JWST Discoveries and the Hypersphere World-Universe Model: Transformative New Cosmology

Twenty-six years ago, a small committee report built upon earlier studies to articulate a compelling and poetic vision for the future of astronomy. This vision called for an infrared-optimized space telescope with an aperture of at least four meters. With the support of their governments in the US, Europe, and Canada, 20,000 people brought this vision to life as the 6.5-meter James Webb Space Telescope (JWST). The telescope is working perfectly, delivering much better image quality than expected [1]. JWST is one hundred times more powerful than the Hubble Space Telescope and has already captured spectacular images of the distant universe. A view of a tiny part of the sky reveals many well-formed spiral galaxies, some over thirteen billion light-years away. These observations challenge the standard Big Bang Model (BBM), which posits that early galaxies should be small and lack well-formed spiral structures. JWST’s findings are prompting scientists to reconsider the BBM in its current form. Throughout the history of science, technological advancements have led to new results that challenge established theories, sometimes necessitating their modification or even abandonment. This happened with the geocentric model four centuries ago, and the BBM may face a similar reevaluation as JWST provides more images of the distant universe. In 1937, P. Dirac proposed the Large Number Hypothesis and the Hypothesis of Variable Gravitational Constant, later incorporating the concept of Continuous Creation of Matter in the universe. The Hypersphere World-Universe Model (WUM) builds on these ideas, introducing a distinct mechanism for matter creation. WUM is proposed as an alternative to the prevailing BBM. Its main advantage is the elimination of the “Initial Singularity” and “Inflation”, offering explanations for many unresolved problems in Cosmology. WUM is presented as a natural extension of Classical Physics with the potential to bring about a significant transformation in both Cosmology and Classical Physics. Considering JWST’s discoveries, WUM’s achievements, and 87 years of Dirac’s proposals, it is time to initiate a fundamental transformation in Astronomy, Cosmology, and Classical Physics. The present paper is a continuation of the published article “JWST Discoveries—Confirmation of World-Universe Model Predictions” [2] and a summary of the paper “Hypersphere World-Universe Model: Digest of Presentations John Chappell Natural Philosophy Society” [3]. Many results obtained there are quoted in the current work without full justification;interested readers are encouraged to view the referenced papers for detailed explanations.

Theoretical Modeling of Luminous Efficacy for High-Power White Light-Emitting Diodes

The photometric characteristics of high-power white light-emitting diode （LED） devices are investigated. A theoretical model for the luminous efficacy o[ high-power white LED devices and LED systems is proposed. With the proposed theoretical model, the mechanism of the luminous efficacy decrease is explained. Meanwhile, the model can be used to estimate the luminous efficacy oF LEDs under general operation conditions, such as different operation temperatures and injection currents. The wide validity of the luminous efficacy model is experimentally verified through the measurements of different types of LEDs. The experimental results demonstrate a high estimation accuracy. The proposed models not only can be applied to estimate the LED photometric performance, but also is helpful for reliability research of LEDs.

基于太阳辐照度实时计算隧道洞外亮度的方法研究

为解决城市隧道运营过程中隧道洞外亮度L20(S)全天逐时变化差异大且实时获取困难的问题,结合3D打印隧道缩尺模型,提出以太阳辐照度为输入变量,将天空亮度、地面景物亮度耦合的L20(S)实时计算方法。以北京芦花路隧道为测量对象,利用隧道缩尺模型代替实际隧道探究地面景物亮度变化规律,建立地面景物亮度与太阳辐照度的量化回归模型;利用太阳辐照度将CIE模型、Perez模型的计算值与实测值进行对比验证,以误差较小、计算较简便的CIE模型作为天空亮度模型,其误差在晴天工况和阴天工况下分别为4.26%、6.11%。对比耦合后的L20(S)计算模型在不同季节、不同天气条件下的计算值与实测值,平均误差均在10%以内,表明该隧道洞外亮度实时计算方法在全季节、全气候条件下具有准确性和适用性。

基于维度情绪模型的智能化灯光交互镜面装置设计研究

探究智能家居场景中用户情绪与灯光效果的情感化交互设计方法。基于维度情绪模型,解析用户情绪对灯光色彩、灯光动态变化的偏好;基于深度学习技术,建立多模态情绪识别与维度情绪表示方法;通过设计智能化灯光交互镜面装置,实现用户情绪与灯光色彩、灯光动态变化的创新交互方式。构建了情感化的灯光交互设计方案,实现了一种实时对用户情绪做出反馈的智能化灯光交互镜面装置。提出了情绪识别与情感化灯光交互的设计方法,可以为情感化的智能家居产品设计提供实践经验与思路,展开情感化交互设计探索的新视角。

基于驾驶行为的快速路交织区发光标线效果评估

快速路交织区主动管控策略对提高快速路运行效率、改善行车环境、提升行车安全等具有重要意义。主动发光标线是一种新型道路交通安全主动管控设施,因其智能可控、虚实变换、应急预警等功能特点,越来越受到关注和逐步被推广应用。为探究发光标线这一新型道路标线在快速路交织区对行车安全的作用效果,从驾驶人角度出发,基于驾驶模拟试验,分析发光标线对驾驶行为的影响特征,评估发光标线作用效果。通过设计夜间环境下普通标线和发光标线两种驾驶模拟试验场景方案,获取驾驶行为数据,从行车安全性、舒适性和驾驶人操纵表现3方面选取速度标准差、横向偏移标准差、纵向加速度均方根值、加速度标准差、平均速度、油门功效6项指标构建评价指标体系。进一步分析各项指标在不同标线场景下的差异显著性及效应量水平,最后采用可拓物元方法构建综合评价模型,对比两种标线方案的作用效果。研究结果表明:发光标线对交织区及临近交织区路段驾驶行为特性具有较显著的影响,发光标线下驾驶人横向位置感知和操纵水平提升,车速调控能力提高,车辆行驶更加平稳。基于可拓物元模型综合评价结果表明,在快速路交织区及临近交织区路段发光标线作用效果均优于普通标线,有利于提升快速路交织区行车安全。

面向复杂地质目标的地震采集观测系统优化方法及应用

采集观测系统优化设计是提高地震资料质量和降低采集成本的一个重要手段。提高复杂地质目标陡坡带阴影区的反射能量是目前观测系统优化设计的一个难点。为此,提出了一种面向复杂地质目标的地震采集观测系统优化方法。首先,在三维模型上利用菲涅耳带半径,对高斯束照明能量重新优化,提高正演模拟的精度,提取各目的层面元接收能量和逆向照明能量。其次,根据不同地质目标和地表障碍物情况采用三种方法对观测系统进行优化:(1)基于目的层面元接收能量均匀性的炮点自动加密;(2)基于目的层逆向照明能量的炮点加密范围优化;(3)基于地表障碍物范围和目的层能量均匀性双重约束的炮点优化。将该方法用于胜利探区BS和G94北两个区块,有效提升了地震资料成像精度。

ADC图影像组学预测Luminal B型乳腺癌新辅助化疗疗效的初步研究

目的构建基于基线期全容积ADC图影像组学模型,并联合临床特征,构建临床-影像组学模型,探讨其在预测Luminal B型肿块样乳腺癌新辅助化疗后获得病理完全缓解的价值。方法搜集2016年1月~2020年6月期间经粗针穿刺活检证实的164例Luminal B型浸润性乳腺癌患者进行回顾性研究,并根据HER-2状态的不同,将Luminal B型乳腺癌分为HER-2阴性组和HER-2阳性组。患者在新辅助化疗前行3.0 T MRI检查,采用ITK-SNAP软件勾画肿瘤容积数据,A.K软件提取影像组学特征。对于提取到的组学特征,使用基于Python 3.6和Sklearn的开源软件FAE,使用上采样的技术对不均衡的样本进行扩增,对每个特征进行标准化,通过比较Pearson相关系数去除冗余特征,并且对比多种特征选择方法和不同分类器。对Luminal B(不区分HER-2状态)组及其亚组分别构建影像组学模型,并结合临床因素,构建临床-影像组学联合预测模型。使用10折交叉验证进行模型评估,选择验证集最高的模型作为最优模型。最后采用受试者操作特征(ROC)曲线分析模型的诊断效能,并用DeLong测试比较影像组学模型和临床-影像组学模型预测效能。结果164例Luminal B型患者中,17例(10.4%)新辅助化疗获得完全缓解(PCR),147例(89.6%)为非病理完全缓解(nPCR)。Luminal B(HER-2阴性)亚组为105例,PCR率为6.7%(7/105),Luminal B(HER-2阳性)亚组为59例,PCR率为16.9(10/59)。在Luminal B(不区分HER-2状态)组及Luminal B(HER-2阳性)亚组中,PCR组的肿瘤囊变坏死率均低于nPCR组,且两者之间的差异有统计学意义(P<0.05)。在Luminal B(不区分HER-2状态)组中,影像组学模型验证集曲线下面积(AUC)为0.709(95%CI:0.5766~0.8279),临床-影像组学模型验证集AUC为0.793(95%CI:0.6617~0.8996),DeLong测试P>0.05;在Luminal B(HER-2阳性)亚组中,影像组学模型验证集AUC为0.849(95%CI:0.7107~0.9630),临床-影像组学模型验证集AUC为0.890(95%CI:0.7956~0.9689),DeLong测试P>0.05;Luminal B(HER-2阴性)亚组的临床特征均无统计学意义,影像组学模型的验证集AUC为0.758(95%CI:0.5248~0.9580)。结论(1)基线期ADC图影像组学模型对Luminal B型乳腺癌新辅助化疗后获得病理完全缓解有一定预测价值,联合临床特征后预测效能有所提高,但无统计学意义;(2)基线期ADC图影像组学模型在预测Luminal B型不同亚组乳腺癌新辅助化疗后获得病理完全缓解方面有一定的价值,Luminal B(HER-2阳性)亚组预测效能优于Luminal B(HER-2阴性)亚组,Luminal B(HER-2阳性)亚组进一步联合临床特征后预测效能无明显提升。

Space luminous environment adaptability of missile-borne star sensor

To solve the problem of stray interference to star point target identification while a star sensor imaging to the sky, a study on space luminous environment adaptability of missile-borne star sensor was carried out. By Plank blackbody radiation law and some astronomic knowledge, irradiancies of the stray at the star sensor working height were estimated. By relative astrophysical and mathematics knowledge, included angles between the star sensor optical axis point and the stray at any moment were calculated. The calculation correctness was verified with the star map software of Stellarium. By combining the upper analysis with the baffle suppression effect, a real-time model for space luminous environment of missile-borne star sensor was proposed. By signal-noise rate （SNR） criterion, the adaptability of missile-borne star sensor to space luminous environment was studied. As an example, a certain type of star sensor was considered when imaging to the starry sky on June 22, 2011 （the Summer Solstice） and September 20, 2011 （August 23 of the lunar year, last quarter moon） in Beijing. The space luminous environment and the adaptability to it were simulated and analyzed at the star sensor working height. In each period of time, the stray suppression of the baffle is analyzed by comparing the calculated included angle between the star sensor optical axis point and the stray with the shielded provided by system index. When the included angle is larger than the shielded angle and less than 90~, the stray is restrained by the baffle. The stray effect on star point target identification is analyzed by comparing the irradiancy of 6 magnitude star with that of the stray on star sensor sensitization surface. When the irradiancy of 6 magnitude star is 5 times more than that of the stray, there is no effect on the star point target identification. The simulation results are identicat with the actual situation. The space luminous environment of the missile-borne star sensor can be estimated real-timely by this model. The adaptability of the star sensor to space luminous environment can be analyzed conveniently. A basis for determining the relative star sensor indexes, the navigation star chosen strategy and the missile launch window can be provided.

Hypersphere World-Universe Model: Basic Ideas

Hypersphere World-Universe Model (WUM) envisions Matter carried from the Universe into the World from the fourth spatial dimension by Dark Matter Particles (DMPs). Luminous Matter is a byproduct of Dark Matter (DM) self-annihilation. WUM introduces Dark Epoch (spanning from the Beginning of the World for 0.45 billion years) and Luminous Epoch (ever since for 13.77 billion years). Big Bang discussed in Standard Cosmology (SC) is, in our view, transition from Dark Epoch to Luminous Epoch due to Rotational Fission of Overspinning DM Supercluster’s Cores and self-annihilation of DMPs. WUM solves a number of physical problems in SC and Astrophysics through DMPs and their interactions: Angular Momentum problem in birth and subsequent evolution of Galaxies and Extrasolar systems;Fermi Bubbles—two large structures in gamma-rays and X-rays above and below Galactic center;Coronal Heating problem in solar physics—temperature of Sun’s corona exceeding that of photosphere by millions of degrees;Cores of Sun and Earth rotating faster than their surfaces;Diversity of Gravitationally-Rounded objects in Solar system and their Internal Heating. Model makes predictions pertaining to Rest Energies of DMPs, proposes New Type of their Interactions. WUM reveals Inter-Connectivity of Primary Cosmological Parameters and calculates their values, which are in good agreement with the latest results of their measurements.

利用生物信息学分析开发luminal型乳腺癌自噬相关基因预后模型

目的建立基于大规模自噬相关基因的luminal型乳腺癌预后预测模型。方法利用TCGA数据库乳腺癌数据,分别筛选luminal型与非luminal型乳腺癌、癌旁组织中差异表达的自噬相关基因。单因素和多因素Cox回归建立luminal型乳腺癌自噬相关基因预后模型。Kaplan-Meier曲线和生存依赖的受试者工作特征曲线评估预后模型的准确性。结果基于差异表达自噬相关基因,建立了一个3基因(BAG1、CD46、DIRAS3)预后模型预测luminal型乳腺癌患者总生存期。3年、5年和10年的曲线下面积分别为0.708、0.752和0.837。结论 3基因预后模型可以有效预测luminal型乳腺癌患者预后,或许今后可为luminal型乳腺癌的临床治疗提供决策依据。

Hypersphere World-Universe Model

Dirac’s themes were the unity and beauty of Nature. He identified three revolutions in modern physics: Relativity, Quantum Mechanics and Cosmology. In his opinion: “The new cosmology will probably turn out to be philosophically even more revolutionary than relativity or the quantum theory, perhaps looking forward to the current bonanza in cosmology, where precise observations on some of the most distant objects in the universe are shedding light on the nature of reality, on the nature of matter and on the most advanced quantum theories” [Farmelo, G. (2009) The Strangest Man. The Hidden Life of Paul Dirac, Mystic of the Atom. Basic Books, Britain, 661 p]. In 1937, Paul Dirac proposed the Large Number Hypothesis and the Hypothesis of the variable gravitational “constant”;and later added the notion of continuous creation of Matter in the World. The developed Hypersphere World-Universe Model (WUM) follows these ideas, albeit introducing a different mechanism of matter creation. In this paper, we show that WUM is a natural continuation of Classical Physics and it can already serve as a basis for a New Cosmology proposed by Paul Dirac.

World-Universe Model—Alternative to Big Bang Model

This manuscript provides a comparison of the Hypersphere World-Universe Model (WUM) with the prevailing Big Bang Model (BBM) of the Standard Cosmology. The performed analysis of BBM shows that the Four Pillars of the Standard Cosmology are model-dependent and not strong enough to support the model. The angular momentum problem is one of the most critical problems in BBM. Standard Cosmology cannot explain how Galaxies and Extra Solar systems obtained their substantial orbital and rotational angular momenta, and why the orbital momentum of Jupiter is considerably larger than the rotational momentum of the Sun. WUM is the only cosmological model in existence that is consistent with the Law of Conservation of Angular Momentum. To be consistent with this Fundamental Law, WUM discusses in detail the Beginning of the World. The Model introduces Dark Epoch (spanning from the Beginning of the World for 0.4 billion years) when only Dark Matter Particles (DMPs) existed, and Luminous Epoch (ever since for 13.8 billion years). Big Bang discussed in Standard Cosmology is, in our view, transition from Dark Epoch to Luminous Epoch due to Rotational Fission of Overspinning Dark Matter (DM) Supercluster’s Cores. WUM envisions Matter carried from the Universe into the World from the fourth spatial dimension by DMPs. Ordinary Matter is a byproduct of DM annihilation. WUM solves a number of physical problems in contemporary Cosmology and Astrophysics through DMPs and their interactions: Angular Momentum problem in birth and subsequent evolution of Galaxies and Extrasolar systems—how do they obtain it;Fermi Bubbles—two large structures in gamma-rays and X-rays above and below Galactic center;Diversity of Gravitationally-Rounded Objects in Solar system;some problems in Solar and Geophysics [1]. WUM reveals Inter-Connectivity of Primary Cosmological Parameters and calculates their values, which are in good agreement with the latest results of their measurements.

Hypersphere World-Universe Model: Evolution of the World

The main objective of this paper is to discuss the Evolution of a 3D Finite World (that is a Hypersphere of a 4D Nucleus of the World) from the Beginning up to the present Epoch in frames of World-Universe Model (WUM). WUM is the only cosmological model in existence that is consistent with the Law of Conservation of Angular Momentum. To be consistent with this Fundamental Law, WUM introduces Dark Epoch (spanning from the Beginning of the World for 0.45 billion years) when only Dark Matter (DM) Macroobjects (MOs) existed, and Luminous Epoch (ever since for 13.77 billion years) when Luminous MOs emerged due to Rotational Fission of Overspinning DM Superclusters’ Cores and self-annihilation of Dark Matter Particles (DMPs). WUM envisions that DM is created by the Universe in the 4D Nucleus of the World. Dark Matter Particles (DMPs) carry new DM into the 3D Hypersphere World. Luminous Matter is a byproduct of DMPs self-annihilation. By analogy with 3D ball, which has two-dimensional sphere surface (that has surface energy), we can imagine that the 3D Hypersphere World has a “Surface Energy” of the 4D Nucleus. WUM solves a number of physical problems in contemporary Cosmology and Astrophysics through DMPs and their interactions: Angular Momentum problem in birth and subsequent evolution of Galaxies and Extrasolar systems—how do they obtain it;Fermi Bubbles—two large structures in gamma-rays and X-rays above and below Galactic center;Missing Baryon problem related to the fact that the observed amount of baryonic matter did not match theoretical predictions. WUM reveals Inter-Connectivity of Primary Cosmological Parameters and calculates their values, which are in good agreement with the latest results of their measurements. In 2013, WUM predicted the values of the following Cosmological parameters: gravitational, concentration of intergalactic plasma, and the minimum energy of photons, which were experimentally confirmed in 2015-2018. “The Discovery of a Supermassive Compact Object at the Centre of Our Galaxy” (Nobel Prize in Physics 2020) made by Prof. R. Genzel and A. Ghez is a confirmation of one of the most important predictions of WUM in 2013: “Macroobjects of the World have cores made up of the discussed DM particles. Other particles, including DM and baryonic matter, form shells surrounding the cores”.

Luminal型乳腺癌胞膜蛋白相关预后模型的构建与验证

目的Luminal型乳腺癌是最常见的一种乳腺癌分子亚型,构建有效的预后模型与寻找有效的治疗靶点对luminal型乳腺癌患者有重要的临床意义。胞膜蛋白(PMPs)在肿瘤的发生发展中发挥着重要作用,本研究着力于构建PMPs相关预后模型,并在此基础上探索可能的治疗靶点。方法从TCGA数据库中下载luminal型乳腺癌的转录组测序数据及临床信息作为训练集,通过筛选差异表达PMPs基因,运用预后相关基因构建PMPs预后模型。同时从GEO数据库中下载相关数据,以验证本研究中所构建模型的效能。结果在建构的预后模型中,ADRA1B、CD99L2、EZR、IYD、RGS9BP和SLC16A2基因高表达与预后负相关,而DUS1L、KIT、MS4A1、PI3和SUSD2基因的表达则与预后正相关。通过所构建的模型计算出各患者的风险评分,并结合其总生存时间和生存状态,发现高风险组患者的预后均较差。结论从PMPs预后基因中筛选出11个可用于建立luminal型乳腺癌预后模型的最佳基因,这个模型可能为临床上luminal型乳腺癌患者提供有效的预后预测。

JWST Discoveries—Confirmation of World-Universe Model Predictions

In 1937, P. Dirac proposed the Large Number Hypothesis and Hypothesis of Variable Gravitational Constant [1], and later added notion of Continuous Creation of Matter in the World [2]. Developed Hypersphere World-Universe Model (WUM) follows these ideas, albeit introducing different mechanism of Matter creation. Most direct observational evidence of validity of WUM are: 1) Microwave Background Radiation and Intergalactic Plasma speak in favor of existence of Medium;2) Laniakea Supercluster with binding mass ~1017M⊙ is home to Milky Way (MW) galaxy and ~105 other nearby galaxies, which did not start their movement from Initial Singularity (see Figure 1);3) MW is gravitationally bounded with Virgo Supercluster (VSC) and has Orbital Angular Momentum calculated based on distance of 65 Mly from VSC and orbital speed of ~400 km·s-1, which far exceeds rotational angular momentum of MW;4) Mass-to-light ratio of VSC is ~300 times larger than that of Solar ratio. Similar ratios are obtained for other superclusters (see Figure 2). These ratios are main arguments in favor of the presence of tremendous amounts of Dark Matter (DM) in the World. JWST discoveries confirm the most important predictions of WUM in 2018: 1) Absolute Age of World is 14.22 Gyr;2) Dark Epoch (spanning for Laniakea Supercluster (LSC) from the Beginning of World for 0.45 Gyr) when only DM Macroobjects (MOs) form and evolve;3) Luminous Epoch (ever since, 13.77 Gyr for LSC) when Luminous MOs (superclusters, galaxies, extrasolar systems, etc.) emerge;4) Transition from Dark Epoch to Luminous Epoch is due to Explosive Rotational Fission of Overspinning (surface speed at equator exceeding escape velocity) DM Supercluster’s Cores and self-annihilation of DM Particles (DMPs);5) MOs of World form from top (Superclusters) down to Galaxies and Extrasolar systems in parallel around different Cores made up of different DMPs;6) 3D Finite Boundless World presents a Patchwork Quilt of different Luminous Superclusters, which emerged in different places of World at different Cosmological times.

基于雾气分布的大气光幕估计去雾算法

由于雾霾天气下空气中介质粒子的影响,成像设备所捕获的图像通常会存在对比度低、色彩丢失等问题。针对这些问题,本文提出一种基于雾气分布的大气光幕估计去雾算法。首先,将Fade方法提取的初始雾气分布图像进行阈值分割与细化处理得到较为准确的雾气分布信息。其次,通过分析景深、雾浓度、大气光幕之间的关系建立大气光幕估计模型。最后,通过亮度权重图与自适应大气光阈值选取大气光区域,获取较为准确的大气光,进而恢复退化场景。实验与结果表明,本文算法恢复的图像清晰自然,去雾效果彻底,并且能够保留图像中的细节信息。

Luminal B型乳腺癌预后相关基因模型的建立与临床应用

目的基于Luminal B型乳腺癌的预后高度差异性建立预后风险评分模型,指导并预测Luminal B型乳腺癌患者预后生存能力。方法选取癌症基因组图谱(TCGA)数据库中194例Luminal B型乳腺癌数据集和119例癌旁正常乳腺组织进行差异基因表达分析。结合生物信息学方法,通过差异基因表达分析得到与预后相关的基因组,利用最小绝对收缩和选择算子(least absolute shrinkage and selection operator,LASSO)Cox回归分析构建预后模型,即对该基因组在正常乳腺组织与乳腺癌组织的差异表达构建与预后相关的风险模型,并对模型的临床应用进行验证。同时探讨该风险模型可能触发的分子机制。免疫组织化学法检测2015-01-01-2022-12-31南昌市人民医院乳腺中心64例三阳性乳腺癌组织相关基因的表达。结果利用LASSO Cox回归分析构建预后模型,当纳入11个基因时风险效能最高,数据集验证其95%置信区间差异有统计学意义,其1、3和5年的受试者工作特征(ROC)曲线下面积分别为0.975、0.829和0.885,且高危组预后较差,差异有统计学意义,均P<0.05。单因素Cox回归分析结果发现,风险评分与预后相关,HR=5.72,95%CI为3.34~9.81,P<0.001;多因素Cox回归分析结果显示,风险评分(HR=8.91,95%CI为4.23~18.72,P<0.001)和年龄(HR=1.03,95%CI为1.00~1.06,P=0.047)与预后相关。列线图直观有效地展示了不同变量对预后结局的影响,以及纳入与预后相关的因素构建列线图模型,评估列线图模型的C-index值结果显示,模型C-index值为0.84,95%CI为0.75~0.92,P<0.001;富集通路分析结果显示,高风险组显著富集在可变剪接氨酰-tRNA合成等通路,低风险组富集在细胞因子-细胞因子受体、原发性免疫缺陷和趋化因子受体等信号通路;肿瘤微环境与风险评估相关性显示,大部分免疫细胞在低风险组中得分高。免疫组织化学检测结果显示,ERCC6L、COL11A1、NEURL1、CXCL9、ROPN1、PPP1R16B和PIGR在三阳性乳腺癌组织标本中呈阳性表达,TLCD1、ABCA10、TMEM273和ARHGAP40呈弱阳性表达。结论构建的风险模型评分可为临床医生提供定量方法来预测预后,可以作为Luminal B型乳腺癌患者预后的生物标志物。

晴朗无云天空光谱辐射的近似计算模型

利用大气光学质量和大气气溶胶光学厚度的经验公式,由H ITRAN数据库获得大气分子谱线参数,基于辐射传输方程,给出了晴朗无云天空光谱辐射的近似计算模型。根据该近似计算模型对晴朗无云天空光谱辐射亮度进行的计算结果表明:天空光谱辐射亮度曲线上存在明显的O2和H2O吸收线;晴朗无云天空辐射的光谱分布偏蓝,天空亮度主要集中在短波段部分;太阳角小的天空光谱亮度出现“红移”现象;由于大气厚度变大,近地平的天空辐射亮度较大。

道路照明阈限亮度差简化计算模型

为了解决现行道路照明可见度计算过程中阈限亮度差的计算过于复杂的问题,基于ANSI/IESNA RP-8-00规范中阈限亮度实验的计算模型,利用定值刺激法进行阈限对比实验和根据韦伯—费昔勒定律进行理论推导,分别得到了简化的阈限亮度差计算模型。为了使阈限亮度差计算模型更符合道路照明的实际情况,给出了用于修正模型的负对比修正系数、识别时间修正系数和年龄修正系数。分别利用这2个模型和RP-8-00中的模型计算了某条件下的道路照明可见度,结果表明,用这2个简化模型的计算得到的结果与用RP-8-00中的模型计算得到的结果吻合。

基于ST-CSLBP的混合时空背景建模算法

针对背景建模方法对场景光照变化较为敏感,提出融合时间预测和空域纹理信息设计全新的时空-对称ST-CSLBP算子,构建基于ST-CSLBP直方图的混合时空背景模型,融合时域分布统计法和空域背景各自的优势,以同时适应长时光照以及短时的光照变化。实验表明,该算法与现有背景建模算法相比,具有较好的准确率和检索率。