections,adverse drug reactions and also the risk of developing antibiotic resistance.The search is therefore on-going to find a safer,effective and acceptable alternative.A recent meta-analysis did not support routine circumcision for normal boys with no risk factors.Vaccinium Macrocarpon(cranberry),commonly used against UTI in adult women,is also effective in reducing the number of recurrences and related antimicrobial use in children.Sodium pentosanpolysulfate,which prevents bacterial adherence to the uroepithelial cells in animal models,has shown conflicting results in human trials.When combined with antibiotic,Lactobacillus acidophilus(LA-5) and Bifidobacterium,by blocking the in vitro attachment of uropathogenic bacteria to uroepithelial cells,significantly reduce in the incidence of febrile UTIs.Deliberate colonization of the human urinary tract of patients with recurrent UTI with Escherichia-coli(E.coli) 83972 has resulted in subjective benefit and less UTI requiring treatment.The non-pathogenic E.coli isolate NU14 DeltawaaL is a candidate to develop liveattenuated vaccine for the treatment and prevention of acute and recurrent UTI.Diagnosing and treating dysfunctional elimination syndromes decrease the incidence of recurrent UTI.A meta-analysis found the lack of robust prospective randomized controlled trials limited the strength of the established guidelines for surgical management of vesicoureteral reflux.In conclusion,several interventions,other than antibiotic prophylaxis,for the prevention of recurrent UTI have been tried and,although showing some promise,they do not provide so far a definitive effective answer.Finding suitable alternatives still requires further high quality research of those seemingly promising interventions.展开更多
Objective: To evaluate Chinese medicine(CM) formula Bazheng Powder(八正散) as an alternative therapeutic option for female patients with recurrent urinary tract infection(RUTI). Methods: A randomized double-blinded tr...Objective: To evaluate Chinese medicine(CM) formula Bazheng Powder(八正散) as an alternative therapeutic option for female patients with recurrent urinary tract infection(RUTI). Methods: A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula(10 herbs) and antibiotics placebo for 4 weeks, or antibiotics for 1 week followed by 3 weeks of placebo and CM formula placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated. Results: A total 122 eligible patients were enrolled, with 61 cases in each group. The clinical cure rate by the intent-to-treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group(P>0.05). Bacteria were cleared from 88.5%(54/61) of patients in the CM group and 82.0%(50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1%(5/61) and 14.0(7/61) in the CM and antibiotics groups, respectively(P>0.05). Conclusion: CM formula Bazheng Powder is a good alternative option for RUTI treatment.(Registration No. NCT01745328)展开更多
文摘Urinary tract infection(UTI) is one of the most commonchildhood infections.Permanent renal cortical scarring may occur in affected children,especially with recurrent UTIs,leading to long-term complications such as hypertension and chronic renal failure.To prevent such damage,several interventions to prevent UTI recurrences have been tried.The most established and accepted prevention at present is low dose long-term antibiotic prophylaxis.However it has a risk of break through infections,adverse drug reactions and also the risk of developing antibiotic resistance.The search is therefore on-going to find a safer,effective and acceptable alternative.A recent meta-analysis did not support routine circumcision for normal boys with no risk factors.Vaccinium Macrocarpon(cranberry),commonly used against UTI in adult women,is also effective in reducing the number of recurrences and related antimicrobial use in children.Sodium pentosanpolysulfate,which prevents bacterial adherence to the uroepithelial cells in animal models,has shown conflicting results in human trials.When combined with antibiotic,Lactobacillus acidophilus(LA-5) and Bifidobacterium,by blocking the in vitro attachment of uropathogenic bacteria to uroepithelial cells,significantly reduce in the incidence of febrile UTIs.Deliberate colonization of the human urinary tract of patients with recurrent UTI with Escherichia-coli(E.coli) 83972 has resulted in subjective benefit and less UTI requiring treatment.The non-pathogenic E.coli isolate NU14 DeltawaaL is a candidate to develop liveattenuated vaccine for the treatment and prevention of acute and recurrent UTI.Diagnosing and treating dysfunctional elimination syndromes decrease the incidence of recurrent UTI.A meta-analysis found the lack of robust prospective randomized controlled trials limited the strength of the established guidelines for surgical management of vesicoureteral reflux.In conclusion,several interventions,other than antibiotic prophylaxis,for the prevention of recurrent UTI have been tried and,although showing some promise,they do not provide so far a definitive effective answer.Finding suitable alternatives still requires further high quality research of those seemingly promising interventions.
基金Supported by Chinese Academy of Traditional Chinese Medicine Joint Innovation Research Project(No.ZZ070808)Traditional Chinese Medicine Dominant Disease Clinical Research Project(No.CACMS08Y0016)Capital Featured Clinical Application and Promotion Project(No.Z151100004015132),China
文摘Objective: To evaluate Chinese medicine(CM) formula Bazheng Powder(八正散) as an alternative therapeutic option for female patients with recurrent urinary tract infection(RUTI). Methods: A randomized double-blinded trial was performed. Eligible female patients with RUTI were recruited from one hospital and two community health centers. By using a blocked randomization scheme, participants were randomized to receive a CM formula(10 herbs) and antibiotics placebo for 4 weeks, or antibiotics for 1 week followed by 3 weeks of placebo and CM formula placebo. Clinical cure rate and microbiological cure and recurrence after treatment were evaluated. Results: A total 122 eligible patients were enrolled, with 61 cases in each group. The clinical cure rate by the intent-to-treatment approach was 90.2% for the CM group and 82.0% for the antibiotics group(P>0.05). Bacteria were cleared from 88.5%(54/61) of patients in the CM group and 82.0%(50/61) in the antibiotics group. The recurrence rate in recovered patients at the 6-month follow-up was 9.1%(5/61) and 14.0(7/61) in the CM and antibiotics groups, respectively(P>0.05). Conclusion: CM formula Bazheng Powder is a good alternative option for RUTI treatment.(Registration No. NCT01745328)
